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http://dx.doi.org/10.1016/j.jiec.2018.06.017

Agglomeration of human dermal fibroblasts with ECM mimicking nano-fragments and their effects on proliferation and cell/ECM interactions  

Ahmad, Taufiq (Department of Bioengineering, Hanyang University)
Shin, Young Min (Department of Bioengineering, Hanyang University)
Lee, Jinkyu (Department of Bioengineering, Hanyang University)
Shin, Hyeok Jun (Department of Bioengineering, Hanyang University)
Perikamana, Sajeesh Kumar Madhurakart (Department of Bioengineering, Hanyang University)
Shin, Heungsoo (Department of Bioengineering, Hanyang University)
Publication Information
Journal of Industrial and Engineering Chemistry / v.67, no., 2018 , pp. 80-91 More about this Journal
Abstract
Here, we engineered spheroids by using ECM mimicking nano-fragments (NFs) with fibroblasts and investigated their effect on proliferation and cell/ECM interactions. NF incorporation resulted in formation of a stable spheroid, which improved proliferation and viability of cells by assisting oxygen transport confirmed by LOX-1 staining. In addition, hypoxic and apoptotic genes were significantly downregulated in spheroids with PD-NFs. Furthermore, ECM and cell junction proteins were highly expressed. Overall, our findings suggest that incorporation of NFs within spheroids for assembly with various cell types can be an alternative approach for 3D cell culture in many applications.
Keywords
Nano-fragment (NF); NF-spheroids; Hybrid spheroids; Composite spheroid; 3D culture; Polydopamine; ECM;
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1 F. Guilak, D.M. Cohen, B.T. Estes, J.M. Gimble, W. Liedtke, C.S. Chen, Cell Stem Cell 5 (2009) 17.   DOI
2 Y.-P. Lo, Y.-S. Liu, M.G. Rimando, J.H.-C. Ho, K.-h. Lin, O.K. Lee, Sci. Rep. 6 (2016) 21253.   DOI
3 I.A. Janson, A.J. Putnam, J. Biomed. Mater. Res. A 103 (2015) 1246.   DOI
4 R. Edmondson, J.J. Broglie, A.F. Adcock, L. Yang, Assay Drug Dev. Technol. 12 (2014) 207.   DOI
5 D. Antoni, H. Burckel, E. Josset, G. Noel, Int. J. Mol. Sci. 16 (2015) 5517.   DOI
6 S.L. Chia, C.Y. Tay, M.I. Setyawati, D.T. Leong, Small 11 (2015) 702.   DOI
7 C.L. Rettinger, A.B. Fourcaudot, S.J. Hong, T.A. Mustoe, R.G. Hale, K.P. Leung, Cell Tissue Res. 358 (2014) 395.   DOI
8 V. Mironov, R.P. Visconti, V. Kasyanov, G. Forgacs, C.J. Drake, R.R. Markwald, Biomaterials 30 (2009) 2164.   DOI
9 X. Cui, Y. Hartanto, H. Zhang, J. Royal Soc. Interface 14 (2017) 20160877.   DOI
10 K. Mineda, J. Feng, H. Ishimine, H. Takada, S. Kuno, K. Kinoshita, K. Kanayama, H. Kato, T. Mashiko, I. Hashimoto, Stem Cells Transl. Med. 4 (2015) 1511.   DOI
11 M.L. Skiles, S. Sahai, L. Rucker, J.O. Blanchette, Tissue Eng. Part A 19 (2013) 2330.   DOI
12 G. Mehta, A.Y. Hsiao, M. Ingram, G.D. Luker, S. Takayama, J. Control. Release 164 (2012) 192.   DOI
13 Z. Cesarz, K. Tamama, Stem Cells Int. 2016 (2015).
14 D. Loessner, K.S. Stok, M.P. Lutolf, D.W. Hutmacher, J.A. Clements, S.C. Rizzi, Biomaterials 31 (2010) 8494.   DOI
15 F. Gattazzo, A. Urciuolo, P. Bonaldo, Biochim. Biophys. Acta Gen. Subj. 1840 (2014) 2506.   DOI
16 P. Bajaj, R.M. Schweller, A. Khademhosseini, J.L. West, R. Bashir, Annu. Rev. Biomed. Eng. 16 (2014) 247.   DOI
17 E. Knight, S. Przyborski, J. Anat. 227 (2015) 746.   DOI
18 E. Fennema, N. Rivron, J. Rouwkema, C. van Blitterswijk, J. de Boer, Trends Biotechnol. 31 (2013) 108.   DOI
19 V. van Duinen, S.J. Trietsch, J. Joore, P. Vulto, T. Hankemeier, Curr. Opin. Biotechnol. 35 (2015) 118.   DOI
20 A. Sachar, T.A. Strom, M.J. Serrano, M.D. Benson, L.A. Opperman, K.K. Svoboda, X. Liu, J. Biomed. Mater. Res. A 100 (2012) 3029.
21 S. Bosi, R. Rauti, J. Laishram, A. Turco, D. Lonardoni, T. Nieus, M. Prato, D. Scaini, L. Ballerini, Sci. Rep. (Nat. Publ. Group) 5 (2015) 9562.
22 V. Krishnan, L.A. Shuman, D.M. Sosnoski, R. Dhurjati, E.A. Vogler, A.M. Mastro, J. Cell. Physiol. 226 (2011) 2150.   DOI
23 Y.M. Shin, Y.B. Lee, H. Shin, Coll. Surf. B: Biointerfaces 87 (2011) 79.   DOI
24 J. Lee, T. Ahmad, M.S. Lee, H. Yang, D.-G. Kim, K. Kim, B. Kwon, H. Shin, Tissue Eng. (2017).
25 Y. Zhu, Z. Mao, C. Gao, RSC Adv. 3 (2013) 2509.   DOI
26 T.G. Kim, T.G. Park, Macromol. Rapid Commun. 29 (2008) 1231.   DOI
27 R. Ravichandran, J.R. Venugopal, S. Sundarrajan, S. Mukherjee, S. Ramakrishna, Biomaterials 33 (2012) 846.   DOI
28 S. Nirasay, A. Badia, G. Leclair, J.P. Claverie, I. Marcotte, Materials 5 (2012) 2621.   DOI
29 R. Luo, L. Tang, S. Zhong, Z. Yang, J. Wang, Y. Weng, Q. Tu, C. Jiang, N. Huang, A.C.S Appl. Mater. Interfaces 5 (2013) 1704.   DOI
30 S.K. Madhurakkat Perikamana, J. Lee, T. Ahmad, Y. Jeong, D.-G. Kim, K. Kim, H. Shin, A.C.S Appl. Mater. Interfaces 7 (2015) 8798.   DOI
31 S.K. Madhurakkat Perikamana, J. Lee, Y.B. Lee, Y.M. Shin, E.J. Lee, A.G. Mikos, H. Shin, Biomacromolecules 16 (2015) 2541.   DOI
32 G. Camussi, M.C. Deregibus, S. Bruno, V. Cantaluppi, L. Biancone, Kidney Int. 78 (2010) 838.   DOI
33 H.H. Yoon, S.H. Bhang, T. Kim, T. Yu, T. Hyeon, B.S. Kim, Adv. Funct. Mater. 24 (2014) 6455.   DOI
34 R.A. Rossello, D.H. Kohn, Commun. Integr. Biol. 3 (2010) 53.   DOI
35 D.J. Richards, Y. Tan, R. Coyle, Y. Li, R. Xu, N. Yeung, A. Parker, D.R. Menick, B. Tian, Y. Mei, Nano Lett. 16 (2016) 4670.   DOI
36 R.A. Rossello, Z. Wang, E. Kizana, P.H. Krebsbach, D.H. Kohn, Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 13219.   DOI
37 C. Frantz, K.M. Stewart, V.M. Weaver, J. Cell Sci. 123 (2010) 4195.   DOI
38 M.W. Bobbie, S. Roy, K. Trudeau, S.J. Munger, A.M. Simon, S. Roy, Investig. Ophthalmol. Vis. Sci. 51 (2010) 3758.   DOI
39 S.S. Ho, K.C. Murphy, B.Y. Binder, C.B. Vissers, J.K. Leach, Stem Cells Transl. Med. 5 (2016) 773.   DOI
40 S. Tajima, Y. Tabata, J. Tissue Eng. Regen. Med. 7 (2013) 801.
41 T.-T. Zhu, W.-F. Zhang, P. Luo, Z.-X. Qian, F. Li, Z. Zhang, C.-P. Hu, Life Sci. 174 (2017) 35.   DOI
42 G. Kagiya, R. Ogawa, F. Hyodo, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo, S. Tominaga, M. Murata, Y. Tanaka, Mol. Ther. Methods Clin. Dev. 3 (2016) 16009.   DOI
43 X. Yin, B.E. Mead, H. Safaee, R. Langer, J.M. Karp, O. Levy, Cell Stem Cell 18 (2016) 25.   DOI
44 M. Ravi, V. Paramesh, S. Kaviya, E. Anuradha, F. Solomon, J. Cell. Physiol. 230 (2015) 16.   DOI
45 Y. Lei, D.V. Schaffer, Proc. Natl. Acad. Sci. U. S. A. 110 (2013) E5039.   DOI
46 L. Seguin, J.S. Desgrosellier, S.M. Weis, D.A. Cheresh, Trends Cell Biol. 25 (2015) 234.   DOI
47 F.G. Giancotti, E. Ruoslahti, Science 285 (1999) 1028.   DOI
48 T.H. Qazi, D.J. Mooney, G.N. Duda, S. Geissler, Biomaterials (2017).
49 G. Turturici, R. Tinnirello, G. Sconzo, F. Geraci, Am. J. Physiol. Cell Physiol. 306 (2014) C621.   DOI
50 S. Breslin, L. O'Driscoll, Drug Discov. Today 18 (2013) 240.   DOI
51 S. Guven, P. Chen, F. Inci, S. Tasoglu, B. Erkmen, U. Demirci, Trends Biotechnol. 33 (2015) 269.   DOI
52 Y. Wang, L. Zhao, C. Tian, C. Ma, J. Wang, Anal. Methods 7 (2015) 10040.   DOI
53 Y. Tan, D. Richards, R. Xu, S. Stewart-Clark, S.K. Mani, T.K. Borg, D.R. Menick, B. Tian, Y. Mei, Nano Lett. 15 (2015) 2765.   DOI
54 J. Park, Y.S. Kim, S. Ryu, W.S. Kang, S. Park, J. Han, H.C. Jeong, B.H. Hong, Y. Ahn, B.S. Kim, Adv. Funct. Mater. 25 (2015) 2590.   DOI
55 M. Yamada, A. Hori, S. Sugaya, Y. Yajima, R. Utoh, M. Yamato, M. Seki, Lab Chip 15 (2015) 3941.   DOI
56 R.L. Carpenedo, A.M. Bratt-Leal, R.A. Marklein, S.A. Seaman, N.J. Bowen, J.F. McDonald, T.C. McDevitt, Biomaterials 30 (2009) 2507.   DOI
57 A.M. Bratt-Leal, R.L. Carpenedo, M.D. Ungrin, P.W. Zandstra, T.C. McDevitt, Biomaterials 32 (2011) 48.   DOI
58 P.R. Baraniak, M.T. Cooke, R. Saeed, M.A. Kinney, K.M. Fridley, T.C. McDevitt, J. Mech. Behav. Biomed. Mater. 11 (2012) 63.   DOI
59 W. Asghar, R. El Assal, H. Shafiee, S. Pitteri, R. Paulmurugan, U. Demirci, Mater. Today 18 (2015) 539.   DOI
60 C.C. Ahrens, Z. Dong, W. Li, Acta Biomater. (2017).
61 Y.M. Shin, W.-G. La, M.S. Lee, H.S. Yang, Y.-M. Lim, J. Mater. Chem. B 3 (2015) 8375.   DOI
62 T. Ahmad, J. Lee, Y.M. Shin, H.J. Shin, S.K. Madhurakat Perikamana, S.H. Park, S. W. Kim, H. Shin, Acta Biomater. 64 (2017) 161.   DOI
63 Y.M. Shin, T.G. Kim, J.-S. Park, H.-J. Gwon, S.I. Jeong, H. Shin, K.-S. Kim, D. Kim, M.-H. Yoon, Y.-M. Lim, J. Mater. Chem. B 3 (2015) 2732.   DOI