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The cholesterol Accumulation decreasing effect of Porpbyra yezoensis extract in kidney of Murine with hypercholesterolemia induced by Triton WR-1339 (Triton WR-1339에 의한 고콜레스테롤증 유발시 해조류 김 추출물의 신장내 콜레스테롤 축적 감소효과)

  • Park, In-Sick;Ahn, Sang-Hyun;Chang, Jae-Man;Kim, Jin-Tack;Kim, Ho-Hyun
    • The Journal of Dong Guk Oriental Medicine
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    • v.7 no.1
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    • pp.43-51
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    • 1998
  • Renal tissues of ICR mouse were intraperitoneally injeced with Porpbyra yezoensis extract(PE) after Triton WR-1339(TX) injection were observed to investigate the cholesterol accumulation decreasing effect of PE. The renal tissues were obtained at hour 24, 48, and 72 after TX injection that were fixed in fromol-calcium solution and were cryocut. The tissue stained by sudan black B for lipid and perchloric acid-naphthoquinone method for cholesterol. The parietal layer of Bowman's capsule is swelled as cuboidal type at hour 48 after TX injection and the lipid blot and cholesterol particle were noticeably increased in glomerulus and these appeared in convoluted tubule, collecting tubule, and Helen's loop. In PE treated group, the lpid blot and cholesterol particle were considerably decreased in glomerulus than TX group. As results indicated that the accumulation of lipid including cholesterol caused by TX injection were mitigated in renal tissues by the antihypercholesterolemia effect of PE.

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Functional Analysis of Fibroblastic Reticular Cells Derived from Mouse Lymph Node via Bidirectional Crosstalk with T Cells (T세포와 양방향 작용을 통한 마우스 림프절로부터 분리된 fibroblastic reticular cell의 기능적 분석)

  • Park, Sung Hee;Lee, Jong-Hwan
    • Journal of Life Science
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    • v.23 no.10
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    • pp.1199-1208
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    • 2013
  • Fibroblastic reticular cells (FRCs) form the structural backbone of the T zone provide a guidance path for immigrating T cells in the lymph node (LN). FRCs may contribute directly to developing T-cell biology in the LN and allow analyses of fundamental aspects of FRC biology related to T cells. FRCs inhibited T-cell apoptosis, and FRC culture supernatants strongly induced the expression of Bcl-xL in T cells against doxorubicin. Coculture of FRC and T cells resulted in rearrangements of the actin cytoskeleton, as well as global changes in the morphology of the FRCs. In addition, when cocultured, the T cells adhered to the FRC monolayer, and the membrane intercellular adhesion molecule (ICAM)-1 was slightly increased by day-dependent manner. In contrast, the expression of soluble ICAM-1 was dramatically increased in a day-dependent manner. Several chemokines, such as CCL5, CXCL1, CXCL5, CXCL16, CCL8, CXCL13, and ICAM-1, and MMPs were expressed in FRCs sensed by tumor necrosis factor (TNF) families. Nuclear factor kappa B ($NF{\kappa}B$)-RelA of the $NF{\kappa}B$ canonical pathway was translocated into FRC nuclear by $TNF{\alpha}$. In contrast, p52 proteolyzed from p100, a counterpart of RelB of the noncanonical $NF{\kappa}B$ pathway, accumulated in the peripheral FRC nucleus by agonistic anti-$LT{\beta}R$ antibody. In summary, we propose a model in which FRCs engage in bidirectional crosstalk to increase the efficiency of T-cell biology. This cooperative feedback loop may help to maintain tissue integrity and function during immune responses.

밀배아 분말첨가가 식빵의 품질특성에 미치는 영향

  • 김래영;전순실;서재수
    • Proceedings of the Korean Journal of Food and Nutrition Conference
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    • 2000.12a
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    • pp.51-51
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    • 2000
  • 식생활의 서구화로 제빵 산업이 발달하고, 빵을 주식으로 하는 인구가 늘고 있다 또한 기존의 재료보다는 기능성이 첨가된 부재료를 활용한 건강 지향적인 식품의 수요가 증가하고 있는 추세이다. 최근 밀배아의 용도 다양화를 위하여 팔은 연구가 진행되고 있으며, 상업적으로 이용되고 있다. 소맥의 제분과정에서 부산물로 얻어지는 밀배에는 식물 중에서 가장 많은 천연 비타민 E 복합체가 이상적인 상태로 함유되어 있다. 밀배아에 들어 있는 비타민 E는 천연 비타민 E 복합체와 합성 비타민 E로 구분되어진다. 천연비타민E는 8가지 이성체를 가진 자연 비타민 E를 말하며, 4종류의($\alpha$$\beta$${\gamma}$$\delta$)의 토코페롤과 4종의 토코페롤의 복합체이다. 비타민 E는 사람을 포함한 고등동물에 필수적인 영양소로 식물성기름, 곡류, 배아 등에 많이 들어 있으며, 여러 이성질체중 $\alpha$-토코페롤이 체내에서 가장 생물학적 활성이 큰 것으로 알려졌으며, 생체막조직에서 인지질의 천연항산화제 역할을 하여 체내대사를 정상으로 유지하는데 큰 기능을 하는 것으로 보고되고 있다. 우리나라에서 식용으로 소비되는 밀은 거의가 수입에 의존하고 있으며, 밀배아는 거의 전량이 가축의 사료용으로 사용되고 있고 근래에 와서는 배아유, 배아떡, 복합 조미료, 쿠키, 배아를 첨가한 국수 등에 이용되고 있다. 따라서 본 실험에서는 식빵제조시 밀배아 분말을 0, 2, 4, 6, 8, 10%씩 첨가하여 기능성 식빵을 제조하였을 때의 반죽의 물성, 호화특성을 살펴보고 빵으로 제조하였을 때의 식빵의 품질 특성으로서 1차 발효 손실률, 굽기 손실률, 부피, 질감, 노화도, 관능적 특성 및 mould-free shelf life를 측정하였다.te, ferric citrate가 유제품에 사용하기에 적합한 것으로 나타났다. 생이용성을 평가하기 위하여 우유에서 low molecular weight components(ILC)를 분리하고 철분과 복합체를 형성시킨 다음, 철분 결핍된 쥐의 소장에서 loop을 형성시켜 ILC-철분 복합체를 injection하여 철분 흡수도를 조사하였다. Ferrous lactate 100ppm에서 약 25.6%흡수되었고 ferric citrate 100ppm은 24.7%, ferrous sulfate는 19.7%흡수되었다. ILC를 첨가하지 않은 100ppm 철분염 용액은 ferrous sulfate를 제외하고는 흡수도가 감소되었다. 철분 결핍된 쥐에게 gavage 방법에 의하여 철분강화우유를 투여하였을 때 철분 25ppm 시료에서는 ferrous sulfate가 12.5%로 가장 높았고 ferrous lactate는 8.1%, ferric citrate는 6.5% 흡수되었다. 철분 100ppm수준에서는 흡수율이 낮아져 ferrous sulfate는 25ppm 시료보다 절반이하 수준이었다. Ferric citrate는 차이가 거의 없었으며 ferrous lactate는 70%수준이었다. 이상의 결과에서 철분강화우유에 사용하기 적합한 철분염은 ferrous lactate, ferric citrate였는데 특히 ferrous lactate는 제품의 이화학적 품질, 생이용성 측면 모두에서 가장 좋은 것으로 나타났다.다 높았으며, 1회당 평균 8.1$\pm$5.1개의 난포란을 회수하였다. investigation can be separated into sampling and analytical uncertainties, it can be used as a criterion where the resources for the inves

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A New PMU (parametric measurement unit) Design with Differential Difference Amplifier (차동 차이 증폭기를 이용한 새로운 파라메터 측정기 (PMU) 설계)

  • An, Kyung-Chan;Kang, Hee-Jin;Park, Chang-Bum;Lim, Shin-Il
    • Journal of Korea Society of Industrial Information Systems
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    • v.21 no.1
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    • pp.61-70
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    • 2016
  • This paper describes a new PMU(parametric measurement unit) design technique for automatic test equipment(ATE). Only one DDA(differential difference amplifier) is used to force the test signals to DUT(device under test), while conventional design uses two or more amplifiers to force test signals. Since the proposed technique does not need extra amplifiers in feedback path, the proposed PMU inherently guarantees stable operation. Moreover, to measure the response signals from DUT, proposed technique also adopted only one DDA amplifier as an IA(instrument amplifier), while conventional IA uses 3 amplifiers and several resistors. The DDA adopted two rail-to-rail differential input stages to handle full-range differential signals. Gain enhancement technique is used in folded-cascode type DDA to get open loop gain of 100 dB. Proposed PMU design enables accurate and stable operation with smaller hardware and lower power consumption. This PMU is implemented with 0.18 um CMOS process and supply voltage is 1.8 V. Input ranges for each force mode are 0.25~1.55 V at voltage force and 0.9~0.935 V at current force mode.

Modified Inside-Out Suture Technique for Meniscus Repair (변형된Inside-Out 술식을 이용한 반월상 연골 봉합술)

  • Ahn Jin-Hwan;Wang Joon-Ho;Yoo Jae-Chul;Kim Hyung-Gun
    • Journal of Korean Orthopaedic Sports Medicine
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    • v.1 no.2
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    • pp.118-123
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    • 2002
  • Purpose: To report modified technique of inside-out suture in repair of tear of postero medial corner of medial meniscus. Operative technique: Arthroscope is placed through anterolateral portal. Suture hook is delivered through anteromedial portal. By rotating the suture hook, it penetrates the inner portion of the torn meniscus from femoral surface to tibial surface of the meniscus for vertically oriented suture. A PDS suture is delivered through the lumen of suture hook, and the suture hook is withdrawn. The both ends of the suture are retrieved through anteromedial portal by a retriever, either grasper or crochet hook.A Zone-specific cannula is positioned below the inferior surface of the meniscus through anterolateral portal. The Looped Needle designed by the authors is delivered through the lumen of the Zone-specific cannula. The suture end of the tibial surface is placed in the loop of the Looped Needle and pulled out to the surface of posteromedial joint line. The suture end of the femoral surface is pulled out in same manner. A transverse skin incision of 1cm size is made adjacent to pulled out suture and the suture is tied. Discussion: Even though modified inside-out suture technique requires longer operation time than conventional inside-out technique, it provides vertically oriented suture and good tissue coaptation. The authors recommend this modified inside-out suture technique to be good alternative in repairing tear of the posteromedial corner of medial meniscus.

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The Estimation of Link Travel Time for the Namsan Tunnel #1 using Vehicle Detectors (지점검지체계를 이용한 남산1호터널 구간통행시간 추정)

  • Hong Eunjoo;Kim Youngchan
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.1 no.1
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    • pp.41-51
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    • 2002
  • As Advanced Traveler Information System(ATIS) is the kernel of the Intelligent Transportation System, it is very important how to manage data from traffic information collectors on a road and have at borough grip of the travel time's change quickly and exactly for doing its part. Link travel time can be obtained by two method. One is measured by area detection systems and the other is estimated by point detection systems. Measured travel time by area detection systems has the limitation for real time information because it Is calculated by the probe which has already passed through the link. Estimated travel time by point detection systems is calculated by the data on the same time of each. section, this is, it use the characteristic of the various cars of each section to estimate travel time. For this reason, it has the difference with real travel time. In this study, Artificial Neural Networks is used for estimating link travel time concerned about the relationship with vehicle detector data and link travel time. The method of estimating link travel time are classified according to the kind of input data and the Absolute value of error between the estimated and the real are distributed within 5$\~$15minute over 90 percent with the result of testing the method using the vehicle detector data and AVI data of Namsan Tunnel $\#$1. It also reduces Time lag of the information offered time and draws late delay generation and dissolution.

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Regional Traffic Information Acquisition by Non-intrusive Automatic Vehicle Identification (비매설식 자동차량인식장치를 이용한 구간교통정보 산출 방법 연구)

  • Kang Jin-Kee;Son Youngtae;Yoon Yeo-Hwan;Byun Sangchul
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.1 no.1
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    • pp.22-32
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    • 2002
  • This paper describes about non-burial AVI (Automatic Vehicle Identification) system using general vehicle as probe car for obtaining more accurate traffic information while conserving road pavement surface. Existing spot traffic detectors have their own limits of not obtaining right information owing to its mathematical method. Burial AVI systems have some defects, causing traffic jam, needing much maintenance cost because of frequent cutting of loop and piezo-electric sensors. Especially, they have hard time to make right detection, when it comes to jamming time. Therefore, in this paper, we propose non-burial AVI system with laser trigger unit. Proposed non-burial AVI system is developed to obtain regional traffic information from normal Passing vehicle by automatic license number recognition technology. We have adapted it to national highway section between Suwon city and Pyong$\~$Taek city(9.5km) and get affirmative results. Vehicle detection rate of laser trigger unit is more than 95$\%$, vehicle recognition rate is 87.8$\%$ and vehicle matching rate is about 14.3$\%$. So we regard these as satisfying results to use the system for traffic information service. We evaluate proposed AVI system by regulation of some institutions which are using similar AVI system and the proposed system satisfies all conditions. For future study, we have plan of detailed research about proper lane number from all of the target lanes, optimal section length, information service period, and data fusion method for existing spot detector.

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Traffic Data Calculation Solution for Moving Vehicles using Vision Tracking (Vision Tracking을 이용한 주행 차량의 교통정보 산출 기법)

  • Park, Young ki;Im, Sang il;Jo, Ik hyeon;Cha, Jae sang
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.19 no.5
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    • pp.97-105
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    • 2020
  • Recently, for a smart city, there is a demand for a technology for acquiring traffic information using an intelligent road infrastructure and managing it. In the meantime, various technologies such as loop detectors, ultrasonic detectors, and image detectors have been used to analyze road traffic information but these have difficulty in collecting various informations, such as traffic density and length of a queue required for building a traffic information DB for moving vehicles. Therefore, in this paper, assuming a smart city built on the basis of a camera infrastructure such as intelligent CCTV on the road, a solution for calculating the traffic DB of moving vehicles using Vision Tracking of road CCTV cameras is presented. Simulation and verification of basic performance were conducted and solution can be usefully utilized in related fields as a new intelligent traffic DB calculation solution that reflects the environment of road-mounted CCTV cameras and moving vehicles in a variable smart city road environment. It is expected to be there.

A Sustainability Study Based on Farm Management Value-Chain Structure (농업경영의 가치사슬 구조에 근거한 지속가능성 연구)

  • Cheong, Hoon-Hui;Kim, Sa-Gyun;Heo, Seoung-Wook
    • Journal of Agricultural Extension & Community Development
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    • v.16 no.2
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    • pp.363-384
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    • 2009
  • This study aimed at finding directions for Korean agriculture to establish a new paradigm of sustainable development. Various problematic issues and concerns in the environment necessitate the transformation of Korea's development paradigm from unconditional growth to "Green Growth" through new policies on green value and review of various advanced researches. In this research, the environment-friendly agriculture's problems, particularly in agribusiness were analyzed. Drawing from Michael Porter's Value Chain Analysis, this research developed a value chain model in agriculture that reflects the environment and the present situations. Future directions in the agriculture sector were also discussed. Korea realized food self-sufficiency through the green revolution in the early 1970s. However, a lot of problems have also occurred, including ground and water pollution and the destruction of ecosystems as a result of the overuse of pesticides and chemical fertilizers. In the late 1970s, the growing interest on environment-friendly agriculture led to the introduction of sustainable methods and techniques. Unfortunately however, these were not innovative enough to foster environment-friendly agriculture. Thereafter, the consumers' distrust on agricultural products has worsened and concerns about health have increased. In view of this, the Ministry of Food, Agriculture, Forestry and Fisheries introduced in December 1993 a system of Quality-Certified Products for organic and pesticide-free agri-foods. Although a fundamental step toward the sustainability of the global environment, this system was not enough to promote environment-friendly agriculture. In 2008, Korea's vision is for "Low Carbon Green Growth" to move forward while also coping with climate change. But primary sectors in a typical value chain do not consider the green value of their operations nor look at production from an environmental perspective. In order to attain sustainable development, there is a need to use less resources and energy than what is presently used in Korean agricultural and value production. The typical value chain should be transformed into a "closed-loop" such that the beginning and the end of the chain are linked together. Such structure allows the flow of materials, products and even wastes among participants in the chain in a sustained cycle. This may result in a zero-waste sustainable production without destroying the ecosystem.

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A 14b 100MS/s $3.4mm^2$ 145mW 0.18um CMOS Pipeline A/D Converter (14b 100MS/s $3.4mm^2$ 145mW 0.18un CMOS 파이프라인 A/D 변환기)

  • Kim Young-Ju;Park Yong-Hyun;Yoo Si-Wook;Kim Yong-Woo;Lee Seung-Hoon
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.5 s.347
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    • pp.54-63
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    • 2006
  • This work proposes a 14b 100MS/s 0.18um CMOS ADC with optimized resolution, conversion speed, die area, and power dissipation to obtain the performance required in the fourth-generation mobile communication systems. The 3-stage pipeline ADC, whose optimized architecture is analyzed and verified with behavioral model simulations, employs a wide-band low-noise SHA to achieve a 14b level ENOB at the Nyquist input frequency, 3-D fully symmetric layout techniques to minimize capacitor mismatch in two MDACs, and a back-end 6b flash ADC based on open-loop offset sampling and interpolation to obtain 6b accuracy and small chip area at 100MS/s. The prototype ADC implemented in a 0.18um CMOS process shows the measured DNL and INL of maximum 1.03LSB and 5.47LSB, respectively. The ADC demonstrates a maximum SNDR and SFDR of 59dB and 72dB, respectively, and a power consumption of 145mW at 100MS/s and 1.8V. The occupied active die area is $3.4mm^2$.