• BMB Reports
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• 제42권11호
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• pp.725-730
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• 2009

Cyclin E1 (CCNE1), a positive regulator of the cell cycle, controls the transition of cells from G1 to S phase. In numerous human tumors, however, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. Herein, we showed that CCNE1 expression was subject to post-transcriptional regulation by a microRNA miR-16-1. This was evident at protein level of CCNE1 as well as its mRNA level. Further evident by dual luciferase reporter assay revealed that two evolutionary conserved binding sites on 3' UTR of CCNE1 were the direct functional target sites. Moreover, we showed that miR-16-1 induced G0/G1 cell cycle arrest by targeting CCNE1 and siRNA against CCNE1 partially phenocopied miR-16-1-induced cell cycle phenotype whereas substantially rescued anti-miR-16-1- induced phenotype. Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy.

• 한국철도학회논문집
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• 제9권5호
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• pp.524-531
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• 2006

Environmental problem is one of important global issues. Transportations are main pollutant emission sources. Although railroad is stilt an environmental-friendly transportation, its environmental impact has been increased continuously. Especially, because a large amount of environmental impact is released from vehicles and facilities, it is necessary to assess and to reduce their environmental impact. Life cycle assessment (LCA) is a representative method which can evaluate environment impact through the whole life cycle of a product or a process. In this study, the environmental impact of seat in the electric motor unit (EMU) was analyzed quantitatively with its material using lift cycle assessment (LCA). As a result, the characteristics of environmental impact were investigated differently with the material of seat. Among ten impact categories, the seat with aluminum and FRP showed the highest ozone depletion (OD). On the other hand, in the seat with stainless steel and plastic, fresh water aquatic ecotoxicity (FAET) and marine water aquatic ecotoxicity (MAET) were high relatively. Therefore, the parts of EMU must be selected considering the characteristics of environmental impact in future.

• 농업생명과학연구
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• 제46권6호
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• pp.197-205
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• 2012

이 논문은 한육우 사육두수 주기를 분석하고 이 주기를 기초로 한육우 사육두수를 예측하였다. 이를 위해 일정한 주기를 가지고 정점과 저점을 반복하는 싸인함수를 활용하였다. 과거 한육우 사육두수의 주기는 짧게는 5년부터 길게는 12년까지의 패턴을 보여주었고, 이러한 주기는 시간이 흐름에 따라 점차 길어지는 양상을 보여주고 있다. 싸인함수를 활용하여 한육우 사육두수를 추정한 결과, 모형의 적합도가 0.95로 매우 높게 나타났다. 이 모형을 이용하여 한육우 사육두수를 예측한 결과, 사육주기에 따라 약간의 차이가 나지만 저점의 사육두수는 160~180만두 정도이고 정점의 사육두수는 320만두~370만두 수준으로 예측되었다. 이러한 예측결과는 사육두수 불안정성에 따른 농가 소득 불안정성을 내포하고 있어 그에 따르는 적절한 정책이 필요함을 시사한다.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.568-574
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• 2021

2020년부터 시행된 「지속가능한 기반시설 관리기본법」에 의해 저수지는 체계적인 유지관리와 성능개선 등의 선제적인 관리로 노후화에 따른 생애주기 비용을 최소화하도록 관리해야 한다. 생애주기를 고려한 유지관리를 위해서는 공용기간이 증가함에 따라 지속적인 성능저하에 의해 수명이 종료되는 시점을 생애 주기적인 관점에서 도출하는 것이 필수적이며 이를 위해서 저수지의 성능저하예측 모델 개발이 요구된다. 본 논문에서는 저수지를 주요 복합시설인 제체, 여수로, 취수시설로 구분하고, 생애주기 유지관리를 위한 성능저하예측 모델을 개발하였다. 모델 개발을 위해 농어촌공사의 농업기반시설 시스템(RIMS; Rural Infrastructure Management System)이 관리 중인 유지관리 정보 데이터를 수집하였으며, 수집된 데이터를 통계적으로 분석하여 모델 개발에 활용 가능한 데이터를 선별하고 추세분석을 통해 모델을 개발하였다. 개발된 모델을 통해 저수지가 현행의 유지관리 체계에서 예상되는 기대수명과 미조치시 예상되는 기대수명을 예측하였으며, 현행 유지관리체계에서의 기대수명은 미조시치 기대수명보다 약 네 배가 증대되는 것으로 나타났다. 본 논문을 통해 제안된 모델을 활용하여 향후 저수지의 생애주기를 고려한 운영관리와 유지보수의 의사결정 지원이 가능할 것으로 판단된다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.2921-2927
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• 2011

Modal Shift from road to rail has been adapted in several countries as one of effective ways of reducing $CO_2$ emissions caused by transport. Generally, effect analysis of $CO_2$ reduction toward modal shift is calculated mainly from use stage and less consideration from other stages of life cycle, even though, in some case of modal shift needs that new line construction or new vehicle manufacturing. In this study, modal shift effect analysis is performed with considering construction, manufacturing vehicle and use stage. As a result we can get total $CO_2$ reduction effect using life cycle thinking and check the necessity of including other life cycle stage not only considering use stage. In conclusion, there is no $CO_2$ reduction effect if the reduction amount of $CO_2$ in use stage is not bigger than allocated annual amount of $CO_2$ in construction and manufacturing vehicle stage. According to this fact, analysing $CO_2$ reduction effect of Modal Shift should be considered not only the use stage.

• Corrosion Science and Technology
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• 제3권2호
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• pp.72-80
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• 2004

Recently, the demand on the practical application of life-cycle cost effective design and rehabilitation of bridges is rapidly growing in civil engineering practice. However, in spite of impressive progress in the researches on the Life-Cycle Cost (LCC), the most researches have only focused on the theoretical point but did not fully incorporate the critical issues for the practical implementation. Thus, this paper is intended to suggest a systemic integrated approach to the practical application of various LCC methodologies for the design and rehabilitation of bridges, For that purpose, hierarchical definitions of LCC models are presented to categorize the approach of LCC assessment applicable for the practical implementation. And then, an integrated LCC system model is introduced with an emphasis on data uncertainty assessment and user-friendly knowledge-based database for its successful implementation. Finally, in order to demonstrate the LCC effectiveness for design and rehabilitation of real bridge structures, illustrative examples are discussed.

• 한국BIM학회 논문집
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• 제6권4호
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• pp.9-17
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• 2016

Currently whole-house refurbishment for substantial energy efficiency improvement of existing housing stock is needed to achieve the targeted 80% CO2 emission reduction. As whole-house refurbishment requires a larger capital investment for lower CO2 emission, the simultaneous use of Life Cycle Costing (LCC) and Life Cycle Assessment (LCA) methodologies are recommended to generate affordable refurbishment solutions. However, two methodologies are difficult to use due to a lack of proper LCC and LCA datasets. As a response to the current problems, many researchers explore potentials in Building Information Modelling (BIM) to improve current construction practice. As a result, a BIM tool - IES IMPACT (Integrated Material Profile And Costing Tool) - has been introduced to the UK construction industry for simultaneous calculation of LCC and LCA. Thus, this research aims at examining the capability and limitation of the IES VE/IMPACT as a BIM tool for whole-house refurbishment. This research reveals that the IES VE/IMPACT is feasible for whole-house refurbishment by providing LCC and LCA information simultaneously for informed decision on refurbishment solution selection. This research shed lights on the current problems lying on the data exchange between two different BIM tools. It is revealed that additional efforts from construction professionals and industry are required to make reliable BIM objects library with LCC and LCA datasets.

• 대한가정학회지
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• 제48권9호
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• pp.41-54
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• 2010

This study attempted to determine how the subjective knowledge related to a consumer's life cycle influences their information search in the decision making process. The data was collected using a total of 349 questionnaires for the final analysis of this study. SPSS 12.0 for windows was used for the data analysis and the detailed analyses included descriptive analysis, factor analysis, reliability tests, one way ANOVA, multiple regression analysis and t-tests. The results of this study showed that there are differences in the subdivisions of subjective knowledge of apparel according to the consumer's life cycle and there is a difference in the types of information searches according to the consumer's subjective knowledge, and the subdivisions of subjective knowledge of the consumers influence their information search. This study showed that although it affected the internal search, the media search, and the store search, it did not influence the personal search in the decision making process.

• 한국주거학회논문집
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• 제13권5호
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• pp.51-58
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• 2002

The purpose of this study is to examine residents' perception and needs for storage according to the family life cycle. In order to achieve our goal, the questionnaire survey is used. We sample the questionnaire surveys of 250 apartment households in Seoul. The data collect by the questionnaire survey was analyzed by examining the frequency, percentage on the SPSS/PC+ Statistics package. The results of the study are obtained as follows: 1) In research on the actual storage condition, residents tend to feel constraint on storage of the season goods and the storage satisfaction on the service area is founded lowest. Therefore, it is needed more efficient space plan on the balcony storage and the interior storage for the season goods. 2) In research on the storage consciousness and attitude, residents tend to keep the goods of no use and prefer to arrange neatly rather than use conveniently. Therefore, it is needed more efficient space in the balcony for the storage of the goods of no use and the colsed furniture rather than the open furniture is suited for arrangement. 3) In research on the storage needs, needs for the built-in furniture in all family life cycle show highly and residents want to a space for the exclusive use of the storage. In a solution, we propose to equip with the interior storage and the exterior cooperative storage

• 한국주거학회논문집
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• 제27권1호
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• pp.1-11
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• 2016

Based on residents' survey data in Seoul, this study attempts to empirically answer to four research questions regarding neighborhood relations (NR) which are necessary for community building: How important NR is compared to other social relations, what factors establish NR, how large NR's geographical extent is, and what are major meeting places among neighbors. A series of statistical analyses demonstrates that characteristics of NR vary greatly by family life cycle. In the stage of couple without child, NR has no significant meaning. NR becomes important from the stage of child care, and it is formed through the medium of children, particularly children's schools in the stage of child of elementary school as well as secondary schools. As the result, NR's geographical boundary extends beyond residential block or multi-family housing (apartment) estate while cafe and restaurant serve as dominant meeting places in these life cycle stages. On the contrary, after children are married and leave home, casual encounters resulted from spatial proximity become an important cause of NR. Likewise neighbors' geographical distribution is relatively concentrated within residential block or apartment estate, while community facilities play a role of meeting places as originally planned and designed.