• BMB Reports
• /
• v.42 no.11
• /
• pp.725-730
• /
• 2009

Cyclin E1 (CCNE1), a positive regulator of the cell cycle, controls the transition of cells from G1 to S phase. In numerous human tumors, however, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. Herein, we showed that CCNE1 expression was subject to post-transcriptional regulation by a microRNA miR-16-1. This was evident at protein level of CCNE1 as well as its mRNA level. Further evident by dual luciferase reporter assay revealed that two evolutionary conserved binding sites on 3' UTR of CCNE1 were the direct functional target sites. Moreover, we showed that miR-16-1 induced G0/G1 cell cycle arrest by targeting CCNE1 and siRNA against CCNE1 partially phenocopied miR-16-1-induced cell cycle phenotype whereas substantially rescued anti-miR-16-1- induced phenotype. Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy.

• Journal of the Korean Society for Railway
• /
• v.9 no.5 s.36
• /
• pp.524-531
• /
• 2006

Environmental problem is one of important global issues. Transportations are main pollutant emission sources. Although railroad is stilt an environmental-friendly transportation, its environmental impact has been increased continuously. Especially, because a large amount of environmental impact is released from vehicles and facilities, it is necessary to assess and to reduce their environmental impact. Life cycle assessment (LCA) is a representative method which can evaluate environment impact through the whole life cycle of a product or a process. In this study, the environmental impact of seat in the electric motor unit (EMU) was analyzed quantitatively with its material using lift cycle assessment (LCA). As a result, the characteristics of environmental impact were investigated differently with the material of seat. Among ten impact categories, the seat with aluminum and FRP showed the highest ozone depletion (OD). On the other hand, in the seat with stainless steel and plastic, fresh water aquatic ecotoxicity (FAET) and marine water aquatic ecotoxicity (MAET) were high relatively. Therefore, the parts of EMU must be selected considering the characteristics of environmental impact in future.

• Journal of agriculture & life science
• /
• v.46 no.6
• /
• pp.197-205
• /
• 2012

This paper analyzes the beef cycle and forecasts the number of Hanwoo. This study uses Sine function for this purpose. Data shows that beef cycle varies from five to twelve years and the cycle becomes longer as time passes. The adjusted $R^2$ of the estimated model is 0.95. The forecasted value based on this model for the number of Hanwoo is 1.6-1.8 million heads in lower bound and 3.2-3.7 million heads in upper bound, where the peak points are slightly different according to cycles. These predicted values imply the instability of number of Hanwoo and corresponding farm income, so we have to prepare adequate policies to cope with it.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.1
• /
• pp.568-574
• /
• 2021

According to the Framework Act on Sustainable Infrastructure Management, which has been enforced since 2020, reservoirs should be managed to minimize life cycle costs caused by aging through preemptive management such as systematic maintenance and performance improvement. For maintenance in consideration of the life cycle, it is essential to derive the end of life due to continuous performance degradation as the common period increases. For this purpose, it is necessary to develop a performance-predicting model for reservoirs. In this study, a reservoir was divided into main complex facilities to develop a model for the maintenance of the life cycle. A model was developed for each facility. For model development, maintenance information data were collected under management by the Rural Community Corporation. The data available for model development were selected by analyzing the collected data. The developed model was used to predict the expected life expectancy of the reservoir in the current maintenance system and the expected life expectancy in the case of no action. By using the developed model, it is expected that it will be possible to support decision making in operation management and maintenance while considering the life cycle of the reservoir.

• Proceedings of the KSR Conference
• /
• 2011.10a
• /
• pp.2921-2927
• /
• 2011

Modal Shift from road to rail has been adapted in several countries as one of effective ways of reducing $CO_2$ emissions caused by transport. Generally, effect analysis of $CO_2$ reduction toward modal shift is calculated mainly from use stage and less consideration from other stages of life cycle, even though, in some case of modal shift needs that new line construction or new vehicle manufacturing. In this study, modal shift effect analysis is performed with considering construction, manufacturing vehicle and use stage. As a result we can get total $CO_2$ reduction effect using life cycle thinking and check the necessity of including other life cycle stage not only considering use stage. In conclusion, there is no $CO_2$ reduction effect if the reduction amount of $CO_2$ in use stage is not bigger than allocated annual amount of $CO_2$ in construction and manufacturing vehicle stage. According to this fact, analysing $CO_2$ reduction effect of Modal Shift should be considered not only the use stage.

• Corrosion Science and Technology
• /
• v.3 no.2
• /
• pp.72-80
• /
• 2004

Recently, the demand on the practical application of life-cycle cost effective design and rehabilitation of bridges is rapidly growing in civil engineering practice. However, in spite of impressive progress in the researches on the Life-Cycle Cost (LCC), the most researches have only focused on the theoretical point but did not fully incorporate the critical issues for the practical implementation. Thus, this paper is intended to suggest a systemic integrated approach to the practical application of various LCC methodologies for the design and rehabilitation of bridges, For that purpose, hierarchical definitions of LCC models are presented to categorize the approach of LCC assessment applicable for the practical implementation. And then, an integrated LCC system model is introduced with an emphasis on data uncertainty assessment and user-friendly knowledge-based database for its successful implementation. Finally, in order to demonstrate the LCC effectiveness for design and rehabilitation of real bridge structures, illustrative examples are discussed.

• Journal of KIBIM
• /
• v.6 no.4
• /
• pp.9-17
• /
• 2016

Currently whole-house refurbishment for substantial energy efficiency improvement of existing housing stock is needed to achieve the targeted 80% CO2 emission reduction. As whole-house refurbishment requires a larger capital investment for lower CO2 emission, the simultaneous use of Life Cycle Costing (LCC) and Life Cycle Assessment (LCA) methodologies are recommended to generate affordable refurbishment solutions. However, two methodologies are difficult to use due to a lack of proper LCC and LCA datasets. As a response to the current problems, many researchers explore potentials in Building Information Modelling (BIM) to improve current construction practice. As a result, a BIM tool - IES IMPACT (Integrated Material Profile And Costing Tool) - has been introduced to the UK construction industry for simultaneous calculation of LCC and LCA. Thus, this research aims at examining the capability and limitation of the IES VE/IMPACT as a BIM tool for whole-house refurbishment. This research reveals that the IES VE/IMPACT is feasible for whole-house refurbishment by providing LCC and LCA information simultaneously for informed decision on refurbishment solution selection. This research shed lights on the current problems lying on the data exchange between two different BIM tools. It is revealed that additional efforts from construction professionals and industry are required to make reliable BIM objects library with LCC and LCA datasets.

• Journal of the Korean Home Economics Association
• /
• v.48 no.9
• /
• pp.41-54
• /
• 2010

This study attempted to determine how the subjective knowledge related to a consumer's life cycle influences their information search in the decision making process. The data was collected using a total of 349 questionnaires for the final analysis of this study. SPSS 12.0 for windows was used for the data analysis and the detailed analyses included descriptive analysis, factor analysis, reliability tests, one way ANOVA, multiple regression analysis and t-tests. The results of this study showed that there are differences in the subdivisions of subjective knowledge of apparel according to the consumer's life cycle and there is a difference in the types of information searches according to the consumer's subjective knowledge, and the subdivisions of subjective knowledge of the consumers influence their information search. This study showed that although it affected the internal search, the media search, and the store search, it did not influence the personal search in the decision making process.

• Journal of the Korean housing association
• /
• v.13 no.5
• /
• pp.51-58
• /
• 2002

The purpose of this study is to examine residents' perception and needs for storage according to the family life cycle. In order to achieve our goal, the questionnaire survey is used. We sample the questionnaire surveys of 250 apartment households in Seoul. The data collect by the questionnaire survey was analyzed by examining the frequency, percentage on the SPSS/PC+ Statistics package. The results of the study are obtained as follows: 1) In research on the actual storage condition, residents tend to feel constraint on storage of the season goods and the storage satisfaction on the service area is founded lowest. Therefore, it is needed more efficient space plan on the balcony storage and the interior storage for the season goods. 2) In research on the storage consciousness and attitude, residents tend to keep the goods of no use and prefer to arrange neatly rather than use conveniently. Therefore, it is needed more efficient space in the balcony for the storage of the goods of no use and the colsed furniture rather than the open furniture is suited for arrangement. 3) In research on the storage needs, needs for the built-in furniture in all family life cycle show highly and residents want to a space for the exclusive use of the storage. In a solution, we propose to equip with the interior storage and the exterior cooperative storage

• Journal of the Korean housing association
• /
• v.27 no.1
• /
• pp.1-11
• /
• 2016

Based on residents' survey data in Seoul, this study attempts to empirically answer to four research questions regarding neighborhood relations (NR) which are necessary for community building: How important NR is compared to other social relations, what factors establish NR, how large NR's geographical extent is, and what are major meeting places among neighbors. A series of statistical analyses demonstrates that characteristics of NR vary greatly by family life cycle. In the stage of couple without child, NR has no significant meaning. NR becomes important from the stage of child care, and it is formed through the medium of children, particularly children's schools in the stage of child of elementary school as well as secondary schools. As the result, NR's geographical boundary extends beyond residential block or multi-family housing (apartment) estate while cafe and restaurant serve as dominant meeting places in these life cycle stages. On the contrary, after children are married and leave home, casual encounters resulted from spatial proximity become an important cause of NR. Likewise neighbors' geographical distribution is relatively concentrated within residential block or apartment estate, while community facilities play a role of meeting places as originally planned and designed.