• Biomedical Science Letters
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• v.21 no.4
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• pp.218-226
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• 2015

The present study investigated the mechanisms of licochalcone B (LicB)-mediated inhibition of the inflammatory response in murine macrophages. RAW264.7 murine macrophages were cultured in the absence or presence of lipopolysacharide (LPS) with LicB. LicB suppressed the generation of nitric oxide and the pro-inflammatory cytokines interleukin (IL)-$1{\beta}$, IL-6 and tumor necrosis factor-${\alpha}$. LicB also inhibited the expression of mRNA for inducible nitric oxide synthase and pro-inflammatory cytokines induced by LPS. Moreover, LicB inhibited nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and activator protein-1 translocation into the nucleus in a dose-dependent manner. Thus, LicB mainly exerts its anti-inflammatory effects by inhibiting the LPS-induced NF-${\kappa}B$ and activator protein-1 signaling pathways in macrophages, which subsequently diminishes the expression and release of various inflammatory mediators. LicB shows promise as a therapeutic agent in inflammatory diseases.

• Korean Medical Education Review
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• v.20 no.1
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• pp.6-14
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• 2018

In recent years, Korean medical schools have shown a growing interest in the longitudinal integrated clerkship (LIC) as a means of improving clinical education. Some overseas medical schools have tried the LIC since the 1970s. In the 1990s, several universities in the United States, Canada, and Australia introduced LICs. A variety of studies have confirmed positive results of the LIC. Traditional block-rotation is a discipline-based, inpatient-centered practice. Instead, under the LIC system, a medical student responsible for a panel of longitudinal patients observes developments of their diseases, serving several departments simultaneously. Overseas medical schools have different LIC models depending on their affiliate hospitals' sizes and characteristics. The purpose of this study is to introduce LIC practices in Harvard Medical School and University of California San Francisco, which could be applied by Korean medical schools. This paper also aims to find out the strategies that have been able to help the two US medical schools implement the LIC successfully.

• Journal of Broadcast Engineering
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• v.24 no.3
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• pp.463-471
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• 2019

This paper proposes a method for reducing the complexity of LIC (Local Illuminance Compensation) for bi-directional inter prediction. The LIC performs local illumination compensation using neighboring reconstruction samples of the current block and the reference block to improve the accuracy of the inter prediction. Since the weight and offset required for local illumination compensation are calculated at both sides of the encoder and decoder using the reconstructed samples, there is an advantage that the coding efficiency is improved without signaling any information. Since the weight and the offset are obtained in the encoding prediction step and the decoding step, encoder and decoder complexity are increased. This paper proposes two methods for low complexity LIC. The first method is a method of applying illumination compensation with offset only in bi-directional prediction, and the second is a method of applying LIC after weighted average step of reference block obtained by bidirectional prediction. To evaluate the performance of the proposed method, BD-rate is compared with BMS-2.0.1 using B, C, and D classes of MPEG standard experimental image under RA (Random Access) condition. Experimental results show that the proposed method reduces the average of 0.29%, 0.23%, 0.04% for Y, U, and V in terms of BD-rate performance compared to BMS-2.0.1 and encoding/decoding time is almost same. Although the BD-rate was lost, the calculation complexity of the LIC was greatly reduced as the multiplication operation was removed and the addition operation was halved in the LIC parameter derivation process.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2018.11a
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• pp.163-164
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• 2018

본 논문에서는 양방향 예측 모드에서 LIC(Local Illuminance Compensation)의 복잡도 감소를 위한 방법을 제안한다. 제안하는 방법은 현재 CU 가 양방향 예측 모드일 경우 움직임 보상 단계에서 예측 블록 두 개를 가중 평균을 낸 뒤 LIC 를 수행함으로써 양방향 예측모드에서 LIC 를 한번만 수행하여 기존 LIC 대비 낮은 복잡도를 보인다. 제안하는 방법의 성능 평가를 위하여 RA(Random Access) 조건에서 MPEG 표준 실험 영상의 B, C, D 클래스를 이용하여 BD-rate 를 VTM-2.0.1 과 비교한다. 실험결과로서 본 논문에서 제안하는 방법이 VTM2.0.1 대비 BD-rate 성능 관점에서 Y, U, V 각각에 대하여 평균 0.17, 0.17, 0.23 의 성능 향상을 보인다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.462-470
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• 2015

This study examined for which socio-economic difference effects on brain function and Problem behavior syndrome in children. About a children with no disorders, diseases or cognitive dysfunction-30 were from LIC children and another 30, from MC ones, the study was conducted by measuring and analyzing the data using brain function analysis and K-CBCL from January to April, 2013. The results of the study are as follows. First, it was found that the ratio of LIC's theta(${\Theta}$) and SMR waves and that of delta(${\delta}$), high beta(${\beta}h$), alpha(${\alpha}$) and low beta(${\beta}l$) waves showed significantly higher values than MC children. Second, concerning the symptoms of child behavioral problems, LIC showed significantly higher values than MC children in symptoms of the body, depression and anxiety, social immaturity, thinking problems, attention problems, aggression, internalization, externalization, overall behavioral problems, and emotional instability. MC children showed significantly higher values than LIC chidren in symptoms of social, academic-performance, total social skills. In conclusion, the significant difference of the brain functions and the symptoms of child behavioral problems between LIC and MC children showed that the socio-ecnomic difference has an influence on the same functions and symptoms above.

• Proceedings of the KIPE Conference
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• 2017.11a
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• pp.121-122
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• 2017

ITER AC/DC 컨버터(Converter)는 핵융합 발생을 위해 토카막의 초전도코일에 제어된 전류를 공급하여 플라즈마 발생, 형상 유지, 소멸하는 기능을 한다. 만일 컨버터 또는 초전도코일에 이상이 발생하면 즉시 보호동작이 실행되어야 한다. 이를 위해 설계된 F-LIC(Fast Local Interlock Controller)은 즉시 작동하여 Bypass 및 Make Switch 트리거, 차단기 작동 등을 순차적으로 수행한다. ITER Interlock System의 기기는 중요성이 고려되어 높은 신뢰도가 요구된다. 본 논문에서는 F-LIC 회로분석과 Telcordia SR-332 Standard에 의한 부품고장률 산출방법을 사용하여 FMEDA를 분석하고, 이를 통하여 회로구성 부품의 고장이 미치는 영향과 F-LIC 제어모듈의 SIL-2 등급의 적합성을 분석하였다.

• Biomedical Science Letters
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• v.17 no.1
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• pp.85-88
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• 2011

Tumor angiogenesis, which is essential for tumor growth and tumor metastasis, depends on angiogenic factors produced by tumor cells and/or infiltrating cells such as endothelial cells and immune cells in tumor tissue. Previously, we reported that licochalcone A (LicA), an important bioactive compound of Glycyrrhiza inflate, suppresses angiogenesis, tumor growth and metastasis. In this study, we evaluated the effect of LicA on angiogenin production in colon cancer cells because angiogenin is an essential factor to regulate angiogenesis and tumor progression. When we examined the angiogenin levels in three human colon cancer cells, HT-29, SW480 and Caco-2, LicA treatment significantly reduced the amounts of angiogenin among three cancer cell lines. In an in vivo study in which mice were implanted with HT-29 cells, oral administration of LicA reduced angiogenin in tumor tissues when compared with vehicle-administered mice. These results suggest that reduced angiogenin in response to LicA treatment may play essential role to inhibit tumor growth, angiogenesis as well as metastasis.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.14 no.2
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• pp.97-117
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• 2003

This study analyzed the functions, organizational structure and activities of NCLIS, LIC and Resource in USA and UK. In result, NCLIS as an independent agency within executive branch performs the powerful advisory function to U.S. Congress and government agencies and supports to improve the library and information services with IMLS conducting the government policies. LIC and Resource in UK renders advisory function to improve library and information services with government fund although they are only committee under the Department for Culture , Media and Sports.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2018.11a
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• pp.165-166
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• 2018

본 논문에서는 LIC(Local Illumination Compensation) 방법의 pipeline 문제를 완화하고 계산 복잡도를 줄이는 방법을 제안한다. LIC 는 현재 코딩하는 블록과 해당 블록의 참조블록의 주변에 존재하는 복원 샘플을 이용하여 선형 모델을 구한다. 따라서, 주변 샘플의 복원이 완료되기 전까지 LIC 를 수행할 수 없다는 pipeline 문제가 발생한다. 본 논문에서는 복원이 완료된 주변 샘플을 사용하지 않고, 차분 신호를 사용하여 LIC를 수행하는 방법을 제안한다. 본 논문에서 제안하는 방법의 성능을 평가하기 위하여 VTM 2.0.1 과 BD-rate 비교를 한다. 실험 결과로써 VTM 2.0.1 대비 Y 성분에 대해 평균 0.13%, U 성분에 대해 평균 -0.08%, V 성분에 대해 평균 -0.09%의 BD-rate 이득을 보인다.

• BLOOD RESEARCH
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• v.53 no.4
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• pp.314-319
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• 2018

Background Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI. Methods In this cross-sectional study, 119 patients with TI (mean age years) were randomly selected and compared with 120 patients who had a diagnosis of thalassemia major (TM). Correlations of LIC, as determined by R2-MRI, with SF and ALT levels, were assessed in all participants. A P-value <0.05 was considered statistically significant. Results SF and LIC levels were lower in patients with TI than in those with TM; only ferritin values were significant. We found a statistically significant relationship between SF and LIC, with cut-off estimates of SF in patients with TI who had splenectomy and those who entered puberty spontaneously (916 and 940 ng/mL, respectively) with LIC >5 mg Fe/g dry weight (P<0.0001). A significant relationship was also found for patients with TI who had elevated ALT level (63.5 U/L), of 3.15 times the upper normal laboratory limit, using a cut-off for LIC ${\geq}5mg\;Fe/g\;dry\;weight$. Conclusion We determined the cut-off values for ALT and SF indicating the best time to start iron chelation therapy in patients with TI, and found significant correlations among iron overload, SF, and ALT.