• 대한지역사회영양학회지
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• 제4권1호
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• pp.57-63
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• 1999

This study was done to investigate the blood pressure, BMI and serum lipids of cerebrovascular accident patients in Seoul. The subjects were 195 Korean urban cerebrovascular accident patients who were hospitalized at Dong Seo Oriental Hospital in Seoul from June, 1997 to December, 1997. There were more cerebral infarction patients(164) than cerebral hemorrhage patients(31). Cerebral infraction patients were prevalent for subjects in their sixties, but cerebral hemorrhage patients were most commonly in their fifties. The BMI of cerebral infarction accidents was significantly higher than that of cerebral hemorrhage patients(p<0.05). Mean diastolic blood pressure of cerebral hemorrhage patients was significantly higher than that of the cerebral infarction patients(p<0.05). The mean systolic blood pressure of the cerebral hemorrhage patients was higher than that of the cerebral infarction patients, not statistically significant. The serum total cholesterol and glucose levels of the cerebral infarction patients was significantly higher than those of the cerebral hemorrhage patients(p<0.05). Serum total cholesterol(p<0.01), triglyceride(p<0.05) and LDH(p<0.01) levels of female subjects were significantly higher than those of male subjects. Serum total cholesterol has a negative correlation with serum GOT and GPT, but has a positive correlation with triglyceride. Serum triglyceride has a negative correlation with diastolic blood pressure but has a positive compellation with serum glucose.

• 한국식품영양학회지
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• 제17권4호
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• pp.356-367
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• 2004

This study was performed to evaluate the effectiveness of a nutritional education program conducted by public health center in Jinju city for obese women. The subjects of this study consisted of 27 obese women(BMI $\geq$ 25) aged 35∼55 years in Jinju area, and the educational period was 6 weeks. We evaluated the anthropometric parameters and biochemical indices, dietary habits, dietary behaviors, nutritional attitude of obese women before and after the nutritional education. And also daily intake during the educational period were measured. Weight, obesity index, BMT, waist circumferences and hip circumferences of obese women were significantly decreased(p<0.001) after nutritional education, but changes of WHR, systolic blood pressure and diastolic blood pressure were not significant. There were no significant difference in total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, LDH and blood glucose level in serum before and after the nutritional education, but the indices tend to decrease after the nutritional education. There was significantly different change of dietary behaviors in 3 items among the dietary behavior after the nutritional education. Their dietary habit, dietary behavior and nutritional attitude scores were significantly improved after the nutritional education. Mean daily energy intakes was low compared with the RDA as 78.88%. The average carbohydrates, protein, fat ratio on the energy intakes was 63 : 17 : 20. The proportion of energy intake from snacks the was 12.91${\pm}$6.15%.

• Journal of Acupuncture Research
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• 제26권5호
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• pp.85-94
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• 2009

Objectives : This study was designed to investigate the effect of pharmacopuncture of Mori Cortex on galactosamine-induced liver injury in rats. Methods : Male Sprague-Dawley rats were divided into 5 groups; Normal, liver injury not induced and not treated group. Control, the liver injury-induced and not treated group. Saline group, the liver injury-induced and saline injection at $BL_{18}$. HA-1 and HA-2 group, the liver injury-induced and pharmacopuncture of Mori Cortex applied to $BL_{18}$, each $1.3{\mu}g/g$, $2.6{\mu}g/g$. Then we observed the changes of ${\gamma}$-GTP, GOT, GPT, LDH, total cholesterol, triglyceride, total bilirubin. Results : Pharmacopuncture of Mori Cortex treatment significantly inhibited the activities of ${\gamma}$-GTP, GOT, total cholesterol, triglyceride and total bilirubin in HA-1 group. ${\gamma}$-GTP, GTP, LDH, ${\gamma}$-GTP levels were significantly inhibited in HA-2 group. Conclusions : These results demonstrate that the reduce of hepatic enzyme activation and lipid accumulation by pharmacopuncture of Mori Cortex may be by an antioxidant properties of Mori Cortex.

• 한방재활의학과학회지
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• 제27권1호
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• pp.1-17
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• 2017

Objectives This study aimed to investigate the effect of Bangkibokryeong-tang (BBT, Fangjifuling-tang) on blood glucose and body fat in high-fat diet-induced obese mice. Methods The experimental animals were divided into five groups- normal diet-fed control (ND), high-fat diet-fed control (HFD), HFD+BBT 75, HFD+BBT 150, and HFD+olistat as a positive drug control group. Markers of obesity, such as body weight, organ weight, diet efficiency, and serum levels of total cholesterol, triglycerides, lipid content, leptin, adiponectin, glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transferase (GPT)/lactate dehydrogenase (LDH), blood glucose, and insulin, were measured. Furthermore, results of the oral glucose tolerance test and ${\alpha}-glucosidase$ inhibition activity were examined in obese mice. Results Mice treated with BBT demonstrate lower body and organ weight, and reduced weight gain and food efficiency than that in the HFD-only control group. In addition, BBT decreased lipid accumulation in the liver and the levels of enzymes such as GOT, GPT, and LDH in the serum. Furthermore, the levels of triglycerides, total cholesterol, low density lipoprotein (LDL), and leptin were decreased in the serum but the levels of high density lipoprotein (HDL) and adiponectin were increased in the BBT-treated group compared with the control group. The BBT-treated group also demonstrated decreased blood glucose and insulin concentrations induced by feeding on a high-fat diet and improved glucose tolerance. Conclusions Based on the results above, BBT may reduce body fat and hyperglycemia in HFD-induced obesity. This suggests that BBT may be clinically useful in the treatment of obesity.

• 한국응용과학기술학회지
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• 제36권4호
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• pp.1420-1426
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• 2019

Dawley 계 숫컷 흰쥐(200~210g)를 정상군, CCl₄-대조군, CCl₄-실험군으로 나누어 실험군은 애엽 에탄올 추출물을 1,000mg/kg,b.w의 용량으로 1일1회7일간 경구 투여 후 사염화탄소를 0.6mg/kg,b.w의 용량으로 복강내 주사 후 다음날 개복하여 혈청내의 Alanine aminotransferase(ALT), Aspartate aminotransferase(AST),Alkaline phosphatase(ALP), Glutamyltranspeptidase(γ-GT), Lactate dehydrogenase(LDH)의 활성도와 중성지방, 콜레스테롤 함량을 측정한 결과 애엽 추출물 투여군에서 CCl₄-대조군과 비교하여 유의적인 감소를 나타내었으며, HDL-콜레스테롤은 유의적인 증가를 나타내었다. 간조직중의 지질과산화 함량은 감소를 glutathione함량은 유의적인 증가를 나타내었다 이 실험 결과 애엽 에탄올 추출물은 사염화탄소 투여에 의한 간 손상을 억제하는 보호물질을 함유하고 있음을 알 수 있었다.

• 대한의생명과학회지
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• 제3권2호
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• pp.161-168
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• 1997

나이가 들어가면서 나타나는 여러 가지 변화를 임상적으로 검사하고 측정하므로써 건강상태를 예측하는 것은 노화를 지연시키고 건강한 삶을 유지하는데 상당히 유용하고 기초적인지표가 될 것이다. 점차 증가일로에 있는 노인성 질환의 여러 문제점을 해결하기 위해 노령인구 집단을 정상군과 치매군으로 구분하여 13종의 임상화학 검사를 시행한 결과, 두 집단 사이에서, 임상 생화학적 검사의 양상이 다를 것이라는 예측대로의 결과를 얻을 수 있었다. 즉, serum albumin, APase, glucose, GOT, LDH 등의 수치는 정상군과 치매군 사이에서 현저한 차이를 보이는 반면, bilirubin, BUN, cholesterol, creatinine, total protein 등의 검사 수치에서는 별다른 차이를 볼 수 없었으며 , 그밖에 calcium, GPT, Pi 검사 등의 결과에서도 두 집단 사이에서 차이를 보였다. 이것은 치매가 체내에서 많은 생화학적 변화를 일으킴을 시사하고, 치매 발병에 여러 가지 환경 요인이 영향을 미치게 될 것이라는 결론을 유도할 수 있게 한다.

• 한국어병학회지
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• 제24권3호
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• pp.247-254
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• 2011

이 연구는 FUJI DRI-CHEM 3000의 건식 자동생화학 분석기를 이용하여 조사한 어류 혈액검사 항목 가운데, 적용할 수 있는 분석항목의 활용도를 평가함과 동시에 어류 혈액학적 건강진단에 필요한 분석항목의 참고자료를 얻고자 하였다. 국립수산과학원 내 수면양식연구센터에서 사육 중인 육안적으로 보아 건강한 무지개송어 (Onchorhynchus mykiss), 이스라엘잉어 (Cyprinus carpio), 틸라피아 (Oreochromis niloticus) 및 뱀장어 (Anguilla japonica) 총 200마리를 대상으로 실시하였다. Hemoglobin (Hb), 총단백 (TP), 알부민 (ALB), 알칼리성포스파타제 (ALP), 요소질소 (BUN), 젖산탈수소효소 (LDH), 중성지방 (TG), 총콜레스테롤 (TCHO), 크레아티닌 (CRE), aspartate aminotransferase (AST), alanine aminotransferase (ALT), 포도당 (GLU) 은 FUJI DRI-CHEM 3000 기종을 이용하였다. 그 결과, 이 장비의 검출범위 (detectable range)에서 최고값 (maximum) 과 최저값 (minimum) 을 벗어난 분석항목들 (ALT, TG, LDH, ALB, TCHO, AST, ALP) 이 출현하였다. 이러한 검출범위를 초과한 평균비율을 살펴보면, ALT 및 TG가 67%~61.5%, LDH, ALB 및 TCHO는 36%~17%, AST 및 ALP는 5.5%~0.5%로 나타났다. 반면에, BUN, CRE, GLU, Hb 및 TP의 분석값은 모두 검출범위의 영역 안에서 벗어나지 않았다.

• 대한물리치료과학회지
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• 제9권1호
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• pp.17-24
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• 2002

저 에너지 레이저의 효과를 알아보기 위하여 흰쥐에 3도 화상을 유발시켜 He-Ne IR 레이저 파장을 각각 다른 3 분류 파장을 이용하여 1일 5분씩 7일 동안 조사하여 파장에 따른 혈액화학성분의 활성 변화를 비교 분석하여 얻은 결과는 다음과 같다. 1. AST, ALT, LDH 및 UA의 활성은 대조군에 비해 전체 실험군들에서 유의하게 증가되었으며 CHOL 과 ALP 는 유의하게 감소되었다. 2. ALT 와 ALP는 화상대조군에 비해 전실험군들에서 유의하게 감소되었으나 292Hz 와 4672Hz 치료군들에서는 유의하게 감소되었다. 그러나 UA는 292 Hz 와 1168Hz 치료군들에서는 유의하게 증가되었다. 3. AST, LDH의 활성은 파장 292 Hz 와 4672Hz 치료군들에 비해 1168Hz 치료군에서는 유의하게 감소되었으며, ALP 활성은 4672Hz 치료군에 비해 1168Hz 치료 군에서 유의하게 증가되었다. CHOL 과 LDH의 활성 은 파장 292 Hz 치료군에 비해 1168Hz 와 4672Hz 치료 군들에서 유의하게 감소되었다.

• 대한임상검사과학회지
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• 제56권1호
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• pp.32-42
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• 2024

본 연구는 용혈의 영향과 허용 hemolysis index (HI)를 조사하기 위해 용혈된 검체와 재채혈된 검체의 결과를 비교하였다. 용혈 전·후, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase (Amy), direct bilirubin (D-bil), total bilirubin (T-bil), creatine phosphokinase (CK), gamma glutamyl transferase (GGT), iron, potassium (K), lactate dehydrogenase (LDH), magnesium (Mg), phosphorus (Phos), total protein (TP), uric acid (UA) 항목에서 유의미한 결과를 보였다. LDH, K, iron, AST, CK, GGT, TP, Amy, Phos는 용혈 정도와 결과 사이에 높은 상관관계가 있었다. Quality control (QC) high standard deviation (SD)을 이용하여 구한 허용 HI, HI^QChigh를 비교했을 때 AST, D-bil, CK, LDH는 비슷했지만 Amy, GGT, K, iron, Phos, TP는 장비의 cut-off HI보다 낮은 HI에서부터 영향 받았으며 ALP, ALT는 높게 나왔다. 그리고 paired t-test를 통해 유의미한 결과가 없었던 albumin, cholesterol, triglyceride 항목에서도 HI>200에서는 유의미한 결과가 나왔기 때문에 재채혈하는 것이 바람직하다고 생각되며 HI<100일 때 영향을 받는 항목들이 있었던 연구 결과를 기반하여 약한 용혈이 나타나는 HI>50부터 용혈 기준을 설정하는 것을 권장한다.

• 대한한의학방제학회지
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• 제22권1호
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• pp.177-192
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• 2014

Objective : In order to investigate the effect of Curcumae Longae Rhizoma(CLR) extract on the hepatocellular carcinogenesis and acute liver damage induced by diethylnitrosamine(DENA) and $CCl_4$ in rats. Methods : Experimental groups were subdivided into four; normal group (Nor), acute liver damage and hepatocellular cancer inducing control group (Con), and CLR extract 200mg/kg/day (CAA) or 400mg/kg/day (CAB) administered groups to Con. Thereafter the changes of the body weight, the liver weight and the weight of liver/100g body weight, total cholesterol, HDL cholesterol, triglyceride, the activities of AST, ALT, ALP, LDH, AFP, SOD, catalase were measured. And we observed by optical and electron microscopy. Result : 1. The body weight was decreased in Con compared with Nor for 5 weeks, but increased in Con compared with Nor from 6 week to 9 week. During experimental period of total 9 weeks, CAA and CAB were increased compared with Con. 2. The liver weight was increased significantly (p<0.05) in Con compared with Nor. The weight of liver/100g body weight was increased significantly (p<0.05) in Con compared with Nor and decreased significantly (p<0.05) in CAB compared with Con. 3. The level of total cholesterol was increased in Con and CAA compared with Nor, but there was not statistically significant. The level of triglyceride was decreased in Con compared with Nor. But increased in CAA and CAB compared with Con. The level of HDL-cholesterol was significantly increased (p<0.05) in CAA and CAB compared with Con. 4. The activities of AST, ALT were increased in Con compared with Nor, but decreased in CAA compared with Con, significantly decreased (p<0.05) in CAB compared with Con. 5. The activities of ALP, LDH were increased in Con compared with Nor, but decreased in CAA and CAB compared with Con. 6. The activities of AFP was increased significantly (p<0.05) in Con compared with Nor, but decreased significantly (p<0.05) in CAA and CAB compared with Con. 7. The activities of SOD were increased in Con, CAA and CAB compared with Nor, but decreased in CAA and CAB compared with Con. The activities of Catalase was more increased in CAA and CAB compared than Con. 8. The results of light microscopical observation, a number of hepatocytes were damaged in Con compared with Nor and CAB. 9. According to the electron microscopical observation, irregular nuclear membrane, condensed nucleoplasm was observed in Con, the experimental group was observed in the nucleus of the well-preserved and evenly developed nucleoplasm. Conclusions : These results suggest that administration of CLR extract suppress or retard on the hepatocellular carcinogenesis and acute liver damage induced by DENA and $CCl_4$ in rats.