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http://dx.doi.org/10.12925/jkocs.2019.36.4.1420

Protective Effect of Ethanol Extract of Artemisiae vulgaris L. on hepatic injury Induced by Carbon tetrachloride In Rat.  

Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University,)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.4, 2019 , pp. 1420-1426 More about this Journal
Abstract
This study was done to investigate the protective effects of ethanol extract Artemisiae vulgaris L(Av) on carbon tetrachloride(CCl4)intoxicated rats. Male sprague Dawley rats(200~210g)was used. experimental groups were divided into normal group, CCl4-control group, and ethanol extract CCl4-treated group. CCl4-treated groups were injected with CCl4 0.6mg/kg.b.w(i.p). The activities of Alanine aminotransferase(ALT), Aspartate aminotransferase(AST), Alkaline phosphatase(ALP), Glutamyl transpeptidase(γ-GT), Lactate dehydrogenase(LDH) in extract pretrated group was significantly decreased(p<0.05) compared to the CCl4-control group. The contents of triglyceride, cholesterol and lipid peroxide were significantly decreased(p<0.05). whereas the contents of HDL-cholesterol and glutathione(GSH) were significantly increased(p<0.05). These results suggest that extract of Artemisiae vulgaris L(Av) has hepatoprotective effect in the CCl4-intoxicated rats.
Keywords
Artemisiae vulgaris L(Av); enzyme activity; carbon tetrachloride; lipid metabolism; hepatoprotective effect;
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