• Title/Summary/Keyword: LD 50

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Effect of Packaging Films on Quality of 의Chuichung의 Cucumbers during Storage (포장재가 의취청의 오이의 저장 중 품질에 미치는 영향)

  • 박형우;김동만
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.29 no.2
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    • pp.248-251
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    • 2000
  • To investigate the effects of packaging films (functional MA films/FC30, FC50, MA film/0.03 mm LDPE, corrugated paperboard box/control) weight loss, firmness, total ascorbic acid, chlorophill and overall appearence were evaluated. Weight loss of cucumbers packed with FC30 and FC50 at 2$0^{\circ}C$ after 7 days were 1.0 and 0.6%, that of the control was 2.9%, those of LDPE was 0.5%. The firmness of FC30 and FC50 at 2 $0^{\circ}C$ after 7 days were 1.0 and 0.6%, that of the control was 2.9%, those of LDPE was 0.5%. The firmness of FC30-, FC50 and LD was higher than that of the control. Total ascorbic acid contents (TAA) of cucumbers packed with control, LD, FC30 and FC50 box were 9.96, 10.86, 11.37 and 11.29 mg% after 7 days. TAA of FC box was 10% higher than that of the control. Chlorophill content of FC boxes wase 16% higher than of the control. Overall appearence of cucumber packed with FC boxes was better than that of the control.

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Physicochemical Characteristics and Fatty Acid Composition of the Meat from Korean Native Black Pig with Different Slaughter Weight

  • Kim, Il-Suk;Jin, Sang-Keun;Jo, Cheo-Run;Lee, Moo-Ha;Jang, Ae-Ra
    • Preventive Nutrition and Food Science
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    • v.13 no.1
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    • pp.23-27
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    • 2008
  • The Korean native black pig (KNP) have several desirable meat qualities, which are highly demanded by Koreans in spite of its slow growth rate, low feed efficiency, and small litter size. The aim of this study was to evaluate meat quality and fatty acid composition of KNP at different slaughter weight in order to provide information to industry. Ninety female KNP of the same age (220 days) were divided into three groups by live body weights (30 pigs per each group); live weight of 50$\sim$59 kg (T1), 60$\sim$69 kg (T2) and 70$\sim$80 kg (T3), respectively. After slaughtering the longissimus dorsi muscle (LD) and backfat from each group were obtained after 24 hr chilling. Crude protein content and shear force of LD from T3 was higher than that from T1 and pH of LD was significantly lower in that from T1 than from T2 and T3. Color measurement indicated that LD of T2 group had a higher $L^*$-value and lower $a^*$-value than those of T1 and T3. Slaughter weight of KNP generally did not affect the fatty acid composition of LD and backfat but the content of oleic acid (C18:1) of T2 in LD was significantly higher than those of T1 and T3. The results may provide basic information to industry to promote the production and processing of KNP, and assist in meeting the Korean consumer's demand.

Case Report : Latissimus Dorsi Flap for Secondary Breast Reconstruction after Partial TRAM Flap Loss (유경 횡복직근피판술 후 발생한 부분 피판괴사 및 지방괴사의 넓은등근피판을 이용한 재건 치험례)

  • Song, Jae Min;Yang, Jung Duk;Lee, Sang Yun;Jung, Ki Ho;Jung, Ho Yun;Cho, Byung Chae
    • Archives of Plastic Surgery
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    • v.36 no.1
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    • pp.75-79
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    • 2009
  • Purpose: The transverse rectus abdominis musculocutaneous(TRAM) flap is the most commonly used autogenous tissue flap for breast reconstruction. Postoperatively, partial flap loss or fat necrosis are relatively common and it may result in a smaller breast volume with marked contour irregularities. These defects are not easy to reconstruct with local tissue rearrangement or with breast implants. The current authors present the results of 2 patients who underwent Latissimus dorsi(LD) flap reconstruction to correct partial flap or fat necrosis that developed after TRAM flap breast reconstruction. Method: Case1: A 50 - year - old woman with left breast cancer visited for breast reconstruction after radical mastectomy. Initially, breast reconstruction with pedicled TRAM was performed. Postoperatively partial flap necrosis was developed. Secondary breast reconstruction using LD flap was done. Case2: A 51 - year - old woman with left breast cancer visited for breast reconstruction after radical mastectomy. Initially, breast reconstruction with pedicled TRAM was performed. Postoperatively fat necrosis was developed. Secondary breast reconstruction using LD flap was done. Results: Secondary breast reconstruction using LD flap survived completely and produce successful reconstruction. There was no significant complication in both patients. Conclusion: LD flap provides sufficient, vascularized skin and soft tissue. The flap can be molded easily to replace deficient tissue in all areas of the breast. These attributes make it an ideal candidate for salvage of the partially failed TRAM flap breast reconstructio.

Single Dose Toxicity Test of Bojungikkeehapdaechilkitang water extract in Male and Female ICR Mice (보중익기합대칠기탕(補中益氣合大七氣湯) 추출물의 ICR마우스에서 경구 단회투여독성 평가)

  • Bae, Young-Chul;Choi, Bin-Hye;Kim, Dong-Woo;Hur, Jin-Il;Kim, Dae-Jun;Byun, Joon-Seok
    • The Journal of Internal Korean Medicine
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    • v.26 no.2
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    • pp.369-378
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    • 2005
  • An herbal water extract of Bojungikkeehapdaechilkitang(BDT) was prepared to test it for single-dose and repeated-dose toxicity, genotoxicity and reproductive toxicity, and to obtain a 50% lethal dose$(LD_{50})$, approximated lethal dose(ALD), and approximated target organs for BDT. The extract was tested on female and male ICR mice according to KFDA Guideline 1999-61 at doasge level of 2000, 1000, 500, 250 and 125mg/kg/10mL In this study, clinical signs, mortalities and gross findings of principal organs were observed for 14 days of single dosing, and afterwards in some cases. The ALD and $LD_{50}$ of BDT extract obtained in this study was>2000mg/kg for both male and female ICR mice. Also, any possible digestive toxicity of BDT extract was found to be above 1000mg/kg in both male and female ICR mice. The results of this study strongly suggest that BDT extract has no toxic effect at dosage level below 500mg/kg.

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Responses of Edwardsiella tarda to innate immunity of olive flounder, Paralichthys olivaceus (넙치, Paralichthys olivaceus의 비특이적 방어기작에 대한 Edwardsiella tarda 균의 반응)

  • Ha, Su-Jin;Woo, Sung-Ho;Lee, Deok-Chan;Park, Soo-Il
    • Journal of fish pathology
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    • v.21 no.3
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    • pp.189-199
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    • 2008
  • This paper aims to compare difference with the in an ability of their resistance and survival against in a non-specific defence mechanism of the olive flounder, between the virulent and the avirulent E. tarda strains. The tested E. tarda strains, we divided into the virulent and the avirulent strain groups on the basis of a value of 50% lethal dose (LD50) for the olive flounder weighed 10.3 g in average. The strains of LD50 101.6~104.2 cfu/fish were grouped as virulent strains, such as KE-1, KE-3, KE-5 and FSW910410. The group of avirulent strains as LD50 exceeded 108.7 cfu/fish were included the strains, SU100 and AL92448. A test was conducted to understand the survival ability of each strain in the mucus of the skin and the intestine of olive flounders. The results showed KE-1, KE-3, KE-5 and FSW910410 were highly to survive between 6 hours and 24 hours in intestine. The survival ability in the bile of olive flounder the number of avirulent strains declined during incubation but the virulent strain showed the number of alive bacteria having sustained or increased. In the test for the survival of bacteria in fresh sera of olive flounder, the virulent strains also had tendency to multiply. Concerning the tested bacteria internalization into the head kidney macrophages and the intracellurar replication in the macrophages of olive flounder. The virulent strains exhibited strong internalization, followed high rate replication. According to the results, virulent strains of E. tarda revealed more ability to resist and survive in the face of humoral and cellular defence factors than avirulent strains.

Radioresistance of Acorus calamus to Gamma Ray Irradiation

  • Lee, Ja-Hyun;Kang, Si-Yong;Lee, Geung-Joo;Lee, Seong-Gene;Kim, Sun-Kook;Han, Tae-Ho
    • FLOWER RESEARCH JOURNAL
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    • v.19 no.2
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    • pp.119-125
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    • 2011
  • Acorus calamus is an indigenous hydrophyte used as phytoremediation and water purification as well as medicinal herb. Irradiation of gamma ray was performed to investigate the effect on radioresistance of A. calamus on in vitro. Various doses (20-500 Gy) of gamma rays were irradiated to in vitro plantlets. The effect of irradiation was studied on survival rate, shoot formation and growth rate. The survival and multiplication rate was remarkably decreased with the increase of radiation dose. The growth of plantlets was significantly increased in comparison to the control at low doses. The hermetic effect of radiation was appeared in A. calamus. It was significantly decreased or interrupted above 250 Gy. The mean 50% lethal dose ($LD_{50}$) was extremely high as 240 Gy. We conclude that A. calamus had remarkably high radioresistance compared with other plant species.

Community-acquired Legionnaires' Disease in a Newly Constructed Apartment Building

  • Ryu, Sukhyun;Yang, Kyungho;Chun, Byung Chul
    • Journal of Preventive Medicine and Public Health
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    • v.50 no.4
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    • pp.274-277
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    • 2017
  • Objectives: Legionnaires' disease (LD) is a severe type of pneumonia caused by inhalation of aerosols contaminated with Legionella. On September 22, 2016, a single case of LD was reported from a newly built apartment building in Gyeonggi province. This article describes an epidemiologic investigation of LD and identification of the possible source of infection. Methods: To identify the source of LD, we interviewed the patient's husband using a questionnaire based on the Legionella management guidelines from the Korea Centers for Disease Control and Prevention. Water samples from the site were collected and analyzed. An epidemiological investigation of the residents and visitors in the apartment building was conducted for 14 days before the index patient's symptoms first appeared to 14 days after the implementation of environmental control measures. Results: Legionella pneumophila serogroup 1 was isolated from the heated-water samples from the patient's residence and the basement of the apartment complex. Thirty-two suspected cases were reported from the apartment building during the surveillance period, yet all were confirmed negative based on urinary antigen tests. Conclusions: The likely source of infection was the building's potable water, particularly heated water. Further study of effective monitoring systems in heated potable water should be considered.

Detecting Android Emulators for Mobile Games (Focusing on Detecting Nox and LD Player) (모바일 게임용 안드로이드 에뮬레이터 탐지 기법 (Nox와 LD Player 탐지 기법 중심으로))

  • Kim, Nam-su;Kim, Seong-ho;Pack, Min-su;Cho, Seong-je
    • Journal of Software Assessment and Valuation
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    • v.17 no.1
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    • pp.41-50
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    • 2021
  • Many game and financial apps have emulator detection functionality to defend against dynamic reverse engineering attacks. However, existing Android emulator detection methods have limitations in detecting the latest mobile game emulators that are similar to actual devices. Therefore, in this paper, we propose a method to effectively detect Android emulators for mobile games based on Houdini module and strings of a library. The proposed method detects the two emulators, Nox and LD Player through specific strings included in libc.so of bionic, and an analysis of the system call execution process and memory mapping associated with the Houdini module.

Acute Ecotoxicity Evaluation of 3 Emulsifiable Concentrates Containing Garlic Extract, Zanthoxylum Extract, and Lemon Grass Oil Originated from Plant (식물추출물 마늘 추출액, 잔톡실럼 정유, 레몬그라스 정유 함유 유제 3종의 생태독성평가)

  • You, Are-Sun;Hong, Soon-Sung;Jeong, Mihye;Park, Kyung-Hun;Chang, Hee-Seop;Lee, Je Bong;Park, Jae-Yup
    • The Korean Journal of Pesticide Science
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    • v.16 no.4
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    • pp.376-382
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    • 2012
  • Environment-friendly agro-materials are are likely to be preferred to chemical insecticides recently. For this reason, many studies are conducted to develop environment-friendly insecticides containing natural materials. This study was also conducted so as to assess ecotoxicity for Emulsifiable concentrate (EC) containing 30% of garlic extract or two plant essential oils (Zanthoxylum, Lemongrass) expected to prevent from pests and be used for agro-materials. Target species used to assess acute toxicity were invertebrate (Daphina magna), fish (Oryzias latipes), honeybee (Apis mellifera L.) and earthworm (Eisenia fetida). The $EC_{50}$ values for of garlic extract 30% EC, Zanthoxylum oil 30% EC and lemongrass oil 30% EC to Daphina magna were 3.3, 10, and $10mg\;L^{-1}$, respectively. The category of garlic extract 30% EC was moderately toxic, while those of Zanthoxylum oil 30% EC and lemongrass oil 30% EC were slightly toxic according to standard of USEPA. $EC_{50}$ for both of Zanthoxylum oil 30% EC and lemongrass oil 30% EC were more than $10mg\;L^{-1}$ then they were considered as slightly toxicity. In case of acute toxicity test to fish, $LC_{50}$ of garlic extract 30% EC was $3.3mg\;L^{-1}$. Zanthoxylum oil 30% EC and lemongrass oil 30% EC indicated $LC_{50}$ > $10mg\;L^{-1}$. Classification of acute toxicity to all test substances was in Korea criteria. Acute contact and oral toxicity test to Honeybee were conducted. As a result, $LD_{50}$ of all test substances were more than 100 a.i. ${\mu}g\;bee^{-1}$ in the acute contact test while $LD_{50}$ of garlic extract 30% EC was 4.4 a.i. ${\mu}g\;bee^{-1}$ and $LD_{50}$ of Zanthoxylum oil 30% EC and lemongrass oil 30% EC were more than 100 a.i. ${\mu}g\;bee^{-1}$. In case of acute toxicity test to earthworm, $LC_{50}$ of garlic extract 30% EC, Zanthoxylum oil 30% EC and lemongrass oil 30% EC were 267, 592, and $430mg\;kg^{-1}$, respectively. In conclusion, if the safety for earthworm is confirmed, these substances are expected to be use for environment-friendly insecticide materials with low risk against ecosystem and contribute to developing environment-friendly agro-materials.

Studies on Physicochemical and Biological Properties of Depolymerized Alginate from Sea tangle, Laminaria japonicus by Thermal Decomposition 8. Effects of Depolymerized Alginate on Serum Lipid Composition and Its Single-Dose Toxicity yin Oral Route in Rats (다시마 (Laminaria japonicus) Alginate의 가열가수분해에 따른 물리$\cdot$화학적 및 생물학적 특성에 관한 연구 8. 저분자 Alginate투여에 의한 랫드의 혈청지질의 성분 변화 및 경구급성독성 실험)

  • KIM Yuck-Yong;CHO Young-Je
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.34 no.3
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    • pp.173-178
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    • 2001
  • This study was performed to know the hypocholesterolemic effect of depolymerized alginate obtained by hydrolysis of alginate through a heating process at $121^{\circ}C$. The changes of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and phospholipid levels in serum, as well as the atherogenic index were elucidated in rats for 35 days. In order to evaluate single-dose toxicity of HAG-50 in rats via oral routes, induction any mortalities and abnormal signs in clinical finding, body weight, gross findings and histopathological finding, and estimation of $LD_{50}$ were elucidated. Total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and phospholipid levels in the serum significantly decreased and resulted in the decrease of atherogenic index in rats fed diets containing $5\%\;and\;10\%$ HAG-50 (p<0.01). HAG-50 did not induce any mortalities and abnormal signs in clinical findings, body weights, gross findings and histopathological findings in single-dose toxicity test via oral routes of rats, after which it was impossible to estimate $LD_{50}$ values.

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