• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1561-1566
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• 2006

Sebum is secreted due to the effect of androgen, which start to be secreted at puberty. Androgens have profound effects on the physiology of the sebaceous gland, Using the human sebocyte cell line SZ95, we investigated the inhibitory effect of Chelidonii Harba (CH) on the subum production. Our results showed that numerous cytoplasmic lipid droplets were examined by Oil red staining and lipid droplets were increased markedly by testosterone. Cell viability was dose-dependently decreased by CH as compared with untreated cells, while total lipid content and cholesterol slightly were increased by CH. Testosterone significantly stimulated the synthesis of total lipid and the synthesis of specific sebaceous lipids such as cholesterol and triglyceride. Combined treatment with CH and testosterone resulted in a lower lipid synthesis than with testosterone alone. Especially cholesteol content was reduced by combined treatment with CH and testosterone. These results indicate that CH inhibits the testosterone-induced lipid synthesis in SZ95 cells and acts antagonistically to androgen at the cellular level.

• Journal of Acupuncture Research
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• v.38 no.3
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• pp.219-226
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• 2021

Background: The objective structured clinical examination (OSCE) is a widely used method to assess the clinical performance of students in clinical practice. Although OSCE has been used for undergraduate students of Korean medicine, this has not been widely reported. Methods: In 2020, the practical course for acupuncture and moxibustion medicine (acupuncture, electroacupuncture, pharmacopuncture, auricular acupuncture, and burning acupuncture) was taught using flipped learning, according to clinical practice guidelines, and assessed by the OSCE. The appropriateness of this model of education and its evaluation using OSCE were evaluated using a 5-point Likert scale, and the results were analyzed. Results: Of the respondents, 67% reported that the OSCE accurately reflected their competency, and 82% reported that online video lectures helped them to improve their clinical skills. The average adequacy score of the model was > 3.7/5, and the average adequacy score of the checklist used in the OSCE was > 4.1/5 for all 5 clinical application skills. The difference in the mean self-efficacy score between students who had taken the OSCE and those students who had not taken the OSCE, was highest in the burning acupuncture group (0.923). Conclusion: This study showed that students' satisfaction with the OSCE was high and flipped learning was an effective education model. In the future, models representing the human body or simulated patients should be used to evaluate students' skills and attitude.

• Journal of Oriental Neuropsychiatry
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• v.33 no.4
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• pp.453-462
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• 2022

Objectives: The purpose of this clinical case study was to report the effect of Korean medicine treatment on a stroke patient with cognitive impairment, dysuria, and gait disturbance. Methods: The patient was treated with Korean medicine, including herbal medicine, acupuncture, moxibustion, and cupping. We administered the Korean version of the Mini-Mental Status Examination (MMSE-K) Global Deterioration Scale (GDS) and Manual Muscle Test (MMT) and investigated the frequency of nocturia to evaluate the effectiveness of the treatment and improvement in symptoms. Results: After Korean medicine treatment, the patient's symptoms were significantly improved. according to the MMSE-K, frequency of nocturia, and MMT results. Conclusions: This clinical case study suggests that Korean medicine treatment, including Wuchasinkihwan-gagam could be an effective treatment for stroke patients with symptoms of cognitive impairment, dysuria, and gait disturbance.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.58-67
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• 2010

Objectives: The objective of this study was to evaluate the correlations between the Weak Children Questionnaire result and K-CBCL score. Also, this study was designed to define the cut off values of Heart Weak Scores by using 'K-CBCL' which represents the total behavior problems scores 50T in order to detect Heart Weak in Children Methods: 271 elementary school students in Daejeon answered the questionnaire and the data was analyzed. Results: There were high correlations between Heart Weak Score and K-CBCL which in a total behavior problems scores. The cut off values of Heart Weak Score, K-CBCL, a total behavior problems scores 50T, were calculated by ROC curve analysis. To diagnose as a Heart Weak Children, the correspondent cut off values for Heart Weak Score were 11 in boys and 8 in girls. Conclusions: To diagnose as a Heart Weak in Children, the correspondent cut off values for Heart Weak Score were 11 in boys and 8 in girls.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.111-123
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• 2017

Objectives: To develop and investigate the reliability of the pathologic aging scale based on korean medical theory and korean medical pattern identification for dementia. Methods: We searched the textbook of korean neurophychiatry and Donguibogam and selected items through professional consensus. We compared between dementia(n=40) and normal elderly(n=38) and tested the reliability of two scales. Results: After professional consensus, we drafted the Korean Medical Pathologic Aging Scale(12 items, Likert 3 scale) and Korean Medical Pattern Identification for Dementia(4 patterns, 28 items, Likert 5 scale). On Korean Medical Pathologic Aging Scale, There is no significant difference between two groups. We had good internal consistency(Cronbach's alpha = 0.6) and test-retest reliability(r=0.631) but low inter-rater reliability(r=0.430). On Korean Medical Pattern Identification for Dementia, dementia patients diagnosed with Qi deficiency are significantly more than those in normal group. We had fairly good internal consistency(Cronbach's alpha = 0.574) and excellent test-retest(kappa= .800) and inter-rater reliability(kappa = .733). Conclusions: Korean Medical Pattern Identification for Dementia is appropriate for diagnosing korean medical pattern. But Korean Medical Pathologic Aging Scale isn't appropriate to discriminate dementia from normal elderly because of many subjective items. Therefore objective measurement of sensory dysfunction would be needed to measure pathologic aging based on korean medical theory.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.1
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• pp.16-21
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• 2014

Micro needle roller therapy has been used for cosmetic purposes, such as reducing skin winkles and improving elasticity of skin. It is claimed that micro needle roller therapy has potentials for connective tissue regeneration by facilitating collagen synthesis. Therefore, there seems to be a possibility that connective tissue regenerating potential of micro needle roller therapy could influence the hair growth cycle. This study, we investigated the hair growth-promoting effects of micro needle roller therapy. C57BL/6 mice were devided into three groups as follows: normal saline-treated, minoxidil-treated, and micro needle roller therapy-received group. Hair growth activity was evaluated by handscopic and microscopic observations. Sections of dorsal skin were stained with hematoxylin and eosin. Expression of BrdU, FGF, and VEGF was detected by immunohistochemical staining. Micro needle roller therapy enhanced the development of hair follicle during anagen. Immunohistochemical analysis revealed that micro neeld roller therapy incresed the expression of BrdU and FGF in the hair follicles of C57BL/6 mice. Furthermore, micro needle roller therapy upregulated mRNA expression of VEGFR-2, FGF-2, EGF - growth factors that play a central role in hair follicle development during anagen. These results suggest that Micro needle roller therapy can potentially be used for the treatment of alopecia.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.3
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• pp.15-29
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• 2019

Objectives The purpose of this study is to investigate the clinical studies on the effect of herbal medicine in type 1 diabetes in children and to seek better approach of herbal medicine to treat type 1 diabetes in children. Methods This study researched randomized controlled trials through various databases in the world about herbal medicine treatments in type 1 diabetes in children. Results 10 out of 337 studies were selected and analyzed. All studies were conducted in China. All studies were using herbal medicines, as an adjunctive treatment to the main regimen. As a result, the integrated Chinese medicine and western medicine lowered FPG by -1.56 mmol/L and 2hPG by -1.94 mmol/L on average, respectively. The HbA1c also decreased by -1.11% in the treatment group compared to the control group. Total efficacy of the treatment was 1.21 times more effective in the treatment group than in the control group. Conclusions Based on the results of the studies, it seems that the herbal medicine for the treatment of type 1 diabetes in children will be effective as a combination with conventional medicines. Further research is needed to prove the findings of this observatoional studies.

• The Journal of Korean Medicine
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• v.36 no.3
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• pp.84-97
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• 2015

Objectives: The purpose of this study was to investigate and analyze the demands for educational programs on clinical trials of Korean medicine devices, and develop training programs based on the needs of Korean medicine. Methods: This research was conducted targeting 26 volunteer applicants who had participated in clinical trials of Korean medicine devices within the last five years (2010-2015). The survey was carried out between May 1, 2015 and May 26, 2015 via e-mail. After receiving questionnaire replies, the material was established. Using obtained data, frequency analyses were performed using SPSS 20.0 version. Results: 92% of the researchers who participated in the survey expected introduction of educational programs on clinical trials and anticipated that programs contain information that can meet the needs of each researcher. In addition, according to the analysis, introducing expert certification for clinical trials of Korean medicine devices is necessary, and offering related graduate courses are also needed. Conclusions: As a result of this study, researchers had difficulties during clinical trials of Korean medicine devices. If the educational programs were to be developed and institutional frameworks support them effectively, it would prove to be helpful to researchers in clinical trials.

• Journal of Pharmacopuncture
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• v.11 no.4
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• pp.39-48
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• 2008

Objective The purpose of this study is to investigate the difference of treatment effects and allergic responses to stiff neck between Bee Venom Pharmacopuncture and Sweet Bee Venom Pharmacopuncture. Methods Forty one patients who felt stiff neck were randomly divided into two groups, a Bee Venom Pharmacopuncture group(group I) and a Sweet Bee Venom Pharmacopuncture group(group II). Evaluations of the treatment effects were made before and after a treatment using Visual Analog Scale(VAS), Neck Disability Index(NDI), Clinical Evaluation Grade(CEG). The comparison of allergic responses was measured with VAS. The obtained data were analyzed and compared with SPSS. Results The group I and group II showed significant improvement(p<0.05) according to the VAS, NDI, CEG. And the differences between the two groups were insignificant according to VAS, NDI, CEG. But allergic responses such as localized edema, localized itching were significantly lower in group II than group I. Conclusions It seems that there are no big different treatment effects between the two groups. Sweet Bee Venom Pharmacopuncture appears to be more effective measurement against allergic reactions than the Bee Venom Pharmacopuncture. Further studies are needed for the comparison of Bee Venom Pharmacopuncture and Sweet Bee Venom Pharmacopuncture.

• Journal of Acupuncture Research
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• v.33 no.3
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• pp.75-87
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• 2016

Objectives : The purpose of this study is to investigate the effects of acupuncture and moxibustion treatment at SP6(Sanyinjiao) on the temperature change of feet in healthy adults and evaluate whether SP6 has an effect on cold hypersensitivity of feet. Methods : Subjects of this study were 61 healthy adults consisting of 21 in the acupuncture treatment group, 21 in the moxibustion treatment group and 19 in the control group, selected at random. After starting the experiment, the subjects laid straight on their back and relaxed for 30 minutes. Pictures were then taken of their feet by DITI 3 times before and after treatment. The treatment was carried out by either 15 minutes of acupuncture or 2 pieces of moxibustion at SP6. Whilst the control group rested lying straight. After taking pictures the temperatures of LR2, GB42, ST42, KI1, center of the plantar, and center of the calcaneus were checked and the SPSS for Windows Version 20.0 was used to evaluate the statistical significance by the paired t-test, Wilcoxon signed-ranks test(in group) and the Mann-Whitney U-test(between the groups). Results : Some temperature changes before and after treatment were observed in each of the 12 areas, most of which were not significant. But as a result of comparing the temperature difference of all the samples without dividing the area of each group, the mean temperatures in the acupuncture and moxibustion group were significantly elevated. A comparison between the groups showed the mean temperature of the acupuncture and moxibustion group to be significantly elevated, more so than the control group. Conclusion : The result of this study suggests acupuncture and moxibustion treatment at SP6 has the effect of the rising temperature of feet temporarily.