• The Journal of Pediatrics of Korean Medicine
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• v.12 no.1
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• pp.277-287
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• 1998

The present study is designed that the herb medicines which are returned to kidney, pancreas and are known by efficacy in growth are supplied to pigs, thereafter the effects to growth and secretion of growth hormone in serum is investigated. For this purpose the 24 days old pigs, which are crossbreeding, castrated are used. The conclusions are that after 4 weeks' supply of herb medicinal compounds, pigs' weight gain has increased in low nutritional group with statistical meaning(p〈0.05). And one day's weight gain has increased with statistical meaning(p〈0.05) in all groups. Regarding food take, the second nutritional group has more significant increase than control group. Utilization rate of nutrition doesn't have any statistical meaning in all groups, but it has the tendency that as herb medicinal compounds are added, utilization rate of nutrition is increased. Increase of vertebra lengths and level of growth hormone in serum according to supply of herb medicinal compound don't have any statistical meaning because of small sample size, but 10 - 20 % increase of vertebra lengths and 10 - 30 % increase of level of growth hormone are observed.

• Korean Journal of Pharmacognosy
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• v.46 no.4
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• pp.321-326
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• 2015

The prevalence of diabetes mellitus continues to rise alarmingly because of industrialization of society. The aim of this study was to investigate the antidiabetic effects of black ginseng extract (BGE) which was performed panax ginseng. First we examined the inhibitory effects of BGE on ${\alpha}$-glucosidase. But there was no practical effects in our observations. We, also, investigate the effects of BGE on glucose uptake of skeletal muscle using 2-NBDG in $C_2C_{12}$ myotube. BGE significantly improved the glucose uptake considered as a lowered blood glucose level. Effects of GBG05-FF on fasting blood glucose and glycated hemoglobin (HbA1c) were investigated in streptozotocin (STZ)-induced diabetic mouse. After injection of STZ, fasting blood glucose and glycated hemoglobin rapidly increased. But STZ-induced diabetic mouse treated with GBG05-FF significantly reduced the level of fasting blood glucose and HbA1c. This results showed that supplementation of BGE improve the diabetic parameters and BGE have a potentiality as a functional food for Diabetes mellitus.

• Journal of Oriental Neuropsychiatry
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• v.21 no.1
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• pp.43-57
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• 2010

Objectives: This study was designed to assess neuroprotective effects of herb medicine against Alzhheimer's disease related brain damage in organotypic hippocampal slice culture. Methods: We induced dementia related brain damage in organotypic hippocampal slices by $\beta$-amyloid. Those slices were treated with herb medicines - Hwangryeonhaedoktang, Sopungsoongiwon. Using by PI staining, the extents of cell death were assessed. After that, we selected the best effective one among those herb medicines and the major components of that medicine were studied to reveal neuroprotective effects and related proteins by using PI stating. Results: In PI staining, Sopungsoongiwon is the best effective herb medicine between Hwangryeonhaedoktang and Sopungsoongiwon. Notopterygii Rhizoma, Corni Fructus, Areca Catechu, Aurantii Fructus Immaturus, Plantaginis Semen is the best effective one among the components of Sopungsoongiwon. Conclusions: We suggested that purgative effect would be the best effetive medicine on dementia related brain damage between clearing heat and toxic materials.

• The Journal of Korean Medicine
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• v.32 no.4
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• pp.48-67
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• 2011

Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induced hepatotoxicity was reviewed on a basis of toxicological assessment. Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide. Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.

• The Journal of Korean Medicine
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• v.21 no.2
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• pp.14-24
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• 2000

Objectives : To direct methods of management and development of herbs and their derived products, and at the end of this study to inform the process of making new herbal drug regulations in Korea. Methods : This study analyzed the regulations and laws of western medicine drugs. Results : We have got some herbal prescriptions which are not in the eleven books of oriental medicine now in use but which have proved effective. We need to establish standards for permissions to produce medical products through those prescriptions. Besides, we need the special permissions to produce herbal products through prescriptions, especially those which have been used to treat incurable diseases. And, we can contribute to globalization of oriental medicine and to well situating of herb products and medicinal acupunctures if we produce them according to international standards. It is thought that herbal medicine has no side effect in the medical society in Korea. But, it is getting popular to administer herbal medicine and western medicine together. Thus, the side effects of taking both medicines at the same time should be documented. Conclusions : Herbal medicines and herbal products should be under the control over the whole process of production, circulation, and sales. Now, it is time for herbal medicine to be known to all over the world. Therefore, herbal medicine must meet and adhere to the standards set by the western society and WHO.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.1
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• pp.53-58
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• 2012

The aim of this study was to investigate the antimicrobial, antiperspirant and deodorant effect of herb mixtures including Schisandra chinensis(SC). This herb mixtures including Schisandra chinensis was made of Astragalus membranaceus(AM), Triticum aestivum(TA), Atractylodes japonica(AJ) and peppermint essential oil extracted from Mentha piperita(MP). We examined antimicrobial activity, antiperspirant activity and L-leucine dehydrogenase activity of the herbal extracts. We found that the mixture of SC and MP have the best antimicrobial effects on B. subtilis subsp. spizizenii and mixture of SC, AJ, AM and TA have best antiperspirant effect. Moreover, the combination of SC and AM showed the most inhibitory effect on L-leucine dehydrogenase activity. These results suggested that the herb mixtures Including Schisandra chinensis have good antimicrobial and antiperspirant effects.

• Proceedings of the Korean Society of Food Hygiene and Safety Conference
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• 2001.10a
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• pp.163-164
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• 2001

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.185-199
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• 2007

Purpose: This study was designed to establish safety and efficacy of using herbal medicine during pregnancy. Methods : We searched through 23 sources, which had been previously published frome 1988 to 2007, concerned patients that used herbal medicine during pregnancy. We searched diseases for that used herbal medicine, kinds of herbal medicine taken, the period of herbal medicine taken, the duration of herbal medicine taken and results of herbal medicine taken. Results: 1. Whaltae(habitual abortion) was the most of diseases that used herbal medicine during pregnancy. Second disease was hyperemesis gravidum. Third disease was Taegibulan (fetal restlessness). 2. The most of Herb medicines of used for Whaltae was Kyoesamultang and Anjeonecheontang. The most of Herb medicines of used for hyperemesis gravidum was Bosaengtang. The most of Herb medicines of used for Taegibulan was Kyoesamultang. 3. The time of herbal medicine taken mostly was the first period of pregnancy. The rate was 78%. 4. The duration of herbal medicine taken mostly was $18.58{\pm}14.24day$ at mean. 5. The rate of normal delivery was 85% and herbal medication during pregnancy does not cause any deformity to the newborn and of patients used herbal medicine. 6. The patients of taken herbal medicines were recovered from their symptoms and prevented miscarriage. The rate of recovery was 87%. Conclusion: The results of this study show that herbal medication during pregnancy is effective to cure disease and maintain the pregnancy. It is thought that have to actively try to treat diseases and symptoms on pregnancy by using herbal medicine.

• Journal of Oriental Neuropsychiatry
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• v.22 no.2
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• pp.177-198
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• 2011

Objectives : By analyzing and comparing indications, components and their doses of herb medicines, which were recorded in insomnia chapters of medical books, we examined historical changes and made clear documentary ground of medications. Methods : 1. 10 books which were noted in insomnia part of "The Eastern Medical Textbook of neuropsychiatry" and 13 books were mentioned in same part of "Uibujeonrok" were selected as reference. 2. We searched article database such as KISS, riss4U and journals issued by the Korean society of oriental neuropsychiatry. Finally, 39 books which were noted in 3 literature reviews, were chose as reference. 3. In reference books, we collected the herb medicines in chapters related to insomnia. 4. In case of no section associated with insomnia in books, we found prescriptions related to insomnia in whole chapters. 5. If the chief virtue of medication was not primarily for insomnia, we excluded applied or added herb medicines. 6. We classified prescriptions into small groups which had same name, and then rearranged them in chronological order. Results and Conclusions : 1. Banha-tang(banxiatang) of "Hwangjenaegyeong Youngchu" was the first-recorded prescription used for insomnia. 2. The chapter of insomnia appeared in "Chunkeumyobang" at first. 3. Ondam-tang(Wendantang) was most cited prescription in medical books. It was recorded totally 19 books from "Chunkeumyobang" to "Hyeoljeungron". 4. We suspects indications, components, dosage of medication of insomnia in Donguibogam were revised according to author's clinical experience and circumstances.

• Journal of Oriental Neuropsychiatry
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• v.20 no.3
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• pp.15-33
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• 2009

Objectives : To study for classifying indications and procedure of historical changes, as a preliminary study, we collected and arranged prescriptions of headaches in medical documents after "Hwang-Je-Nae-Gyeong". Methods : 1. The researcher reviewed books, as a bibliography, recording to associate with a headaches in "UI-Bu-Jeon-Rok". 2. In reference books, we collected and arranged the herb medicines related to headaches in chapter of them. 3. In case of no chapter associated with headaches in books, we found prescriptions related to headaches and rearranged them. 4. Applied or added herb medicines were excluded, if the chief virtue was not primarily for headaches. 5. Prescriptions for signs to headaches related to dizziness were excluded. 6. Prescriptions for signs to associated with tremor were excluded. 7. We excluded prescriptions of headaches for dermatological disease. Results and conclusions : 1. Thirty seven documents were referred to the section of a headche in "UI-Bu-Jeon-Rok". 2. Prescriptions of "Sang-Han-Ron", which were related to headaches, were repeatedly quoted in chinese medical publications. 3. Nameless prescriptions of headaches were recorded from earlier books to later publications. 4. It started to record prescriptions of headaches separately from "Hawl-In-Seo" in 1107. 5. Described how to discriminate Naesang from Oegam, but prescriptions of headache were not listed in Dongwon Yi's "Nae-Oe-Sang-Byeon-Hok-Ron" which was published in 1247.