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The Antidiabetic Effects of Black Ginseng Extract(BGE)and Geumsan Black Ginseng 05-FF(GBG05-FF) on In Vitro and In Vivo Assay  

Seo, Yun-Soo (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Shon, Mi-Yae (International Ginseng and Herb Research Institute)
Kong, Ryong (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Kang, Ok-Hwa (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Zhou, Tian (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Kim, Do-Yeon (International Ginseng and Herb Research Institute)
Park, Jong-Dae (International Ginseng and Herb Research Institute)
Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.4, 2015 , pp. 321-326 More about this Journal
Abstract
The prevalence of diabetes mellitus continues to rise alarmingly because of industrialization of society. The aim of this study was to investigate the antidiabetic effects of black ginseng extract (BGE) which was performed panax ginseng. First we examined the inhibitory effects of BGE on ${\alpha}$-glucosidase. But there was no practical effects in our observations. We, also, investigate the effects of BGE on glucose uptake of skeletal muscle using 2-NBDG in $C_2C_{12}$ myotube. BGE significantly improved the glucose uptake considered as a lowered blood glucose level. Effects of GBG05-FF on fasting blood glucose and glycated hemoglobin (HbA1c) were investigated in streptozotocin (STZ)-induced diabetic mouse. After injection of STZ, fasting blood glucose and glycated hemoglobin rapidly increased. But STZ-induced diabetic mouse treated with GBG05-FF significantly reduced the level of fasting blood glucose and HbA1c. This results showed that supplementation of BGE improve the diabetic parameters and BGE have a potentiality as a functional food for Diabetes mellitus.
Keywords
Black ginseng; $C_2C_{12}$; Type 1 diabetes mellitus; Fasting blood glucose; Glycated hemoglobin;
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