생약학회지 (Korean Journal of Pharmacognosy)

  • 제46권4호
  • /
  • Pages.321-326
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  • 2015
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

흑삼추출물(BGE)과 금산흑삼표준화소재(GBG05-FF)의 In Vitro와 In Vivo상에서의 항당뇨효과

The Antidiabetic Effects of Black Ginseng Extract(BGE)and Geumsan Black Ginseng 05-FF(GBG05-FF) on In Vitro and In Vivo Assay

  • 서윤수 (원광대학교 약학대학 한약학과 한약연구소) ;
  • 손미례 ((재)금산국제인삼약초연구소) ;
  • 공룡 (원광대학교 약학대학 한약학과 한약연구소) ;
  • 강옥화 (원광대학교 약학대학 한약학과 한약연구소) ;
  • 주전 (원광대학교 약학대학 한약학과 한약연구소) ;
  • 김도연 ((재)금산국제인삼약초연구소) ;
  • 박종대 ((재)금산국제인삼약초연구소) ;
  • 권동렬 (원광대학교 약학대학 한약학과 한약연구소)
  • Seo, Yun-Soo (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Shon, Mi-Yae (International Ginseng and Herb Research Institute) ;
  • Kong, Ryong (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Kang, Ok-Hwa (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Zhou, Tian (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Kim, Do-Yeon (International Ginseng and Herb Research Institute) ;
  • Park, Jong-Dae (International Ginseng and Herb Research Institute) ;
  • Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
  • 투고 : 2015.11.30
  • 심사 : 2015.12.11
  • 발행 : 2015.12.31
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초록

The prevalence of diabetes mellitus continues to rise alarmingly because of industrialization of society. The aim of this study was to investigate the antidiabetic effects of black ginseng extract (BGE) which was performed panax ginseng. First we examined the inhibitory effects of BGE on ${\alpha}$-glucosidase. But there was no practical effects in our observations. We, also, investigate the effects of BGE on glucose uptake of skeletal muscle using 2-NBDG in $C_2C_{12}$ myotube. BGE significantly improved the glucose uptake considered as a lowered blood glucose level. Effects of GBG05-FF on fasting blood glucose and glycated hemoglobin (HbA1c) were investigated in streptozotocin (STZ)-induced diabetic mouse. After injection of STZ, fasting blood glucose and glycated hemoglobin rapidly increased. But STZ-induced diabetic mouse treated with GBG05-FF significantly reduced the level of fasting blood glucose and HbA1c. This results showed that supplementation of BGE improve the diabetic parameters and BGE have a potentiality as a functional food for Diabetes mellitus.

키워드

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