• The Journal of Korean Medicine
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• v.40 no.3
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• pp.139-176
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• 2019

Objectives: This study aims to review the herbal medicines containing substances banned by World Anti-Doping Agency(WADA), and to consider criteria for the using of herbal medicines. Methods: Using foreign(Pubmed, Cochrane, Embase, Google Scholar, WANFANG, CiNii) and domestic databases (NDSL, OASIS, RISS), we analyzed the content and pharmacokinetics of the prohibited substances in herbal medicines. Results: Herbal medicines containing the prohibited substances proposed in Korea, China, and Japan are Ephedrae Herba, Cannabis Semen, Strychni Semen, Strychni Ignatii Semen, Pinelliae Tuber, Rhizoma Pinelliae, Chelidonii Herba, Papaveris Fructus Deseminatus, Liriopis Tuber, Rehmanniae Radix Recens, Cistanchis Herba, Ponciri Fructus Immaturus, Aurantii Fructus Immaturus, Moschus, Testudinis Plastrum, Otariae Testis et Penis, and Hominis Placenta. Of these, when using Ephedrae Herba, Cannabis Semen, Strychni Semen, Moschus, Strychni Ignatii Semen, and Otariae Testis et Penis, caution is needed in relation to the doping test. Other herbal medicines are considered safe for the doping test. In addition, by analyzing data related to higenamine added to the WADA's prohibited list of doping since 2017, we don't recommend using Nelumbinis Plumula. And in the case of the other herbal medicines containing higenamine, it is considered that care should be taken in doping test depending on the amount of usage. Conclusions: As a result of analyzing the herbal medicines which are in prohibited list about doping, we were able to know the criteria and precautions to use when prescribing the herbal medicines. Further research will be needed about common used herbal medicines and the amount of detection depending on extraction and boiling method.

• Journal of Korean Traditional Oncology
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• v.25 no.2
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• pp.23-36
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• 2020

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

• Journal of Korean Medicine Rehabilitation
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• v.31 no.3
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• pp.31-55
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• 2021

Objectives This study was designed to review the effect of herbal medicine on animal model and patients with osteoporosis. Methods The databases in Korea and overseas were searched with term as osteoporosis, Chinese medicine, Korean medicine, herbal medicine. Among the results, we reviewed studies published in 2011 to 2020. 420 articles were primarily selected and after processing through flowchart, finally 72 studies were selected. Results Above 72 studies, 71 studies showed that the herbal medicine was effective on treating osteoporosis, using macroscopical, osteological, histological, hematological analysis and urinalysis. Conclusions Using herbal medicine for treating osteoporosis is effective in various pathways. But further study should be conducted to clarify its treatment mechanisms and effectiveness.

• Korean Journal of Pharmacognosy
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• v.50 no.1
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• pp.25-31
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• 2019

The zebrafish (Danio rerio) is an established model organism for several pathophysiological conditions which are related to human diseases. In this study, we tested the preventive effect of eight herbal extracts, which show the inhibitory effect of advanced glycation end products (AGEs) or aldose reductase (AR) in our previous study, on high glucose (HG)-induced retinal vessel dilation in larval zebrafish and analyzed the change of hyaloid vasculature. HG-induced zebrafish hyaloid vasculatures were significantly increased in the thickness compared to untreated zebrafish (P<0.001, n=6~10). Eight herbal extracts were found to have significant retinal vessel dilation on the inhibitory activity. Particularly, Brandisia hancei (twigs and fruits), Castanopsis orthacantha (leaves and twigs), Litsea japonica (leaves and twigs), Spenceria ramalana (whole plant), and Synedrella nodiflora (leaves and stems) showed potent inhibitory activity against retinal vessel dilation in HG-induced larval zebrafish.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.4
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• pp.125-140
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• 2021

Objectives This study aims to find out the recent trend of the herbal medicine treatment in children's stomatitis in China, and propose better methods to treat children's stomatitis in Korea. Methods The randomized controlled trials (RCT) relevant to 'Herbal medicine treatment on children's stomatitis' were searched using China Academic Journal (CAJ). The search method we used included search formula, (SU = '口內炎' + '口腔炎' + 'stomatitis') and (SU = '儿童' + '小儿' + 'children' + 'child') from 2000 to September 2021. Results A total of 9 RCTs were selected and analyzed. All reports showed that oral administration of herbal medicine were effective and improved clinical symptoms. The most-used herbal medicine category was Heat-clearing medicine (淸熱藥). Conclusions The literatures from China have shown that herbal medicine improves children's stomatitis. These outcomes may be helpful for the treatment of children's stomatitis in Korea. However, further studies are needed to develop treatment guidelines for children's stomatitis.

• Journal of Pharmacopuncture
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• v.17 no.4
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• pp.55-60
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• 2014

Objectives: This study was designed to evaluate the efficacy and the safety of constitutional herbal tea for treating chronic fatigue with no diagnosed cause, which is called Mibyeong in Korea. Methods: Males and females with ages between 40 and 59 years who had complained of fatigue for 1 month consistently or for 6 months intermittently without a definite cause were recruited. At the same time, a Chalder fatigue scale (CFS) score of 19 was essential for participation in this study. Sixty five subjects completed the entire process, including blood tests and tests with medical devices. Five assessments of health status were accomplished over 8 weeks by using the CFS and the visual analogue scale (VAS). To ensure that the constitutional herbal tea was being safely used, we conducted and analyzed renal function and liver function tests. For the diagnosis of the Sasang constitution, the Sasang Constitutional Analysis Tool (SCAT) was used, and a specialist in Sasang constitutional medicine made the final diagnosis based on the SCAT result. Constitutional herbal tea was served four weeks after the first visit. The subjects took the constitutional herbal tea twice a day for one month. Results: The results are as follows: The CFS and the VAS scores were significantly improved for the subjects in the constitutional herbal tea. No abnormalities were found on the blood tests to evaluate safety after taking the constitutional herbal tea. The improvements in the CFS and the VAS scores due to the constitutional herbal tea had no significant differences according to the Sasang constitution. Conclusion: Constitutional herbal tea may be used to reduce fatigue and improve health and has no adverse effect on either the kidney or the liver.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.2
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• pp.130-141
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• 2016

Objectives : This study was to performed to investigate the effect of herbal steam therapy on acne vulgaris. Methods : 6 patients with acne vulgaris were treated with korean medicine therapy (herbal medicine and acupunture) including herbal steam therapy. We evaluated the effect by Korean Acne Grading System(KAGS) and Pictures. Results : After treatment, the KAGS Grade of all patients treated with korean medicine therapy including herbal steam therapy is 1. Based on this, we could find that korean medicine therapy including herbal steam therapy is effective and available to ameliorate for the symptoms of acne vulgaris. Conclusions : This clinical cases study shows us that korean medicine therapy including herbal steam therapy seem to be effective to improve symptoms of acne vulgaris. Further studies will be needed to identify herbal steam therapy is beneficial to acne vulgaris.

• The Journal of Internal Korean Medicine
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• v.39 no.6
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• pp.1290-1295
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• 2018

Objectives: This case reports a certain level of improvement for asymptomatic proteinuria with short-term administration of herbal medicine. Methods: In the first treatment phase, the patient was treated with Dangguisu-san (DGSS) for his rib fracture. In the second treatment phase, the patient was treated with a herbal formulation of Astragali and Angelicae Sinensis (A&As particle) for asymptomatic proteinuria. Results: Treatment with herbal medicine resulted in a decrease in the patient's complaints regarding symptoms. Also, proteinuria-related items in hematology and urinalysis were improved. Conclusions: Herbal medicine therapy may be effective for proteinuria treatment.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.4
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• pp.114-125
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• 2020

Objectives : The aim of this study is to review the topical anesthetic effect of herbal medicine. Methods : Using domestic database(OASIS, RISS) and foreign database(Pubmed, Embase, Cochrane library, CNKI), clinical studies about efficacy of herbal medicine as topical anesthetics were searched. Only randomized controlled trials(RCT) were selected and analyzed. Results : Total 647 studies were searched. After screening process, 5 articles were selected. 2 were from Chinese database and 3 were from English database. Articles were about clinical use of herbal medicine as topical anesthetics and compare their efficacy with conventional topical anesthetics. Out of 5 articles, 4 articles used pain rating scales recorded by subjects as outcome measurement. All studies showed lower pain score in herbal medicine using groups. 4 studies showed that there was no statistically significant difference in pain score between herbal medicine using group and conventional topical anesthetics using group. Conclusions : The results suggest that topical anesthetics using herbal medicine is as effective as or maybe even more effective than conventional topical anesthetics. However, experimental design and composition of intervention were all different, which provides inaccuracy when comparing the experimental results. Also, sample sizes were small and the number of RCTs were insufficient to identify full list of herbs that have potentials to be used topical anesthetics. Further studies need to be conducted to find out potentials of herbal medicine as topical anesthetics.

• The Journal of Korean Medicine
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• v.34 no.2
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• pp.59-65
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• 2013

Objectives: This case report was conducted to introduce the effectiveness of herbal decoction on patients with chronic immune thrombocytopenic purpura (ITP). Methods: We closely observed two patients who were admitted to the Department of Internal Medicine 1 of Kyung-Hee Korean Medical Hospital due to ITP. We gave a herbal decoction to these patients and then analyzed the changes in their general conditions as well as blood test results. Results and Conclusions: The treatment with herbal decoctions was helpful for ITP patients.