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In vivo Screening of Herbal Extracts on High Glucose-induced Changes in Hyaloid-Retinal Vessels of Zebrafish  

Lee, Yu-Ri (Herbal Medicine Division, Korea Institute of Oriental Medicine (KIOM))
Jung, Seung-Hyun (Herbal Medicine Division, Korea Institute of Oriental Medicine (KIOM))
Lee, Ik Soo (Herbal Medicine Division, Korea Institute of Oriental Medicine (KIOM))
Kim, Joo Hwan (Department of Life Science, Gachon University)
Kim, Young Sook (Herbal Medicine Division, Korea Institute of Oriental Medicine (KIOM))
Kim, Jin Sook (Herbal Medicine Division, Korea Institute of Oriental Medicine (KIOM))
Publication Information
Korean Journal of Pharmacognosy / v.50, no.1, 2019 , pp. 25-31 More about this Journal
Abstract
The zebrafish (Danio rerio) is an established model organism for several pathophysiological conditions which are related to human diseases. In this study, we tested the preventive effect of eight herbal extracts, which show the inhibitory effect of advanced glycation end products (AGEs) or aldose reductase (AR) in our previous study, on high glucose (HG)-induced retinal vessel dilation in larval zebrafish and analyzed the change of hyaloid vasculature. HG-induced zebrafish hyaloid vasculatures were significantly increased in the thickness compared to untreated zebrafish (P<0.001, n=6~10). Eight herbal extracts were found to have significant retinal vessel dilation on the inhibitory activity. Particularly, Brandisia hancei (twigs and fruits), Castanopsis orthacantha (leaves and twigs), Litsea japonica (leaves and twigs), Spenceria ramalana (whole plant), and Synedrella nodiflora (leaves and stems) showed potent inhibitory activity against retinal vessel dilation in HG-induced larval zebrafish.
Keywords
Zebrafish; Diabetic complications; Diabetic retinopathy; Herbal medicines;
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