대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제35권4호
  • /
  • Pages.125-140
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  • 2021
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  • 1226-8038(pISSN)
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  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지
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소아 구내염의 한약치료에 대한 임상연구 동향: 중의학 무작위대조군 임상시험을 중심으로

A Review of Recent Clinical Studies of Herbal Medicine Treatment for Children's Stomatitis : Focusing on Randomized Controlled Trials in Traditional Chinese Medicine

  • 허유진 (대구한의대학교 부속 대구한방병원 한방소아청소년과) ;
  • 이신희 (대구한의대학교 부속 대구한방병원 한방소아청소년과) ;
  • 조연수 (대구한의대학교 부속 대구한방병원 한방소아청소년과)
  • Heo, Yu Jin (Department of Pediatrics, Daegu Korean Medicine Hospital of Daegu Haany University) ;
  • Lee, Shin Hee (Department of Pediatrics, Daegu Korean Medicine Hospital of Daegu Haany University) ;
  • Cho, Yun Soo (Department of Pediatrics, Daegu Korean Medicine Hospital of Daegu Haany University)
  • 투고 : 2021.10.25
  • 심사 : 2021.11.18
  • 발행 : 2021.11.30
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초록

Objectives This study aims to find out the recent trend of the herbal medicine treatment in children's stomatitis in China, and propose better methods to treat children's stomatitis in Korea. Methods The randomized controlled trials (RCT) relevant to 'Herbal medicine treatment on children's stomatitis' were searched using China Academic Journal (CAJ). The search method we used included search formula, (SU = '口內炎' + '口腔炎' + 'stomatitis') and (SU = '儿童' + '小儿' + 'children' + 'child') from 2000 to September 2021. Results A total of 9 RCTs were selected and analyzed. All reports showed that oral administration of herbal medicine were effective and improved clinical symptoms. The most-used herbal medicine category was Heat-clearing medicine (淸熱藥). Conclusions The literatures from China have shown that herbal medicine improves children's stomatitis. These outcomes may be helpful for the treatment of children's stomatitis in Korea. However, further studies are needed to develop treatment guidelines for children's stomatitis.

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참고문헌

  1. College of Oriental Medicine Compilation Committee of Ophthalmology & Otolaryngology & Dermatology. Korean medicine otorhinolaryngology. 2nd ed. Busan: Sunwoo. 2016:339.
  2. Jeong JY, Han KH. Common skin diseases in Korea. 1st ed. Seoul: Mdworld. 2009:348-52.
  3. National health insurance service, health insurance review & assement service. 2019 National health insurancce statistical yearbook. 1st ed. Gangwongdo: Hanaro vocational training center. 2019:601
  4. Nolan A, McIntosh WB, Allam BF, Lamey PJ. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med. 1991;20(8):389-91. https://doi.org/10.1111/j.1600-0714.1991.tb00950.x
  5. Crighton AJ. Oral medicine in children. Br Dent J. 2017;223(9):706-12. https://doi.org/10.1038/sj.bdj.2017.892
  6. Gherunpong S, Tsakos G, Sheiham A. The prevalence and severity of oral impacts on daily performances in Thai primary school children. Health Qual Life Outcomes. 2004;2(1):1-8. https://doi.org/10.1186/1477-7525-2-1
  7. Department of Pediatrics Nationwide Korean Medicine College. Pediatrics of Korean medicine. 3rd ed. Seoul: Uisungdang. 2020:109.
  8. Eilers J, Epstein JB. Assessment and measurement of oral mucositis. Semin Oncol Nurs. 2004;20(1):22-9. https://doi.org/10.1053/j.soncn.2003.10.005
  9. Sunagawa M, Yamaguchi K, Tsukada M, Ebihara N, Ikemoto H, Hisamitsu T. Kampo (traditional Japanese herbal) formulae for treatment of stomatitis and oral mucositis. Medicines. 2018;5(4):130. https://doi.org/10.3390/medicines5040130
  10. Gu YH, Huang YX, Qiu ZY, Xu ZB, Li DD, Chen L, Jiang J, Gao LZ. Vitamin B2 functionalized iron oxide nanozymes for mouth ulcer healing. Sci China Life Sci. 2020;63(1):68-79. https://doi.org/10.1007/s11427-019-9590-6
  11. Nguyen S, Hiorth M. Advanced drug delivery systems for local treatment of the oral cavity. Ther Deliv. 2015;6(5):595-608. https://doi.org/10.4155/tde.15.5
  12. Chou CY, Huh YS, Won JS, Kim CH. A case of gu-chang, treated with external therapy and herbal medicine. J Korean Med Ophthalmol Otolaryngol Dermatol 2008; 21(2):184-90.
  13. The Korean Society of Herbal Medicine. Bonchohak. 3rd ed. Seoul: Yeongminsa. 2014:199-201, 206-7, 216-21, 231-8, 240-1, 247-8, 356-7, 584-6.
  14. Cai QH, Li XM, Cai YD, Xiao DM, Wang MG, Zhang W, Ma SF, Hong LJ, Zhou HX, Zhang Q, Zhang XY, Lin J. A randomized controlled, multi-center clinical study of kouyanqing granules in treatment of infantile herpetic stomatitis (syndrome of yin-deficiency and windheat). Drug Evaluation Res. 2020;43(9):1792-6.
  15. Wang HY. Therapeutic effect of jiawei sanwu huangqin decoction on children with recurrent aphthous ulcer of heart and spleen heat accumulation syndrome [Master]. [Hebei]: North China University of Science and Technology; 2019. 46p.
  16. Fang J, Hu JX. The clinical observation on the effect of qingxinpi keli in treating 63 cases of heat accumulated in heart and spleen type aphtha in children. J Pediatr of TCM. 2018;14(3):43-6.
  17. Zhang Y. Observation on clinical curative effects of modified xiexin daochi decoction in herpetic stomatitis. J of Chengdu Univ of TCM. 2016;39(2):98-100.
  18. Zhong SX. Clinical observation on the effect of additional xiehuang san in treating herpetic stomatitis in children (Damp-heat syndrome of spleen and stomach [Master]. [Wenjiang]: Chengdu University of TCM; 2015. 46p.
  19. Qian HH. Clear mist particles in the treatment of infantile herpetic stomatitis clinical of cases of excessive heat. [Master]. [Nanjing]: Nanjing University of Chinese Medicine; 2014. 32p.
  20. Jiang HY. Clinical study of combination of traditional Chinese medicine with western medicine in treatment of 40 child patients with herpetic stomatitis. Forum on TCM. 2014;29(6):34.
  21. Shao H. The clinical observation on clinical curative effects of xiepishengqing decoction in 30 children with herpetic somatitis. Nei Mongol J of TCM. 2014;33(35):20.
  22. Lu CF, Li ZL, Xue QJ, Meng QC. Clinical study of combination of traditional Chinese medicine with western medicine in treatment of 40 child patients with herpetic stomatitis. J Pediatr Pharm. 2006;12(5):55-7.
  23. Montgomery-Cranny JA, Wallace A. Rogers HJ, Hughes SC, Hegarty AM, Zaitoun H. Management of recurrent aphthous stomatitis in children. Dent Update. 2015; 42(6):564-72. https://doi.org/10.12968/denu.2015.42.6.564
  24. O' Donnell SC, Marshman Z, Zaitoun H. "Surviving the sting": the use of solicited diaries in children and young people with oral mucosal disease. Int J Paediatr Dent. 2013;23(5):352-8. https://doi.org/10.1111/ipd.12028
  25. Jung HS, Park JH, Ryuk SW, Lee KG. A literal study on the gu-chang. Korean J. Oriental Medical Physiology & Pathology. 2002;16(1):32-44.
  26. Jung JY, Lee H. A study of literature review on the etiology & pathologic mechanism and on the acupunture & moxibustion treatment for gu-chang. J of Haehwa Medicine. 2004;13(1):243-54.
  27. Ha NY, Lee JH, Lee JE, Nam SU. A follow-up study of clinical characteristics of recurrent aphthous stomatitis patients treated with herbal medicine. J Int Korean Med. 2017;38(5):812-9. https://doi.org/10.22246/jikm.2017.38.5.812
  28. Kim TJ, Kim YM, Kim HT. A case of recurrent aphthous stomatitis Improved by Korean medical treatments - focus on the effectiveness of chungyeoldodam-tanggagam and dangguisoo-san plus Yuhyangjeongtong-sangagam. J Korean Med Ophthalmol Otolaryngol Dermatol. 2020;33(2):140-55. https://doi.org/10.6114/JKOOD.2020.33.2.140
  29. Kim JH. A case report of patient with recurrent aphthous stomatitis and pompholyx treated with modified palmulgunja-tang. J Sasang Constitut Med. 2020;32(2):80-95. https://doi.org/10.7730/JSCM.2020.32.2.80
  30. Kim JY, Kim JS, Son JH, Son JH, Seon JK, Kang K, Jang SW, Son JY, Ryu BH. Efficacy of gaminiyukmijihwang-tang on recurrent aphthous stomatitis. Korean J Orient Int Med. 2012;33(2):231-42.
  31. Oh SH. Herpes simplex virus infection in children. Korean J of Pediatric Infectious Diseases. 1997;4(1): 37-42. https://doi.org/10.14776/kjpid.1997.4.1.37
  32. Shin MH, Roh SS, Gim BT. Literatual study on gu-chang. J Korean Med. 1992;13(1):163-76.
  33. Cho G. Seongjechongrok vol.116. 1st ed. Seoul: Hanseongsa. 1977:213.
  34. Quinn B, Stone R, Uhlenhopp M, McCann S, Blijlevens N. Ensuring accurate oral mucositis assessment in the European group for blood and marrow transplantation prospective oral mucositis audit. Eur J Oncol Nur. 2007; 11(1):S10-8. https://doi.org/10.1016/S1462-3889(07)70003-0
  35. Gilchrist F, Rodd H, Deery C, Marshman Z. Assessment of the quality of measures of child oral health-related quality of life. BMC Oral Health. 2014;14(1):1-17. https://doi.org/10.1186/1472-6831-14-1
  36. Oh MH. Ethical considerations for clinical trials performed in children. Korean J Pediatr. 2009;52(1):1-5. https://doi.org/10.3345/kjp.2009.52.1.1