• 대한화장품학회지
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• 제45권2호
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• pp.139-150
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• 2019

자외선에 의해 자외선 차단 효율이 상승하는 선크림에 대한 연구를 수행하였다. Ethylhexyl methoxycinnamate (OMC)는 가장 널리 쓰이는 자외선 차단제이고, OMC에 대한 광안정성 연구는 오랫동안 수행되어왔다. OMC는 자외선에 의해 trans구조가 cis구조로 변하거나, dimer를 비롯한 광반응물을 생성하여 자외선 차단효율이 떨어진다고 알려져 왔다. 하지만 본 연구에서는 OMC나 isoamyl p-methoxycinnamate(IMC)와 같이 메톡시신나메이트 구조를 공유하는 자외선 차단제들이 실제 사용조건과 유사한 조건에서 자외선에 노출 시키고 잘 설계된 실험 방법으로 in vitro SPF 수치를 측정하였을 때 오히려 자외선 차단 효율이 증가하는 것을 발견하였다. 이것은 자외선에 의해서 생성된 광반응물과 OMC간의 ${\pi}-{\pi}$ stacking을 통한 ${\pi}-{\pi}^*$ 전이 에너지 변화(UV activated transition) 때문인 것으로 생각된다. 이 발견을 선크림 개발에 적용하기 위해서는 함께 사용되는 에몰리언트의 극성 및 상용성을 적절히 고려해야 한다. 상용성이 좋은 극성 에몰리언트를 포함하면 자외선에 의해 OMC가 광반응물을 생성하지 않기 때문에 발견의 효과가 감소하는 것으로 보인다. 이러한 작용 기전(UV activated SPF boosting)을 바탕으로 상업용 수준의 선크림을 제조하여 평가해보았다. 그 결과 자외선(2 MED)에 노출되었을 때 in vitro SPF 수치는 50.69에서 72.33으로 42.69%로 증가하였고 in vivo SPF 평가에서는 53.7을 얻어 같은 조건의 대조군의 선크림(SPF 34.4 이하) 대비 56.10% 이상 높게 측정되었다. 따라서 OMC와 IMC가 특정 조건에서 UV sensor처럼 작용하여, 자외선에 노출 되었을 때 자외선 차단 효율을 높일 수 있는 선크림을 제조할 수 있었다.

• Korean Journal of Acupuncture
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• 제36권1호
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• pp.36-43
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• 2019

Objectives : Carbon dioxide ($CO_2$) laser, a high power laser has been used for pain management, dermatology, and surgery and laser acupuncture and moxibustion as well, since it had been oscillated in 1964 at Bell Telephone Laboratories in the US. The purpose of this study is to investigate the history of $CO_2$ laser acupuncture through reviewing studies published in early stage of laser medicine. Methods : To investigate the early history of $CO_2$ laser acupuncture, studies were searched in the electronic databases, including PubMed, ScienceDirect, CNKI, Wanfang, J-STAGE, CiNii, KTNP, and OASIS, since 1964. Articles in English, Chinese, Japanese and Korean were included, and there were no limitations in literature types such as reviews, essays, clinical trials, animal experiments and veterinary research. Results : We found that the first $CO_2$ laser application to acupoints was done by a research team in Shanghai in 1976. They used $CO_2$ laser for acupuncture treatment and it was also the first laser acupuncture treatment in China. Since the first case report of $CO_2$ laser for leukopenia, it has been applied to various diseases in China, Korea, Japan and other western countries. It has been widely applied in the fields of dentistry and veterinary medicine, as well as clinical applications. Conclusions : Not only $CO_2$ laser can be used as laser acupuncture by stimulating the acupoints and meridians, but also can produce moxibustion effect by using heat stimulus. Therefore, it is expected that it will be used in various clinical fields in the future.

• 한국융합학회논문지
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• 제12권8호
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• pp.1-11
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• 2021

본 연구의 목적은 '복압성 요실금'을 키워드로 검색된 연구들의 경향과 특성을 단어 빈도를 통해 분석하고, 워드 임베딩을 사용하여 그 관계를 모델링 하고자 하였다. 의학 서지 데이터베이스인 MEDLINE에 등록되어 있는 복압성 요실금 연구 9,868개 논문들의 초록 문자 데이터를 Python 프로그램을 이용하여 추출하였다. 그런 다음 빈도 분석을 통해 10개의 키워드를 선택하였다. 키워드 관련 단어들의 유사도는 Word2Vec 머신러닝 알고리즘으로 분석하였다. 그리고, t-SNE 기법을 사용하여 단어의 위치와 거리가 시각화하였고, 이에 따라 그룹을 분류하여 이를 분석하였다. 복압성 요실금과 관련된 연구는 1980년대 이후 빠르게 증가했다. 키워드 분석을 통해 논문 초록에서 가장 많이 사용된 키워드는 '여성', '요도', '수술'로 나타났다. Word2Vec 모델링을 통해 복압성 요실금 관련 연구에서 주요 키워드들과 가장 높은 연관성을 나타내는 단어들에는 '여성', '절박', '증상' 등이 있었다. 그리고, t-SNE 기법을 통해 키워드와 관련 단어들은 복압성 요실금의 증상, 신체 기관의 해부학적 특성, 그리고 수술적 중재를 중심으로 하는 3개의 그룹으로 분류될 수 있었다. 본 연구는 초록을 구성하는 단어들의 키워드 빈도 분석 및 워드임베딩 방식을 이용하여 복압성 요실금 관련 연구들의 동향을 살펴본 최초의 연구이다. 본 연구의 결과는 향후 연구자들이 복압성 요실금 관련 연구 분야의 주제와 방향성을 선택하는 데 있어 기초자료로 활용될 수 있을 것이다.

• 지역사회간호학회지
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• 제32권4호
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• pp.430-444
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• 2021

Purpose: This study is an integrated literature review to analyze health problems and social determinants of multicultural adolescents in South Korea. Methods: An integrative review was conducted according to Whittemore & Knafl's guideline. An electronic search that included publications from 2018 to 2020 in the PubMed, EMBASE, Cochrane Library, CINAHL, RISS, and KISS databases was conducted. Of a total of 67 records that were identified, 13 finally met full inclusion criteria. Text network analysis was also conducted to identify keywords network trends using NetMiner program. Results: The health problems of multicultural adolescents were classified into mental health (depression, anxiety, suicide and acculturative stress) and health risk behaviors (smoking, risky drinking, smartphone dependence and sexual behavior). As social determinants affecting the health of multicultural adolescents, the biological factors such as gender, age, and visible minority, and the psychological factors such as acculturative stress, self-esteem, family support, and ego-resiliency were identified. The sociocultural factors were identified as family economic status, residential area, parental education level, and parents' country of birth. As a result of text network analysis, a total of 41 words were identified. Conclusion: Based on these results, mental health and health risk behaviors should be considered as interventions for health promotion of multicultural adolescents. Our findings suggest that further research should be conducted to broaden the scope of health determinants to account for the effects of the physical environment and health care system.

• 한방재활의학과학회지
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• 제32권1호
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• pp.107-124
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• 2022

Objectives This study aimed to identify optimal combinations of acupoints used to treat chemotherapy-induced peripheral neuropathy (CIPN). Methods We searched four international databases (MEDLINE, EMBASE, the Allied and Complementary Medicine Databases [AMED], and China National Knowledge Infrastructure [CNKI]) and five Korean databases (DBpia, Research Information Sharing Service [RISS], Korean Studies Information Service System [KISS], Oriental Medicine Advanced Searching Integrated System [OASIS], and KoreaMed) to identify randomized controlled trials (RCTs) that used acupuncture to treat CIPN. Network analysis was performed on the acupoints used in more than three included articles. We constructed a network by calculating the Jaccard similarity coefficient between acupoints and applied minimum spanning tree. Then, modularity analysis, degree centrality (Cd), and betweenness centrality (Cb) were used to analyze properties of the acupoints. Results A total of 25 articles were included. 24 acupoints were extracted from 25 articles. The combinations of acupoints having the highest Jaccard similarity coefficient were {EX-UE9, EX-LE10} and {ST36, SP6}. In the modularity analysis, acupoints were classified to six modules. ST40, EX-UE11, and KI6 had the highest Cd value while ST40, GB34 had the highest Cb value. Conclusions This study found the systematic framework of acupoint combinations used in CIPN studies. This study is expected to provide new perspectives of CIPN treatment to therapists. A RCT is in progress of using the network of this study as a guideline. If significant results are derived from the RCT, it will be possible to lay the groundwork to consider acupuncture for CIPN treatment.

• 대한본초학회지
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• 제38권6호
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• pp.1-27
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• 2023

Objectives : To investigate the modern research achievements of agarwood and its association with the efficacy of herbal medicine based on the in vivo and in vitro activities of volatile compounds detected in agarwood. Methods : Databases such as PubMed and ScienceOn were searched for medicinal in vivo and in vitro activity studies on agarwood. They were categorized into "medicine and pharmacy" and "others not related to medicine and pharmacy," and the studies on medicine and pharmacy were organized according to active efficacy. The efficacy and virtue of agarwood as identified in the book (or herbal medicine/herbology) corresponded to modern medical terms and diseases in reference to the . Separately, the Gas Chromatography & Mass spectrometer (GC-MS) analysis results of agarwood from a total of 5 production areas of Aquilaria crassna from Vietnam, Indonesia, Malaysia, Myanmar, and Cambodia as identified in previous studies were consulted to search for research papers on the medicinal activity of the 13 compounds of the aromatic sesquiterpene family detected in agarwood, and they were categorized according to topic. Results : There were 123 studies on the medicinal activity of agarwood. Overall, 46 studies on single extracts of agarwood reported activities such as improving mental health, including anti-anxiety and stability, and antiallergic, antioxidant, antibacterial, and digestive system protective effects. In total, 59 papers on the activities of single compounds isolated from agarwood reported anti-inflammatory and mental health benefits. Separately, 13 compounds detected in agarwood, such as α-agarofuran and β-caryophyllene, were reported by 110 studies to have anticancer, stabilizing, antibacterial, and anti-inflammatory activities. There were also papers on the cultivation methods and resin formation conditions of agarwood trees unrelated to the efficacy of herbal medicine. Conclusion : Among the pharmacological papers, a total of 57 papers corresponded to the effects of agarwood in traditional herbal medicine, including 33 papers related to agarwood extracts and 24 papers analyzing 8 types of sesquiterpenes, such as β-caryophyllene and cedrol, from previous studies. Based on the research findings of each paper, it was possible to correlate the effects of agarwood in traditional herbal medicine with the achievements of modern pharmacological research. In addition, further research is anticipated in new areas related to traditional herbal medicine, including the improvement of mental health such as anti-depression, as well as activities related to anticancer, antioxidant, and hair growth.

• 재활치료과학
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• 제12권4호
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• pp.23-37
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• 2023

목적 : 본 연구에서는 국제기능장애 건강분류: 아동 청소년 버전(International Classification of Functioning, Disability and Health-Children and Youth version, ICF-CY) 프레임워크를 활용하여 개별화교육계획(individualized education plan, IEP) 협력적 팀 중재에 대해 체계적으로 고찰하고자 한다. 이를 통해 국내에서 IEP 협력적 팀 중재 속 작업치료사의 전문적인 영역을 마련하는 데 근거를 만들고, 개별화교육계획에서 협력적 팀 접근 중재의 목표를 통해 전문가로서 작업치료사의 역할에 대한 기반을 마련하고자 한다. 연구방법 : EBSCOhost, ProQuest, Web of Science를 통하여 2013년 1월부터 2023년 2월까지의 국외 논문을 검색하였다. 국외 검색어에는 "Special education", "Individualized education plan (IEP)", "IEP process", "IEP implementation", "Occupational therapy"를 사용하였다. 2차 분류를 통해 최종 10편의 연구를 분석하였다. 결과 : 분석 대상 연구의 근거 수준은 무작위 실험설계 연구가 가장 많았고, 중재 대상은 자폐성 장애가 가장 많았으며, 중재 방법은 환경 개선이 가장 많이 적용되었다. ICF-CY를 이용한 IEP 협력적 팀 중재의 목표 분석을 통해 활동에 관하여 5편, 참여와 관련하여 4편, 신체 구조 및 신체 기능과 관련하여 1편인 것으로 확인되었다. 결론 : IEP에서 협력적 팀 접근 중재 속 작업치료사의 역할은 중재의 목표에서 중요한 역할임을 확인할 수 있었다. 이를 기반으로 국내의 IEP에서 협력적 팀 접근의 전문가 중 하나로 작업치료사의 전문성을 설명할 수 있는 근거가 될 것으로 보인다.

• 원예과학기술지
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• 제32권1호
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• pp.123-128
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• 2014

This study investigated the exercise intensity and energy expenditure involved in two gardening activities (planting transplants and sowing seeds in a garden plot) and four common physical activities (running, skipping rope, walking, and throwing a ball) in children. Eighteen children aged 11 to 13 years (mean age, $12.3{\pm}0.7$ years) participated in this study. The children made two visits to a high tunnel in Cheongju, Chungbuk, South Korea and performed randomly selected activities. Each activity was performed for 10 min, with a 5-min rest period between activities. The children wore a Cosmed $K4b^2$ (Cosmed $K4b^2$; Cosmed, Rome, Italy), which is a portable calorimetric monitoring system, to measure indicators of metabolic cost such as oxygen uptake and energy expenditure. The children's heart rates during the activities were measured by radiotelemetry (Polar T 31; FitMed, Kempele, Finland). We found that the two gardening and four physical activities performed by the 11-13 years old children in this study were moderate-to high-intensity physical activities [i.e.,$5.4{\pm}0.7$ to $9.1{\pm}1.4$ metabolic equivalents (METs)]. Running ($9.1{\pm}1.4$ METs) and skipping rope ($8.8{\pm}1.1$ METs) were high-intensity physical activities, whereas walking ($6.1{\pm}0.9$ METs), planting transplants ($5.8{\pm}1.1$ METs), throwing a ball ($5.6{\pm}1.1$ METs), and sowing seeds ($5.4{\pm}0.7$ METs) were moderate intensity physical activities. Running and skipping rope were significantly more intense than the other activities (P < 0.0001). The gardening tasks such as planting transplants and sowing seeds in a garden plot showed similar exercise intensities and energy costs as walking and throwing a ball. This study indicates that gardening can be used as a physical activity intervention to provide health benefits similar to more common physical activities such as walking and running.

• 동의생리병리학회지
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• 제31권2호
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• pp.118-125
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• 2017

The purpose of this study is to investigate the blood pressure reducing effect of Qi-Ju-Di-Huang-Wan (QJDHW) in adults with essential hypertension by using methods of systemic review and meta-analysis. Major search engines, such as PubMed, EMBASE, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, KISS, NDSL, RISS, OASIS, DBpia and so on, were used. The search period we used is from the start date of the search engine to October 30, 2016 and no language limits were placed. Randomized controlled trials using QJDHW in adults with essential hypertension were searched and extracted by two independent researchers. Meta-analysis was performed on outcome variables of the total effective rate (TER), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Risk of bias (RoB) of Cochrane was used to assess methodological quality. Thirteen studies were finally selected. We observed that the combined treatment of QJDHW and antihypertensive drug had 3.6 times the odds ratio of TER for blood pressure lowering than a single use of an antihypertensive drug. Additionally, mean differences of SBP and DBP were -8.88 mmHg (95% Confidential Interval (CI) -12.77 mmHg, -5.00 mmHg, P<0.00001), -7.09 mmHg (95% CI -9.93, -4.25, P <0.00001), respectively. Single use of QJDHW did not reduce blood pressure more than an antihypertensive drug. All items of RoB were unclear and the methodological quality was low. Our analysis suggests that the combination of QJDHW and antihypertensive drugs may be more effective in reducing blood pressure than a single antihypertensive drug. But due to low methodological quality, careful interpretation will be needed and systematic long-term clinical trials will be required.

• Journal of Preventive Medicine and Public Health
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• 제22권2호
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• pp.248-258
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• 1989

As a result of cost-benefit analysis by making a macroscopic approach to the health screening projects conducted 4 times since 1950 for the insured people of the Korea Medical Insurance Corporation, the following conclusions were reached. 1. The direct costs put into the health screening project, and the time costs which were paid by examinees or calculated in terms of social costs have been estimated. The results is that the lowest estimation was 10,337 million won and the highest 15,141 million won when a minimum of 1.5 hours of time spent and a maximum 4 hours were applied. 2. In terms of the psychiatric benefits, the lowest estimation was 5,341 million won while the highest was 5,585 million won. 3. In terms of the benefits for each kind of diseases, the lowest estimation of 37,188 million won and highest estimation of 74,383 million won have been calculated for the liver diseases. And for the cardiovascular diseases, the minimum estimation was 14,475 million won while the maximum was 20,532 million won. In case of pulmonary tuberculosis, with external effect benefits being included, the estimation ranged from the minimum of 1,649 million won to the maximum of 1,832 million won. And the estimation of benefits for diabetes mellitus and renal diseases ranged from 89 million won to 92 million won and from 4,567 million won to 7,598 million won respectively. 4. In comparing costs and benefits, as a results of comparing each highest and lowet estimation a range of minimum 46,708 million won and maximum 98,071 million won of benefits has been gained.