Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Qu-Ji-Du-Huang-Wan for Essential Hypertension : Systemic Review and Meta-analysis

본태성 고혈압에 대한 기국지황환(杞菊地黄丸)의 효과에 관한 체계적 고찰 및 메타 분석

  • Han, In Sik (Department of Korean Internal Medicine, College of Korean Medicine, Sang-ji University) ;
  • Shin, Ji Hye (Department of Korean Internal Medicine, College of Korean Medicine, Sang-ji University) ;
  • Cho, Yoon Young (Department of Korean Internal Medicine, College of Korean Medicine, Sang-ji University) ;
  • Park, Hae Mo (Department of Preventive Medicine, College of Korean Medicine, Sang-ji University) ;
  • Yang, Chang Sop (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Jeong, Min Jeong (Department of Pediatrics, College of Korean Medicine, Woosuk University) ;
  • Jang, Insoo (Department of Internal Medicine, College of Korean Medicine, Woosuk University) ;
  • Sun, Seung Ho (Department of Korean Internal Medicine, College of Korean Medicine, Sang-ji University)
  • 한인식 (상지대학교 한의과대학 한방내과학교실) ;
  • 신지혜 (상지대학교 한의과대학 한방내과학교실) ;
  • 조윤영 (상지대학교 한의과대학 한방내과학교실) ;
  • 박해모 (상지대학교 한의과대학 예방의학교실) ;
  • 양창섭 (한국한의학연구원 임상연구부) ;
  • 정민정 (우석대학교 한의학대학 한방소아과학교실) ;
  • 장인수 (우석대학교 한의학대학 한방내과학교실) ;
  • 선승호 (상지대학교 한의과대학 한방내과학교실)
  • Received : 2016.12.23
  • Accepted : 2017.03.28
  • Published : 2017.04.25
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Abstract

The purpose of this study is to investigate the blood pressure reducing effect of Qi-Ju-Di-Huang-Wan (QJDHW) in adults with essential hypertension by using methods of systemic review and meta-analysis. Major search engines, such as PubMed, EMBASE, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, KISS, NDSL, RISS, OASIS, DBpia and so on, were used. The search period we used is from the start date of the search engine to October 30, 2016 and no language limits were placed. Randomized controlled trials using QJDHW in adults with essential hypertension were searched and extracted by two independent researchers. Meta-analysis was performed on outcome variables of the total effective rate (TER), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Risk of bias (RoB) of Cochrane was used to assess methodological quality. Thirteen studies were finally selected. We observed that the combined treatment of QJDHW and antihypertensive drug had 3.6 times the odds ratio of TER for blood pressure lowering than a single use of an antihypertensive drug. Additionally, mean differences of SBP and DBP were -8.88 mmHg (95% Confidential Interval (CI) -12.77 mmHg, -5.00 mmHg, P<0.00001), -7.09 mmHg (95% CI -9.93, -4.25, P <0.00001), respectively. Single use of QJDHW did not reduce blood pressure more than an antihypertensive drug. All items of RoB were unclear and the methodological quality was low. Our analysis suggests that the combination of QJDHW and antihypertensive drugs may be more effective in reducing blood pressure than a single antihypertensive drug. But due to low methodological quality, careful interpretation will be needed and systematic long-term clinical trials will be required.

Keywords

References

  1. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine. Cardiovascular and Neurological Medicine in Korean Medicine. Seoul: Koonja; 2010. p. 435-7.
  2. Bureau of Healthcare Policy, Ministry of Health and Welfare. 2014 Second year of National Health and Nutrition Examination Survey the sixth term, 2015. p. 52-3.
  3. Lawes CM, Bennett DA, Parag V, Woodward M, Whitlock G, Lam TH, et al. Blood pressure indices and cardiovascular disease in the Asia Pacific region: a pooled analysis. Hypertension (Dallas, Tex: 1979). 2003;42(1):69-75. https://doi.org/10.1161/01.HYP.0000075083.04415.4B
  4. The board of establishing guideline for diagnosis in the Korean society of hypertension. Guideline for the diagnosis and management of hypertension in the Korean society of hypertension. 2013. p. 33-7.
  5. Baek HG, An JJ, Jo HK, Yoo HR, Kim YS, Seol IC. Korean Herbal Medicine on Hypertension : A Systematic Review in Korean Internal Medicine's Studies. Korean journal of oriental medicine, Daejon university. 2009;18(2):81-8.
  6. Kim CS, Kim YE, Kim C, Kim JH, Yea SJ, Song MY. Analysis of Research Articles on Oriental Herbal Medicines for Hypertension. Kor. J. Oriental Preventive Medical Society. 2011;15(3):17-38.
  7. Kim HR, Son HG. Prevalence of Hypertension and Its Risk Factors among Aged 65 and over in Korea. The Journal of Korean Biological Nursing Science. 2012;14(4):282-90. https://doi.org/10.7586/jkbns.2012.14.4.282
  8. Gao HQ, Wang Y, Wang JH, Wang HM, Yan JJ. Clinical analysis of the treatment with Tianma Gouteng decoction combined with Lycium-rehmanniapill. Modern Journal of Integrated Traditional Chinese and Western Medicine. 2012;21(2):129-30.
  9. Yue ZJ, Zhou ZD, Li DH, Zhang HY, Mu Y. The effect of blood pressure and renal blood flow for essential hypertension’s rat using the method to tonify kidney. Chinese Journal of Experimental Traditional Medical Formulae. 2009;15(1):42-4.
  10. An IH, Kim SG. Effect of the water extract of Gi Kook Jee Hwang Tang on the blood pressure of rabbits. Journal of Korean Medicine. 1989;10(1):93-8.
  11. National Evidence-based Healthcare Collaborating Agency (NECA). NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. Chapter 6. The evaluation for risk of bias. Seoul, NECA, 2011. p. 64-71.
  12. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343.
  13. Jiang W. Clinical efficacy of Qiju Dihuang pills in elderly patients with isolated systolic hypertension. 2015(4):17-8.
  14. Liao HY. The clinical study of Qi ju Dihuang Pill on elderly isolated systolic hypertension. Guangzhou: Guangzhou University of Chineses Medicine; 2014.
  15. Zhang J. The clinical study of enrich the kidney and nourish the liver on elderly isolated systolic hypertension. Guangzhou Guangzhou University of Chinese Medicine; 2011.
  16. Guan HL, Zhang J, Liao HH. 30 cases clinical study to treat senile systolic hypertension using the method of nourishing kidney and emolliating the liver. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine. 2014;14(2):12-4.
  17. Zhu CQ. Effective Analysis about treating senile hypertension using Qiju Dihuang Wan combined with Nifedipine Controlled released Tablets. China Medicine and Pharmacy. 2012;2(3):119-21.
  18. Huang Q. Qiju Dihuang Wan combined with Nifedipine in the Treatment of Liver and Kidney Yin Deficiency Hypertension Randomized Controlled Study. Journal of Practical Traditional Chinese Internal Medicine. 2016;30(11):1-4.
  19. Zhang J. Clinical study on essential hypertension using Chinese medicine combined with western medicine. Journal of Practical Traditional Chinese Medicine. 2015;30(9):830-1.
  20. Du BJ, Huang ZF, Kong XC. The effect of blood plasma Ang II, ET and CGRP on Qiju Dihuang Wan combined with felodipine sustained release tablets. Information on Traditional Chinese Medicine. 2009;26(4):53-4.
  21. Li W, Chen HG, You W. 60 cases report to treat hypertension using Qiju Dihuang Wan. China's naturopathy. 2012;20(2):37-8.
  22. Zheng Y, Lin Z, Zheng P, Ye MF. Effects of Songling Xuemaikang Capsule combinded with Qiju Dihuang pill on vascular endothelial function in patients with elderly hypertension with deficiency of liver and kidney and internal static blood obstruction. Chinese Journal of Experimental Traditional Medical Formulae. 2016;22(8):164-8.
  23. Wang YC. Protective effect of Qiju Dihuang Decoction on renal damage in early hypertension. Journal of Changchun University of Traditional Chinese Medicine. 2014;30(1):107-8.
  24. Jiang LL. Clinical effect for treating essential hypertension using Qiju Dihuang Wan combined with tianma gouten yin. Guide of China Medicine. 2012;10(27):271-2.
  25. Yun YG. Dong-ui Bang-je & cheo-bang hae-seol. Seoul: Eui Seong Dang Publishing Co.; 2007. p. 516.
  26. Hu X. 30 cases report for treating hypertension with yin deficiency and yang hyperactivity using Qiju Dihuang Wa combined with Apocynum venetum tea. Chinese and Foreign Medical Research. 2013;11(36):51-2.
  27. Choi KW, Lee YS. The Concept of Frailty: A Review of the Literature. Korean J Rehabil Nurs. 2008;11(2):67-73.
  28. Bao RJ. Chinese traditional medicine treatment for renal hypertension. Henan Traditional Chinese Medicine. 2013;33(5):713-4.

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