• 제목/요약/키워드: Korea red ginseng

검색결과 622건 처리시간 0.019초

Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway

  • Mitra, Ankita;Rahmawati, Laily;Lee, Hwa Pyoung;Kim, Seung A.;Han, Chang-Kyun;Hyun, Sun Hee;Cho, Jae Youl
    • Journal of Ginseng Research
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    • 제46권5호
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    • pp.690-699
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    • 2022
  • Background: Few studies reported the therapeutic effect of Korean Red Ginseng (KRG) in lung inflammatory diseases. However, the anti-inflammatory role and underlying molecular in cadmium-induced lung injury have been poorly understood, directly linked to chronic lung diseases (CLDs): chronic obstructive pulmonary disease (COPD), cancer etc. Therefore, in this study we aim to investigate the therapeutic activities of water extract of KRG (KRG-WE) in mouse cadmium-induced lung injury model. Method: The anti-inflammatory roles and underlying mechanisms of KRG-WE were evaluated in vitro under cadmium-stimulated lung epithelial cells (A549) and HEK293T cell line and in vivo in cadmium-induced lung injury mouse model using semi-quantitative polymerase chain reaction (RT-PCR), quantitative real-time PCR (qPCR), luciferase assay, immunoblotting, and FACS. Results: KRG-WE strongly ameliorated the symptoms of CdSO4-induced lung injury in mice according to total cell number in bronchoalveolar lavage fluid (BALF) and severity scores as well as cytokine levels. KRG-WE significantly suppressed the upregulation of inflammatory signaling comprising mitogen-activated protein kinases (MAPK) and their upstream enzymes. In in vitro study, KRG-WE suppressed expression of interleukin (IL)-6, matrix metalloproteinase (MMP)-2, and IL-8 while promoting recovery in CdSO4-treated A549 cells. Similarly, KRG-WE reduced phosphorylation of MAPK and c-Jun/c-Fos in cadmium-exposed A549 cells. Conclusion: KRG-WE was found to attenuate symptoms of cadmium-induced lung injury and reduce the expression of inflammatory genes by suppression of MAPK/AP-1-mediated pathway.

Ginsenoside derivatives and quality characteristics of fermented ginseng using lactic acid bacteria (유산균을 이용한 발효인삼의 ginsenoside 유도체 및 품질특성)

  • Kang, Bok-Hee;Lee, Kun-Jae;Hur, Sang-Sun;Lee, Dong-Sun;Lee, Sang-Han;Shin, Ki-Sun;Lee, Jin-Man
    • Food Science and Preservation
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    • 제20권4호
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    • pp.573-582
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    • 2013
  • This study was done in order to investigate the bioconversion of ginsenoside, as well as the quality characteristics of fermented ginseng, by using lactic acid bacteria. Quality characteristics such as the thin layer chromatography(TLC) pattern, ginsenosides, total phenolic content, electron donating ability, and total sugar of fermenting ginseng and red ginseng were analyzed. The ginsenoside Rg2r, Rh2s and Rh2r of the fermented ginseng and red ginseng for 65 hours at a temperature of $37^{\circ}C$ were not detected. The ginsenoside Rg1 and Re contents have decreased, while the Rh1, Rg2s, Rd, Rg3r, and Rg3s have increased due to fermentation. The ginsenoside Rg3 of the fermented red ginseng has increased and the contents were $114.83{\sim}131.68{\mu}g/mL$ (control $104.56{\mu}g/mL$). The total phenolic content and electron donating ability of the red ginseng have totally decreased after 7 days of fermentation. The total phenolic contents of the fermented ginseng and red ginseng with different lactic acid bacteria did not show any tendency as different strains. The electron donating ability of the fermented ginseng has increased; however, the electron donating ability of the red ginseng has decreased. The total sugars of the fermented ginseng and red ginseng with different lactic acid bacteria have also decreased.

The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice

  • Oh, Mi-Jeong;Kim, Hyun-Ju;Park, Eun-Young;Ha, Na-Hee;Song, Mun-Gyu;Choi, Sang-Hyun;Chun, Boe-Gwun;Kim, Dong-Hoon
    • Journal of Ginseng Research
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    • 제41권1호
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    • pp.52-59
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    • 2017
  • Background: Korean Red Ginseng extract (KRG, Panax ginseng Meyer) and its constituents have been used for treating diabetes. However, in diet-induced obese mice, it is unclear whether KRG can enhance the glucose-lowering action of rosiglitazone (ROSI), a peroxisome proliferator-activated receptor gamma synthetic activator. Methods: Oral glucose tolerance tests (oGTTs) were performed after 4 days of treatment with a vehicle (CON), KRG [500 mg/kg body weight (b.w.)], ROSI (3.75 mg/kg b.w, 7.5 mg/kg b.w, and 15 mg/kg b.w.), or ROSI and KRG (RK) in obese mice on a high-fat diet. Adipose tissue morphology, crown-like structures (CLSs), and inflammation were compared by hematoxylin-eosin staining or quantitative reverse transcription polymerase chain reaction. Results: The area under the glucose curve (AUC) was significantly lower in the RK group (15 mg/kg b.w. and 500 mg/kg b.w. for ROSI and KRG, respectively) than in the CON group. There was no significant difference in the AUC between the CON and the other groups. Furthermore, the AUC was significantly lower in the RK group than in the ROSI group. The expression of the Ccl2 gene and the number of CLSs were significantly reduced in the RK group than in the CON group. Conclusion: Our results show a potential enhancement of ROSI-induced improvement of glucose regulation by the combined treatment with KRG.

The history of ginseng cultivation in Ganghwa area (강화 지역의 인삼 재배 역사)

  • Lee, Sungdong
    • Journal of Ginseng Culture
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    • 제2권
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    • pp.9-16
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    • 2020
  • Ginseng was first addressed ever in the medical record in HyangYakGooGupBang (鄕藥救急方), the oldest Korean medical book published in Kingdom of Goryeo (918-1392) when Ganghwa was the provisional capital city at the time. It is believed that ginsengs in Ganghwa were planted and cultivated from 1100s. Intensive ginseng production in Ganghwa began when Ganghwa became the special district of the Kaesong Ginseng Union (開城人蔘組合) in 1920s, this intensive production continued till the Korean War in 1950. After the Korean War ended in 1953, ginseng production was resumed. In 1967, Ganghwa Ginseng Association (江華蔘業組合) was founded. The total acreage of ginseng harvested was nearly 200 ha in 1967 and it increased to ha 900 in 1974. By mid-1970s, Ganghwa became the largest ginseng region in Korea by total production and acreage. Most of ginseng roots cultivated in Ganghwa are six years old. Ganghwa, which was already well-known for red ginseng productions, has become even more famous for ginseng production.

Clinical Effectiveness of Korea Ginseng on Climacteric Disturbances and Its Possible Mechanism of Action

  • Ogita, Sacchio
    • Proceedings of the Ginseng society Conference
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    • 고려인삼학회 1990년도 Proceedings of International Symposium on Korean Ginseng, 1990, Seoul, Korea
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    • pp.20-24
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    • 1990
  • The climacteric is that phase in the aging process during which a woman passes from the reproductive to the non-reproductive stage. The signals, such as hot flashes, vaso-motoric disturbances, perspiration, stiff shoulders, emotional symptoms, are refereed to as climacteric disturbances. Treatment of climacteric symptoms centers on estrogen replacement and transquilizers, but there are many problems to be solved to use these hormones/drugs as far as dosage, duration and complications are concerned. The care of women during the climacteric years should provide relief of distressing symptoms with as high a degree of safety as possible. From this viewpoint, we used red ginseng powder to those patients with high menopausal index successfully. We studied its mechanism of action and proved that red ginseng improved the micro-circulation system via improvement of erythrocyte deferability which enhanced sex steroidgenesis consequently

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Clinical Effectiveness of Korea Ginseng on Climacteric Bisturbances and Its Possible Mechanism of Action (갱년기 질환에 대한 고려인삼의 임상효능과 작용기전)

  • Ogita, Sacchio
    • Journal of Ginseng Research
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    • 제14권2호
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    • pp.162-166
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    • 1990
  • The climacterium is that phase in the aging precess during which a woman passes from the reproductive to the non-reporductive stage. The signals, such as hot flashes, vaso-motoric disturbances, perspiration, stiff shoulders, emotinal symptoms, are refered to as climacteric disturbances. Treatment of climacteric symptoms centers around estrogen replacement and transfuilizers, but there are many problems to be solved to use these hormones/drugs as far as dossage, duration and complications are concerned. The care of women during the climacteric years should provide relief of distressing symptoms with as high a degree of safety as possible. From this view point, we used red ginseng powder to those patients with high menopausal index successfully. We studied its mechanism of action and proved that red ginseng improved the micro-circulation system via improvement of erythrocyte reformability which enhanced sex steroidgensis consequently.

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Antigenicity Studies of the Aqueous Extract of Red Ginseng in Guinea Pigs

  • Lee, Jong-Wha;Rhee, Man-Hee;Park, Ki-Hyun
    • Archives of Pharmacal Research
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    • 제17권3호
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    • pp.154-160
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    • 1994
  • The antigenicity of the aqueous extract of red ginseng (ARG) was evaluated using the following assay procedures : 1. active systemic anaphylaxis (ASA) in guinea pigs, 2 active cutaneous anaphylaxis (ACA) in guinea pigs, 3 passive cutaneous anaphylaxis (PCA) in guinea pigs, 2.active cutaneous anaphylaxis (ACA) in guinea pigs, 3. passive cutanepous anaphylaxis (PCA) in guina pigs with serum for guina pigs sensitized with ARG and 4. passive hemagglutination (PHA) with serum from guinea pigs sensitized with ARG. 1. ASA : No anaphylaxis reaction was observed in any of the sensitized guinea pigs by elictitation with ARG. 2. ACA : No skin reaction was observed in sensitized guinea pigs after intrademal injection of ARG. 3. PCA in guinea pigs : PCA titer of sera from all the sensitized animals was less than 10 in eliciation with ARG. 4. PHA reaction : When eythrocytes coated with challenge antigen were added to sensitized sera, the hemagglutination titer was less than 1. These results suggest that ARG has no antigenicity under the conditions used. And the dose levels of ARG employed in the present experiment were confirmed not to suppress immune reactions.

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The changes and meanings in the volume of Korea red ginseng trade in late chosun dynasty (조선후기 고려홍삼 무역량의 변동과 의미)

  • Lee, Chulsung
    • Journal of Ginseng Culture
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    • 제1권
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    • pp.67-77
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    • 2019
  • This study tried to evaluate the official Korea Red Ginseng(Hongsam) trade in 19th century. The Hongsam trade activities of the 19th century also show that the collected amount of Posam taxes (Hongsam taxes) alone outweigh the amount of cost spent during the same time period to launch tributary actions. It is quite obvious that the Chosun dynasty, supported by the developed techniques of ginseng cultivation and preservation methods, managed to stop the silver leaks while also stimulating the domestic commerce, handicraft business and mining operations, by exporting Hongsam to China and importing raw material and other finished products in return. The Chosun government also managed to secure considerable amount of marginal profit which at times mounted to almost 2 hundred thousand Nyangs of silver during the latter half of the 19th century thanks to this Hongsam trade activities, and accumulated the hoof-shaped pieces of silver ingot at the office of Ministry of Taxation. Even under the mostly undesirable political environment featuring unjustified deeds of the powerful houses, the commercial activities were being strongly maintained, and the transactions conducted by merchants of the Gaeseong, Euiju areas and the capital city were prospering.

Bifidus Fermentation Increases Hypolipidemic and Hypoglycemic Effects of Red Ginseng

  • Trinh, Hien-Trung;Han, Sang-Jun;Kim, Sang-Wook;Lee, Young-Chul;Kim, Dong-Hyun
    • Journal of Microbiology and Biotechnology
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    • 제17권7호
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    • pp.1127-1133
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    • 2007
  • Antihyperlipidemic and antihyperglycemic effects of Red Ginseng (RG, steamed and dried root of Panax ginseng C.A.Meyer, family Araliaceae), major component of which is ginsenoside Rg3, and Bifidodoterium-fermented RG (FRG), major component of which is ginsenoside Rh2, were investigated. Orally administered RG and FRG potently reduced the serum triglyceride levels in com-oil-induced hypertriglycemidemic mice as well as total cholesterol and triglyceride levels in Triton WR-1339-induced hyperlipidemic mice. Of the saponin and polysaccharide fractions of RG and FRG, the polysaccharide fraction inhibited postprandial blood glucose elevation of maltose- or starch-loaded mice and reduced the blood triglyceride levels in com-oil-induced hypertriglycemidemic mice. The saponin fraction and its ginsenosides Rg3 and Rh2 reduced blood triglyceride and total cholesterol levels in Triton WR1339-induced hyperlipidemic mice. The inhibitory effect of FRG and its main constituents against hyperlipidemia and hyperglycemia in mice were more potent than those of RG. These findings suggest that hypolipidemic and hypoglycemic effects of RG can be enforced by Bifidus fermentation and FRG may improve hyperlipidemia and hyperglycemia.

Beneficial Effect of Korea Red Ginseng on Halitosis; Attenuation of H2S Induced Inflammatory Mediators and cystathionine γ-lyase Expression (고려홍삼의 구강악취 억제기능; H2S 생성에 따른 염증매개 유전자 및 cystathionine γ-lyase의 약화기능)

  • Choi, Ki-Seok;Lee, So-Jung;Lee, Jeong-Sang;Hong, Kyung-Sook;Kim, Jeong-Gon;Kim, Yoon-Jae;Hahm, Ki-Baik
    • Journal of Ginseng Research
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    • 제33권4호
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    • pp.367-377
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    • 2009
  • Halitosis is a generally accepted marker of diseases in the oral cavity and of systemic and gastrointestinal disorders. Based on these authors' previous findings (that (1) there is a close association between H. pylori infection and halitosis; (2) Korea red ginseng may suppress the colonization of H. pylori, fight H. pylori-induced cytotoxicity, and impose significant anti-inflammatory actions in patients with chronic gastritis; and (3) H. pylori infection is linked with the generation of significant levels of volatile sulfur compounds (VSCs), and the levels of VSCs correlate significantly with H. pylori-associated mucosal damages), in the current study, the authors documented the molecular mechanisms of Korea red ginseng's efficacy in ameliorating halitosis. When the RAW 264.7 cells were treated with the $H_2S$ releasing compound NaHS, the mRNA expression of cystathionine ${\gamma}$-lyase (CSE), IL-6, COX-2, and iNOS were more significantly induced compared with the vehicle-treated group. The cytoskeletal components of ezrin's and moesin's mRNA expressions were elevated by NaHS treatment accompanied by the activation of MAPK, p38, and ERK. Korea red ginseng pretreatment reduced both the NaHS-induced CSE expression and the proinflammatory genes (e.g., IL-6, COX-2, and iNOS) in a concentration-dependent manner. The ERM expression and the phosphorylation of p38 were also significantly reduced by Korea-red-ginseng pretreatment. Overall, Korea red ginseng pretreatment imposed significant anti-inflammatory effects through the downregulation of the NaHS-triggered proinflammatory gene expression, CSE, and ERM mRNA expression. Korea red ginseng could thus be said to be a key remedy of halitosis and to be effective in relieving gastric inflammation.