• Journal of Korean Elementary Science Education
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• v.43 no.1
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• pp.95-107
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• 2024

In this study, we explored the mediating effect of grit in the relationship between elementary school science teachers' perceived personal pedagogical content knowledge (pPCK) and enacted pedagogical content knowledge (ePCK). Drawing on insights from a review of the literature, we developed a research hypothesis model that set pPCK, ePCK, and grit as latent variables. Pearson correlation was conducted to examine the interrelationships among the latent variables. Structural equation modeling (SEM) was then employed to analyze the model fit. Additionally, bootstrap analysis was performed to specifically investigate the mediating effect of grit in the relationship between pPCK and ePCK. The Pearson correlation analysis indicated statistically significant correlations among the measurement variables. Meanwhile, the SEM analysis revealed that the measurement model aligned with the research hypothesis model. Furthermore, the bootstrap analysis demonstrated that grit had a statistically significant mediating effect in the relationship between elementary school science teachers' perceived pPCK and ePCK. These findings quantitatively examine the importance and impact of grit in the teacher expertise domain, providing valuable insights for the development of teachers' expertise and teacher education research within elementary school science classes.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.3973-3980
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• 2014

Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg). The present study was undertaken to explore the association of this SNP with susceptibility to prostate adenocarcinoma along with its structural and functional impacts in the Pakistani population in a case-control study. Three-dimensional structure of human TP53 with Pro72Arg polymorphism was predicted through homology modeling, refined and validated for detailed structure-based assessment. We also carried out a HuGE review of the previous available data for this polymorphism. Different genetic models were used to evaluate the genotypes association with the increased risk of PCa (Allelic contrast: OR=0.0.34, 95%CI 0.24-0.50, p=0.000; GG vs CC: OR=0.17, 95%CI 0.08-0.38, p=0.000; Homozygous: OR=0.08, 95%CI 0.04-0.15, p=0.000; GC vs CC: OR=2.14, 95%CI 1.01-4.51, p=0.046; Recessive model: OR=0.10, 95%CI 0.05-0.18, p=0.000; Log Additive: OR=3.54, 95%CI 2.13-5.89, p=0.000) except the Dominant model (OR=0.77, 95%CI 0.39-1.52, p=0.46). Structure and functional analysis revealed that the SNP in the proline rich domain is responsible for interaction with HRMT1L2 and WWOX. In conclusion, it was observed that the Arg coding G allele is highly associated with increased risk of prostate adenocarcinoma in the Pakistani population (p=0.000).

• Journal of The Korean Association For Science Education
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• v.36 no.1
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• pp.87-101
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• 2016

This study analyzes the content validity of descriptive tests developed for elementary schools, in order to acquire basic data to improve them. Various descriptive tests were collected and tested for differences in proportions between two-dimensional classification of educational objectives and the level of behavioral objectives. Results show that the descriptive tests developed by elementary school teachers mainly focused on "knowledge" and "understanding," and that content validity for behavioral levels to be low. Nine elementary school teachers were interviewed to understand the result. From the interviews, we found both internal and external factors that cause low content validity. The main internal factors were teachers' ability to make two-dimensional classification of educational objectives, the teachers' consideration of students' level, item level of difficulty, the ease of scoring, and path dependence. The main external factors were curriculum, parents, and administration. Based on the results, we suggested the factors related to elementary school teachers' PCK of descriptive tests.

• School Mathematics
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• v.17 no.2
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• pp.309-329
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• 2015

This study is to provide didactical implications for teaching and learning of radian through a analysis of investigation result about pre-service teachers' understanding of radian. The results of this study are as follows. First, pre-service teachers understood the radian as ${\frac{180^{\circ}}{\pi}}$, rather than as the definition. Secondly, the definition style of radian affected the problem solving strategy for the measurement of the angle. Thirdly, pre-service teachers had insufficient content knowledge about properties of measurement as a pure number of radian. Lastly, They failed to describe the usefulness of circular measure. We suggested the definition of radian in textbooks should be changed from ${\frac{180^{\circ}}{\pi}}$ to mathematical definition of radian. And the general angle should be stated as the reason why the domain of trigonometric function is real numbers.

• Journal of The Korean Association of Information Education
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• v.24 no.1
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• pp.59-69
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• 2020

The purpose of this study is to design the framework of evaluation on learner's cognitive skill for artificial intelligence(AI) education through computational thinking. To design the rubric and framework for evaluating the change of leaner's intrinsic thinking, the evaluation process was consisted of a sequential stage with a) agency that cognitive learning assistance for data collection, b) abstraction that recognizes the pattern of data and performs the categorization process by decomposing the characteristics of collected data, and c) modeling that constructing algorithms based on refined data through abstraction. The evaluating framework was designed for not only the cognitive domain of learners' perceptions, learning, behaviors, and outcomes but also the areas of knowledge, competencies, and attitudes about the problem-solving process and results of learners to evaluate the changes of inherent cognitive learning about AI education. The results of the research are meaningful in that the evaluating framework for AI education was developed for the development of individualized evaluation tools according to the context of teaching and learning, and it could be used as a standard in various areas of AI education in the future.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4623-4627
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• 2014

Background: The epidermal growth factor receptor (EGFR) plays a vital role in the activation and inactivation of receptor tyrosine kinases. Mutations in exons 19 and 21 of EGFR are commonly found to be associated with non small cell lung carcinoma and triple negative breast cancer, enhancing sensitivity to EGFR targeting chemotherapeutic agents. Since amplification and prolonged activation of EGFR molecules have been identified in oral squamous cell carcinomas (OSCC), we investigated whether OSCCs carried mutations in exons 19 and 21 of EGFR to their incidence. Materials and Methods: Tumor chromosomal DNA isolated from forty surgically excised oral squamous cell carcinoma tissues was subjected to PCR amplification with intronic primers flanking exons 19 and 21 of the EGFR gene. The PCR amplicons were subsequently subjected to direct sequencing to elucidate the mutation status. Results: Data analysis of the EGFR exon 19 and 21 coding sequences did not show any mutations in the forty OSCC samples that were analyzed. Conclusions: To the best of our knowledge, this is the first study to have investigated the genetic status of exons 19 and 21 of EGFR in Indian OSCCs and identified that mutation in EGFR exon 19 and 21 may not contribute towards their genesis. The absence of mutations also indicates that oral cancerous lesions may not be as sensitive as other cancers to chemotherapeutic agents targeting EGFR.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3719-3724
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• 2013

Background: RASSF1A has been reported to be a candidate tumor suppressor in non-small cell lung cancer (NSCLC). However, the association between RASSF1A promoter methylation and NSCLC remains unclear, particularly in regarding links to clinicopathologic features. Methods: Eligible studies were identified through searching PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases. Studies were pooled and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also performed to evaluate publication bias. Results: Nineteen studies involving 2,063 cases of NSCLC and 1,184 controls were included in this meta-analysis. A significant association was observed between RASSF1A methylation and NSCLC in the complete data set (OR = 19.42, 95% CI: 14.04-26.85, P < 0.001). Pooling the control tissue subgroups (heterogeneous/autologous) gave pooled ORs of 32.4 (95% CI, 12.4-84.5) and 17.7 (95% CI, 12.5-25.0) respectively. Racial subgroup (Caucasian/Asian) analysis gave pooled ORs of 26.6 (95% CI, 10.9-64.9) and 20.9 (95% CI, 14.4-30.4) respectively. The OR for RASSF1A methylation in poorly-differentiated vs. moderately/well-differentiated NSCLC tissues was 1.88 (95% CI, 1.32-2.68, P<0.001), whereas there were no significant differences in RASSF1A methylation in relation to gender, pathology, TNM stage and smoking behavior among NSCLC cases. Conclusion: This meta-analysis suggests a significant association between RASSF1A methylation and NSCLC, confirming the role of RASSF1A as a tumor suppressor gene. Large-scale and well-designed case-control studies are needed to validate the associations identified in the present meta-analysis.

• The Journal of Korean Association of Computer Education
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• v.5 no.2
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• pp.21-28
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• 2002

This paper proposes a new approach to rollback-recovery using multi-agent in distributed computing system. Previous rollback-recovery protocols are dependent on inherent communication and operating system, which causes a decline of computing performance in distributed computing system. By using multi-agent, we propose rollback-recovery protocol that is independent on operating system. We define three kinds of agent. One is a recovery agent that performs rollback-recovery protocol after a failure. Other is an information agent that constructs domain knowledge as a rule of fault tolerance and information during failure-free operation. The other is facilitator agent that controls the efficient communication between agents. Also we propose rollback-recovery protocol using multi-agent and simulated the proposed rollback-recovery protocol using JAVA and agent communication language in CORBA environment.

• Journal of Korean Elementary Science Education
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• v.35 no.3
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• pp.362-376
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• 2016

The purpose of this paper was to analyze the characteristics of Korean science curriculum and the differences with the other country. For this purpose, the USA was selected as the target country for comparison. The comparison focused on goals and contents in science curriculum document. The goals for science education in both countries were similar. But the goal setting level was different. Also, four objectives were suggested in Korean curriculum and nine objectives in the USA to achieve the general objective. Korean curriculum was composed of such grades system as 3rd & 4th grades, 5th & 6th grades and content area as 'materials and energy', 'life and the earth' in content system. And the USA composed in the such grade system as K, Grade 1, 2, 3, 4 and 5. Also the elements to be learned is suggested in the strand. And in the area of the earth and space in the Korean Curriculum, there are elements emphasized in the content area, cognitive area, context category and practical activities learning objective category. But the USA covered most of those elements evenly. Korean curriculum focused on learning of certain elements in certain grades, but the USA curriculum is to learn several elements evenly in every grade. It will be future topics of research to investigate the effect of curriculum with different emphasis of improving students' scientific knowledge and learning through further study.

• Journal of Korean Library and Information Science Society
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• v.50 no.4
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• pp.249-272
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• 2019

This study aims to investigate the experiences of librarians/staff members who are responsible for facilitating makerspaces in public libraries, including their works and core competencies, their needs and experiences of training, and future plans in makerspaces. To do that, we carried out semi-structured interviews with 11 librarians/staff members and 1 library director from 7 public library makerspaces. Findings show that the participants received financial supports from the government agencies or/and relied on their library budget to run makerspaces. They identified competencies such as technology literacy, domain knowledge, teaching/programming, willingness to learn and curiosity, communication skills, leadership, and design-thinking. They have future plans for expanding spaces, purchasing equipments, program development, and so on. We believe findings could be useful for those who currently manage or plan to implement a public library makerspace by understanding practical issues and training needs in makerspaces.