• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Journal of Satellite, Information and Communications
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• v.3 no.1
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• pp.41-47
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• 2008

Line-of-sight communications cannot easily support korean armed forces because of mountainous terrain. ADD(Agency for Defense Development) introduced ANASIS(Army Navy Air-force Satellite Information System) to meet the Korean warfighter's operational needs. Currently, army's military satcom terminal is designed for either fixed site or on-the-pause operation. The US army is under development of multi-band integrated on-the-move satellite terminals to let the army's communication capability to keep pace with globally deployable Joint Task Force for network-centric application. In this paper we analyzed X-band and Ka-band link and subsystem requirement. Our focus here is to describe key technical issues. Especially, On the basis of 3dB beam width of 0.9m antenna, Tracking accuracy and disturbances compensation signal processing on-the-move of Antenna Tracking system is analyzed. Also, protocol is analyzed that minimize blockage on the move due to an obstacle. when the received signal blocked, it stop to transmit burst signal and retransmit when blockage removed through received synchronization signal monitoring. Analyzed specification will be used to make prototype terminal to analyze risk for mass production

• Journal of the Korean Society for Marine Environment & Energy
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• v.18 no.3
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• pp.179-188
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• 2015

This study reviewed the type of the project and developmental plan related to ocean energy development in the coastal land boundaries and the ocean, and suggested the efficient scoping method through the diagnosis of the key items of environmental impact assessment (EIA) in the coastal area. The major projects are the construction of tidal power plant, tidal current power plant, and offshore wind power plant in the public water, and also those are the construction of solar power plants in the coastal land boundaries. While the project plans on a large scale such as the construction of tidal power plant, it is important to consider both property of usefulness of the designated areas and harmony analysis with marine space availability based on the adequacy of the site selection and relevance of plan with the master plan for reclamation and strategic environmental assessment (SEA). And also it needs to be considered the careful checkup on the EIA checklist referring to the type of project, effective post-monitoring, and suggestion of mitigating methods to minimize the environmental impacts during the stage of actual environmental impact assessment. Introduction of a system of integrated marine environmental impact assessment should be considered for reasonable and effective manage to developmental projects on the marine spatial area.

• Journal of Information Technology and Architecture
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• v.11 no.1
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• pp.63-73
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• 2014

As the advance of WWW, unstructured data including texts are taking users' interests more and more. These unstructured data created by WWW users represent users' subjective opinions thus we can get very useful information such as users' personal tastes or perspectives from them if we analyze appropriately. In this paper, we provide various analysis efficiently for unstructured text documents by taking advantage of OLAP (On-Line Analytical Processing) multidimensional cube technology. OLAP cubes have been widely used for the multidimensional analysis for structured data such as simple alphabetic and numberic data but they didn't have used for unstructured data consisting of long texts. In order to provide multidimensional analysis for unstructured text data, however, Text Cube model has been proposed precently. It incorporates term frequency and inverted index as measurements to search and analyze text databases which play key roles in information retrieval. The primary goal of this paper is to apply this text cube model to a real data set from in an Internet site sharing hotel information and to provide multidimensional analysis for users' reviews on hotels written in texts. To achieve this goal, we first build text cubes for the hotel review data. By using the text cubes, we design and implement the system which provides multidimensional keyword search features to search and to analyze review texts on various dimensions. This system will be able to help users to get valuable guest-subjective summary information easily. Furthermore, this paper evaluats the proposed systems through various experiments and it reveals the effectiveness of the system.

• Korean Journal of Microbiology
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• v.43 no.4
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• pp.250-255
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• 2007

The RecA protein of Deinococcus radiodurans is essential for the extreme radiation resistance of this organism. The central steps involved in recombinational DNA repair require DNA-dependent ATP hydrolysis by recA protein. Key feature of RecA protein-mediated activities is the interactions with ssDNA and dsDNA. The ssDNA is the site where RecA protein filament formation nucleates and where initiation of DNA strand exchange takes place. The effect of sequence heterogeneity of ssDNA was examined in this experiment. The rate of homopolymeric synthetic ssDNA-dependent ATP hydrolysis was constant or nearly so over a broader range of pHs. For poly(dT)-dependent ATP or dATP hydrolysis, rates were generally faster, with a broader optimum between pH 7.0 and 8.0. Activities of RecA protein were affected by the ionic environment. The ATPase activity was shown to have different sensitivity to anionic species. The presence of glutamate seemed to slimulate the hydrolytic activity. Dr RecA protein was shown to require $Mg^{2+}$ ion greater than 2 mM for binding to etheno ssDNA and the binding stoichiometry of 3 nucleotide for RecA protein monomer.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.41
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• pp.49.1-49.8
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• 2019

Background: The purpose of this study was to review the clinical features of oromaxillofacial infections in patients presenting to a hospital emergency ward, to identify the key factors affecting the requirement for hospitalization, and the potential risk factors predisposing to a prolonged length of hospital stay. Methods: A retrospective medical record review of the 598 patients treated for oromaxillofacial infection from 2013 to 2017 at the oral and maxillofacial surgery department, Yangsan Pusan National University Hospital, was conducted. The following information was collected from each patient: sex, age, past medical history, site of infection, etiology, admission or outpatient care, level of C-reactive protein (mg/dL), fascial spaces involved, treatment method, and duration of hospitalization. Chi-squared tests were used to identify risk factors, which were further analyzed using multivariable logistic regression. Results: A total of 606 patients were eligible for inclusion in the study, of which eight were excluded due to having incomplete charts; thus, 598 patients were included: 55% were male, mean patient age was 47.1 ± 19.9 years, and 12.9% of patients were diabetic. Furthermore, 71.2% of patients had infection originating in the mandible; the most common tooth of origin was lower posterior, and 29.8% of patients were hospitalized. Risk factors for hospital admission were elderly patients with concurrent disease, elevated C-reactive protein level, and multiple-space infection in the oromaxillofacial area. The duration of hospitalization was correlated with both diabetes and age. Conclusions: The requirement for hospital admission is determined by the severity of the infection; even severe infections, once treated with appropriate surgery, have no relation to the length of hospital stay. The important risk factors for increased duration of hospitalization are diabetes mellitus and older age. The understanding of risk factors associated with a prolonged hospital stay during the treatment of oromaxillofacial infection will aid in treatment planning as well as highlight the importance of adequate diabetes control in patients at risk of such infection.

• Journal of the Korean Institute of Landscape Architecture
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• v.27 no.3
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• pp.1-17
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• 1999

The purpose of this study is to evaluate the creation techniques of artificial wetland, one of biotopes developed to promote biodiversity in urban areas, and to look for improvement steps. Specifically, artificial wetland creation techniques were categorized into living environment and living creature classification. Being living conditions for creations, habitat environment was reviewed with a focus on water and soil environments. Living creatures were classified into plants, insects, fish, and birds. The evaluation of creation techniques was done in post-construction evaluation while considering the creation of habitats for living creatures. Intervention by users, changes in living environment and living species, and relevance of creation techniques were reviewed. Key results of this study are as follows. (1) Water environment for the living environment of creatures provides a suitable environment conditions for the living of creatures through a process easing the use of piped water. Various water depths and embankment appear to have a positive impact on the living of aquatic life. In particular, embankment covered in soil naturally played an important role as a place for the activities of aquatic insects and young fish as well as the growth of aquatic plants. (2) Various aquatic and ground plants to promote insect-diversity, shallow water, and old-tree logs had contributed greatly in increasing the types and number of insects. Aquatic insects. Aquatic insects were seen much particularly in areas where aquatic plants are rich but water is shallow than any other areas. (3) A space piled with stone to provide habitats for fish was not much used. However, it was observed that fish used embankment built with natural stones and embankment using logs in areas where water is deep. In addition, it was confirmed that 1,500 fish that had been released propagated using various depths and places for birth. (4) It was analyzed that techniques (creation of island, log setting, and creation of man-made bird nests) to provide habitats and to attract birds are not serving their roles. In such a case, it is believed that species had not increased due to the smallness as well as isolated features of the area. Based on theoretical review, they are judged to be areas that are likely to be used when a greater variety of birds is introduced. It is judged that attracting and keeping more birds at the site, such spaces need to be linked systematically in the future in terms of building eco-network while ensuring an adequate living areas. (5) In the study areas, users intervened greatly. As a result, a blockage was created preventing the normal growth of plants and non-indigenous plants were introduced. In order to limit the intervention by users, setting enough buffer zones, and environment education programs were urgently required. D/H=1>Hyangkyo> houses on the river>temples>lecture halls. D/H ratio of the backside areas is as follows. D/H=1>Hyangkyo>houses on the river>lecture halls. 4. Inner garden were planted deciduous than evergreen trees with Lagerstroemia indica. Enclosed dominant trees were planted by Pinus densiflora, Querces seuata. construct GEM strain, and examined for the expression and functional stability in microcosms.

• Journal of Oriental Neuropsychiatry
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• v.21 no.2
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• pp.157-169
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• 2010

Objectives : The aim of this study was to investigate the characteristics of Hwa-Byung(HB) patients, draw the clinical key issue of HB, and provide the data as the basis for development of Clinical Guideline of HB. Methods : The study participants included 151 subjects who thought they have HB in 9 site. For all patients, we used HB epidemiologic study protocol, which include the Korean version of the Structured Clinical Interview for the DSM-IV Diagnosis (SCID-1), diagnostic criteria of HB, symptoms check list, pattern identification tool, psychiastric psychological questionaires, and Framingham coronary risk score(FRS). Results : 1. For all participants, 62 % of subjects were diagnosed with HB. These patients had comorbid DSM-IV diagnoses with depression (65%) and anxiety (27%). But 22% of these patients had only HB. 2. HB patients had various physical symptoms when visiting, were diagnosed as various disease, and undergone medical treatments in the past. Among the diagonsed illness, Gastronitestinal diseases (51.6%), psychiatric disorders(40.9%), endocrine diseases(39.8%) were being the most frequent. The frequent physical symptoms of HB patients reported were chest discomfort, head ache, pallpitation, frequent sigh, amnesia, shoulder pain, dry mouth, eye fatigue etc. 3. HB patients had high scores in psychologic questionares, CES-D, STAI, and STAXI. It means that HB patients might be low-level emotional stability. 4. Participant had negative opinion about the treatment of HB that it would be difficult or impossible (65.7%), but they neglect the need of medical treatment. Conclusions : This result shows that HB is comorbid with various psychiatric disease, but it has different physio-psychological symptoms from others and there were only HB patients. so we identify HB is independent disease. Moreover, there were the wrong perception of HB which blocking treatments. These problems support that the neccesity of development of Clinical Guideline of HB.

• Journal of Korea Port Economic Association
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• v.28 no.2
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• pp.1-27
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• 2012

As more manufacturing and global businesses are being pulled into the port area, the idea of a Port Business Valley (PBV) is being pondered as it would create jobs and added value. The PBV would be centered around the harbor and be connected to the port, a logistics district, an industrial district, and the city. The resulting domestic and foreign investment in logistics, industry, business, tourism, living, etc. would vitalize the geographical characteristics of Incheon Port. It would also generate the largest amount of ripple effects between industries in the PBV. However, up until recently, the most frequently offered examples of planning that have helped logistics of a port to grow that have used a PBV have been those of Busan New Port and Gwangyang Port. However, this study is the result of the recent inception of the idea of creating a PBV centered around Incheon Port and the need for experts to develop a plan for such a PBV in Incheon by conducting a site specific study. The aim of this study is to set up the concept of PBV and establish PBV model of Incheon Port. In addition, this study identifies construct factors and their strategies for establish PBV of Incheon Port and then, shows the key factors and related-strategies on Fuzzy-AHP analysis from a survey of logistics experts with Incheon Port.

• Korean Journal Plant Pathology
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• v.3 no.3
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• pp.210-216
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• 1987

A computer program written to predict blast occurrence based on micro climatic events was developed and tested as an on-site microcomputer in field plots in 1984 and 1985. A microcomputer unit operating on alkaline batteries; continuously monitored air temperature, leaf wetness, and relative humidity; interpreted the microclimate information in relation to rice blast development and displayed daily values (0-8) of blast units of severity (BUS). Cumulative daily BUS values (CBUS) were highly correlated with blast development on the two susceptible cultivars, M-201 and Brazos grown in field plots. When CBUS values were used to predict the logit of disease proportions, the average coefficients of determination $(R^2)$ between these two factors were 71 to $91\%$, depending on cultivar and year. This was a significant improvement when compared to 61 to $79\%$ when days were used as a predictor of logit disease severity. The ability of CBUS to predict logit disease severity was slightly less with Brazos than M-201. This is significant inasmuch as Brazos showed field resistance at mid-sea­son. The results in this study indicate that the model has the potential for future use and that the model could be improved by incorporating other variables associated with host plants and pathogen races in addition to the key environmental variables.