• The KIPS Transactions:PartC
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• 제17C권2호
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• pp.135-144
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• 2010

U-City pursues personalized service by collecting contexts through sensors located over the city and presenting the service automatically depending not on the user's request but on the situations that are needed. To provide the personalized service, however, contexts collected through various sensors are needed, and they include private information. Therefore, it is important to keep a balance between the convenience by presenting service and protecting private information. In this paper, we classify and grade person's various contexts requested in the personalized service environment. Based on these, we make decisions on whether to present the service or not by profile-matching between user profile and service profile. Also, we propose an efficient privacy-protection management scheme to encrypt transmitted private information and to control key distribution.

• Archives of Pharmacal Research
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• 제22권3호
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• pp.243-248
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• 1999

Sialic acids are key determinants for biological processes, such as cell-cell interaction and differentiation. Sialyltransferases contribute to the diversity in carbohydrate structure through their attachment of sialic acid in various terminal positions on glycolipid and glycoprotein (N-linked and O-linked) carbohydrate groups. Gal$\beta$ 1,3(4)GlcNAc $\alpha$2,3-sialyltransferase (ST3Gal III) is involved in the biosynthesis of $sLe^{X}$ and sLe^{a}$ known as selection ligands and tumor-associated carbohydrate structures. The appearance and differential distribution of ST3Gal III mRNA during mice embryogenesis [embryonic (E) days; E9, E11, E13, E15] were investigated by in situ hybridization with digoxigenin-labeled RNA probes coupled with alkaline phosphatase detection. On E9, all tissues were positive for ST3Gal III mRNA expression whereas ST3Gal III mRNA on E11 was not detected throughout all tissues. On E13, ST3GAl III mRNA was expressed in different manner in various tissues. In this stage, ST3Gal III mRNA was positive only in the liver, pancreas and bladder. On E15, specific signal for ST3GAl III was detected in the liver, lung and forebrain. These results indicate that ST3Gal III is differently expressed at developmental stages of mice embryo, and this may be importantly related with regulation of organogenesis in mice.

• Journal of The Geomorphological Association of Korea
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• 제20권3호
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• pp.79-94
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• 2013

Gyeongju in Saro or Silla one of ancient kingdoms in Yeongnam region of southeast Korea, had been developed as a capital city for thousand years despite its unfavorable geographical location being leaned to the southeastern part of the Korean Peninsula. Although this rare case in the world resulted from various facts relevant to political capability and intelligence of the ancient Gyeongju people, the geomorphic characteristics played a key role for its political development. In this paper, we discuss the establishment and growth of ancient kingdoms in Gyeongju area in terms of geomorphological factors such as the Taebaek and Sobaek mountain ranges, distribution of fault lines and alluvial fans along the eastern coast of the peninsula, characteristics of the coastal regions. That is, abundant grain supply from alluvial fans in Gyeongju and surrounding areas, high population-carrying capacity of land and positioning of an ancient supercity were made possible by the geomorphological contributions. Furthermore, Gyeongju could hold the lead in competition with surrounding kingdoms by accumulation of wealth and military superiority derived from production and circulation of salt and iron works. Gyeongju had become the capital of ancient kingdoms due to the geomorphic advantages during the ancient times in Korea.

• Biomolecules & Therapeutics
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• 제27권6호
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• pp.553-561
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• 2019

Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast, vagina, cervix, the gastrointestinal tract, and skin. Rab25 plays key roles in tumorigenesis, mainly by regulating epithelial differentiation and proliferation. However, its role in skin physiology is relatively unknown. In this study, we demonstrated that Rab25 knock-out (KO) mice show a skin barrier dysfunction with high trans-epidermal water loss and low cutaneous hydration. To examine this observation, we investigated the histology and epidermal differentiation markers of the skin in Rab25 KO mice. Rab25 KO increased cell proliferation at the basal layer of epidermis, whereas the supra-basal layer remained unaffected. Ceramide, which is a critical lipid component for skin barrier function, was not altered by Rab25 KO in its distribution or amount, as determined by immunohistochemistry. Notably, levels of epidermal differentiation markers, including loricrin, involucrin, and keratins (5, 14, 1, and 10) increased prominently in Rab25 KO mice. In line with this, depletion of Rab25 with single hairpin RNA increased the expression of differentiation markers in a human keratinocyte cell line, HaCaT. Transcriptomic analysis of the skin revealed increased expression of genes associated with skin development, epidermal development, and keratinocyte differentiation in Rab25 KO mice. Collectively, these results suggested that Rab25 is involved in the regulation of epidermal differentiation and proliferation.

• Smart Structures and Systems
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• 제24권5호
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• pp.631-639
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• 2019

Finite element analysis is one of the important methods to study the structural performance. Due to the simplification, discretization and error of structural parameters, numerical model errors always exist. Besides, structural characteristics may also change because of material aging, structural damage, etc., making the initial finite element model cannot simulate the operational response of the structure accurately. Based on Bayesian methods, the initial model can be updated to obtain a more accurate numerical model. This paper presents the work on the field test, modal identification and model updating of a Chinese reinforced concrete pagoda. Based on the ambient vibration test, the acceleration response of the structure under operational environment was collected. The first six translational modes of the structure were identified by the enhanced frequency domain decomposition method. The initial finite element model of the pagoda was established, and the elastic modulus of columns, beams and slabs were selected as model parameters to be updated. Assuming the error between the measured mode and the calculated one follows a Gaussian distribution, the posterior probability density function (PDF) of the parameter to be updated is obtained and the uncertainty is quantitatively evaluated based on the Bayesian statistical theory and the Metropolis-Hastings algorithm, and then the optimal values of model parameters can be obtained. The results show that the difference between the calculated frequency of the finite element model and the measured one is reduced, and the modal correlation of the mode shape is improved. The updated numerical model can be used to evaluate the safety of the structure as a benchmark model for structural health monitoring (SHM).

• Journal of Korea Port Economic Association
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• 제25권3호
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• pp.303-320
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• 2009

Korea has achieved a remarkable growth by pursuing externally-oriented growth policy since 1960s. That is, we imported raw materials and spare parts, manufactured them into products and exported them, which led to successful economic development. Therefore, our marine business has played an important roles as one of key industries. The development of marine business has contributed to efficient distribution and cost reduction in addition to production of added value and creation of employment creation, which improved external competitive power. In spite of economic importance of marine business, national perception on it is in general low and its developmental conditions are considerably poor. Therefore, this study aims to speculate the effect of Port-related business on regional economy using regional input-output tables.

• Journal of the Korean Solar Energy Society
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• 제31권4호
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• pp.41-47
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• 2011

The volumetric solar receiver is a key element of solar power plants using air. The solar flux distribution inside the receiver should be a priori known for its heat transfer analysis. Previous works have not considered characteristics of the solar flux although they change with radiative properties of receiver materials and receiver geometries. A numerical method, which is based on the Monte Carlo ray-tracing method, was developed in the current work. The solar flux distributions inside multi-channeled volumetric solar receivers were calculated when light is concentrated at the KIER solar furnace. It turned out that 99 percentage of the concentrated solar energy is absorbed within 15mm channel length for the channel radius smaller than 1.5mm. If the concentrated light is assumed to be diffuse, the absorbed solar energy at the channel entrance region is over predicted while the light penetrates more deeply into the channel. Once the presented results are imported into the heat transfer analysis, one could examine effects of material property and geometry of the receiver on air temperature profiles.

• Journal of the Korea Society of Computer and Information
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• 제15권9호
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• pp.87-97
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• 2010

A set of definitions for traceability and quick recall service function were urgently needed to facilitate handling of events threatening food safety caused by livestock diseases or germ contaminations. However, the research on the unified management system for both international and domestic livestock products distribution was scarce. The livestock products traceability evaluation model proposed in the paper was composed of four modules: the Forward Transaction Trace (FTT) module, the Backward Record Trace (BRT) module, the Forward Product Trace (FPT) module, and the Origin Pedigree (OP) module. The evaluation indexes for each module was included and finally a pilot system evaluating the proposed management model was suggested and displayed. The result of the paper was expected to be a solution to the distributed traceability system and the proposed traceability management model could be expected to any food traceability.

• Journal of Veterinary Science
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• 제22권4호
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• pp.50.1-50.10
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• 2021

Background: Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a potential threat to the dairy industry. Objectives: The aim of this study is to detect and clarify the genetic diversity of BPV circulating in dairy cows in Xinjiang, China. Methods: 122 papilloma skin lesions from 8 intensive dairy farms located in different regions of Xinjiang, China were detected by polymerase chain reaction. The genetic evolution relationships of various types of BPVs were analyzed by examining this phylogenetic tree. Results: Ten genotypes of BPV (BPV1, BPV2, BPV3, BPV6, BPV7, BPV8, BPV10, BPV11, BPV13, and BPV14) were detected and identified in dairy cows. These were the first reported detections of BPV13 and BPV14 in Xinjiang, Mixed infections were detected, and there were geographical differences in the distribution of the BPV genotypes. Notably, the BPV infection rate among young cattle (< 1-year-old) developed from the same supply of frozen sperm was higher than that of the other young cows naturally raised under the same environmental conditions. Conclusions: Genotyping based on the L1 gene of BPV showed that BPVs circulating in Xinjiang China displayed substantial genetic diversity. This study provided valuable data at the molecular epidemiology level, which is conducive to developing deep insights into the genetic diversity and pathogenic characteristics of BPVs in dairy cows.

• Journal of Ginseng Research
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• 제45권5호
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• pp.575-582
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• 2021

Background: In ginseng, there exists a glycolipoprotein complex with a special form of lipid LPAs called Gintonin. The purpose of this study is to show that Gintonin has a therapeutic effect on rheumatoid arthritis through LPA2 receptors. Methods: Fibroblast-like synoviocytes (FLS) were treated with Gintonin and stimulated with interleukin (IL)-1β. The antioxidant effect of Gintonin was measured using MitoSOX and H₂DCFDA experiments. The anti-arthritic efficacy of Gintonin was examined by analyzing the expression levels of inflammatory mediators, phosphorylation of mitogen-activated protein kinase (MAPK) pathways, and translocation of nuclear factor kappa B (NF-κB)/p65 into the nucleus through western blot. Next, after treatment with LPAR2 antagonist, western blot analysis was performed to measure inflammatory mediator expression levels, and NF-κB signaling pathway. Carrageenan/kaolin-induced arthritis rat model was used. Rats were orally administered with Gintonin (25, 50, and 100 mg/kg) every day for 6 days. The knee joint thickness, squeaking score, and weight distribution ratio (WDR) were measured as the behavioral parameters. After sacrifice, H&E staining was performed for histological analysis. Results: Gintonin significantly inhibited the expression of iNOS, TNF-α, IL-6 and COX-2. Gintonin prevented NF-κB/p65 from moving into the nucleus through the JNK and ERK MAPK phosphorylation in FLS cells. However, pretreatment with an LPA2 antagonist significantly reversed these effects of Gintonin. In the arthritis rat model, Gintonin suppressed all parameters that were measured. Conclusion: This study suggests that LPA2 receptor plays a key role in mediating the anti-arthritic effects of Gintonin by modulating inflammatory mediators, the MAPK and NF-κB signaling pathways.