• 한국CDE학회논문집
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• 제9권2호
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• pp.112-121
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• 2004

As customers demands are rapidly changing, a product life cycle is getting shorter and a product model is forced to be changed frequently. An ejecting design system becomes more important for high productivity to eject a product in high temperature without any damage. For example, an ejector pin that is a key component of the system can cause high local stresses and strains in the molding at the time of ejection. The number, the size, and the location of pins are important to make a smooth ejection. Therefore we propose an analytical approach with the aid of designer’s experience to calculate a total release force and pressure distribution so that the number, the size, and the location of pins can be easily determined. As a part of the result, the design system is built by Intent! with AutoCAD 2000 and a video player deck example is presented to verify the approach.

• IMMUNE NETWORK
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• 제13권5호
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• pp.168-176
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• 2013

In the last few years major progress has been made in better understanding the role of natural killer (NK) cells in hepatitis C virus (HCV) infection. This includes multiple pathways by which HCV impairs or limits NK cells activation. Based on current genetic and functional data, a picture is emerging where only a rapid and strong NK cell response early on during infection which results in strong T cell responses and possible subsequent clearance, whereas chronic HCV infection is associated with dysfunctional or biased NK cells phenotypes. The hallmark of this NK cell dysfunction is persistent activation promoting ongoing hepatitis and hepatocyte damage, while being unable to clear HCV due to impaired IFN-${\gamma}$ responses. Furthermore, some data suggests certain chronically activated subsets that are $NKp46^{high}$ may be particularly active against hepatic stellate cells, a key player in hepatic fibrogenesis. Finally, the role of NK cells during HCV therapy, HCV recurrence after liver transplant and hepatocellular carcinoma are discussed.

• BMB Reports
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• 제42권4호
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• pp.185-188
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• 2009

Transcripts contain introns that are usually removed from premessenger RNA (MRNA) in the process of pre-mRNA splicing. After splicing, the mature RNA is exported from the nucleus to the cytoplasm. The splicing and export processes are coupled. UAP56 protein, which is ubiquitously present in organisms from yeasts to humans, is a DExD/H-box family RNA helicase that is an essential splicing factor with various functions in the prespliceosome assembly and mature spliceosome assembly. Collective evidence indicates that UAP56 has an essential role in mRNA nuclear export. This mini-review summarizes recent evidence for the role of UAP56 in pre-mRNA splicing and nuclear export.

• Journal of Microbiology and Biotechnology
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• 제26권3호
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• pp.567-571
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• 2016

We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.

• ETRI Journal
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• 제26권2호
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• pp.122-135
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• 2004

Although frame-based MPEG-4 video services have been successfully deployed since 2000, MPEG-4 video coding is now facing great competition in becoming a dominant player in the market. Object-based coding is one of the key functionalities of MPEG-4 video coding. Real-time object-based video encoding is also important for multimedia broadcasting for the near future. Object-based video services using MPEG-4 have not yet made a successful debut due to several reasons. One of the critical problems is the coding complexity of object-based video coding over frame-based video coding. Since a video object is described with an arbitrary shape, the bitstream contains not only motion and texture data but also shape data. This has introduced additional complexity to the decoder side as well as to the encoder side. In this paper, we have analyzed the current MPEG-4 video encoding tools and proposed efficient coding technologies that reduce the complexity of the encoder. Using the proposed coding schemes, we have obtained a 56 percent reduction in shape-coding complexity over the MPEG-4 video reference software (Microsoft version, 2000 edition).

• 만화애니메이션 연구
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• 통권36호
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• pp.573-592
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• 2014

Following rapid development of software and hardware technologies and increasing enhancement in arithmetic capability, there are more and more content that can be accommodated and processed in video games, which is also increasingly complex and fine. Cutscene as a main narrative method have been developed, which have become necessary to express some key plots and important scenarios in games. Good cutscene can strengthen engagement of players with virtual world in games and make players share affection and sorrow with roles in games; while badly-designed cut-scene or overused cut-scene will impair immersion of players and affect players' gaming experience; for this reason, developers should not continue cut-scene design just from opinions of designers nor make players passive receivers, instead, they should reduce as much as possible interruption by cut-scene to players' immersion and grant players with better immersion. After all, only designs depending on demands and preferences of players by having some knowledge of impacts of cut-scene on players' immersion can be accepted by players.

• 한국미생물·생명공학회지
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• 제40권3호
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• pp.278-281
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• 2012

Not much is known about the membrane trafficking of TRPV1, a key player in pain transduction. Rab11-FIP3, which plays a role in various intracellular transportation pathways, has been reported to interact with TRPV1. In this study, in order to examine the role of Rab11-FIP3 in the membrane trafficking of TRPV1, Rab11-FIP3 expression in dorsal root ganglion (DRG) was inhibited using a siRNA technique. Transportation of TRPV1 to membranes was found to decrease when Rab11-FIP3 expression was inhibited, consistent with the results obtained with TRPV1-transfected HEK cells. Taken together, these results indicate that Rab11-FIP3 plays a role in the membrane trafficking of TRPV1.

• BMB Reports
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• 제54권6호
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• pp.285-294
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• 2021

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.

• Journal of Smart Tourism
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• 제3권4호
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• pp.33-41
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• 2023

This study examines the factors influencing e-sports product consumption among Chinese e-sports game players. We focus on the popular game "King of Glory" and use surveys to collect player data. Our findings show that e-sports product characteristics significantly impact consumption experiences, while incentive factors also influence consumption willingness. External factors have minimal impact. Additionally, souvenir products and festival events are key in driving e-sports consumption. This research explores the consumption willingness of Chinese e-sports players, the world's largest consumer market. Understanding their needs can help companies develop targeted marketing strategies, unlocking the commercial potential of e-sports and promoting industry growth.

• 공학교육연구
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• 제8권1호
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• pp.71-83
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• 2005

본 논문에서는 자바 언어를 학습하는데 있어 효율성을 증가시키기 위해 인터넷 기반 자율학습시스템이 제안되었다. 제안된 자율학습시스템은 JWP(Java Web Player)라고 불리며 Java Web Start 기술을 활용하여 웹상에서 실행이 가능한 자바 애플리케이션 프로그램이다. 또한 본 논문에서는 컴퓨터 언어를 학습하는데 있어 3가지 중요한 일련의 과정인 개념학습과정, 프로그래밍 실습과정, 그리고 학습 성취도 평가과정을 Java Web Start 기술을 이용하여 JWP에 통합하였다. 제안된 시스템은 학습과정을 교육공학적인 측면에서 멀티미디어 요소를 강화하였기 때문에 학습자가 흥미를 가지고 자발적으로 학습을 할 수 있도록 설계되었다. 더욱이 JWP 에는 효율적인 자바 언어 학습을 위해 학습내용에 대한 설명이 음성으로 출력되며, 이때 이와 관련된 이미지와 텍스트들이 동기화되어 동시에 화면에 표시된다. 더욱이 소스파일의 코딩, 에디팅, 실행 그리고 디버깅 등을 쉽게 할 수 있는 컴파일러가 삽입되어 있어 편리한 자바 언어 실습환경을 제공한다. 마지막으로 각 단원별 돌발퀴즈와 마무리 테스트를 통하여 학습자가 자신의 학습상황을 체크하여 반복학습을 할 수 있도록 유도하였다.