• Journal of Korean Neurosurgical Society
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• v.60 no.3
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• pp.335-347
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• 2017

Intravenous recombinant tissue plasminogen activator had been the only approved treatment for acute ischemic stroke since its approval in 1995. However, the restrictive time window, numerous contraindications, and its low recanalization rate were all limitations of this modality. Under those circumstances, endovascular stroke therapy went through a great evolution during the past two decades of intravenous thrombolysis. The results of the 2013 randomized trials for endovascular stroke therapy were neutral, although they were limited by insufficient imaging screening at enrollment, early-generation devices with less efficacy, and treatment delays. Huge progress was made in 2015, as there were five randomized clinical trials which all demonstrated the safety and efficacy of endovascular stroke treatment. Despite differences in detail patient enrollment criteria, all 5 trials employed key factors for good functional recovery; (1) screening with non-invasive imaging to identify the proximal occlusion and exclude a large infarct core, (2) using highly effective modern thrombectomy devices mainly with stent retriever, and (3) establishment of a fast workflow to achieve effective reperfusion. The results of those trials indicate that modern thrombectomy devices can allow for faster and more effective reperfusion, which can lead to improved clinical outcomes compared to intravenous thrombolysis alone. These advances in mechanical thrombectomy are promising in the global fight against ischemic stroke-related disability and mortality. Two current mainstreams among such mechanical thrombectomy techniques, "stent retriever thrombectomy" and "direct clot aspiration", are the topic of this review. Stent retriever thrombectomy using Solitaire and Trevo retriever will be firstly discussed. And, the commonalities and the differences between two major clot aspiration thrombectomy techniques; a direct aspiration first pass technique (ADAPT) and forced arterial suction thrombectomy (FAST), will be additionally explained. Finally, details regarding the combination of direct clot aspiration and stent retriever thrombectomy, the switching strategy and the Solumbra technique, will be described.

• Journal of Distribution Science
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• v.10 no.7
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• pp.23-31
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• 2012

The purpose of this study is to investigate existing world economic science theories and concepts of sustainable development as well as create original system of criteria and indicators to assess potential and conditions for sustainable development from a regional perspective and based on the above justify proposals for public authorities to improve methods of economic regulation for regional development. To achieve the goal evolution process of existing theories and concepts of sustainable development and "green growth" have been studied in terms of its adaptation to the spatial development of Kazakhstan, comparative dynamics of natural resources consumption in the Asia-Pacific region and Kazakhstan were investigated as well. Methodology. World best theory and practice methods for assessment of the level of sustainable development of the country and some of its territories were also studied. We selected the best system of criteria and indicators for assessment of economic, social and environmental sustainability of regional systems. Methods offered in this article are based on traditional and new factors of economic development and conditions for operation of regional systems. Indicators are chosen with a glance to basic goals for future development of regions in Kazakhstan. It is recommended to use two levels of methodology offered by author, namely national and regional, and at the local level later (districts, municipalities, cities). The results. Method offered by the author has been tested based on materials and statistics of regions in Kazakhstan. Suitability and usability of the proposed system of criteria and indicators for measuring of economic, social and environmental sustainability of regional systems was proved. Based on this analysis it was found out that there are regions in Kazakhstan that differ from each other by most of key indicators of sustainable regional development and this tendency is increasing. Conclusions and recommendations. As a result of this analysis, the authors have substantiated a number of proposals on methods of analysis to be used, improvement of methods of regional development, implementation of institutional reforms, as well as improvement of regional statistics. This article provides recommendations that can be successfully used in the management practices by public authorities to implement a new regional strategy focused on sustainable development in future.

• Development and Reproduction
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• v.18 no.4
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• pp.233-240
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• 2014

The early growth response protein 1 (Egr-1) is a widely reported zinc finger protein and a well known transcription factor encoded by the Egr-1 gene, which plays key roles in many aspects of vertebrate embryogenesis and in adult vertebrates. The Egr-1 expression is important in the formation of the gill vascular system in flounders, which develops during the post-hatching phase and is essential for survival during the juvenile period. However, the complete details of Egr-1 expression during embryo development in olive flounder are not available. We assessed the expression patterns of Egr-1 during the early development of olive flounders by using reverse transcription polymerase chain reaction (RT-PCR) analysis. Microscopic observations showed that gill filament formation corresponded with the Egr-1 expression. Thus, we showed that Egr-1 plays a vital role in angiogenesis in the gill filaments during embryogenesis. Further, Egr-1 expression was found to be strong at 5 days after hatching (DAH), in the development of the gill vascular system, and this strong expression level was maintained throughout all the development stages. Our findings have important implications with respect to the biological role of Egr-1 and evolution of the first respiratory blood vessels in the gills of olive flounder. Further studies are required to elucidate the Egr-1-mediated stress response and to decipher the functional role of Egr-1 in developmental stages.

• Journal of Korean Home Economics Education Association
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• v.8 no.2
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• pp.65-79
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• 1996

This study proposes a model curriculum for Vocational Home Economics High School in the 7th Curriculum Revision. The model in the study is first drawn from the assumptions that reflect ever changing demands of industrial society for Home Economics education. Another perspective employed in the study is historical analysis that focuses on the evolution of the Vocational Home Economics Curricula from the 1st through the 6th revision. This study also employes comparative research tools for the national level comparison such as USA, Japan, Taiwan, and Korea. The proposed model curriculum in this study is concluded from those step-by-step studies as follows：1) Problem definition and design in current curriculum for Vocational Home Economics high school； 2) Needs and roles analysis of Vocational Home Economics high school for the future； and 3)Historical analysis of our curriculum revisions in the past and coparative analysis with other countries. Authors conducted this research project for 3 month period from June 15, 1996 to September 15, 1996. During this period, authors collected the data and information through those method as an extensive literature review, survey and interview, and curriculum specialist conference. The key and critical features of the proposed curriculum in the study are as follows：1) In the numbers of department, a proposed model curriculum offers 8 as opposed to 6 in the 6th revision, reflecting two additional departments of “Elderly Welfare”and “Cosmotology”. 2) In the statement of educational objectives, a model curriculum emphasizes a more concrete statement to each specific skills according to the changing societal needs. 3) In the numbers of total subject matters, there would be 40 in the new as opposed to 23 in the current curriculum. Among these changes, 17 would occurr in the newly introduced subject matters, while 11 would simply change the subject matter name. Among 40 subject matter, “Introduction to Computer” and “Home Economics in Vocational Education”would be required subject matter. 4) In the total numbers of required unit for graduation in three years, a model offers 86∼132 unit. A maximum unit for each subject matter would be 12.

• Korean Journal of Construction Engineering and Management
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• v.10 no.3
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• pp.102-110
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• 2009

Although several research efforts have been directed to fast-tracking to reduce the total delivery time, few researches have been studied on concurrent engineering in construction projects. The focus of fast-tracking is primarily on overlapping independent activity pairs. In comparison, the focus of concurrent engineering is on overlapping dependent activity pairs. Dependent activities are much harder to overlap successfully. This paper presents a simulation-based Concurrent Engineering methodology to optimize the overall duration of a set of design activities in a project by modelling key factors that determine the duration of individual activities and overlap between dependent activities. This methodology involves determining how much to overlap activities, how to decide which activities to overlap and the corresponding cost and time tradeoffs using a discrete event model solution. This simulation model, therefore, can be used as a reference on decision-making to define optimum point between time and cost.

• Journal of the Economic Geographical Society of Korea
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• v.20 no.4
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• pp.486-502
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• 2017

This study investigated the formation process and networks of Korean Clean Development Mechanism(CDM) industry. It aimed to reveal the factors and the drivers for the formation processes of this industry in the specific place. Based on the analysis of the Project Design Documents(PDDs) of the CDM projects and the collected project data by international institutions, surveys, and interviews were done. On the basis of these data, the analysis on the industrial change as complex emergent effects by the network evolution caused by adaptive activity of firms is conducted. In the time of the genesis, a kind of serendipity that the industrial activities of Korean firms meet to new system, CDM, In the changing process of the Korean CDM industry, the role of policies fo Korean Government was important to promote the new and renewable energy projects of the power companies. In the time of restructuring, Korean government policies formed new initial conditions for the new domestic GHGs reduction industry. In this processes, the localization of knowledge acted as a key driver for the formation of the Korean CDM industry.

• Proceedings of the Materials Research Society of Korea Conference
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• 2012.05a
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• pp.55.2-55.2
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• 2012

Intensive theoretical and experimental studies have been carried out at Korean Institute of Science and Technology (KIST) on controlling the bio absorbing rate of the Mg alloys with high mechanical strength through tailoring of electrochemical potential. Key technology for retarding the corrosion of the Mg alloys is to equalize the corrosion potentials of the constituent phases in the alloys, which prevented the formation of Galvanic circuit between the constituent phases resulting in remarkable reduction of corrosion rate. By thermodynamic consideration, the possible phases of a given alloy system were identified and their work functions, which are related to their corrosion potentials, were calculated by the first principle calculation. The designed alloys, of which the constituent phases have similar work function, were fabricated by clean melting and extrusion system. The newly developed Mg alloys named as KISTUI-MG showed much lower corrosion rate as well as higher strength than previously developed Mg alloys. Biocompatibility and feasibility of the Mg alloys as orthopedic implant materials were evaluated by in vitro cell viability test, in vitro degradation test of mechanical strength during bio-corrosion, in vivo implantation and continuous observation of the implant during in vivo absorbing procedures. Moreover, the cells attached on the Mg alloys was observed using cryo-FIB (focused ion beam) system without the distortion of cell morphology and its organ through the removal of drying steps essential for the preparation of normal SEM/TEM samples. Our Mg alloys showed excellent biocompatibility satisfying the regulations required for biomedical application without evident hydrogen evolution when it implanted into the muscle, inter spine disk, as well as condyle bone of rat and well contact interface with bone tissue when it was implanted into rat condyle.

• KIISE Transactions on Computing Practices
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• v.21 no.1
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• pp.46-51
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• 2015

The explosive growth of data and the rapidly changing technical social evolution new analysis paradigm for predicting and reacting the future the past and present ig data. Prescriptive analysis has a fundamental difference because can support specific behaviors and results according to user's goals with defin researchers establish judgments and activities achiev the goals. However research methods not widely implemented and even the terminology, Prescriptive analysis, is still unfamiliar. This paper thus propose an infrastructure in the prescriptive analysis field with key considerations for enhancing capability of researchers through a case study based on InSciTe Advisory developed with scientific big data. InSciTe Advisory system s developed in 2013, and offers a prescriptive analytics report which contains various As-Is analysis results and To-Be analysis results 5W1H methodology. InSciTe Advisory therefore shows possibility strategy aims to reach a target role model group. Through the availability and reliability of the measurement model the evaluation results obtained relative advantage of 118.8% compared to Elsevier SciVal.

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.529-541
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• 2015

Collaborative learning of collective intelligence-based model is also ideal in higher education did not yet consensus still in the theoretical level. To become collective intelligence-based collaborative learning is to mobilize the competence of the various members should be promoted as much as possible with their own services designed to actively participate in and contribute to the goals of the joint. Is still based collaborative learning model of collective intelligence, which does the actual model is not developed in education is a key program in creative fusion judge called talent. The evolution of the main features of the house just in shaping the content of a modern lecture geureohagi need to check from time to time to see and pay attention. As part of this study, attempts were associated with the tvN planning and attention to trying connector Executive Lecture show "Creative Club 199" content. Well oriented intention to converge the needs of the times, but it is even more compelling naeeotda implement the collective intelligence based on 'how' the reality is that together with the participants.

• Journal of Electrochemical Science and Technology
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• v.1 no.1
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• pp.50-56
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• 2010

$La_{0.6}Sr_{0.4}Co_{0.2}Fe_{0.8}O_{3-\delta}$ (LSCF) powders with different particle sizes, synthesized through a citrate complexation method and a gel-casting technique, are used to fabricate porous LSCF cathodes with graded microstructures via tape casting. To create porous electrodes with desired porosity and pore structures, graphite and starch are used as pore former for different layers of the graded cathode. Examination of the microstructures of the as-prepared LSCF cathode using an SEM revealed that both grain size and porosity changed gradually from the catalytically active layer (near the electrodeelectrolyte interface) to the current collection layer (near the electrode-interconnect interface). Impedance analysis showed that a 3-layer LSCF cathode with graded microstructures exhibited much-improved performance compared to that of a single-layer LSCF cathode, corresponding to interfacial resistance of 0.053, 0.11, and 0.27 $\Omega{\cdot}cm^2$ at 800, 750, and $700^{\circ}C$ respectively.