• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.322.3-323
• /
• 2002

Curcumin derived from turmeric (Curcuma longa L.. Zingiberaceae) has been shown to possess marked chemopreventive activities, but the underlying molecular mechanisms remain unclear. In the present work. curcumin was found to inhibit 12-Ο-tetradecanoylphorbol-13-acetate(TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICr mouse skin as determined by Western and Northern blot analysis as well as immunohistochemical staining. Curcumin treatment atlenuated TPA-stimulated epidermal NF-${\kappa}$B activation. which was associated with its blockade of degradation and phosphorylation of the inhibitory protein l${\kappa}$ Bu and also of subequent translocation of the p65 subunut to nucleus. (omitted)

• Proceedings of the KSME Conference
• /
• 2003.04a
• /
• pp.2083-2088
• /
• 2003

This study was performed to analyze the velocity and temperature distributions of the land aquaculture tank for fish breeding. In this study, we analyzed the velocity and temperature distributions in aquarium tank, and the finite volume method and standard ${\kappa}-{\epsilon}$ turbulence model with the SIMPLE computational algorithm are used to study the water flow in the aquarium. The main calculation parameters of the aquarium tank are the inlet flow rate with from 0.5 to 2.0L/M.

• 한국데이터정보과학회:학술대회논문집
• /
• 2006.04a
• /
• pp.163-169
• /
• 2006

This paper deals with the comparison of parameter estimation methods in a 3-parameter Kappa distribution which is sometimes used in flood frequency analysis. The method of moment estimation(MME), L-moment estimation(L-ME), and maximum likelihood estimation(MLE) are applied to estimate three parameters. The performance of these methods are compared by Monte-carlo simulations. Especially for computing MME and L-ME, ike dimensional nonlinear equations are simplied to one dimensional equation which is calculated by the Newton-Raphson iteration under constraint. Based on the criterion of the mean squared error, the L-ME is recommended to use for small sample size $(n\leq100)$ while MLE is good for large sample size.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.11
• /
• pp.924-931
• /
• 2009

The two-dimensional turbulent flow around the horn-type rudder has been examined in the present study by using the commercial code FLUENT. The standard ${\kappa}-{\epsilon}$ model is used as a closure relationship. The geometry of horn rudder is based on the NACA 0020 airfoil. The simulations for various angle attack (${\alpha}$) and yaw angle(${\delta}$) are carried out. The effect of Reynolds number is also investigated in this study. The cavitation is more possible when the yaw angle is $6^{\circ}$ and it is more serious as Reynolds number increases.

• Journal of the Korean Society of Combustion
• /
• v.7 no.2
• /
• pp.49-61
• /
• 2002

Numerical simulation is performed for stagnating turbulent flows of impinging and countercurrent jets by the Reynolds stress model(RSM). Results are compared with those of the ${\kappa}-{\varepsilon}$ model and available data to assess the flow characteristics and turbulence modes. Three variants of the RSM tested are those of Gibson and Launder(GL), Craft and Launder(GL-CL) and Speziale, Sarkar and Gatski(SSG). As well known, the ${\kappa}-{\varepsilon}$ model overestimates turbulent kinetic energy near the wall significantly. Although the RSM is superior to the ${\kappa}-{\varepsilon}$ model, it shows considerable difference according to how the redistributive pressure-strain term is modeled. Results of the RSM for countercurrent jets are improved with the modified coefficients for the dissipation rate, $C_{{\varepsilon}1}\;and\;C_{{\varepsilon}2}$ suggested by Champion and Libby. The performance of the three variants of the RSM model for stagnating flows are assessed.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.3
• /
• pp.533-539
• /
• 2011

Sulfuretin is one of the main flavonoids produced by Rhusverniciflua. Sulfuretin has been shown to exhibit many pharmacological activities including anti-oxidant, anti-obesity, anti-inflammatory and anti-mutagenic activities. However, the anti-skin photoaging effects of sulfuretin has not yet been reported. In the present study, we investigated the inhibitory effect of sulfuretin on the expression levels of MMP-1 and -3 in the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed sulfuretin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB-induced MAPK/NF-${\kappa}B$/p50 activation and MMP expression were completely blocked by pretreatment of sulfuretin. Taken together, sulfuretin could prevent UVB-induced MMP expressions through inhibition of MAPK/NF-${\kappa}B$/p50 activation.

• Journal of the Korean Statistical Society
• /
• v.26 no.2
• /
• pp.171-180
• /
• 1997

Effects of order misspecification on statistical behavior of unit root tests are studied. We derive the limiting distributions of the Dickey-Fuller test statistics whose numerators are of the form c .int. W dW + .kappa. where W is a standard Brownian motion on [0, 1] and c is a real number. The term .kappa. is a major consequence of order misspecification and its explict expression is derived. Based on an analysis of .kappa., effects of order misspecification on unit root tests for AR(2), ARMA(1, 1), and AR(3) models are investigated.

• 한국전산유체공학회:학술대회논문집
• /
• 2002.05a
• /
• pp.79-87
• /
• 2002

The present work analyzed the effect of mixing vane shape on the flow structure and heat transfer downstream of mixing vane in a subchannel of fuel assembly, by obtaining velocity and pressure fields, turbulent intensity, flow-mixing factors, heat transfer coefficient and friction factor using three-dimensional RANS analysis. NJl5, NJ25, NJ35, NJ45, which were designed by the authors, were tested to evaluate the performances in enhancing the heat transfer. Standard $\kappa-\epsilon$ model is used as a turbulence closure model, and, periodic and symmetry conditions are set as boundary conditions. The flow blockage ratio is kept constant, but the twist angle of mixing vane is changed. The results with three turbulence models( $\kappa-\epsilon$, $\kappa-\omega$, RSM) were compared with experimental data.

• Journal of Advanced Marine Engineering and Technology
• /
• v.23 no.2
• /
• pp.216-225
• /
• 1999

Four turbulent $k-{varepsilon}$models(i.e standard model modified models with streamline curvature modification and/or preferential dissipation modification) are applied in order to analyze the tur-bulent flow of wall-attaching offset jet. The upwind numerical scheme was adopted in the present analyses. The streamline curvature modification results in slightly better prediction while the preferential dissipation modification does not. The obtained analytic results will be used as refer-ences for further study regarding Reynolds stress model. In addition this paper introduced a method of increasing nozzle outlet velocity gradually for numercal convergence. Even though the method was simple it was efficient in view of convergent speed CPU running time computer memory storage programming etc.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.8
• /
• pp.635-642
• /
• 2009

The three-dimensional turbulent wingtip vortex flows have been examined in the present study by using the commercial code FLUENT. The standard ${\kappa}-{\varepsilon}$ model is used as a closure relationship. The wing is constructed by using an elliptic body whose aspect ratio is 3.8 and the NACA 16-020 airfoil section. The simulations for various angle attack (${\alpha}=0^{\circ}$, $5^{\circ}$, and $10^{\circ}$) are carried out. The effect of Reynolds number is also investigated in this study. As the angle attack increases, the wingtip vortex becomes stronger. However, the relative vortex strength to inlet velocity decreases as Reynolds number increases.