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Sulfuretin Inhibits Ultraviolet B-induced MMP Expression in Human Dermal Fibroblasts  

So, Hong-Seob (Department of Microbiology, Wonkwang University School of Medicine)
Kim, Seung-Hoon (Department of Pharmacology, Seonam University Medical School)
Lee, Young-Rae (Department of Biochemistry, Chonbuk National University Medical School)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.25, no.3, 2011 , pp. 533-539 More about this Journal
Abstract
Sulfuretin is one of the main flavonoids produced by Rhusverniciflua. Sulfuretin has been shown to exhibit many pharmacological activities including anti-oxidant, anti-obesity, anti-inflammatory and anti-mutagenic activities. However, the anti-skin photoaging effects of sulfuretin has not yet been reported. In the present study, we investigated the inhibitory effect of sulfuretin on the expression levels of MMP-1 and -3 in the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed sulfuretin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB-induced MAPK/NF-${\kappa}B$/p50 activation and MMP expression were completely blocked by pretreatment of sulfuretin. Taken together, sulfuretin could prevent UVB-induced MMP expressions through inhibition of MAPK/NF-${\kappa}B$/p50 activation.
Keywords
UVB; MMP; NF-${\kappa}B$; HDFs; Sulfuretin;
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