• 대한전기학회:학술대회논문집
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• 대한전기학회 1994년도 하계학술대회 논문집 C
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• pp.1505-1508
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• 1994

Lately in KEPCO, the power plant capacity has increasingly become larger than before and it has become difficult to get R.O.W for T/L. Therefore KEPCO decided to increase its system voltage level from 345kV to 765kV. By doing this, KEPCO would like to expand its transmission capability by less T/L route. In 765kV system, we should consider various kinds of environmental impacts that can be neglected in lower voltage level. These environmental impacts are very important factor in T/L design. That can be changed greatly according to the selected conductor. And also conductor selection has relation with the economy of T/L construction directly. This paper deals with some general factors to be considered and basic principles about the conductor and ground wire selection for 765KV T/L with referring to the experiences of foreign utilities.

• 대한방사선기술학회지:방사선기술과학
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• 제2권1호
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• pp.15-22
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• 1979

Author made a experiment on the exposure dose with various intensifying screens in taking chest roentgenogram and obtained the results as follows; 1. Special speed type was the most sensitive intensifying screen, the r(gamma) value of this screen was distributed from 2.6 to 2.9. 2. The resolution activity of intensifying screen was inversely proportional to its sensitivity. If, the sensitivity and detail of the fine detail speed type intensifying screen at 100 KV were 100, those of the special speed type were 549 and 54.44 respectively. 3. If the exposure dose of the fine detail type intensifying screen was 1.0 at 60 KV, that of the special speed type intensifying screen was 0.1 at 80KV, and the skin dose of patient was as follows; it was 64.8 mRad at 60KV in mid speed type, 8.1 mRad at 80KV in super high speed type, and 7.2 mRad at 80KV in special speed type intensifying screen respectively.

• Biomolecules & Therapeutics
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• 제14권2호
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• pp.102-105
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• 2006

We examined the effects of psoralen derivatives on a rapidly activating delayed rectifier $K^+$ channel (hKv1.5) cloned from human heart and stably expressed in $Ltk^-$ cells. Using the whole cell configuration of the patch-clamp technique, we found that the five psoralen derivatives inhibited hKv1.5 current. Especially, 4-(2-Propenyloxy)-7H-furo[3,2-g][1]benzopyran-7-one (compound 5) was more potent than the inhibition of the hKv1.5 current of psoralen. The compound 5 inhibited the hKv1.5 current in a concentration-, time-, and voltage-dependent manner. These results suggest that the compound 5 is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.

• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.225-232
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• 2017

We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent $K^+$ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent $IC_{50}$ value of $2.86{\pm}0.52{\mu}M$ and a Hill coefficient of $0.77{\pm}0.1$. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not use-dependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentration-dependent and state-independent manner independently of serotonin reuptake.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.112-112
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• 2003

Voltage-gated $K^{+}$ (Kv) channels represent a structurally and functionally diverse group of membrane proteins. These channels play an important role in determining the length of the cardiac action potential and are the targets for antiarrhythmic drugs. Many $K^{+}$ channel genes have been cloned from human myocardium and functionally contribute to its electrical activity. One of these channels, Kv1.5, is one of the more cardiovascular-specific $K^{+}$ channel isoforms identified to date and forms the molecular basis for an ultra-rapid delayed rectifier $K^{＋}$ current found in human atrium. Thus, the blocker of hKv1.5 is expected to be an ideal antiarrhythmic drug for atrial fibrillation. Chelidonine was isolated from Chelidonium majus L. We examined the effect of chelidonine on the hKv1.5 current expressed in Ltk-cells using whole cell mode of patch clamp techniques. Chelidonine selectively inhibited the hKv1.5 current expressed in Ltk-cells in a concentration-dependent manner, whereas did not affect the HERG current expressed in HEK-293 cells. Additionally, chelidonine reduced the tail current amplitude recorded at -50 mV after 250 ms depolarizing pulses to +60 mV, and slowed the deactivation time course resulting in a 'crossover' phenomenon when the tail currents recorded under control conditions and in the presence of chelidonine were superimposed. We found that chelidonine also inhibited the $K^{+}$ current in isolated human atrial myocytes where hKv1.5 channels were predominantly expressed. Furthermore, we examined the effects of chelidonine on the action potentials in rabbit hearts using conventional microelectrode technique. Chelidonine prolonged the action potential durations (APD) of atrial, ventricular myocytes and Purkinje fibers in a dose-dependent manner. However, the effect of chelidonine on atrial APD was frequency-dependent whereas the effect of chelidonine on the APDs of ventricular myocytes and Purkinje fibers was not frequency- dependent. Also, the selective action of chelidonine on heart was more potent than dofetilide, $K^{+}$ channel blocker.

• The Korean Journal of Physiology and Pharmacology
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• 제3권5호
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• pp.471-479
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• 1999

The Kv channel activity in vascular smooth muscle cell plays an important role in the regulation of membrane potential and blood vessel tone. It was postulated that increased blood vessel tone in hypertension was associated with alteration of Kv channel and membrane potential. Therefore, using whole cell mode of patch-clamp technique, the membrane potential and the 4-AP-sensitive Kv current in cerebral arterial smooth muscle cells were compared between normotensive rat and one-kidney, one-clip Goldblatt hypertensive rat (lK,lC-GBH rat). Cell capacitance of hypertensive rat was similar to that of normotensive rat. Cell capacitance of normotensive rat and 1K,lC-GBH rat were $20.8{\pm}2.3$ and $19.5{\pm}1.4$ pF, respectively. The resting membrane potentials measured in current clamp mode from normotensive rat and 1K,lC-GBH rat were $-45.9{\pm}1.7$ and $-38.5{\pm}1.6$ mV, respectively. 4-AP (5 mM) caused the resting membrane potential hypopolarize but charybdotoxin $(0.1\;{\mu}M)$ did not cause any change of membrane potential. Component of 4-AP-sensitive Kv current was smaller in 1K,lC-GBH rat than in normotensive rat. The voltage dependence of steady-state activation and inactivation of Kv channel determined by using double-pulse protocol showed no significant difference. These results suggest that 4-AP-sensitive Kv channels playa major role in the regulation of membrane potential in cerebral arterial smooth muscle cells and alterations of 4-AP-sensitive Kv channels would contribute to hypopolarization of membrane potential in 1K,lC-GBH rat.

• The Korean Journal of Physiology and Pharmacology
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• 제10권5호
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• pp.243-249
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• 2006

The effect of genistein, widely used as a specific tyrosine kinase inhibitor, on rat brain Kv1.5 channels which were stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Genistein inhibited Kv1.5 currents at +50 mV in a concentration-dependent manner, with an $IC_{50}$ of $54.7{\pm}8.2\;{\mu}M$ and a Hill coefficient of $1.1{\pm}0.2$. Pretreatment of Kv1.5 with protein tyrosine kinase inhibitors ($10\;{\mu}M$ lavendustin A and $100\;{\mu}M$ AG1296) and a tyrosine phosphatase inhibitor ($500\;{\mu}M$ sodium orthovanadate) did not block the inhibitory effect of genistein. The inhibition of Kv1.5 by genistein showed voltage-independence over the full activation voltage range positive to 0 mV. The activation (at +50 mV) kinetics was significantly delayed by genistein: time constant for an activation of $1.4{\pm}0.2$ msec under control conditions and $10.0{\pm}1.5$ msec in the presence of $60\;{\mu}M$ genistein. Genistein also slowed the deactivation of the tail currents, resulting in a crossover phenomenon: a time constant of $11.4{\pm}1.3$ msec and $40.0{\pm}4.2$ msec under control conditions and in the presence of $60\;{\mu}M$ genistein, respectively. Inhibition was reversed by the application of repetitive depolarizing pulses, especially during the early part of the activating pulse. These results suggest that genistein directly inhibits Kv1.5 channels, independent of phosphotyrosine-signaling pathway.

• 한국방사선학회논문지
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• 제1권3호
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• pp.5-10
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• 2007

복부 단순방사선 촬영은 흉부촬영에 이어 가장 많이 검사가 이루어지고 있는 실정인 것이 임상현장이므로 환자의 피폭선량에 대한 연구가 필수적으로 진행이 이루어 질 필요성이 대두가 된다. 그 결과는 다음과 같았다. 1. 관전압이 60-85kV 증가 시 표면선량은 증가하고, 촬영거리를 50-150cm로 20cm씩 증가함에 mAs도 증가시킨 결과 표면선량은 감소되었다. 2. 심부선량 백분율은 60-75kV에서는 4cm 깊이, 80-85kV에서는 6cm 깊이에서 50% 이하를 나타내었으며, 60kV에서는 12cm 깊이, 65-85kV에서는 14cm 깊이에서 5% 이하를 나타났다. 3. 전방산란율은 60-85kV까지 관전압이 증가 시 10-11.78%까지 증가함을 나타내었다. 후방 산란율은 관전압이 60-85kV 증가 시 25-37%로 증가하였다. 측방산란율은 음극 측에서는 관전압이 60-85kV 증가 시 1.63-2.95%로 완만하게 증가하나 양극측은 그 반대로 감소하는데 그 원인은 heel effect 현상 때문인가 사료된다. 후방산란율이 가장 크고, 그 다음이 전방산란율, 측방산란율 순으로 작아짐을 알 수 있다.

• 전기의세계
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• 제43권4호
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• pp.50-56
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• 1994

본 기술해설에서는 한전의 765KV 송전계통에 적용하기 위해 연구조사된 보호계전방식의 이모저모를 소개하고자 한다.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1992년도 학술발표회 초록집
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• pp.50-54
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• 1992