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Effects of Psoralen Derivatives on hKv1.5 Current  

Eun Jae-Soon (College of Pharmacy, Woosuk University)
Kim Dae-Keun (College of Pharmacy, Woosuk University)
Leem Jae-Yoon (College of Pharmacy, Woosuk University)
Lee Kyung-A (College of Pharmacy, Woosuk University)
Park Hoon (College of Pharmacy, Woosuk University)
Kwon Jin (Korea National College of Rehabilitation & Welfare)
Jung Young-Hoon (College of Pharmacy, SungKyunKwan University)
Kwak Yong-Geun (Department of Pharmacology, Chonbuk National University Medical School)
Publication Information
Biomolecules & Therapeutics / v.14, no.2, 2006 , pp. 102-105 More about this Journal
Abstract
We examined the effects of psoralen derivatives on a rapidly activating delayed rectifier $K^+$ channel (hKv1.5) cloned from human heart and stably expressed in $Ltk^-$ cells. Using the whole cell configuration of the patch-clamp technique, we found that the five psoralen derivatives inhibited hKv1.5 current. Especially, 4-(2-Propenyloxy)-7H-furo[3,2-g][1]benzopyran-7-one (compound 5) was more potent than the inhibition of the hKv1.5 current of psoralen. The compound 5 inhibited the hKv1.5 current in a concentration-, time-, and voltage-dependent manner. These results suggest that the compound 5 is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.
Keywords
hKv1.5 channel; antiarrhythmic drug; Psoralen derivatives;
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Times Cited By KSCI : 1  (Citation Analysis)
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