• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.7
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• pp.960-965
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• 2010

To develop Corni Fructus as a cancer preventive food material, the in vitro cytotoxicities and in vivo antitumor activities of various concentrations of 80% Corni Fructus ethanol extract (CFEE) were investigated using sarcoma-180 cancer cell. Viability was decreased and cell death rate was increased in both dose- and time-dependent manners in cells treated with CFEE at 10, 100, 300, and $500\;{\mu}g/mL$ concentrations for 24, 48, and 72 hr. Proliferation was also inhibited more than 60% in cells treated with CFEE at the $100\;{\mu}g/mL$ concentration for 48 hr. In addition, the morphology of cells treated with CFEE at the 100 and $500\;{\mu}g/mL$ concentrations was distorted with shrunken cell masses and lower cell numbers compared to the control cells. In the cells treated with CFEE, the formation of apoptotic bodies and nuclear condensation were observed in dose dependent manners. CFEE also increased DNA fragmentation values at the 100 and $500\;{\mu}g/mL$ concentrations. The apoptosis induced by CFEE was connected to the proteolytic activation of caspase-3. When CFEE was administered at 100 and 300 mg/kg, ip, for 7 consecutive days in mice inoculated with sarcoma-180 cancer cell, the life span of the mice was found to be longer than that of the control mice that did not receive the extract. These results suggest that Corni Fructus may be used as a potential cancer preventive food material.

• Archives of Pharmacal Research
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• v.20 no.4
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• pp.368-371
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• 1997

In an effort to increase of the antitumor activity of 2(S)-$2^{I}$,$5^{I}$-trihydroxy-7, 8-dimethoxyflavanone isolated from Scutellaria indica, we synthesized its analogues, II, III and IV. They showed potent cytotoxicity in vitro against cancer cell lines, L1210, K562 and A549. On the basis of $ED_50$ values against the cancer cell lines, III exhibited about 2-7 times stronger activity than I against various cell lines. We tested the antitumor activity of the analogues against Sarcoma 180 cells in vivo and evaluated the structure-activity relationship. The antitumor activity appeared to be related to the hydrogen bond between carbonyl group at C-4 and hydroxyl group at C-5, in contrast to cytotoxic action.

• YAKHAK HOEJI
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• v.38 no.6
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• pp.795-799
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• 1994

Some components and antitumor effect of antler and fermented antler with Bacillus P-92 were determined. By fermenting the antler with Bacillus P-92, the amount of free amino acids, polypeptides and other compounds were increased. The free amino acid of the fermented antler was 6-fold higher than those of the untreated antler. Sarcoma 180 cells were intraperitoneally implanted into ICR mice to determine the effect of fermented antler and untreated antler on life span prolongation. The life span of ICR mouse treated with antler and fermented antler were prolonged to 24.4% and 39.2%(p<0.05), and survival rates were 22% and 33%, respectively. In addition, the induction of neutrophil was 2.3-fold and 3.4-fold, respectively.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.51 no.11
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• pp.541-545
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• 2002

This paper proposes the new narrow erase method to erase wall charges formed in an AC plasma display panel (PDP) cell. In the proposed method, pulse timing of switch at the sustain period is adjusted for inducing, a weak discharge. Then, after the narrow erase, the voltage of the X electrode is set to differ from that of the Y electrode. For the proposed method, the measured maximum address voltage margin was 38.3V at Y_Rest voltage of 100V and sustain voltage of 180${\sim}$185V. However, for the conventional method, in which the X and Y electrodes are set to be of equal voltage after the narrow erase, the measured maximum address voltage margin was 31.3V at Y_Rest voltage of 150V and sustain voltage of 180V. This result shows that the measured maximum voltage margin for the proposed method is about 7V(22%) higher than that for the conventional method.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2002.04b
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• pp.180-180
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• 2002

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.180-180
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• 2005

• 한국신재생에너지학회:학술대회논문집
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• 2008.10a
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• pp.14-16
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• 2008

자동차 구동용 연료전지 스택에 적용된 분리판에 대하여 연료전지 내부의 수분분포 및 농도를 측정할 수 있는 중성자 가시화 기법을 이용하여 구조진단을 실시하여 유로의 분기부 및 180도 회전부의 수분 응축과 같은 국부적인 Flooding 현상과 분리판의 반응면적 전체에 대한 불균일한 수분분포를 확인하였다. 신규 개발 스택에 적용된 분리판은 이러한 구조진단 결과를 바탕으로 변형된 유로 도입을 통한 180도 회전부 제거, 냉각수 입구와 인접한 부분에서 교차하게 되는 수소 출구 부분의 수분응축에 의한 Flooding 현상을 완화하기 위한 냉각수 유로를 적용하여 중성자 가시화 기법을 통하여 동일한 가습조건에서 부하에 따른 분리판 반응면적 전체에 대한 수분분포를 조사하였다.

• The Transactions of the Korean Institute of Power Electronics
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• v.13 no.4
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• pp.270-277
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• 2008

Capacitor Commutated Converter HVDC system is required the small reactive power. It has the advantage of an application to the week grid because the firing angle ${\alpha}$ can be increased to a value well beyond $180^{\circ}$. In this paper, The three HVDC converter arrangements which are the CCC(Capacitor Commutated Converter) and the CSCC(Controlled Series Capacitor Convertor) and Conventional Converter are compared the dynamic character. and it find that the CCC HVDC is operating with more reliability. The simulation was conducted to the PSCAD/EMTDC.

• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.1589-1591
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• 2005

현재 기존선에 설치되어 있는 ATS 지상신호시스템은 고속화에 어려움이 있으며 만약 열차운행속도 180km/h급 틸팅차량이 안전하게 운행하고자 한다면, 첨단기술을 이용한 차상신호시스템이 도입이 필요하다. 지상신호시스템의 고속화 적용에 가장 큰 장애 요인으로 작용하는 기관사 시인성 연구 결과에서도 열차 운행속도 160km/h 까지는 가능하나 그 이상의 속도에서는 기관사의 피로도 및 오동작 확률이 높아지므로 기존선 고속화를 위해 신호시스템을 차상신호 시스템으로 개량하는 것이 적합한 것으로 알려져 있다. 본 논문은 최고운행속도 180km/h급 틸팅차량 TTX(Tilting Train eXpress)에 적합한 차상신호장치의 기본설계방안을 제시한다.

• Journal of Pharmacopuncture
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• v.7 no.2
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• pp.43-56
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• 2004

Objectives : In order to investigate effects and immune improvement of distilled red-ginseng herbal Acupuncture, expression of Cox-1, Cox-2, and mRNA of Bcl-2 and Bax were analyzed in A549 cell in vivo. Survival time and expression of cytokine mRNA were measured for the mice with Sarcoma-180 induced abdominal cancer. Methods : Balb/c mouse was treated with distilled red-ginseng Herbal Acupuncture at Wisu($BL_{21}$) and Chung- wan($CV_{12}$) to investigate anti-cancer effects and immune response. Results : 1. For expression of mRNA of Cox-1 using RT-PCR, the control group and the experiment groups didn't show significant differences. For Cox-2, both experiment groups and the normal group showed significant differences. 2. For expression of mRNA of Bcl-2 using RT-PCR, experiment groups showed slight decrease compared to the control group. For Bax, no significant changes were shown between the control group and experiment groups. 3. For survival time, all of experiment groups showed 11.1% increase compared to the control group. 4. For IL-2 and IL-4 productivity using Flow cytometry, all of experiment groups didn't show any significance. 5. For IL-2 productivity using ELISA, all of experiment groups didn't show any significance. 6. For expression of cytokine mRNA using RT-PCR, significant increase of IL.-2 and IL-4 were witnessed in the experiment group II compared to the control group. Significant increase of IL-10 was shown in all off experiment groups compared to the control group. Conclusion : According to the results, we can expect that distilled red-ginseng Herbal Acupuncture may be further effccts in anti-cancer and immune improvement if increasing concentration.