YAKHAK HOEJI (약학회지)
- Volume 38 Issue 6
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- Pages.795-799
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Antitumor Activity of Fermented Antler on Sarcoma 180 in Mice
복수암 생쥐에 대한 발효녹용의 항암작용
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Kim, Dong-Hyun
(Kyung Hee University, College of Pharmacy)
;
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Han, Sang-Bum
(Kyung Hee University, College of Pharmacy)
;
- Yu, Ki-Ung (Kyung Hee University, College of Pharmacy) ;
- Kim, Yu-Suk (Kyung Hee University, College of Pharmacy) ;
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Han, Myung-Joo
(Kyung Hee University, Department of Food Science and Nutrition)
- Published : 1994.12.30
Abstract
Some components and antitumor effect of antler and fermented antler with Bacillus P-92 were determined. By fermenting the antler with Bacillus P-92, the amount of free amino acids, polypeptides and other compounds were increased. The free amino acid of the fermented antler was 6-fold higher than those of the untreated antler. Sarcoma 180 cells were intraperitoneally implanted into ICR mice to determine the effect of fermented antler and untreated antler on life span prolongation. The life span of ICR mouse treated with antler and fermented antler were prolonged to 24.4% and 39.2%(p<0.05), and survival rates were 22% and 33%, respectively. In addition, the induction of neutrophil was 2.3-fold and 3.4-fold, respectively.