• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 A
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• pp.241-243
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• 1998

This paper describes a new method for the faster shape optimization of the electromagnetic devices. In a conventional iterative method of shape design optimization using design sensitivity based on a finite element method, meshes for a new shape of the model are generated and a discretized system equation is solved using the meshes in each iteration. They cause much design time. To save this time, a polynomial approximation of the finite element solution with respect to the geometric design parameters using Taylor expansion is constructed. This approximate state variable expressed explicitly in terms of design parameters is employed in a gradient-based optimization method. The proposed method is applied to the shape design of quadrupole magnet.

• 생명과학회지
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• 제24권10호
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• pp.1085-1091
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• 2014

본 연구는 지방전구세포에서 selenate가 지방세포의 분화와 초기 분화조절 연관 selenoprotein의 유전자발현 양상을 조사하기 위하여 실시하였다. Selenate의 농도를 달리하여($0-100{\mu}M$) 지방전구세포가 confluent한 시기, 지방세포분화 유도 초기(day0-day2), 분화유도 중기(day2-day4), 또는 분화전기간(day0-day6)으로 구분하여 처리한 다음 세포내 지방구형성과 소포체(ER)스트레스 및 selenoptotein 유전자들의 발현 양상을 분석하였다. Selenate에 의한 지방세포분화 억제효과는 지방세포가 post-confluent (cell cycle arrest), 분화유도 초기(mitotic clonal expansion), 또는 지속적인 처리가 주어진 상태에서 농도 의존적으로 나타났다(p<0.05). 그러나 selenate를 분화유도 중기(post-mitotic growth arrest)에 처리되었을 때는 세포분화억제 효과가 감소하였다. Seps1와 Sepp1의 selenoprotein 유전자들은 mitotic clonal expansion시기에 높게 발현하였다가 post-mitic growth period에는 급격한 발현감소현상을 나타내었다(p<0.05). 본 연구 결과는 selenate에 의한 지방전구세포의 분화억제효과는 세포분화초기에 효과적인 기능이 있음을 보여 주었으며, selenoprotein의 분화유도초기와 중기의 변환지점에 이들 유전자들의 급격한 발현변화가 selenate에 의한 지방세포의 분화억제와 관련이 있는 것으로 보여진다.

• 대한기계학회논문집A
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• 제38권10호
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• pp.1049-1056
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• 2014

전자 부품을 이루고 있는 재료들은 여러 다른 열팽창계수를 가지고 있다. 새롭게 개발된 재료나 적용하려는 온도범위가 다른 경우에는 실제 제품을 구성하고 있는 그 재료 자체의 열팽창계수를 측정할 필요가 있으며 이에 대한 신뢰성 있는 측정방법이 필요하다. 재료의 온도가 변화하면, 그에 부착된 스트레인 게이지 저항체의 출력은 기계적인 하중뿐 아니라 온도변화에 의해서도 복합적으로 발생한다. 본 논문에서는 이러한 스트레인 게이지의 특성을 이용하여 온도가 증가함에 따라 변하는 변형률을 측정하고 이로부터 재료의 열팽창계수를 구하는 방법을 실험적으로 제시하였다. 실험의 신뢰성을 검증하기 위해서 일반적으로 열팽창계수가 잘 알려진 탄소강, 알루미늄 및 구리시편을 사용해서 열팽창계수를 측정하고 그 결과를 비교하여 열팽창계수 측정방법의 신뢰성을 평가하였다. 또한 이 방법을 전자 패키지를 구성하고 있는 새로운 전자재료에 적용하여 무섬유 패키지 기판의 온도에 따른 열팽창계수를 측정하였다.

• 대한기계학회논문집A
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• 제38권8호
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• pp.831-836
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• 2014

본 연구에서는 한국원자력연구원 내에 설치될 예정인 소듐시험 시설인 SELFA(Sodium Thermal-hydraulic Experiment Loop for Finned-tube Sodium-to-Air heat exchanger) 내에서 정상상태 가동온도가 $510^{\circ}C$의 고온 압력용기인 팽창탱크에 대해 고온 건전성 평가를 수행하였다. 팽창탱크에 대해 3 차원 유한요소해석에 기초하여 고온설계 기술기준인 ASME Section III Subsection NH 와 프랑스의 RCC-MRx 코드를 따라 크리프-피로 손상평가를 수행하였다. 평가결과 팽창탱크는 크리프-피로 설계 과도 하중 하에서 구조적 건전성을 유지하는 것으로 나타났다. 316L 스테인리스강 재질의 동 압력용기에 대해 정량적 코드 비교 분석을 수행하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1990년도 추계학술대회 논문집 학회본부
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• pp.267-271
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• 1990

This paper describes a 3-Phase Quasi-Resonant DC Link Inverter (3-phase QRI), which has two operating modes, ie. inverting mode and rectifying mode. First the 3-Phase QRI is simplified and the resonant circuit is analyzed in comparison with two resonant DC-to-DC converters. This analysis shows that the maximum voltage of resonant capacitor is limited to twice the input voltage irrespective of operating modes. A new simple control method in rectifying mode is suggested, which does not require any other element in power circuit. The characteristic of 3-Phase Quasi Resonant Inverter has been verified by simulation using the proposed control method.

• Structural Engineering and Mechanics
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• 제16권1호
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• pp.35-46
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• 2003

The histories and distributions of dynamic stresses in an orthotropic hollow cylinder under sinusoidal impact load are obtained by making use of eigenfunction expansion method in this paper. Dynamic equations for axially symmetric orthotropic problem are founded and results are carried out for a practical example in which an orthotropic hollow cylinder is in initially at rest and subjected to a dynamic interior pressure $p(t)=-{\sigma}_0(sin{\alpha}t+1)$. The features of the solution appear the propagation of the cylindrical waves. The other hand, a dynamic finite element solution for the same problem is also got by making use of structural software (ABAQUS) program. Comparing theoretical solution with finite element solution, it can be found that two kinds of results obtained by two different solving methods are suitably approached. Thus, it is further concluded that the method and computing process of the theoretical solution are effective and accurate.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.377-378
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• 2006

Thermal management technology is a critical element in all new chip generations, caused by a power multiplication combined with a size reduction. A heat sink, mounted on a base plate, requires the use of special materials possessing both high thermal conductivity (TC) and a coefficient of thermal expansion (CTE) that matches semiconductor materials as well as certain packaging ceramics. In this study, nano tungsten coated copper powder has been developed with a wide range of compositions, 90W-10Cu to 10W-90Cu. Powder technologies were used to make samples to evaluate density, TC, and CTE. Measured TC lies among theoretical values predicted by several existing models.

• 대한수학회논문집
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• 제15권2호
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• pp.285-308
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• 2000

We generalize bi-orthogonal (non-orthogona) MRA to frame MRA in which the family of integer translates of a scaling func-tion forms a frame for the initial ladder space V0. We investigate the internal structure of frame MRA and establish the existence of a dual scaling function, and show that, unlike bi-orthogonal MRA, there ex-ists a frame MRA that has no (frame) 'wavelet'. Then we prove the existence of a dual wavelet under the assumption of the existence of a wavelet and present easy sufficient conditions for the existence of a wavelet. Finally we give a new proof of an equivalent condition for the translates of a function in L2(R) to be a frame of its closed linear span.

• Natural Product Sciences
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• 제17권4호
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• pp.273-278
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• 2011

In this study, the effects of a methanol (MeOH) extract of Carduus crispus L. (Asteraceae) on adipogenesis was investigated in 3T3-L1 cells. To differentiate preadipocytes to adipocytes, confluent 3T3-L1 preadipocytes were treated with a hormone mixture, which included isobutylmethylxanthine, dexamethasone, and insulin (MDI). The methanol extract of C. crispus significantly decreased fat accumulation by inhibiting adipogenic signal transcriptional factors in MDI-induced 3T3-L1 cells in a dose-dependent manner. In MTT assays and on PI-staining, methanol extract of C. crispus inhibited the proliferation of 3T3-L1 cells during mitotic clonal expansion (MCE). The anti-adipogenic effect of the Carduus extract seemed to be associated with the upregulation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways within the first 2 days after MDI treatment. These results suggest that methanol extract of C. crispus might be beneficial for the treatment of obesity.

• IMMUNE NETWORK
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• 제7권2호
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• pp.80-86
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• 2007

Background: CD40-activated B (CD40-B) cells might be an attractive source of autologous antigen-presenting cells (APCs) for immunotherapy due to the convenience to obtain from peripheral blood and expand in vitro. Moreover, CD40-B cells were found to be comparable with DCs in their capacity to raise antigen-specific CD8+ T cells. Here, we have established K562 cells expressing CD40L to expand CD40-activated B cells used for APCs. Methods: After activation of B cell by K562/CD40L, CD40-B cells were examined by counting B cell numbers. Surface expression of CD54, CD80, CD86 and HLA class II was measured by flow cytometry. The CD40-B cells were tested for its function as APC by mixed lymphocyte reactions (MLR) and by induction of T cell responses specific for pp65 peptide in vitro. Results: The expansion of B cells by K562/CD40L increased about 6-folds compared with anti-CD40 or K562. Furthermore, the expression of CD54, CD80, CD86 and HLA class II was up-regulated by K562/CD40L. B cells by K562/CD40L showed comparable antigen presentation activity with mature DCs as shown in MLR, INF-${\gamma}$ ELISPOT assay. Conclusion: These results suggest that K562/CD40L could be used to generate activated B cells as potent APCs which could be useful for cellular vaccination and adoptive immunotherapy.