• 한국토양비료학회지
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• 제37권2호
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• pp.109-115
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• 2004

가축분 퇴비가 토양의 생화학적 특성에 미치는 영향을 조사하고자, 농업과학기술원 시험포장에 시용량 ($8Mg\;ha^{-1}$, CM-8구: $29Mg\;ha^{-1}$, CM-29구: $57Mg\;ha^{-1}$, CM-57구)을 달리하여 돈분퇴비를 시비하고 봄배추를 재배하면서 생육시기별로 토양을 채취하여 biomass, 효소활성도의 변화를 조사하였으며, 그 결과를 요약하면 다음과 같다. 토양효소 활성은 NPK구의 경우 대조구에 비하여 낮았으나 퇴비구에서는 증가하여 CM-57구에서 protease, Phosphomonoesterase 그리고 dehydrogenase의 활성이 각각 2.3, 1.6 및 2.4배 증가하였다. Protease와 phosphomonoesterase의 경우 재배기간중 모든 처리구에서 생육중기에 가장 높은 활성을 나타내었다. Biomass는 퇴비의 시용랑에 따라 증가하여 biomass C의 함량은 CM-57구에서 $466mg\;kg^{-1}$으로 대조구에 비하여 4.3배, biomass N과 P는 각각 3.4배, 2.8배 증가하였다. 한편 NPK구에서는 biomass C와 N은 증가하였으나 biomass P는 낮았다. 퇴비구에 있어서 biomass N과 P는 배추의 생육중기에 최고치에 달하였으나 biomass C의 함량은 생육초기에 증가하여 수확기까지도 높은 함량을 유지하였다. 평균 biomass C:N:P 비율은 11:2:1이었으며, 토양의 유기 탄소 및 질소함량에 대한 biomass C와 N의 비율은 각각 1.1 및 3.6%이었다. 재배토양의 protease와 dehydrogenase는 biomass C 및 P와 고도로 유의한 상관관계를 나타내었다.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.260-266
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• 2014

This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to the pharmacokinetic profile and therapeutic efficacy of PX after intramuscular (IM) injection. In the pharmacokinetic study in rats, systemic exposure and pharmacokinetic parameters of PX after a single IA dose were compared with systemic exposure and pharmacokinetic parameters of PX after administration of the same dose IM (0.6 mg/kg). The anti-inflammatory and analgesic effects of IA PX were evaluated simultaneously in a monoiodoacetate-induced osteoarthritis rat model. The plasma PX concentration rapidly rose following IA injection, and it was comparable to the plasma PX concentration following IM injection, suggesting the rapid efflux of the drug molecule from the joint cavity. However, in the efficacy study, the IA PX administration significantly reduced the knee swelling by reducing the level of prostaglandin $E_2$ in the joint, compared to that following administration of IA vehicle and after administration of the IM PX dose. In addition, we found that the anti-inflammatory and anti-nociceptive efficacies of IA PX were synergistically increased upon co-treatment with hyaluronic acid (HA), a potent agent for the treatment of osteoarthritis, at the weight ratio of 1:1 or 1:2, and these effects were more pronounced than those following administration of HA or PX alone. In conclusion, this study demonstrated the efficacy of the IA use of PX alone and/or in combination with HA in osteoarthritis.

• 한국토양비료학회지
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• 제32권1호
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• pp.76-83
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• 1999

가축분 퇴비가 토양의 미생물상에 미치는 영향을 조사하고자 농업과학기술원 시험포장에 시용량($8Mg\;ha^{-1}$, CM-8구: $29Mg\;ha^{-1}$, CM-29구: $57Mg\;ha^{-1}$, CM-57구)을 달리하여 돈분퇴비를 시비하고 봄배추를 재배하면서 생육시기별로 토양을 채취하여 미생물상을 조사한 결과를 요약하면 다음과 같다. 미생물의 생균수는 무비구(대조구)에 비하여 화학비료구(NPK구)에서 세균, 방선균, 사상균수는 높았으나 세균 중에서 Bacillus속과 형광성 Pseudomonas속 균수는 현저히 낮았다. 반면에 퇴비 구에서는 Bacillus속을 제외한 모든 미생물이 시용량에 비례하여 증가하였고, 퇴비 $57Mg\;ha^{-1}$ 시용구(CM-57)에서는 세균 사상균, 방선균, 형광성 Pseudomonas속 균수가 대조구에 비하여 각각 3.4, 2.3, 3.2, 3.1배 높았다. 퇴비구에 있어서 세균(Bacillus속 포함)의 경우 배추의 생육초기에 정점에 도달하였으나, 형광성 Pseudomonas속은 생육후기에 사상균과 방선균은 수확기에 최고의 밀도를 보였다. 한편 토양미생물의 근권효과는 형광성 Pseudomonas속이 가장 컸다. 재배토양의 화학성분은 pH를 제외한 모든 항복에서 퇴비시용량에 비례하여 증가하는 경향이었으며, NPK구의 경우 EC와 K함량은 $0.89dS\;m^{-1}$ 및 $1.64cmol^+kg^{-1}$로 각각 대조구에 비하여 3.4 및 5.0배로서 모든 처리구 가운데 가장 높았다. 배추의 수량은 대조구가 $44Mg\;ha^{-1}$이었으나 퇴비구에서는 시용량에 비례하여 증수되어 CM-57구에서 $163Mg\;ha^{-1}$으로 처리구 중 가장 많은 수량을 거두었고 NPK구에서는 이보다 적은 $143Mg\;ha^{-1}$이었다.

• IMMUNE NETWORK
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• 제16권2호
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• pp.140-145
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• 2016

Ophiocordyceps sinensis is a natural fungus that has been valued as a health food and used in traditional Chinese medicine for centuries. The fungus is parasitic and colonizes insect larva. Naturally occurring O. sinensis thrives at high altitude in cold and grassy alpine meadows on the Himalayan mountain ranges. Wild Ophiocordyceps is becoming increasingly rare in its natural habitat, and its price limits its use in clinical practice. Therefore, the development of a standardized alternative is a great focus of research to allow the use of Ophiocordyceps as a medicine. To develop an alternative for wild Ophiocordyceps, a refined standardized extract, CBG-CS-2, was produced by artificial fermentation and extraction of the mycelial strain Paecilomyces hepiali CBG-CS-1, which originated from wild O. sinensis. In this study, we analyzed the in vitro immune-modulating effect of CBG-CS-2 on natural killer cells and B and T lymphocytes. CBG-CS-2 stimulated splenocyte proliferation and enhanced Th1-type cytokine expression in the mouse splenocytes. Importantly, in vitro CBG-CS-2 treatment enhanced the killing activity of the NK-92MI natural killer cell line. These results indicate that the mycelial culture extract prepared from Ophiocordyceps exhibits immune-modulating activity, as was observed in vivo and this suggests its possible use in the treatment of diseases caused by abnormal immune function.

• 한국육종학회지
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• 제41권4호
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• pp.574-578
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• 2009

"고풍적축면"은 "안동적축면"과 "뚝섬적축면"을 교배하여 육성한 적축면 잎상추 품종이다. 기존의 같은 type의 품종보다 추대가 늦은 중만생 품종이며, 적색발현이 좋아, 안토시안닌 함량이 29.4 mg/100 g으로 "뚝섬적축면"보다 10배이상 많았으며 수확후 $4^{\circ}C$에서 3주간 이상 저장이 가능하였다. 재배 적기는 연중재배가 가능하나 시험재배결과 평난지에서는 봄, 가을에 고랭지에서는 봄, 여름, 가을에 노지 및 비가림하우스 재배가 가능한 품종이다. 수확 가능한 엽수는 52매이며, 주중은 330 g으로 상품수량성은 19.5 ton/ha로 뚝섬적축면 보다 17% 증수되었다.

• 대한한방내과학회지
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• 제24권2_4호
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• pp.975-986
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• 2003

Introduction: Guillain-Barre syndrome(GBS) is defined as a recognizable clinical entity that is characterized by rapidly evolving symmetric limb weakness, a loss of tendon reflexes, absent or mild sensory signs, and variable autonomic dysfunctions. Recently there is an opinion that Acute Inflammatory Demyelinating Polyradiculoneuropathy'(AIDP) is more effective than 'GBS' for the symptoms. These symptoms are applicable to rheumatic arthritis(痺), flaccid paralysis of limb(?) caused by wind, cold and dampness(風, 寒, 濕) from an oriental medical view point. On this, we reported one case that diagnosed as 'complex of rheumatic arthritis(痺) and flaccid paralysis of limb(?)' at our oriental medical hospital. Result: we considered these symptoms as 'complex of rheumatic arthritis(痺), flaccid paralysis of limb(?)'. In accordance with the result, we treated the patient with Chung-Sang Tong-Jung On-Ha(淸上通中溫下). We concluded that external factors such as wind, cold and dampness(風, 寒, 濕) and internal factors like vital energy's disharmony(生氣不調和) affected the patient.

• BMB Reports
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• 제29권5호
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• pp.429-435
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• 1996

To investigate the structure-antagonistic relationship of the cyclohexapeptide L-659,877, a selective NK-2 tachykinin receptor antagonist, seven analogues were chemically synthesized by a solid phase method. The agonistic and antagonistic activities of the analogues were evaluated by contraction assay using the smooth muscle of guinea pig trachea (GPT) containing the NK-2 receptor. It was shown that the aromatic ring of Phe at position 3 and the sulfur group of Met at position 6 in L-659,877 were essential for binding to the NK-2 receptor. Decrease in antagonistic activity of L-659,877 caused by substituting Leu for Nle at position 5 indicates that the ${\gamma}$ methyl group and side chain length of Leu plays an important role in its antagonistic action. Although the activity was slightly lower than L-659,877, cyclo $[{\beta}Ala^{8}]NKA(4-10)$ (analogue 1) showed potential antagonistic activity for the NK-2 receptor. It was confirmed that the expansion of the ring in L-659,877 by substitution of ${\beta}Ala$ for Gly at position 4 stabilized its conformation monitored by CD spectra. The results suggest that analogue 1 can be used as a new leader compound to design a more powerful, selective, and stable NK-2 receptor antagonist.

• Journal of Korean Biological Nursing Science
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• 제12권2호
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• pp.97-105
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• 2010

Purpose: The purpose of this study was to examine the effect of yoga and health calisthenics program in the middle aged women on physiological index and life satisfaction. Methods: This research was an one group pretest-posttest design. A pre and post measurement tool of the program was applied to measure body weight, obesity, rate of body fat, vital capacity, inhalation rate of oxygen, sit-up, grasping power, total physical response, body anteversion, body mass index (BMI), total physical strength, physical strength, health age, life satisfaction. Data collected from this tool was analyzed by SPSS in paired t-test. Results: The results were summarized as follows: yoga program group, the body weight, obesity, BMI, %body fat of the decreased. The results of pulmonary yoga group, vital capacity and inhalation rate of oxygen, total physical strength examination results showed a significant difference. Conclusion: In this study, the yoga program was effective in positive on body composition and physical strength, life satisfaction in middle aged women.

• 동의생리병리학회지
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• 제17권6호
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• pp.1368-1375
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• 2003

Treatise Yin-Yang is based on Chun-chu-shi-dae and composed in Jen-guk-shi-dae and the systemic constant is effected at the age of Han-dae. This study needs the deep philosophic understanding and principal. In conclusion, the parting and meeting of Yin-Yang is conducted by the parting and meeting of Three-yin-three-yang. In addition, this theory is based on the Taoism. Yin-Yang is embodied by Sky-Ground-Sun-Moon, had the meaning of time and place and accomplished their own rules with identification as one. Taechung and Gwangmyeng are the concretely applied form of the parting and meeting of Yin-Yang at human body. The parting and Meeting of Three-Yin- Three-Yang has six types symbols of circulated Yin-Yang. They have Six-meeting space structure as match like up-down, backside and front-side, left-side and right-side. These pairs express symbolized meaning of creation of Saeng-jang-shu-chang and also apply the same things.

• 동의생리병리학회지
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• 제25권5호
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• pp.908-913
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• 2011

Major symptoms of Raynaud's Disease are pain, edema, cyanosis, and redness of hands, feet, nose, and etc. The purpose of this report is to show the curative effect of herbal medicine for Raynaud's Disease. We provided Prescription of Modified Woogyu-yeum(Yougui-yinjiaweifang ) to patient who was diagnosed with Raynaud's Disease three times a day for 22 days. We observed changes of symptoms through Digital Infrared Thermographic Imaging, taking photos of both hands, and collecting the survey answered by the patient. Modified Woogyu-yeum reduced pain, edema, and redness of both hands. The frequency of cyanosis decreased after the treatment. Digital Infrared Thermographic Imaging proved a rise in temperature of fingertips after the treatment. In conclusion, Modified Woogyu-yeum showed the possibility of effect on Raynaud's Disease.