• 교육철학
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• 제39호
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• pp.191-221
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• 2009

The aim of this study is to analyse of elements and structure of consciousness theory in the 1887 Psychology written by John Dewey, and to research its educational implications. Conclusions are as follows: Firstly, consciousness theory articulated in first edition of Dewey's Psychology was influenced by neo-Hegelian G. S. Hall, and then characteristics of its theory was metaphysical and idealistic. But after of researching the work of William James, his approach to consciousness changed surprisingly from idealistic to experimental. His experimental approach and scientific attitude to it influenced the formation and development of advanced theories in his epistemology, axiology and pedagogy. Secondly, the structure of consciousness expressed by Dewey has three forms such as knowledge, feeling and will(or volition). This forms are too dynamic and unitary. Dewey considered cognition, feeling, will to be integral functions of each self. The tripartite functions of self, moreover, are unified in will. In other word, will combines subjective feeling and objective knowledge as one self. Will regulates impulse because it powers some stimulus into activity of self. In this view point, his theory of consciousness differs from traditional theories about consciousness for emphasizing dynamic relations and functions. Thirdly, Dewey's theory of consciousness will give some important implications to educational field. It is necessary to fundamental arguments about conscious conditions of learners as a human. For it is impossible to establish some aim of learning, to organize meaningful contents of learning, and also to create some effective methods of learning without consideration of this conditions. And it is important to construct and organize the contents and methods of learning for widening and deepening of educational experiences. Then consciousness and experiences of learners interact each other, so then they will produce some meaningful results of learning in this process.

• Biomolecules & Therapeutics
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• 제27권6호
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• pp.553-561
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• 2019

Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast, vagina, cervix, the gastrointestinal tract, and skin. Rab25 plays key roles in tumorigenesis, mainly by regulating epithelial differentiation and proliferation. However, its role in skin physiology is relatively unknown. In this study, we demonstrated that Rab25 knock-out (KO) mice show a skin barrier dysfunction with high trans-epidermal water loss and low cutaneous hydration. To examine this observation, we investigated the histology and epidermal differentiation markers of the skin in Rab25 KO mice. Rab25 KO increased cell proliferation at the basal layer of epidermis, whereas the supra-basal layer remained unaffected. Ceramide, which is a critical lipid component for skin barrier function, was not altered by Rab25 KO in its distribution or amount, as determined by immunohistochemistry. Notably, levels of epidermal differentiation markers, including loricrin, involucrin, and keratins (5, 14, 1, and 10) increased prominently in Rab25 KO mice. In line with this, depletion of Rab25 with single hairpin RNA increased the expression of differentiation markers in a human keratinocyte cell line, HaCaT. Transcriptomic analysis of the skin revealed increased expression of genes associated with skin development, epidermal development, and keratinocyte differentiation in Rab25 KO mice. Collectively, these results suggested that Rab25 is involved in the regulation of epidermal differentiation and proliferation.

• Biomolecules & Therapeutics
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• 제27권6호
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• pp.584-590
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• 2019

Luteolin, a widespread flavonoid, has been known to have neuroprotective activity against various neurologic diseases such as epilepsy, and Alzheimer's disease. However, little information is available regarding the hypnotic effect of luteolin. In this study, we evaluated the hypnotic effect of luteolin and its underlying mechanism. In pentobarbital-induced sleeping mice model, luteolin (1, and 3 mg/kg, p.o.) decreased sleep latency and increased the total sleep time. Through electroencephalogram (EEG) and electromyogram (EMG) recording, we demonstrated that luteolin increased non-rapid eye movement (NREM) sleep time and decreased wake time. To evaluate the underlying mechanism, we examined the effects of various pharmacological antagonists on the hypnotic effect of luteolin. The hypnotic effect of 3 mg/kg of luteolin was not affected by flumazenil, a GABAA receptorbenzodiazepine (GABAAR-BDZ) binding site antagonist, and bicuculine, a GABAAR-GABA binding site antagonist. On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist. From the binding affinity assay, we have found that luteolin significantly binds to not only A1R but also A2AR with $IC_{50}$ of 1.19, $0.84{\mu}g/kg$, respectively. However, luteolin did not bind to either BDZ-receptor or GABAAR. From these results, it has been suggested that luteolin has hypnotic efficacy through A1R and A2AR binding.

• Steel and Composite Structures
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• 제33권4호
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• pp.595-614
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• 2019

In cold-formed steel (CFS) structures, such as trusses, transmission towers and portal frames, the use of back-to-back built-up CFS unequal angle sections are becoming increasingly popular. In such an arrangement, intermediate welds or screw fasteners are required at discrete points along the length, preventing the angle sections from buckling independently. Limited research is available in the literature on axial strength of back-to-back built-up CFS unequal angle sections. The issue is addressed herein. This paper presents an experimental investigation on both the welded and screw fastened back-to-back built-up CFS unequal angle sections under axial compression. The load-axial shortening and the load verses lateral displacement behaviour along with the deformed shapes at failure are reported. A nonlinear finite element (FE) model was then developed, which includes material non-linearity, geometric imperfections and modelling of intermediate fasteners. The FE model was validated against the experimental test results, which showed good agreement, both in terms of failure loads and deformed shapes at failure. The validated FE model was then used for the purpose of a parametric study to investigate the effect of different thicknesses, lengths and, yield stresses of steel on axial strength of back-to-back built-up CFS unequal angle sections. Five different thicknesses and seven different lengths (stub to slender columns) with two different yield stresses were investigated in the parametric study. Axial strengths obtained from the experimental tests and FE analyses were used to assess the performance of the current design guidelines as per the Direct Strength Method (DSM); obtained comparisons show that the current DSM is conservative by only 7% on average, while predicting the axial strengths of back-to-back built-up CFS unequal angle sections.

• 국제물리치료학회지
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• 제9권4호
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• pp.1683-1686
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• 2018

Low back pain (LBP) is the most common reason for seeking physical therapy (PT) care. Recent studies suggest that axial loading can have a positive impact on the intervertebral disc by improving its tensile strength. Further, whole body vibration (WBV) appears to improve spinal muscle relaxation. Therefore, this case study describes the use of axial loading using a mini-trampoline in a female with chronic LBP. This case report is a single subject design. This patient is a 29-year-old female with a six-month history of low back pain following a motor vehicle accident. MRI found herniated discs at L4 and L5, clinical tests were positive for pain in the L4 and L5 dermatome and myotome the slump test was positive for neural tension, and LBP was constant at 4-6/10 over the past four months. She received axial loading exercises using a mini-trampoline and performed six sessions that were, scheduled twice a week for three weeks. Her Oswestry Disability Index (ODI) score improved from 40% at the time of her first visit to 22% at her final visit. Pain measure on the Numeric Pain Rating Scale (NPRS) after the first treatment was 7/10, and her pain after the final treatment was 0/10. These changes in the pain scores are clinically significant and exceed the minimal clinically important difference (MCID). This patient had a significant improvement in her pain using the NPRS and the ODI. This case study suggests that axial loading may be an effective treatment for some individuals with discogenic chronic low back pain.

• Steel and Composite Structures
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• 제33권1호
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• pp.37-66
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• 2019

In cold-formed steel structures, such as trusses, wall frames and portal frames, the use of back-to-back built-up cold-formed stainless-steel lipped channels as compression members are becoming increasingly popular. The advantages of using stainless-steel as structural members are corrosion resistance and durability, compared with carbon steel. The AISI/ASCE Standard, SEI/ASCE-8-02 and AS/NZS do not include the design of stainless-steel built-up channels and very few experimental tests or finite element analyses have been reported in the literature for such back-to back cold-formed stainless-steel channels. Current guidance by the American Iron and Steel Institute (AISI) and the Australian and New Zealand (gAS/NZS) standards for built-up carbon steel sections only describe a modified slenderness approach, to consider the spacing of the intermediate fasteners. Thus, this paper presents a numerical investigation on the behavior of back-to-back cold-formed stainless-steel built-up lipped channels. Three different grades of stainless steel i.e., duplex EN1.4462, ferritic EN1.4003 and austenitic EN1.4404 have been considered. Effect of screw spacing on the axial strength of such built-up channels was investigated. As expected, most of the short and intermediate columns failed by either local-global or local-distortional buckling interactions, whereas the long columns, failed by global buckling. All three grades of stainless-steel stub columns failed by local buckling. A comprehensive parametric study was then carried out covering a wide range of slenderness and different cross-sectional geometries to assess the performance of the current design guidelines by AISI and AS/NZS. In total, 647 finite element models were analyzed. From the results of the parametric study, it was found that the AISI & AS/NZS are conservative by around 10 to 20% for cold-formed stainless-steel built-up lipped channels failed through overall buckling, irrespective of the stainless-steel grades. However, the AISI and AS/NZS can be un-conservative by around 6% for all three grades of stainless-steel built-up channels, which failed by local buckling.

• Archives of Pharmacal Research
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• 제20권6호
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• pp.560-565
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• 1997

The physicochemical properties of melatonin (MT) in propylene glycol (PG) and 2-hydroxypropyl-.betha.-cyclodextrin $(2-HP{\beta}CD)$ vehicles were characterized. MT was endothermally decomposed as determined by differential scanning calorimetry (DSC). Melting point and heat of fusion obtained were $116.9{\pm}0.24^{\circ}C $.and $7249{\pm}217 cal/mol$., respectively. MT as received from a manufacture was very pure, at least 99.9%. The solubility of MT in PG solution increased slowly until reaching 40% PG and then steeply increased. Solubility of MT increased linearly as concentration of $2-HP{\beta}CD$ without PG INCREASED$(R^2=0.993)$. MT solubility in the mixtures of pg and $2-HP{\beta}CD$ also increased linearly but was less than the sum of its solubility in $2-HP{\beta}CD$ and PG individually. The MT solubility was low in water, simulated gastric or intestinal fluid but the highest in the mixture of PG(40v/v%) and $2-HP{\beta}CD$ (30w/v%) although efficiency of MT solubilization in $2-HP{\beta}CD$ decreased as the concentration of PG increased. MT was degraded in a fashion of the first order kinetics $(r^2>0.90)$. MT was unstable in strong acidic solution (HCl-NaCl buffer, pH 1.4) but relatively stable in other pH values of 4-10 at $70^{\circ}C$. In HCl-NaCl buffer, MT in 10% PG was more quickly degraded and then slowed dpwm at a higher concentration. However, the degradation rate constant of MT in 2-HP.betha.CD was not changed significantly when compared to the water. The current studies can be applied to the dosage formulations for the purpose of enhancing percutaneous absorption or bioavailability of MT.

• 지구물리와물리탐사
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• 제8권1호
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• pp.34-40
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• 2005

직경 96 m 까지의 배열을 이용하는 microtremor 방법을 통해 호주의 미고결 제4기 Yarra Delta 퇴적물의 30-50 m 심도까지의 S 파 속도구조를 비파괴적으로 추정할 수 있었다. 두 실트층(Cool Island silt 와 Fishermans Bend silt)이 주해석대상인데, $5\%$의 정밀도로 이 층들의 S 파 속도를 얻을 수 있었으며, 상부의 좀 더 역약한 층(Vs: 130 m/sec) 및 하부의 약간 단단한 층(Vs: 235 m/sec)으로 구별된다. 이 층들 하부에 이미 역층으로 알려진 단단한 층(Vs: 500 - 650 m/sec)도 구별해내었다. 단일 수진기 별로 수평/수직 성분 스펙트럼비를 이용한 지표 횡단 결과로 연약한 실트층 두께의 변화를 빠르게 파악할 수 있으나 단지 정성적이며, 복잡한 지질단면의 경우에 정량적인 S 파 분포를 알기 위해서는 배열방법이 사용되어야 할 것이다.

• Archives of Plastic Surgery
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• 제48권5호
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• pp.503-510
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• 2021

Facial feminization surgery (FFS) incorporates aesthetic and craniofacial surgical principles and techniques to feminize masculine facial features and facilitate gender transitioning. A detailed understanding of the defining male and female facial characteristics is essential for success. In this first part of a two-part series, we discuss key aspects of the general preoperative consultation that should be considered when evaluating the prospective facial feminization patient. Assessment of the forehead, orbits, hairline, eyebrows, eyes, and nose and the associated procedures, including scalp advancement, supraorbital rim reduction, setback of the anterior table of the frontal sinus, rhinoplasty, and soft tissue modifications of the upper and midface are discussed. In the second part of this series, bony manipulation of the midface, mandible, and chin, as well as soft tissue modification of the nasolabial complex and chondrolaryngoplasty are discussed. Finally, a review of the literature on patient-reported outcomes in this population following FFS is provided.

• 디지털융복합연구
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• 제19권12호
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• pp.389-395
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• 2021

본 연구는 핸드메이드 대표 서비스인 Etsy와 idus 애플리케이션의 사용자 경험을 평가하고자 한다. 이를 위해 20~50대 11명을 대상으로 피터 모빌의 사용자 경험 요소를 기초로 한 설문조사를 진행하였다. 그리고 심층인터뷰를 통하여 문제점을 발견하고 제시 제임스 가렛의 사용자 경험 요소 프레임워크의 5단계에 따라 사용자 경험 문제점을 분석하였다. 실험 결과, 이들 앱들의 사용자 경험 개선을 위한 범용적으로 통용되는 비주얼 인터페이스 적용, 가독성을 위한 간략한 텍스트 제공, 정보 구조에서 유사한 기능의 반복 지양, 문화와 국가를 고려한 디자인 패턴 적용을 제안한다. 이 연구를 통해 핸드메이드 플랫폼의 쇼핑 경험이 어떠한지 분석함으로써 글로벌 플랫폼으로 활성화하기 위한 기초자료를 제공하는데 의의가 있다.