• The Journal of Internal Korean Medicine
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• v.34 no.2
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• pp.155-164
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• 2013

Objectives : This study aimed to evaluate the single oral dose toxicity of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus in male and female ICR mice. Methods : In this single oral toxicity study, non-fermented and fermented Jaeumganghwa-tang (Ziyinjianghuo-tang) were administered to male and female ICR mice as an oral dose of 500, 1000 and 2000 mg/kg. After single administration, body weight changes, general behavior, adverse effects and mortality were determined for 14 days. Serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There were no mortality or signs of toxicity for 14 days. There were also no significant differences in body weights, organ weights, or serum chemistry values between treatment and control groups. Conclusions : These results indicate that the 50% lethal dose of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acipophullus may be over 2000 mg/kg. This finding can be expected to provide scientific evidence for the safety of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.1
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• pp.150-159
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• 2020

Objectives: This case report describes the management of three patients with menopausal disorder treated with Jaeumganghwa-tang, an herbal extract in national health insurance. Methods: Three patients suffering from Menopause disorder were hospitalized and treated with herbal extract Jaeumganghwa-tang for 4 weeks. This study was measured by Kupperman's Index, Menopause Rating Scale and EuroQol-Five Dimensions. Results: The symptoms of menopausal disorder have improved after treating with Jaeumganghwa-tang. Also the Kupperman's Index and Menopause Rating Scale have decreased, while the EuroQol-Five Dimensions has increased. Conclusions: As seen in these three cases, Jaeumganghwa-tang in herbal extract form has effects on the management of menopause disorder.

• The Journal of Internal Korean Medicine
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• v.43 no.3
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• pp.493-501
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• 2022

Objectives: This study aimed to report the effects of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Gyeongok-go on a patient with asthma. Methods: A 54-year-old female patient was treated with herbal medicine, including Jaeumganghwa-tang, Gyeongok-go, acupuncture, and moxibustion treatment. The effects of treatments were evaluated using the modified medical research council dyspnea scale (mMRC), St. George's Respiratory Questionnaire (SGRQ), and Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA). Results: Following treatment, the mMRC score decreased from 2 to 1, the SGRQ score decreased from 60.53 to 25.61, and the QLQAKA score increased from 44 to 72. In the SGRQ, symptom scores decreased from 70.67 to 57.49, activity scores from 36.22 to 25.96, and impact scores from 72.15 points to 15.44 points. In QLQAKA, symptom scores increased from 18 to 21, emotional scores from 7 to 13, environmental scores from 6 to 14, and activity scores from 13 to 24. Conclusion: The results suggest that Jaeumganghwa-tang and Gyeongok-go could be effective in treating patients with asthma.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.251-256
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• 2016

Objective: This case report examines the effects of Jaeumganghwa-tang as a treatment option for Sjögren’s syndrome.Methods: We provided the patient with Jaeumganghwa-tang twice a day, as well as acupuncture and bee venom therapy (both twice a week), for 30 days. Symptoms were charted and evaluated using the European League Against Rheumatism (EULAR) Sjögren’s Syndrome Patient Reported Index (ESSPRI).Results: The patient’s ESSPRI score decreased from 8 to 6 after the 30-day treatment.Conclusions: Jaeumganghwa-tang may be helpful in alleviating Sjögren’s syndrome.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.125-133
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• 2012

Objectives: Postpartum thyroiditis patient's symptoms are very similar to symptoms of postpartum disease which can be called sanhupung. This study is to report the effect of herbal medicine on sanhupung patient diagnosed of postpartum thyroiditis. Methods: We treated a 32-year-old female patient who had symptoms of postpartum thyroiditis and sanhupung with Jaeumganghwa-tang and Jayumkeonbi-tang. Results: After herbal medicine treatment the symptoms of postpartum thyroiditis such as general weakness, hot flush on the palms and soles of the feet, fever pattern of malaria and symptoms of sanhupung such as arthralgia, depression, imsomnia, sweating were improved. Conclusions: This case report shows that herbal medicine can be used to treat patient with postpartum thyroiditis and Jaeumganghwa-tang, Jayumkeonbi-tang is effective for mitigating the symptoms of postpartum thyroiditis. However, patient is still in thyroxine treatment, and additional care is required.

• Journal of Society of Preventive Korean Medicine
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• v.23 no.3
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• pp.1-12
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• 2019

Objectives : Korean national health insurance data is a useful real-world data representing whole medical bills submitted to Health Insurance Review Agency. This study aims to understand recent benefit trend of insurance herbal preparations for treating bronchiectasis(disease code J47) utilizing insurance data. Methods : We reviewed national health insurance claims data from 2013 to 2017 which have main diagnosis or sub diagnosis code of J47 and with the record of prescribing insurance herbal medication. Frequency analysis was performed to analyze the most frequently prescribed prescription. Results & Conclusions : Both the number of claims statement(770 to 1,746cases) and patients(266 to 484) of insurance herbal preparations increased considerably from 2013 to 2017. Top 10 preparations based on the number of claims statement were 'Samso-eum', 'Yeonkyopaedok-san', 'Socheongryong-tang', 'Bojungikgi-tang', 'Hyangsapyungwi-san', 'Yijin-tang', 'Saengmaek-san', 'Jaeumganghwa-tang', 'Ojeok-san' and 'Gungha-tang'. Top 10 preparations based on the number of patients were 'Samso-eum', 'Socheongryong-Tang', 'Saengmaek-san', 'Yeonkyopaedok-san', 'Haengso-tang', 'Hyangsapyungwi-san', Yijin-tang', 'Jaeumganghwa-tang', 'Bojungikgi-tang' and 'Hyeonggaeyeongyo-tang' in respectiv order. Claims of top 10 frequent preparations occupied more than 60% of total claims. We hope this finding to be utilized as basic data for future research of evidence-based bronchiectasis treatment utilizing Korean traditional medicine.

• The Journal of Korean Medicine
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• v.31 no.5
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• pp.112-123
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• 2010

Objectives: Three yin-tonifying formulae (Ssanghwa-tang, Yukmijihwang-tang and Jaeumganghwa-tang) were applied to investigate their immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in the murine macrophage cell line (RAW 264.7) and in ovalbumin (OVA)-immunized mice. Methods: This study was carried out in nitricoxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes in association with three herbal formulas. C57BL/6 mice were immunized intraperitoneally with OVA/aluminum ($100\;{\mu}g/200\;{\mu}g$/mouse) on days 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured. Results: All three yin-tonifying formulas significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<0.001). Also, these herbal formulas all significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group. Conclusion: These results suggested that the three yin-tonifying formulae could be used as stimulators of immune response.

• The Journal of Internal Korean Medicine
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• v.25 no.2
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• pp.174-182
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• 2004

Object : This study investigates Jaeumganghwa-tang(JGT) has been used for the purpose of prevention and treatment of allergic inflammatory diseases. This study was to investigate the biological effects of JGT. Methods : Cytotoxcicity and inflammatory cytokines secretion with human mast cells(HMC-1) were examined. HMC-1 cells were stimulated with phorbol l2-myristate 13-acetate (PMA) and calcium ionophore A23l87. JGT by itself had no effect on cytotoxicity of HMC-1. The effects of JGT on the secretion of tumor necrosis factor-alpha(TNF-${\alpha}$) and interleukin(IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay(ELISA). Result : It was found that JGT inhibited PMA plus A23187-induced TNF-${\alpha}$ and IL-6 secretion. JGT also inhibited the $NF-{\kappa}$B(p50) expression. Conclusion : These results suggest that JGT inhibits the secretion of inflammatory cytokines in HMC-1 cells through blockade of $NF-{\kappa}B$ activation. Taken together, these effects support a role for JGT as a therapeutic agent in treatment of allergic inflammatory diseases such as asthma.

• The Journal of Internal Korean Medicine
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• v.40 no.1
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• pp.117-125
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• 2019

Objective: This study investigated the effect of Yin deficiency medicine on halitosis patients and the relationship between subjective recognition and objective symptoms of oral malodor. Methods: We administered Yin deficiency medicine, such as Jaeumganghwa-tang, and conducted the Halitosis Associated Life-quality Test (HALT) and $OralChroma^{TM}$. Subjective recognition of halitosis was evaluated using HALT. Objective symptoms of halitosis were evaluated using $OralChroma^{TM}$. In addition, before and after administering medicine, we determined the halitosis according to percentages at the patient's word. Results: The total gas and HALT were not related to each other after Maekmoondong-tang or Saengmaek-san were administered to 10 halitosis patients. Conclusion: Yin deficiency medicine is effective in treating halitosis. Moreover, the subjective recognition and objective symptoms of halitosis are not related to each other.

• Herbal Formula Science
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• v.17 no.2
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• pp.53-63
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• 2009

Objective : To compare the contents of heavy metals, residual pesticides and sulfur dioxide before/after a decoction. Methods : The heavy metal contents before/after a decoction were measured by Inductively Coupled Plasma Atomic Emission Spectrometer (ICP-AES) and mercury analyzer. In order to analyze pesticides in 4 samples we used simultaneous multi-residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide ($SO_2$) were performed by Monier-Williams distillation method. Results: 1. The mean values of heavy metal contents (mg/kg) for the samples were as follows: Jaeumganghwa-tang (before decoction - Pb; 1.190, Cd; 0.184, As; 0.099 and Hg; 0.028, after decoction - Pb; .033, Cd; 0.003, As; 0.005 and Hg; 0.001), Yukmijiwhang-tang (before decoction - Pb; 0.484, Cd; 0.133, As; 0.053 and Hg; 0.009, after decoction - Pb; 0.065, Cd; 0.008, As; 0.007 and Hg; not detected), Bojungikgi-tang (before decoction - Pb; 0.863, Cd; 0.197, As; below 0.016 and Hg; 0.011, after decoction - Pb; 0.071, Cd; 0.009, As; 0.004 and Hg; 0.001) and Ssangwha-tang (before decoction - Pb; 1.511, Cd; 0.212, As; 0.094 and Hg; 0.016, after decoction - Pb; 0.029, Cd; 0.006, As; 0.005 and Hg; 0.0004). 2. Contents (mg/kg) of sulfur dioxide ($SO_2$) before a decoction in Jaeumganghwa-tang, Yukmijiwhang-tang and Ssangwha-tang exhibited 22.7, 107.3 and 5.5, respectively. However, contents of sulfur dioxide after a decoction in all samples were not detected. 3. Contents (mg/kg) of residual pesticides before/after a decoction in all samples were not detected. Conclusion : These results will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide.