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동해, 울릉 분지 심해토의 지반공학특성 (Geotechnical Engineering Characteristics of Ulleung Basin Sediment, East Sea)

  • 이창호;윤태섭;산타마리나;박장준;이종섭
    • 한국지반공학회논문집
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    • 제25권6호
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    • pp.17-29
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    • 2009
  • 에너지 수요의 증가 및 에너지 탐사와 연관되어 해저 지반의 조사가 증가하고 있다. 해수면 2100m 해저 110m 아래에서 얻어진 압력 코어 시료의 메탄 하이드레이트 생산 시험 후 얻어진 사료를 이용하여 울릉 분지 심해토의 지반공학적 특성을 조사하였다. 기본 토성, 광물학적 특성, 화학 조성, 그리고 미세구조 관찰을 위하여 토성 실험, XRD, 그리고 SEM을 실시하였다. 또한, 멀티 센서 압밀셀을 이용하여 두 시료의 압축성, 전단파 및 전자기파 파악하였다. 강도특성은 직접전단실험 이용하여 산정되었다. 주요 광물로는 카오리나이트, 일라이트, 크로라이트(chlorite), 그리고 캘싸이트(calcite)가 관찰되었다. SEM 결과 잘 발달된 내 외부 간극 구조가 관찰되었다. 수직유효응력의 증가에 따라 전단파 속도, 전기비저항, 실수 유전율, 그리고 전기전도도는 이중선형 거동을 보였다. 직접전단실험으로 얻은 마찰각은 약 $21^{\circ}$로 선행연구와 비슷한 결과를 보였다. 본 연구는 가스 하이드레이트와 같은 에너지 자원의 개발 및 새로운 지반공학적 영역의 확보를 위하여 심해 퇴적토의 거동 이해의 중요성을 보여준다.

In-silico annotation of the chemical composition of Tibetan tea and its mechanism on antioxidant and lipid-lowering in mice

  • Ning Wang ;Linman Li ;Puyu Zhang;Muhammad Aamer Mehmood ;Chaohua Lan;Tian Gan ;Zaixin Li ;Zhi Zhang ;Kewei Xu ;Shan Mo ;Gang Xia ;Tao Wu ;Hui Zhu
    • Nutrition Research and Practice
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    • 제17권4호
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    • pp.682-697
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    • 2023
  • BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.

성서에 언급된 채소류에 관한 연구 (A Study on the Vegetables Mentioned in the Bible)

  • 우자원
    • 한국식생활문화학회지
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    • 제22권1호
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    • pp.1-9
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    • 2007
  • This paper is intended to study what kinds of the vegetables are mentioned in the Bible and how they were used in those days. While one hundred and twenty-eight different plants are mentioned in the Bible, there are today 2,384 plant species in modem Israel, most of which have been introduced in recent centuries. These plants obviously did not exist there in biblical times and were only recently introduced from Australia and South America, respectively. This article will study only the vegetables mentioned in the Bible and known to have existed in the old and new testament times. Since the first book devoted exclusively to biblical botany was that of Levinus Lemmens in 1566, the modem systematic study of biblical plants, began with F. Hasselquist, a student of Linnaeus, the founder of modem botany. In 1928, Immanuel Loew approached the subject differently, reviewing all known data pertaining to biblical plants. His work not only discussed biblical plants, but also plants in later Jewish literature, particularly the Talmud. The British scholar G. E. Post provided a broad field study of modem plants in Palestine, Syria, Lebanon, and Jordan. More recent major treatments of the subject include those of A. and H. Moldenke (1952), M. Zohary (1982), N. Hareuveni (1984), and Y. J. Choi(1996). Today, articles on specific biblical plants listed in the Bible can be found in any number of encyclopedias. This study attempts to provide a synthesis of the work of a number of scholars who studied the vegetables and plants mentioned in the Bible. As a preliminary study on the culture of food in the biblical period, this study has focused on the identity and features of the vegetables of the Bible. In only a limited number of instances, because of the paucity of the informations and the broad and generic descriptions of the plants, we can't be certain about the identification of the vegetables named in the Bible. In many instances the traditions established by the Greek, Aramaic, and English translations are helpful, although sometimes they are misleading. This paper subdivides the vegetables into broad areas, the general vegetables and the flavoring herbs. Vegetables formed very important part of the diet in the biblical times. Two main types were used: those whose nutritious seeds could be easily stored and those which were eaten freshly gathered from gardens. Pulse seeds provided a useful source of vegetable protein, while fresh green vegetables were vitamin rich. Pulses could be eaten boiled, or their dried seeds could be ground up into flour and then made into nutritious soups. Fresh vegetables were eaten either raw or lightly cooked, usually by boiling in water. The general vegetables in the Bible are herbs(garden rocket), cucumber(snake cucumber), watermelon, leeks, chicory, and onions. Also the flavoring herbs in the Bible are rue, dill, cummin, black cummin, frankincense, cinnamon, cassia, myrrh, black mustard, coriander, mint, saffron, ginger grass, syrian hyssop, aloes(eagle wood), manna which have the flavor, aroma, and medical values.

콩 단백질 섭취 및 트레드밀 운동이 난소절제 흰쥐의 신체구성, 혈중 대사변인, 에스트라디올 농도 및 에스트로겐 수용체 유전자 발현에 미치는 영향 (Effects of soy protein supplementation and treadmill running exercise on the changes of body composition, blood metabolic markers, estradiol, estrogen receptor gene expression in ovariectomized rats)

  • 김기진
    • 운동과학
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    • 제21권2호
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    • pp.243-254
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    • 2012
  • 본 연구는 폐경에 따른 에스트로겐 대사의 부정적인 영향의 방지 및 처치를 위한 효율적인 대체요법으로서 운동과 콩 단백질 추출물 섭취 프로그램의 활용가능성을 제시하고자 한다. 이에 난소 절제하여 폐경과 동일한 상태를 유도한 흰쥐를 대상으로 8주 동안 트레드밀을 이용한 지구성 운동과 콩 단백질 추출물 섭취의 복합적인 처치가 신체구성 및 골밀도, 혈중 에스트라디올농도, 간 조직에서의 에스트로겐 수용체의 유전자 발현양상, 혈중 글루코스, 중성지방, 인슐린 및 CRP 농도 등의 변화에 미치는 영향을 분석하였다. 난소절제그룹은 체중 및 체지방률이 증가하고, 혈중 에스트라디올농도 및 간 조직에서의 에스트로겐 수용체의 유전자 발현이 감소하였으며, 혈중 중성지방농도는 증가하였다. 8주간의 운동 및 콩 단백질 섭취에 의한 처치 후 에스트라디올농도, 에스트로겐 수용체 및 혈중 변인 등에 긍정적인 효과를 나타냈으나 골밀도에는 영향을 미치지 못한 것으로 나타났다. 따라서 난소절제 흰쥐의 8주간 운동 및 콩 단백질 추출물 처치가 에스트로겐 및 지방대사에 긍정적인 영향을 미칠 수 있는 가능성은 확인 되었으나, 운동강도 및 시간, 콩 단백질의 섭취량을 포함한 처치기간 등에 대한 계속적인 검토가 요구된다고 생각된다.

Phenolic acids in Panax ginseng inhibit melanin production through bidirectional regulation of melanin synthase transcription via different signaling pathways

  • Jianzeng Liu ;Xiaohao Xu ;Jingyuan Zhou;Guang Sun ;Zhenzhuo Li;Lu Zhai ;Jing Wang ;Rui Ma ;Daqing Zhao;Rui Jiang ;Liwei Sun
    • Journal of Ginseng Research
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    • 제47권6호
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    • pp.714-725
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    • 2023
  • Background: Our previous investigation indicated that the preparation of Panax ginseng Meyer (P. ginseng) inhibited melanogenesis. It comprised salicylic acid (SA), protocatechuic acid (PA), p-coumaric acid (p-CA), vanillic acid (VA), and caffeic acid (CA). In this investigation, the regulatory effects of P. ginseng phenolic acid monomers on melanin production were assessed. Methods: In vitro and in vivo impact of phenolic acid monomers were assessed. Results: SA, PA, p-CA and VA inhibited tyrosinase (TYR) to reduce melanin production, whereas CA had the opposite effects. SA, PA, p-CA and VA significantly downregulated the melanocortin 1 receptor (MC1R), cycle AMP (cAMP), protein kinase A (PKA), cycle AMP-response element-binding protein (CREB), microphthalmia-associated transcription factor (MITF) pathway, reducing mRNA and protein levels of TYR, tyrosinase-related protein 1 (TYRP1), and TYRP2. Moreover, CA treatment enhanced the cAMP, PKA, and CREB pathways to promote MITF mRNA level and phosphorylation. It also alleviated MITF protein level in α-MSH-stimulated B16F10 cells, comparable to untreated B16F10, increasing the expression of phosphorylation glycogen synthase kinase 3β (p-GSK3β), β-catenin, p-ERK/ERK, and p-p38/p38. Furthermore, the GSK3β inhibitor promoted p-GSK3β and p-MITF expression, as observed in CA-treated cells. Moreover, p38 and ERK inhibitors inhibited CA-stimulated p-p38/p38, p-ERK/ERK, and p-MITF increase, which had negative binding energies with MC1R, as depicted by molecular docking. Conclusion: P. ginseng roots' phenolic acid monomers can safely inhibit melanin production by bidirectionally regulating melanin synthase transcription. Furthermore, they reduced MITF expression via MC1R/cAMP/PKA signaling pathway and enhanced MITF post-translational modification via Wnt/mitogen-activated protein kinase signaling pathway.

간호대학생의 임상실습 스트레스와 사회심리적 건강의 관계에서 회복탄력성의 매개효과 (The Mediating Effect of Resilience on the Relationship between Clinic Practice Stress and Psychosocial Well-being of Nursing University Students)

  • 김미정;나은하
    • 문화기술의 융합
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    • 제9권6호
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    • pp.595-604
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    • 2023
  • 본 연구는 간호대학생의 임상실습 스트레스와 사회심리적 건강의 관계에서 회복탄력성의 매개효과를 파악하여 간호대학생의 사회심리적 건강을 향상시킬 수 있는 방안 마련에 필요한 기초자료를 제공하고자 시도되었다. 연구대상은 J도와 G시의 2개 대학의 임상실습 경험이 있는 간호학과 3, 4년 175명으로 수집된 자료는 SPSS 23.0을 이용하여 기술통계, independent t-test, ANOVA, Pearson's correlation coefficient을 하였고, Process macro 4.0 프로그램을 통해 매개효과를 검증하였다. 간호대학생의 사회심리적 건강은 임상실습 스트레스(r=.472, p=<.001)와 양의 상관관계, 회복탄력성과(r=-.860, p=<.001)는 음의 상관관계로 나타났다. 임상실습 스트레스와 사회심리적 건강의 관계에서 회복탄력성의 매개효과를 나타내었다. 본 연구결과를 바탕으로 간호대학생의 사회심리적 안녕감 수준을 높이기 위해서는 임상실습 스트레스를 낮추고, 회복탄력성을 높이기 위한 체계적인 프로그램의 개발과 적용이 필요하다.

간호대학생의 진로준비행동에 미치는 영향요인 (Influential Factors on Career Preparation Behavior of Nursing Students)

  • 박꽃송이;채명정
    • 산업융합연구
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    • 제21권12호
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    • pp.141-151
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    • 2023
  • 본 연구의 목적은 간호대학생 전 학년을 대상으로 학습몰입, 진로결정 자기효능감, 전공만족도가 진로준비행동에 미치는 영향을 파악하고자 시도되었다. G광역시와 J도에 소재한 대학의 간호학과 전학년 208명에게 2022년 9월 15일부터 2022년 10월 14일까지 설문지를 통해 자료수집 하였다. 자료 분석은 SPSS 29.0 Program을 이용하여 서술적 통계, t-test, One-way ANOVA, Pearson's correlation, Stepwise Regression Analysis을 사용하였다. 본 연구 결과 진로준비행동은 학습몰입(r=.515, p<.001), 진로결정 자기효능감(r=.681, p<.001), 전공만족도(r=.621, p<.001)는 통계적으로 유의한 양적 상관관계를 나타내었다. 다중회귀분석 결과 진로준비행동에 미치는 영향요인은 진로결정 자기효능감(𝛽=.446, p<.001), 전공만족도(𝛽=.285, p<.001), 3학년(𝛽=.157, p=.001), 학습몰입(𝛽=.133, p=.018), 2학년(𝛽=.106, p=.038) 순이며, 진로준비행동의 설명력은 57.0%이었다. 따라서 간호대학생이 선택한 진로에 탐색을 고려한 진로 프로그램을 통해 맞춤 교육을 제공할 필요가 있다.

Machine Learning-Based Prediction of COVID-19 Severity and Progression to Critical Illness Using CT Imaging and Clinical Data

  • Subhanik Purkayastha;Yanhe Xiao;Zhicheng Jiao;Rujapa Thepumnoeysuk;Kasey Halsey;Jing Wu;Thi My Linh Tran;Ben Hsieh;Ji Whae Choi;Dongcui Wang;Martin Vallieres;Robin Wang;Scott Collins;Xue Feng;Michael Feldman;Paul J. Zhang;Michael Atalay;Ronnie Sebro;Li Yang;Yong Fan;Wei-hua Liao;Harrison X. Bai
    • Korean Journal of Radiology
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    • 제22권7호
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    • pp.1213-1224
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    • 2021
  • Objective: To develop a machine learning (ML) pipeline based on radiomics to predict Coronavirus Disease 2019 (COVID-19) severity and the future deterioration to critical illness using CT and clinical variables. Materials and Methods: Clinical data were collected from 981 patients from a multi-institutional international cohort with real-time polymerase chain reaction-confirmed COVID-19. Radiomics features were extracted from chest CT of the patients. The data of the cohort were randomly divided into training, validation, and test sets using a 7:1:2 ratio. A ML pipeline consisting of a model to predict severity and time-to-event model to predict progression to critical illness were trained on radiomics features and clinical variables. The receiver operating characteristic area under the curve (ROC-AUC), concordance index (C-index), and time-dependent ROC-AUC were calculated to determine model performance, which was compared with consensus CT severity scores obtained by visual interpretation by radiologists. Results: Among 981 patients with confirmed COVID-19, 274 patients developed critical illness. Radiomics features and clinical variables resulted in the best performance for the prediction of disease severity with a highest test ROC-AUC of 0.76 compared with 0.70 (0.76 vs. 0.70, p = 0.023) for visual CT severity score and clinical variables. The progression prediction model achieved a test C-index of 0.868 when it was based on the combination of CT radiomics and clinical variables compared with 0.767 when based on CT radiomics features alone (p < 0.001), 0.847 when based on clinical variables alone (p = 0.110), and 0.860 when based on the combination of visual CT severity scores and clinical variables (p = 0.549). Furthermore, the model based on the combination of CT radiomics and clinical variables achieved time-dependent ROC-AUCs of 0.897, 0.933, and 0.927 for the prediction of progression risks at 3, 5 and 7 days, respectively. Conclusion: CT radiomics features combined with clinical variables were predictive of COVID-19 severity and progression to critical illness with fairly high accuracy.

복합긴장방식이 적용된 세그멘탈 U형 거더 정적 거동 연구 (A Study of Statistic Behavior of Segmental U-shaped Prestressed Concrete Girder Applied with Integrated Tensioning Systems)

  • 장현옥;장일영
    • 한국재난정보학회 논문집
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    • 제20권2호
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    • pp.329-338
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    • 2024
  • 연구목적: 본 연구는 긴장방식을 복합적으로 적용한 세그멘탈 PSC U형 거더에 대한 해석적 거동을 기반으로 실대형 실험체의 휨 거동 결과를 평가하여 거동의 안전성을 검증하고자 한다. 연구방법: 도로교설계기준 한계상태설계법의 사용한계 및 극한한계상태 설계 결과를 바탕으로 40m 실대형 실험체의 가력하중을 산정하고 이에 대한 4점재하방식 정적 하중재하 실험을 수행하였다. 연구결과: 설계하중, 균열하중 및 극한하중이 작용할 때 해석적 처짐값 대비 97.1%, 98.5% 그리고 79.0%에 해당하는 실험체 처짐이 발생하였다. 설계하중, 균열하중 및 극한하중이 작용할 때 균열계는 각 연결부에서 0.009~0.035mm, 0.014~0.050mm, 6.383~5.522mm로 계측되었다. 결론: 균열하중 재하시까지 실험체는 탄성적으로 거동하였고 균열발생 후 극한하중까지 변형율-경화현상을 보이며 작용하중에 대하여 휨 저항 거동이 뚜렷이 나타났음을 확인하였다. 실대형 실험체 연결부(Dry Joint) 균열은 시설물 상태평가 B등급 기준 25% 미만의 결과로써 연결부의 탄성적 거동을 확인하였고 극한하중 제거 후 최종적 잔류 변형은 0.114mm로써 세그먼트 연결부의 안정적 거동을 확인하였다.

Mass spectrometry-based ginsenoside profiling: Recent applications, limitations, and perspectives

  • Hyun Woo Kim;Dae Hyun Kim;Byeol Ryu;You Jin Chung;Kyungha Lee;Young Chang Kim;Jung Woo Lee;Dong Hwi Kim;Woojong Jang;Woohyeon Cho;Hyeonah Shim;Sang Hyun Sung;Tae-Jin Yang;Kyo Bin Kang
    • Journal of Ginseng Research
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    • 제48권2호
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    • pp.149-162
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    • 2024
  • Ginseng, the roots of Panax species, is an important medicinal herb used as a tonic. As ginsenosides are key bioactive components of ginseng, holistic chemical profiling of them has provided many insights into understanding ginseng. Mass spectrometry has been a major methodology for profiling, which has been applied to realize numerous goals in ginseng research, such as the discrimination of different species, geographical origins, and ages, and the monitoring of processing and biotransformation. This review summarizes the various applications of ginsenoside profiling in ginseng research over the last three decades that have contributed to expanding our understanding of ginseng. However, we also note that most of the studies overlooked a crucial factor that influences the levels of ginsenosides: genetic variation. To highlight the effects of genetic variation on the chemical contents, we present our results of untargeted and targeted ginsenoside profiling of different genotypes cultivated under identical conditions, in addition to data regarding genome-level genetic diversity. Additionally, we analyze the other limitations of previous studies, such as imperfect variable control, deficient metadata, and lack of additional effort to validate causation. We conclude that the values of ginsenoside profiling studies can be enhanced by overcoming such limitations, as well as by integrating with other -omics techniques.