• BMB Reports
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• v.46 no.4
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• pp.201-206
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• 2013

Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)-butane] is an isothiocyanate found in some cruciferous vegetables, especially broccoli. Sulforaphane has been shown to display anti-cancer properties against various cancer cell lines. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion. In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane treatment. TPA substantially increased NF-${\kappa}B$ and AP-1 DNA binding activity. Pre-treatment with sulforaphane inhibited TPA-stimulated NF-${\kappa}B$ binding activity, but not AP-1 binding activity. In addition, we found that sulforaphane suppressed NF-${\kappa}B$ activation, by inhibiting phosphorylation of $I{\kappa}B $ in TPA-treated MCF-7 cells. In this study, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by sulforaphane was mediated by the suppression of the NF-${\kappa}B$ pathway in MCF-7 cells.

• Journal of Environmental Impact Assessment
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• v.22 no.1
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• pp.27-37
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• 2013

The fish fauna and disturbance of geographical distributions in the eastern Civilian Control Line of Korea were investigated from May to September 2012. Total 35 species sampled during the period were belonged to 13 families. There were 9 Korean endemic species (25.71%) that distributed in the flows into West and South Sea. Distributions of invasion fishes in the studied streams based on geographical distributions of freshwater fish were total 13 species that classified 1 species, C. cuvieri from foreign country and 12 species from other water systems. Hence there have been anthropogenically introduced from too many years ago. Also groups according to the similarities of each studied stations was divided into 4 groups by similarity 50% because difference in them was considered to effect of domestic invasion species. In conclusion, three streams in the eastern Civilian Control Line of Korea were invaded by many alien fishes. Therefore, we are considered to require precise investigation and monitoring for the preparations to management measure.

• Journal of the Korean Society of Marine Environment & Safety
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• v.26 no.6
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• pp.594-600
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• 2020

The identification of the risk of collision between ships and objects is vital for achieving navigation safety. The purpose of this study is to analyze the phenomenon of ship domain invasion by breakwaters when ships pass between breakwaters. A method for evaluating the domain-invaded area under the conditions of the breakwater was developed. Next, experimental data were obtained and processed using the Automatic Identification System (AIS) of ships sailing near the breakwater at Busan Port to establish a ship domain that could be formed between the breakwaters. The ship domain was then constructed using Fujii's domain. Finally, the phenomenon in which the constructed ship domain was invaded by the breakwater was analyzed. Based on the experimental results, the domain of the ship invaded by the breakwater was identified.

• Knowledge Management Research
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• v.22 no.2
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• pp.227-246
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• 2021

In the context of the global pandemic caused by COVID-19, emergency alert text messages can violate the privacy of confirmed corona positive cases. This study used conjoint analysis to identify the essential information factors and the privacy invasion information factors of local government initiated safety notices. As a result of this study, we found eight essential information factors, including all routes of the confirmed case and ten privacy invasion factors of safety notices. In addition, we found that there is a similarity between the combinations of information perceived to be the most essential and perceived as the most significant privacy invasion; both combinations include the confirmed case's personal and route information. This study ultimately tried to suggest a way to lower the concern about privacy invasion of the confirmed cases without damaging the emergency alert text messages' essential information. We expect that this study will provide researchers and policymakers interested in disaster communication with valuable theoretical and practical implications.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.05a
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• pp.41-42
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• 2003

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2001.10b
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• pp.11-12
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• 2001

• Industry Promotion Research
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• v.8 no.3
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• pp.175-180
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• 2023

On the day of 24 February 2022, Ukraine was invaded by Russia which signed to ensure definitely the Ukraine's national sovereignty, territorial integrity and security under the UN General Assembly Security Council A/49/765, named as the Budapest Agreement. This invasion is the 2nd invasion succeeded in Crimean Peninsula invasion of March 2014 after the Ukraine's national independence in 1991 from the USSR. However this invasion has been continuing for much more than one year. Although Ukraine President appealed the 'peace' toward Russia and claimed also to justify the Budapest Agreement of 1994 toward U.S.A., even any justifications were not appealed. The critical moment of the national abolition could be escaped from the unified desperate spirit of all nations including the president, political-social leaders and military members. Such patriotic and self-help spirits in Ukraine resulted in the active supports from the U.S.A., western and eastern free democratic countries, NATO and EU, and even the neutral countries. Furthermore these supports are increasing much more day-after-day. The lessons which the Ukraine War offers to the Korean national security should be cored with the development of self-reliant national defense capabilities, self-strenuous efforts and unity strengthening of the Korean-U.S. Alliance with the deep confidence.

• Journal of Gastric Cancer
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• v.9 no.3
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• pp.143-151
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• 2009

Purpose: Gastric cancer is prevalent in Korea, therefore the purpose of this study was to determine the clinicopathologic characteristics, 5-year survival rate, and prognostic factors for gastric patients who underwent gastrectomy by a single surgeon. Materials and Methods: A total of 1,435 patients diagnosed with gastric cancer who underwent gastrectomy in the Department of Korean Gastric Cancer Center at Seoul Paik Hospital between September 1998 and August 2003, and the gender, age, location and size of the tumor, visual and histologic analysis, depth of invasion, lymph node metastasis, invasion (perineural, venous, and lymphatic), and surgical method were examined retrospectively. Results: The ratio between males and females was 2.29 : 1, and the average age was 56.7 years. Based on the UICC TNM classification, the patients were distributed as follows: IA 35.4%, IB 14.1%, II 12.6%, IIIA 12.3%, IIIB 8.3% and IV 17.3%. The 5-year survival rate was 69.6%. The results of univariate analysis showed that there were significant differences in the survival rate by age, location and size of tumor, Borrmann type, level of differentiation, Lauren's classification, depth of invasion, metastasis in lymph nodes, UICC TNM stage, invasion (perineural, venous, and lymphatic), and surgical method. Based on multivariate analysis, only the depth of invasion and lymph node metastasis were independent prognostic factors. Conclusion: Although various clinicopathologic characteristics affect the prognostic factors of the patients with gastric cancer, the results of this study showed that the stage of disease, such as depth of invasion and metastasis in lymph nodes, are the most critical factors. There is a need to establish the diagnosis of gastric cancer early and to study and develop various treatment methods based on the diagnostic factors in order to improve the survival of patients with gastric cancer.

• Journal of Environmental Science International
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• v.21 no.8
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• pp.1009-1013
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• 2012

Leptoglossus occidentalis Heidemann, 1910 was newly recorded in Korea as a invasive species at Gyeongsangnam-do, Korea in 2010 and 2011. Leptoglossus Guerin-Meneville, 1831 is also newly recorded Coreid genus in Korea. The diagnostic shape is expanded leaf-like hind tibiae. The origin of this species is North America and it has been rapidly propagated around the world as a pest. This bug recognized as a pest on almost of Pinaceae plants and they suck on developing cones, so the monitoring on the present invasion of this species in Korea is urgent. It was presumed that the invasion of Leptoglossus occidentalis into Korea was before 2010 with present study.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.119-120
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• 2003

One of the most frequent defects in human cancer is the uncontrolled activation of the ras-signaling pathways. Elevated p21 ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues. infiltration into lymphatic vessels and tumor recurrence, We demonstrate that H-ras, but not N-ras, upregulates matrix metalloproteinase(MMP)-2 expression and induces invasive phenotype in MCF10A human breast epithelial cells. (omitted)