• 제목/요약/키워드: Intra-Structure

검색결과 227건 처리시간 0.029초

범죄발생 예측프로그램 설계에 관한 연구 (A Study on the Development of Crime Prediction Program(CPP))

  • 김영환;문정민
    • 한국컴퓨터정보학회논문지
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    • 제11권4호
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    • pp.221-230
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    • 2006
  • 급격하게 변화하는 현대도시의 삶은 도시인의 평균 정주기간을 갈수록 짧아지게 하였으며 이것은 도시 주거지의 정체성을 약화시킴으로써 급격한 강력범죄 발생을 유도하였고 이에 따라 도시안전은 심각하게 저해되었다. 도시는 메크로 할 뿐만 아니라 마이크로 한 특성을 갖는 매우 복합적인 구조로써 범죄발생 또한 범죄자의 개인적인 동기를 포함하여 도시의 사회적, 경제적, 공간적 구성관계 속에서 나타나는 매우 복합적인 현상으로 파악된다. 따라서 본 연구에서는 급속히 증가하는 도시 내의 강력범죄 발생패턴을 사회적, 경제적, 공간적으로 분석하여 그 구조적 역학관계를 메크로하며 마이크로하게 규명함으로써 범죄발생을 유형적 시간적, 공간적으로 예측하는 범죄예측 프로그램의 개발이 필요함을 강조하였다. 나아가 범죄발생과 밀접하게 관련된 다양한 인자들을 도출한다면 도시범죄의 발생구조를 보다 명확히 규명할 수 있을 것이다.

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Unsolved Questions on the Anatomy of the Ventricular Conduction System

  • Oh, Il-Young;Cha, Myung-Jin;Lee, Tae-Hui;Seo, Jeong-Wook;Oh, Seil
    • Korean Circulation Journal
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    • 제48권12호
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    • pp.1081-1096
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    • 2018
  • We reviewed the anatomical characteristics of the conduction system in the ventricles of human and ungulate hearts and then raised some questions to be answered by clinical and anatomical studies in the future. The ventricular conduction system is a 3-dimensional structure as compared to the 2-dimensional character of the atrial conduction system. The proximal part consisting of the atrioventricular node, the bundle of His and fascicles are groups of conducting cells surrounded by fibrous connective tissue so as to insulate from the underlying myocardium. Their location and morphological characters are well established. The bundle of His is a cord like structure but the left and right fascicles are broad at the proximal and branching at the distal part. The more distal part of fascicles and Purkinje system are linear networks of conducting cells at the immediate subendocardium but the intra-mural network is detected at the inner half of the ventricular wall. The papillary muscle also harbors Purkinje system not in the deeper part. It is hard to recognize histologically in human hearts but conducting cells as well as Purkinje cells are easily recognized in ungulate hearts. Further observation on human and ungulate hearts with myocardial infarct, we could find preserved Purkinje system at the subendocardium in contrast to the damaged system at the deeper myocardium. Further studies are necessary on the anatomical characteristics of this peripheral conduction system so as to correlate the clinical data on hearts with ventricular arrhythmias.

퍼지 이진화를 이용한 IVUS 영상의 내막/외막 분할 (Segmentation of Intima/Adventitia of IVUS Image using Fuzzy Binarization)

  • 김광백
    • 한국정보통신학회논문지
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    • 제23권12호
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    • pp.1514-1519
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    • 2019
  • 혈관내 초음파(IVUS)는 인간 관상 동맥의 혈관 벽 구조를 관찰하고 평가하는데 적용되는 영상이다. IVUS는 정기적으로 관상 동맥에서 죽상 동맥 경화 병변을 찾는 데 적용된다. 혈관 구조의 자동 분할은 관상 동맥 장애를 감지하는데 중요하다. 따라서 본 논문에서는 혈관 내 영상에서 퍼지 이진화 기법을 적용하여 효과적으로 내막/외막 영역을 추출하는 방법을 제안한다. 제안된 방법에서는 혈관을 탐색하기 위해 기본적으로 퍼지 이진화 기법을 적용하지만 픽셀 강도의 상이한 균질성을 갖는 경우에는 평균 이진화 기법을 적용한다. 우리는 퍼지 이진화 결과와 평균 이진화 결과를 IVUS 이미지와 차별화하여 혈관벽의 내부/ 외부를 감지하기에 효과적인 자동 분할 방법을 구현하였다. 제안된 방법의 구현 결과로부터 Intima-Media Thickness (IMT) 또는 대상 영역의 부피와 같은 중요한 통계를 쉽게 계산할 수 있도록 하였다.

Molecular insights into the role of genetic determinants of congenital hypothyroidism

  • Kollati, Yedukondalu;Akella, Radha Rama Devi;Naushad, Shaik Mohammad;Patel, Rajesh K.;Reddy, G. Bhanuprakash;Dirisala, Vijaya R.
    • Genomics & Informatics
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    • 제19권3호
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    • pp.29.1-29.10
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    • 2021
  • In our previous studies, we have demonstrated the association of certain variants of the thyroid-stimulating hormone receptor (TSHR), thyroid peroxidase (TPO), and thyroglobulin (TG) genes with congenital hypothyroidism. Herein, we explored the mechanistic basis for this association using different in silico tools. The mRNA 3'-untranslated region (3'-UTR) plays key roles in gene expression at the post-transcriptional level. In TSHR variants (rs2268477, rs7144481, and rs17630128), the binding affinity of microRNAs (miRs) (hsa-miR-154-5p, hsa-miR-376a-2-5p, hsa-miR-3935, hsa-miR-4280, and hsa-miR-6858-3p) to the 3'-UTR is disrupted, affecting post-transcriptional gene regulation. TPO and TG are the two key proteins necessary for the biosynthesis of thyroid hormones in the presence of iodide and H2O2. Reduced stability of these proteins leads to aberrant biosynthesis of thyroid hormones. Compared to the wild-type TPO protein, the p.S398T variant was found to exhibit less stability and significant rearrangements of intra-atomic bonds affecting the stoichiometry and substrate binding (binding energies, ΔG of wild-type vs. mutant: -15 vs. -13.8 kcal/mol; and dissociation constant, Kd of wild-type vs. mutant: 7.2E-12 vs. 7.0E-11 M). The missense mutations p.G653D and p.R1999W on the TG protein showed altered ΔG(0.24 kcal/mol and 0.79 kcal/mol, respectively). In conclusion, an in silico analysis of TSHR genetic variants in the 3'-UTR showed that they alter the binding affinities of different miRs. The TPO protein structure and mutant protein complex (p.S398T) are less stable, with potentially deleterious effects. A structural and energy analysis showed that TG mutations (p.G653D and p.R1999W) reduce the stability of the TG protein and affect its structure-functional relationship.

An Attention-based Temporal Network for Parkinson's Disease Severity Rating using Gait Signals

  • Huimin Wu;Yongcan Liu;Haozhe Yang;Zhongxiang Xie;Xianchao Chen;Mingzhi Wen;Aite Zhao
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제17권10호
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    • pp.2627-2642
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    • 2023
  • Parkinson's disease (PD) is a typical, chronic neurodegenerative disease involving the concentration of dopamine, which can disrupt motor activity and cause different degrees of gait disturbance relevant to PD severity in patients. As current clinical PD diagnosis is a complex, time-consuming, and challenging task that relays on physicians' subjective evaluation of visual observations, gait disturbance has been extensively explored to make automatic detection of PD diagnosis and severity rating and provides auxiliary information for physicians' decisions using gait data from various acquisition devices. Among them, wearable sensors have the advantage of flexibility since they do not limit the wearers' activity sphere in this application scenario. In this paper, an attention-based temporal network (ATN) is designed for the time series structure of gait data (vertical ground reaction force signals) from foot sensor systems, to learn the discriminative differences related to PD severity levels hidden in sequential data. The structure of the proposed method is illuminated by Transformer Network for its success in excavating temporal information, containing three modules: a preprocessing module to map intra-moment features, a feature extractor computing complicated gait characteristic of the whole signal sequence in the temporal dimension, and a classifier for the final decision-making about PD severity assessment. The experiment is conducted on the public dataset PDgait of VGRF signals to verify the proposed model's validity and show promising classification performance compared with several existing methods.

산업관련표(産業關聯表)에 의(依)한 임업구조분석(林業構造分析)과 유발생산액(誘發生産額) -임업(林業)이 한국경제(韓國經濟)에 미치는 영향(影響)- (Analysis of Forestry Structure and Induced Output Based on Input - output Table - Influences of Forestry Production on Korean Economy -)

  • 이승윤
    • Journal of the Korean Wood Science and Technology
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    • 제2권4호
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    • pp.4-14
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    • 1974
  • The total forest land area in Korea accounts for some 67 percent of the nation's land total. Its productivity, however, is very low. Consequently, forest production accounts for only about 2 percent of the gross national product and a minor proportion of no more than about 5 percent versus primary industry. In this case, however, only the direct income from forestry is taken into account, making no reference to the forestry output induced by other industrial sectors. The value added Or the induced forestry output in manufacturing the primary wood products into higher quality products, makes a larger contribution to the economy than direct contribution. So, this author has tried to analyze the structure of forestry and compute the repercussion effect and the induced output of primary forest products when utilized by other industries for their raw materials, Hsing the input-output table and attached tables for 1963 and 1966 issued by the Bank of Korea. 1. Analysis of forestry structure A. Changes in total output Durng the nine-year period, 1961-1969, the real gross national product in Korea increased 2.1 times, while that of primary industries went up about 1. 4 times. Forestry which was valued at 9,380 million won in 1961, was picked up about 2. 1 times to 20, 120 million won in 1969. The rate of the forestry income in the GNP, accordingly, was no more than 1.5 percent both in 1961 and 1962, whereas its rate in primary industries increased 3.5 to 5.4 percent. Such increase in forestry income is attributable to increased forest production and rise in timber prices. The rate of forestry income, nonetheless, was on the decrease on a gradual basis. B. Changes in input coefficient The input coefficient which indicates the inputs of the forest products into other sectors were up in general in 1966 over 1963. It is noted that the input coefficient indicating the amount of forest products supplied to such industries closely related with forestry as lumber and plywood, and wood products and furniture, showed a downward trend for the period 1963-1966. On the other hand, the forest input into other sectors was generally on the increase. Meanwhile, the input coefficient representing the yolume of the forest products supplied to the forestry sector itself showed an upward tendency, which meant more and more decrease in input from other sectors. Generally speaking, in direct proportion to the higher input coefficient in any industrial sector, the reinput coefficient which denotes the use of its products by the same sector becomes higher and higher. C. Changes in ratio of intermediate input The intermediate input ratio showing the dependency on raw materials went up to 15.43 percent m 1966 from 11. 37 percent in 1963. The dependency of forestry on raw materials was no more than 15.43 percent, accounting for a high 83.57 percent of value added. If the intermediate input ratio increases in any given sector, the input coefficient which represents the fe-use of its products by the same sector becomes large. D. Changes in the ratio of intermediate demand The ratio of the intermediate demand represents the characteristics of the intermediary production in each industry, the intermediate demand ratio in forestry which accunted for 69.7 percent in 1963 went up to 75.2 percent in 1966. In other words, forestry is a remarkable industry in that there is characteristics of the intermediary production. E. Changes in import coefficient The import coefficient which denotes the relation between the production activities and imports, recorded at 4.4 percent in 1963, decreased to 2.4 percent in 1966. The ratio of import to total output is not so high. F. Changes in market composition of imported goods One of the major imported goods in the forestry sector is lumber. The import value increased by 60 percent to 667 million won in 1966 from 407 million won in 1963. The sales of imported forest products to two major outlets-lumber and plywood, and wood products and furniture-increased to 343 million won and 31 million won in 1966 from 240million won and 30 million won in 1963 respectively. On the other hand, imported goods valued at 66 million won were sold to the paper products sector in 1963; however, no supply to this sector was recorded in 1963. Besides these major markets, primary industries such as the fishery, coal and agriculture sectors purchase materials from forestry. 2. Analysis of repercussion effect on production The repercussion effect of final demand in any given sector upon the expansion of the production of other sectors was analyzed, using the inverse matrix coefficient tables attached to the the I.O. Table. A. Changes in intra-sector transaction value of inverse matrix coefficient. The intra-sector transaction value of an inverse matrix coefficient represents the extent of an induced increase in the production of self-support products of the same sector, when it is generated directly and indirectly by one unit of final demand in any given sector. The intra-sector transaction value of the forestry sector rose from 1.04 in 1963 to 1, 11 in 1966. It may well be said, therefore, that forestry induces much more self-supporting products in the production of one unit of final demand for forest products. B. Changes in column total of inverse matrix coefficient It should be noted that the column total indicates the degree of effect of the output of the corresponding and related sectors generated by one unit of final demand in each sector. No changes in the column total of the forestry sector were recorded between the 1963 and 1966 figures, both being the same 1. 19. C. Changes in difference between column total and intra-sector transaction amount. The difference between the column total and intra-sector transaction amount by sector reveals the extent of effect of output of related industrial sector induced indirectly by one unit of final demand in corresponding sector. This change in forestry dropped remarkable to 0.08 in 1966 from 0.15 in 1963. Accordingly, the effect of inducement of indirect output of other forestry-related sectors has decreased; this is a really natural phenomenon, as compared with an increasing input coefficient generated by the re-use of forest products by the forestry sector. 3. Induced output of forestry A. Forest products, wood in particular, are supplied to other industries as their raw materials, increasng their value added. In this connection the primary dependency rate on forestry for 1963 and 1966 was compared, i. e., an increase or decrease in each sector, from 7.71 percent in 1963 to 11.91 percent in 1966 in agriculture, 10.32 to 6.11 in fishery, 16.24 to 19.90 in mining, 0.76 to 0.70 in the manufacturing sector and 2.79 to 4.77 percent in the construction sector. Generally speaking, on the average the dependency on forestry during the period 1963-1966 increased from 5.92 percent to 8.03 percent. Accordingly, it may easily be known that the primary forestry output induced by primary and secondary industries increased from 16, 109 million won in 1963 to 48, 842 million won in 1966. B. The forest products are supplied to other industries as their raw materials. The products are processed further into higher quality products. thus indirectly increasing the value of the forest products. The ratio of the increased value added or the secondary dependency on forestry for 1963 and 1966 showed an increase or decrease, from 5.98 percent to 7.87 percent in agriculture, 9.06 to 5.74 in fishery, 13.56 to 15.81 in mining, 0.68 to 0.61 in the manufacturing sector and 2.71 to 4.54 in the construction sector. The average ratio in this connection increased from 4.69 percent to 5.60 percent. In the meantime, the secondary forestry output induced by primary and secondary industries rose from 12,779 million Wall in 1963 to 34,084 million won in 1966. C. The dependency of tertiary industries on forestry showed very minor ratios of 0.46 percent and 0.04 percent in 1963 and 1966 respectively. The forestry output induced by tertiary industry also decreased from 685 million won to 123 million won during the same period. D. Generally speaking, the ratio of dependency on forestry increased from 17.68 percent in 1963 to 24.28 percent in 1966 in primary industries, from 4.69 percent to 5.70 percent in secondary industries, while, as mentioned above, the ratio in the case of tertiary industry decreased from 0.46 to 0.04 percent during the period 1963-66. The mining industry reveals the heaviest rate of dependency on forestry with 29.80 percent in 1963 and 35.71 percent in 1966. As it result, the direct forestry income, valued at 8,172 million won in 1963, shot up to 22,724 million won in 1966. Its composition ratio lo the national income rose from 1.9 percent in 1963 to 2.3 per cent in 1966. If the induced outcome is taken into account, the total forestry production which was estimated at 37,744 million won in 1963 picked up to 105,773 million won in 1966, about 4.5 times its direct income. It is further noted that the ratio of the gross forestry product to the gross national product. rose significantly from 8.8 percent in 1963 to 10.7 percent in 1966. E. In computing the above mentioned ratio not taken into consideration were such intangible, indirect effects as the drought and flood prevention, check of soil run-off, watershed and land conservation, improvement of the people's recreational and emotional living, and maintenance and increase in the national health and sanitation. F. In conclusion, I would like to emphasize that the forestry sector exercices an important effect upon the national economy and that the effect of induced forestry output is greater than its direct income.

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안진(眼診) 설문지 개발 및 안진(眼診) 설문의 허실(虛實) 연관성 연구 (Development of Eyes Inspection Questionnaire(EIQ) and Regression Analysis between EIQ Items and deficiency or excess patterns of Eyes Inspection)

  • 서재호;최진용;오환섭;박영배;박영재
    • 대한한의진단학회지
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    • 제18권2호
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    • pp.75-84
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    • 2014
  • Objectives Eyes, one of visual inspection regions, present important clues to pathological patterns including deficiency and excess patterns to the clinicians. The purpose of this study was to develop Eyes Inspection Questionnaire (EIQ) and to examine which items among the EIQ were more predictive of clinicians' determination for the deficiency and excess patterns. Methods Nine questionnaire items for Visual Inspection of Eyes were extracted through the literature review. These items were presented to the 4 Korean medical doctors who are specialized in visual inspection to conduct the Delphi method. The Korean medical doctors were asked to rate the importance of each items for the corresponding Visual Inspection of Eyes, using a Likert 5-point scale(the 3 points of importance as a cut-off point). Then, out of 75 photographs submitted to the Society of HyungSang Medicine in 2009, 30 portrait pictures were selected as samples. The samples were copied to make 60 sample pictures, and then randomly assigned to 4 clinicians. The 4 clinicians evaluated the 60 samples for excess and deficiency of the eyes and were asked to check the 6 questionnaire items. The results were recorded as 5-points-scale, and their average and standard deviations were calculated. Intra- class reliability test and multi regression test were performed using SPSS 13. Results Intra-class correlation coefficient (ICC) was between 0.750 to 0.841 (P<0.05). Indices for visual inspection of the eyes were: endowment of the bone structure around the eyes; brightness of the eyes; upward deviation of the eyes; eye shapes; and definition of iris. 76.92% of deficiency symptom patterns and 86.42% of the excess symptom patterns matched the patterns predicted by the visual inspection of the eyes, according to the frequency analysis. According to the multiple regression analysis, were significantly related to the excessive symptoms, and to the deficiency symptoms. Conclusion This study is the first attempt of development for checklist of excess and deficiency of Visual Inspection of Eyes and quantitative measurement of excess and deficiency using the Visual Inspection of Eyes by the visual inspection experts. Still, additional studies are needed regarding the relationship visual inspection methods have with existing standards of diagnosis.

한·미 FTA 발효 전후 수출산업의 대미국 비교우위 및 산업내무역 분석 (An Analysis of Comparative Advantage and Intra-Industry Trade in Korean Export Industry in Respect to Korea-U.S. FTA)

  • 심재희
    • 통상정보연구
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    • 제19권4호
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    • pp.175-197
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    • 2017
  • 한 미 FTA 개정 협상이 국가적 현안이 되고 있는 가운데 본 연구는 시장비교우위지수에 의한 경쟁력 분석과 산업내무역 분석을 통해 한 미 FTA 발효를 전후하여 수출산업의 무역구조 변화를 파악하는 데 목적이 있다. 분석 결과, FTA 발효 전후로 대미 상품 및 서비스무역이 각기 흑자와 적자를 지속하고 있으며, 대미 투자는 미국의 대한국 투자를 훨씬 상회하였다. 시장비교우위지수를 활용한 수출상품의 경합보완관계 분석에서 미국과 수출우위의 보완관계를 형성하고 있으며, 산업내무역은 전반적으로 미약하게 나타나고 있는 가운데 일부 품목에서는 저품질 수직적 형태로 이루어지고 있는 것으로 나타났다. 분석 결과를 토대로 다음과 같은 정책적 제언 및 시사점을 제시하고 있다. 첫째, 서비스 무역의 경쟁력을 높여가면서 FTA 개정 협상에서 서비스와 상품부문에 대한 손실과 이익의 균형을 추구한다. 둘째, 경합 품목과 비교열위 품목의 경쟁력을 강화해 가면서 수출우위 품목에 대해서는 미국시장의 소비패턴에 대한 대응력을 강화하고, 생산기술 기반 확충과 원가절감을 통한 기술 및 가격경쟁력을 계속 높여 간다. 셋째, 대미 비교우위를 확보하고 있는 품목에서는 수평적 수직적 분업을 진행하고, 비교열위 품목에서는 수평적 분업을 추진한다.

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질량분석기를 활용한 효과적 이황화결합 분석법 개발 (Mass Spectrometry-Based Strategy for Effective Disulfide Bond Identification)

  • 진종화;민호필;권오승;오현정;김종원;박철환
    • Korean Chemical Engineering Research
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    • 제55권1호
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    • pp.27-33
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    • 2017
  • 이황화결합(Disulfide Bond)은 다양한 생리학적 혹은 병리학적 과정 중 단백질번역 후 변형(Post-Translational Modifications) 과정 중에 형성된다. 그러므로 이황화결합에 대한 정보는 단백질의 화학적 구조를 보다 종합적으로 이해하는데 매우 중요한 일이다. 질량분석기를 이용한 이황화결합 분석은 매우 효과적이며, 현재까지 질량 분석기를 활용한 다양한 이황화결합 분석법들이 개발되었다. 그러나, 대부분의 이황화결합 분석법의 경우, 이황화결합 분석 시 자유-시스테인잔기(Free Thiol Residues) 분석을 고려하지 않았다. 본 연구에서는 이황화결합에 관여하는 시스테인/자유-시스테인에 초점을 두고 총 4단계(1단계: 아미노산 서열을 통한 이황화결합 가능 부위를 예측, 2단계: 자유시스테인의 존재 유무의 확인, 3단계: 질량 분석기를 활용한 이황화결합 분석, 4단계: 이황화결합 분석법의 종합적인 검증)의 분석법을 개발하였다. 나아가, 본 연구에서 개발된 분석 기법을 실제 휴먼 유래 재조합 단백질(HRPE1)에 적용함으로써 개발된 이황화결합 분석법의 효용성을 확인하였다. HRPE1의 경우, 총 6개의 이황화결합(Inter-chain 형태: 1, Intra-chain 형태: 5)으로 구성된 것을 최종 확인하였다.

영동분지(백악기) 남동부의 전기비저항 및 탄성파탐사자료 해석 (Electrical resistivity and seismic reflection mapping for the southeastern part of the Yongdong basin (Cretaceous), Korea)

  • 김지수;한수형;이철우;김복철;양우헌;손호웅;손영관
    • 지구물리
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    • 제3권2호
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    • pp.77-90
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    • 2000
  • 영동분지(백악기) 남동부 지역의 천부 구조를 파악하기 위하여 분지의 경계 부근에서 5 개 측선의 전기비저항 쌍극자탐사와 2 개 측선의 탄성파 반사법탐사를 수행하였다. 또한 분지 안에 존재하는 화산암체 부근에서 총 24 점의 전기비저항 수직탐사와 3 개의 쌍극자탐사를 실시하였다. 분지 경계에 대한 전기비저항값은 쌍극자단면도에서 예상 단층선을 기준으로 약 $1,500\;{\Omega}{\cdot}m$의 대비를 보이며 표준편차 또한 경계 부근에서 가장 크게 나타난다. 분지의 경계 단층은 탄성파 공통발파점자료에서 진폭 대비, 이벤트의 연속성 대비, 초동의 기울기 차이, 복소트레이스 단면도의 특성에 의해 효과적으로 확인되었다. 분지 안의 전기비저항 구조는 쌍극자탐사 및 전기비저항 수직탐사자료 해석 결과 북동방향의 고비저항대가 단속적으로 나타나고 있는데 이것은 남북방향으로 분포하는 북동방향의 경사를 가진 화산암체에 의한 반응으로 해석된다. 이에 대한 자세한 해석을 위해서는 앞으로 자력 및 자기지전류 탐사가 추가로 수행되어야할 것이다.

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