• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3917-3922
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• 2015

Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. We have previously shown the potential biocompatibility, biodegradability and anti-cancer effects of dendrosomal curcumin (DNC). In this study, twenty-seven BALB/c mice were equally divided into control as well as 40 and 80 mg/kg groups of DNC to investigate the involvement of macrophages in the antitumor effects of curcumin in a typical animal model of metastatic breast cancer. At the end of intervention, the tumor volume and weight were significantly reduced in DNC groups compared to control (P<0.05). Histopathological data showed the presence of macrophages in tumor and spleen tissues. Real-time PCR results showed that DNC increased the expression of STAT4 and IL-12 genes in tumor and spleen tissues in comparison with control (P<0.05), referring to the high levels of M1 macrophages. Furthermore treatment with DNC decreased STAT3, IL-10 and arginase I gene expression (P<0.05), indicating low levels of M2 macrophage. The results confirm the role of macrophages in the protective effects of dendrosomal curcumin against metastatic breast cancer in mice.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6513-6519
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• 2015

Background: Recent attention on chemotherapeutic intervention against cancer has been focused on discovering and developing phytochemicals as anticancer agents with improved efficacy, low drug resistance and toxicity, low cost and limited adverse side effects. In this study, we investigated the effects of Curcuma C20-dialdehyde on growth, apoptosis and cell cycle arrest in colon and cervical cancer cell lines. Materials and Methods: Antiproliferative, apoptosis induction, and cell cycle arrest activities of Curcuma C20-dialdehyde were determined by WST cell proliferation assay, flow cytometric Alexa fluor 488-annexin V/propidium iodide (PI) staining and PI staining, respectively. Results: Curcuma C20 dialdehyde suppressed the proliferation of HCT116, HT29 and HeLa cells, with IC50 values of $65.4{\pm}1.74{\mu}g/ml$, $58.4{\pm}5.20{\mu}g/ml$ and $72.0{\pm}0.03{\mu}g/ml$, respectively, with 72 h exposure. Flow cytometric analysis revealed that percentages of early apoptotic cells increased in a dose-dependent manner upon exposure to Curcuma C20-dialdehyde. Furthermore, exposure to lower concentrations of this compound significantly induced cell cycle arrest at G1 phase for both HCT116 and HT29 cells, while higher concentrations increased sub-G1 populations. However, the concentrations used in this study could not induce cell cycle arrest but rather induced apoptotic cell death in HeLa cells. Conclusions: Our findings suggest that the phytochemical Curcuma C20-dialdehyde may be a potential antineoplastic agent for colon and cervical cancer chemotherapy and/or chemoprevention. Further studies are needed to characterize the drug target or mode of action of the Curcuma C20-dialdehyde as an anticancer agent.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.1
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• pp.65-72
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• 2016

Purpose : This study was carried out to find out the relationship between emotion intelligence, learning flow and career stress of nursing students and influence factors for career stress. Methods : This study targeted 197 university students in their freshman-senior year attending College of Nursing located in P Metropolitan City. For collected data, real numbers and percentage, mean and standard deviation and multiple regression analysis were carried out by using PASW 21.0 program and the correlation between emotion intelligence, learning flow and career stress was analyzed with Pearson's correlation coefficients. Results : Emotional self-awareness(M=3.80, SD =.71), clear goals(M=3.39, SD=.90) and school environment stress(M=2.97, SD=.96) were found to be high in the degree of emotion intelligence, learning flow and career stress of the subjects. The relationship between emotion intelligence and learning flow showed a positive correlation(r=.489, p<.01) in the correlation between emotion intelligence, learning flow, career stress and emotion intelligence showed a negative correlation with career stress(r=-.204, p<.01). Emotion intelligence and learning flow show that career stress is predicted significantly (${\beta}$ =-.15, p < .01) and explained a career stress variate as 18%(F = 24.5, p < .01). Conclusion : Emotion intelligence of nursing students was found to be very influential on the degree of learning flow or career stress. Based on the results of this study, replication studies on emotion intelligence and career stress are needed and the development of intervention programs to increase emotion intelligence is needed.

• Korean Journal of Social Welfare
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• v.57 no.2
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• pp.321-350
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• 2005

This study developed a relapse prevention program for substance abusing women and evaluated its effectiveness. The major contents of the program include to enhance cognitive and behavioral coping skills, to identify and expand supportive social networks, and to deal with women-related issues. The program was operated 3 times with 24 female clients in a probation office in Seoul from August 2003 to October 2004. The program changed the participants' attitudes toward substance use and improved their drug-refusal skills. This study mentions that the findings may be useful for practitioners as well as researchers because this study was first one that dealt with a women-only group in Korea. Finally, this study suggests that more studies be conducted in order to provide better understandings on substance abusing women and more effective interventions skills.

• Journal of Korean Public Health Nursing
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• v.27 no.3
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• pp.490-499
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• 2013

Purposes: This study was conducted in order to investigate the effects of passive music listening on psychological well-being and depression in 134 nursing students enrolled in two colleges of nursing in Kyeonggi-do, Korea. Methods: A prospective, pretest and posttest, controlled, quasi-experimental design was used. An intervention group (n= 74) participated in a 14-week passive music listening program before and after each lecture while those who were assigned as a control group (n=60) were given a series of traditional lectures. Analysis of data was performed using chi-square test, independent t-test, and Mann-Whitney U test, using SPSS 19.0. Results: Although no significant difference was observed in psychological well-being (t=0.34, p=.738), depression (z=-3.19, p=.001) showed a significant difference in the experimental group compared to the control group. Conclusions: This study provided evidence of the beneficial impact of passive music listening for nursing students with depression. Conduct of further studies will be needed in order to verify the effects on psychological well-being.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.8 no.3
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• pp.346-356
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• 2001

This paper describes a Q-methodological study on the Perception of comfort in hospital in-patients. The participants completed a 37-item Q sort made up of statements which could be ranked in terms of their relevance to the subjective meaning of comfort. Three interpretable types of comfort were identified through this Q study : Type I, positive medical action style, feel secure and satisfied when medical staff show a positive attitude towards them as patients. They put a high value on prompt responses from medical staff and physical aspects of care like non-invasive procedures or comfortable position. Type II, social relation style, experience a state of comfort when they perceive support or concern from medical staff, relatives or other patients suffering from similar diseases. They feel safe and secure when medical staff are kind and have a good reputation or when the size of the hospital is big enough, Type III, emotional wellbeing style, feel that hope for a healthy life or maintaining self-care activities are highly valuable. They feel safe and comfortable when their privacy is protected. They put worth on independent thinking, strong will, and emotional or psychological comfort. The results of this study can be used as a basis to develop nursing measures for comfort. Further studies on factors which influence perception of comfort and intervention strategies according to the above types of comfort need to be done.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.25 no.2
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• pp.120-133
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• 2018

Purpose: A meta-analysis was conducted to evaluate effectiveness of education programs using video recording and feedback in the improvement of competency in clinical skills for health care majors. Methods: Six databases were searched and inclusion criteria were randomized controlled trials (RCTs) or non-randomized controlled trials (NRTs) reporting level of skill competency using numerical measurements. Data analysis and synthesis were performed using Comprehensive Meta-Analysis software and Revman program. Results: Of 1,568 records, 11 studies met inclusion criteria. Statistically significant effectiveness of education programs using video recording and feedback was identified. A low risk of bias was detected among both RCTs and NRTs. Meta-analysis showed that the intervention groups had more effective improvements in skill competency (standardized mean difference [SMD]: 0.74; 95% CI: 0.33~1.16). Results of subgroup analysis showed higher effects when interventions dealt with one skill, used self-reflection with expert feedback, and included instruction from instructor in the education programs. Conclusion: Findings suggest that schools for health care majors should actively adopt video and feedback based skill training allowing educators to design effective programs. Potential is higher for students to achieve higher competency when they train with one skill at a time, use of instruction and receive feedback from experts.

• Journal of the Korea Convergence Society
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• v.9 no.9
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• pp.407-420
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• 2018

The purpose of this study was to investigate the effects and characteristics of program on health promotion with foreign worker in Korea. The study was conducted using the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Group. The final selected literature was varied in program and outcome variables. Therefore, it was difficult to quantitatively synthesize and it was analyzed through qualitative review. The findings indicate that health promotion programs for foreign workers reduced acculturation stress, depression and anxiety, and increased self-esteem. These findings provide scientific evidence for developing and using health promotion program of foreign workers. Futher development of a variety of health promotion programs and studies of effectiveness review for foreign workers in Korea.

• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.533-540
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• 2018

This study is to find convergent effects of collaborative peer tutoring on communication ability and self-leadership of nursing students. According to the results of Mann-Whitney U and Kruskal-Wallis test using SPSS/WIN 19.0 for the survey of communication and self-leadership before and after experiments, there were significant differences of personality type, discussion preference and leadership in communication, and of motive of admission, leadership and school grades in self-leadership. There were positive correlations between communication and self-leadership before and after treatments. The results of Wilcoxon signed ranked test showed cooperative peer tutoring increased communication ability and self-leadership significantly each(p=.008, p<.001). These results could be used in developing intervention programs for enhancing communication and self-leadership of nursing students after further studies with wider range of subjects and setting control group.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.171-176
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• 2016

Background: Much has been done to examine the psychological impact of cancer treatment, but it remains unclear to what extent anxiety and depression is related to symptom prevalence. The present study concerned the characteristics and frequency of distress as related to symptom prevalence in cancer patients undergoing chemotherapy in Malaysia. Materials and Methods: Participants were 303 consecutive adult cancer patients undergoing chemotherapy in an academic medical center. The short form Memorial Symptom Assessment Scale (MSAS-SF), which covers three domains of symptoms (global distress, physical- and psychological symptoms) was used to cross-sectionally measure symptom frequency and associated distress via self-reporting. One-way ANOVA and t-tests were used to test mean differences among MSAS-SF subscale scores. Results: Complete data were available for 303 patients. The mean number of symptoms was 14.5. The five most prevalent were fatigue, dry mouth, hair loss, drowsiness and lack of appetite. Overall, symptom burden and frequency were higher than in other published MSAS-SF studies. Higher symptom frequency was also found to be significantly related to greater distress in cancer patients undergoing chemotherapy. Conclusions: Patients undergoing chemotherapy suffer from multiple physical and psychological symptoms. Better symptom control or palliative care is needed. Greater frequency of reported symptoms may also indicate a subconscious bid by patients for care and reassurance - thus tailored intervention to manage distress should be offered.