• Title/Summary/Keyword: Internal R&D

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Implementation of an operation module for an integrated network management system of ship-based and offshore plants (해양플랜트 및 선박의 네트워크 통합 관리 시스템 운용 모듈 개발)

  • Kang, Nam-Seon;Lee, Seon-Ho;Lee, Beom-Seok;Kim, Yong-Dae
    • Journal of Advanced Marine Engineering and Technology
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    • v.40 no.7
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    • pp.613-621
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    • 2016
  • This research connected network equipment, including CCTV, PAGA, IP-PBX, and Legacy, in order to enable the operation and configuration of internal IP-based network equipment in maritime plants and vessels, both in the field and from remote places, and to allow for the support of remotely controlling such equipment. It also realized an operating program for the integrated network equipment management system to enable the monitoring and control of equipment status, operation condition, and notifications from distant places. By applying the operating program to satellite stations and vessels sailing on the sea, a performance test was conducted to evaluate data loss and transmission/reception delay in the communication section between the land and vessels. As a result, this research verified the normal operation of CCTV control and of real-time monitoring and control of the network equipment, including PAGA, IP-PBX, and Legacy under the FBB and MVSAT environments. It was observed that the transmission of CCTV video images with a large volume of data as well as the transmission and reception of voice data were found to be slightly delayed, indicating the need to develop technology to compress and convert data for real-time transmission and reception.

A Study on the Technology Evaluation of Development of New Variety of Citrus Unshiu (감귤 신품종(하양조생)개발의 기술가치의 평가)

  • Ko, Seong-Bo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.8
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    • pp.127-132
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    • 2016
  • This study evaluated the economic value of the development of a new variety of Citrus unshiu using the income approach, Net Present Value (NPV), Internal Rate of Return (IRR), and Benefit/Cost (B/C) ratio. The new variety of Citrus unshiu was developed by the national institute of horticultural and herbal science in Korea, rural development administration. The technological evaluation of the development of a new variety of Citrus unshiu can be used to improve the efficiency and practicality of the development of a new variety of citrus. From the research results, the technological value of development of a new variety of Citrus unshui was evaluated at 109,455(discount rate=8%, minimum), 195,040(discount rate=4%, maximum), and 145,375(discount rate=6%, average) million won. The IRR was 51.4%, which was greater than the discount rate(4~8%). The NPV was evaluated at 145.3 billion won(discount rate=6%, average), 195.0 billion won(discount rate=4%, maximum) and 109.4 billion won(discount rate=8%, minimum), all of which were greater than 0. The B/C ratio was evaluated at 60.9(discount rate=6%, average), 81.3(discount rate=4%, maximum) and 46.1(discount rate=8%, minimum), all of which were greater than 1. Therefore, the economic validity of the development of a new variety of Citrus unshiu was identified by this technological evaluation.

Assessment of Flavin-containing Monooxygenase (FMO) Activity by Determining Urinary Ratio of Theobromine and Caffeine in a Korean Population after Drinking a Cup of Coffee

  • Chung, Woon-Gye;Kang, Ju-Hee;Roh, Hyung-Keun;Lee, Kyung-Hoon;Park, Chang-Shin;Cha, Young-Nam
    • The Korean Journal of Physiology and Pharmacology
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    • v.3 no.2
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    • pp.207-213
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    • 1999
  • To examine individual variation in drug metabolism catalyzed by flavin-containing monooxygenase (FMO), 179 Korean volunteers' urinary molar concentration ratio of theobromine (TB) and caffeine (CA) was determined. Their urine was collected for 1 hr (between 4 and 5 hrs) after they drank a cup of coffee containing 115 mg CA and analyzed by an HPLC system. The lowest TB/CA ratio obtained was 0.40, the highest ratio was 15.17 (38-fold difference), and the median ratio for all subjects was 1.87. The mean was 2.66 with 2.36 S.D.. In 134 nonsmokers, the mean ratio was $2.35{\pm}1.93,$ that of 51 males was $2.30{\pm}2.26$ and 83 females was $2.37{\pm}1.85,$ respectively. There was no significant gender difference in the obtained TB/CA ratio (Mann-Whitney test; p=0.518). There were no smokers among the 83 female volunteers. In the remaining 96 male subjects, the ratio obtained in 51 nonsmokers was $2.30{\pm}2.06$ and that of 45 smokers was $3.62{\pm}3.19.$ This indicated that the TB/CA ratio was increased significantly in smokers (p=0.007). However, when the TB/CA ratios (FMO activity) obtained in all 179 Korean volunteers are compared with the urinary concentration ratios of paraxanthine (PX) plus 1,7-dimethylurate (17U) to CA (CYP1A2 activity), there was a weak but significant correlation (Pearson's correlation coefficient test; $r^2=0.28,$ p<0.0001). This indicates that, although the urinary TB/CA ratio mostly represents FMO activity, minor contribution by CYP1A2 activity cannot be ignored. In conclusion, the FMO activity measured by taking the urinary TB/CA ratio from normal healthy Korean volunteers shows marked individual variations without significant gender differences and the increased TB/CA ratio observed in cigarette smokers may have been caused by the increased CYP1A2 activity.

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Cryptosporidium spp., Giardia intestinalis, and Enterocytozoon bieneusi in Captive Non-Human Primates in Qinling Mountains

  • Du, Shuai-Zhi;Zhao, Guang-Hui;Shao, Jun-Feng;Fang, Yan-Qin;Tian, Ge-Ru;Zhang, Long-Xian;Wang, Rong-Jun;Wang, Hai-Yan;Qi, Meng;Yu, San-Ke
    • Parasites, Hosts and Diseases
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    • v.53 no.4
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    • pp.395-402
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    • 2015
  • Non-human primates (NHPs) are confirmed as reservoirs of Cryptosporidium spp., Giardia intestinalis, and Enterocytozoon bieneusi. In this study, 197 fresh fecal samples from 8 NHP species in Qinling Mountains, northwestern China, were collected and examined using multilocus sequence typing (MLST) method. The results showed that 35 (17.8%) samples were positive for tested parasites, including Cryptosporidium spp. (3.0%), G. intestinalis (2.0%), and E. bieneusi (12.7%). Cryptosporidium spp. were detected in 6 fecal samples of Macaca mulatta, and were identified as C. parvum (n=1) and C. andersoni (n=5). Subtyping analysis showed Cryptosporidium spp. belonged to the C. andersoni MLST subtype (A4, A4, A4, and A1) and C. parvum 60 kDa glycoprotein (gp60) subtype IId A15G2R1. G. intestinalis assemblage E was detected in 3 M. mulatta and 1 Saimiri sciureus. Intra-variations were observed at the triose phosphate isomerase (tpi), beta giardin (bg), and glutamate dehydrogenase (gdh) loci, with 3, 1, and 2 new subtypes found in respective locus. E. bieneusi was found in Cercopithecus neglectus (25.0%), Papio hamadrayas (16.7%), M. mulatta (16.3%), S. sciureus (10%), and Rhinopithecus roxellana (9.5%), with 5 ribosomal internal transcribed spacer (ITS) genotypes: 2 known genotypes (D and BEB6) and 3 novel genotypes (MH, XH, and BSH). These findings indicated the presence of zoonotic potential of Cryptosporidium spp. and E. bieneusi in NHPs in Qinling Mountains. This is the first report of C. andersoni in NHPs. The present study provided basic information for control of cryptosporidiosis, giardiasis, and microsporidiosis in human and animals in this area.

A mixed infection of epitheliocystis, Microcotyle sebstes and unknown aetiology in cultured rockfish (Sebastes schlegeli) from farms in Huksan Island (양식 조피볼락(Sebastes schlegeli)의 Epitheliocystis, Microcotyle sebastes 및 미동정 생물체의 혼합감염)

  • Park, Sung-Woo;Yu, Jin-Ha;Lee, Kyung-Hee
    • Journal of fish pathology
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    • v.22 no.1
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    • pp.9-14
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    • 2009
  • Fifteen diseased rockfish (Sebastes schlegeli) were collected from 4 net-cage farms in Huksan island. Some round transparent nodules were observed on gill filaments in fish. Bacteriological and histopathological examinations on the diseased fish were performed. Any pathogenic bacteria could not be isolated from the internal tissues and histopathological alterations were not found in any of the tissues except the gills. Rock fish were infected with epitheliocystis, Microcotyle sebastes and unknown aetiology on the gills. Cysts of epitheliocystis measuring 44.1-68.9 $\mu{m}$ in diameter were mainly found in the distal portion of the gill filaments and sometimes in the middle portion. But host responses were moderate in spite of formation of the epithelial cysts. Some Microcotyle sebastes captured the secondary filaments with clamps on the opisthohaptor. Attachment of the parasites provoked epithelial proliferation and resulted in gill lamellar fusion.Cysts of unknown origins measuring 26-425 $\mu{m}$ in diameter were found in the cartilage of gill filaments. These cysts contained eosinophilic materials and proliferation of cartilage cells was confirmed around the cysts. But there was no significant pathological changes associated with the presence of the cysts except enlargement of the gill filament with the cysts.

Effect of Electrolyte Amounts on Electrochemical Properties of Coin-Type Lithium-Ion Cells (액체전해액의 함량에 따른 리튬이온전지 코인셀의 전기화학적 특성 연구)

  • Yoon, Byeolhee;Han, Taeyeong;Kim, Seokwoo;Jin, Dahee;Lee, Yong min;Ryou, Myung-Hyun
    • Journal of the Korean Electrochemical Society
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    • v.21 no.2
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    • pp.39-46
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    • 2018
  • Many studies on the electrochemical performance of Li secondary batteries have been obtained using coin-type cells due to the ease of assembly, low cost and ensuring reproducibility. The coin-type cell consists of a case, a gasket, a spacer disk, and a wave spring. These structural features require a greater amount of liquid electrolyte to assemble than other types of cells such as laminated cells and cylindrical cells. Nevertheless, little research has been conducted on the effect of excess liquid electrolytes on the electrochemical performances of Li secondary batteries. In this study, we investigate the effect of different amounts of electrolyte on the coin-type cells. The amount of electrolytes is adjusted to 30 and $100mg\;mAh^{-1}$. Cycle performances at room temperature ($25^{\circ}C$) and high temperature ($60^{\circ}C$) and high voltage are performed to investigate the electrochemical properties of the different amount of electrolytes. In the case of the unit cell including the electrolyte of $30mg\;mAh^{-1}$, the discharging capacity retention characteristic is excellent in comparison with the case of $100mg\;mAh^{-1}$ under the high temperature and high voltage condition. The former shows a larger increase in internal resistance than the latter, confirming that the amount of electrolyte significantly influences the discharge capacity retention characteristics of the battery.

Meta- and Gene Set Analysis of Stomach Cancer Gene Expression Data

  • Kim, Seon-Young;Kim, Jeong-Hwan;Lee, Heun-Sik;Noh, Seung-Moo;Song, Kyu-Sang;Cho, June-Sik;Jeong, Hyun-Yong;Kim, Woo Ho;Yeom, Young-Il;Kim, Nam-Soon;Kim, Sangsoo;Yoo, Hyang-Sook;Kim, Yong Sung
    • Molecules and Cells
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    • v.24 no.2
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    • pp.200-209
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    • 2007
  • We generated gene expression data from the tissues of 50 gastric cancer patients, and applied meta-analysis and gene set analysis to this data and three other stomach cancer gene expression data sets to define the gene expression changes in gastric tumors. By meta-analysis we identified genes consistently changed in gastric carcinomas, while gene set analysis revealed consistently changed biological themes. Genes and gene sets involved in digestion, fatty acid metabolism, and ion transport were consistently down-regulated in gastric carcinomas, while those involved in cellular proliferation, cell cycle, and DNA replication were consistently up-regulated. We also found significant differences between the genes and gene sets expressed in diffuse and intestinal type gastric carcinoma. By gene set analysis of cytogenetic bands, we identified many chromosomal regions with possible gross chromosomal changes (amplifications or deletions). Similar analysis of transcription factor binding sites (TFBSs), revealed transcription factors that may have caused the observed gene expression changes in gastric carcinomas, and we confirmed the overexpression of one of these, E2F1, in many gastric carcinomas by tissue array and immunohistochemistry. We have incorporated the results of our meta- and gene set analyses into a web accessible database (http://human-genome.kribb.re.kr/stomach/).

Physicochemical Properties of Hydroxypropylated Rice Starches (하이드록시프로필화 쌀 전분의 이화학적 특성)

  • Choi, Hyun-Wook;Koo, Hye-Jin;Kim, Chong-Tai;Hwang, Seong-Yun;Kim, Dong-Seob;Choi, Sung-Won;Hur, Nam-Youn;Baik, Moo-Yeol
    • Korean Journal of Food Science and Technology
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    • v.37 no.1
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    • pp.44-49
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    • 2005
  • Physicochemical properties of hydroxypropylated rice starches were investigated. Swelling power of hydroxypropylated rice starch increased at relatively lower temperature than native rice starch. Solubility of hydroxypropylated rice starch was lower (1.9-13.4%) than that of native rice starch (2.2-13.8%), and increased with increasing amount of propylene oxide. Pasting temperature ($66.2-70.8^{\circ}C$) and peak viscosity (2,843-3,395cp) of hydroxypropylated rice starch were lower than those of native starch ($71.6^{\circ}C,\;3,976\;cp$) and decreased with increasing amount of propylene oxide, regardless of reaction time. DSC thermal transitions of hydroxypropylated rice starches shifted toward lower temperature. Amylopectin-melting enthalpy of hydroxypropylated rice starch decreased (11.8-9.8J/g) with increasing amount of propylene oxide and was lower than that of native starch (11.9 J/g). These results indicate hydroxypropylation lowered swelling power and gelatinization temperatures of rice starch, because internal bonds of rice starch molecules were sterically weaken by substituted hydroxypropyl groups.

Effect of Meat Products (Seasoned Chicken Product and Patty) Added with Green Tea and Schizandra chinensis on Body Weight, Serum Lipid and Liver in Rats (녹차와 오미자 첨가 육제품(양념계육 및 패티)이 흰쥐의 체중, 혈청지질 및 간조직에 미치는 영향)

  • Kim, Soo-Min;Cho, Young-Suck
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.7
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    • pp.980-986
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    • 2005
  • This study was carried out to investigate the effect of diet (1:1 ratio) added with meat product (seasoning chicken product, patty) containing natural extracts (green tea, Schizandra chinensis) on body weights, internal organs weights, the contents of total cholesterol, HDL-cholesterol, triglyceride and total lipid in plasma and liver. The experimental diets were prepared with basal diet added with $1\%$ natural extracts. These diets were supplied to SD (Sprague-Dawley) rats for 45 days. The body weight of SD rats supplied seasoning chicken and patty containing green tea and Schizandra chinensis tended to be lower than that of SD rats dieted seasoning chicken product and patty product. The contents of plasma cholesterol, HDL-cholesterol, triglyceride and total lipid were decreased in SD rats dieted seasoning chicken and patty with green tea and Schizandra chinensis. However, the contents of plasma cholesterol, HDL-cholesterol, triglyceride and total lipid tended to be increased in SD rats supplied seasoning chicken product and patty only. Hepatic lipid peroxidation measured by TBARS method was not different, compared to that of control. In conclusion, the diets with meat products containing $1\%$ natural extracts were effective in reducing plasma and hepatic cholesterol levels in rats.

A Study on the Influence of Social Regulation on Competition and Innovation: A Case of Fire-retardant Coating Material for Steel Structure Sector in Korea (사회적 규제가 대체재 간 경쟁과 혁신에 미치는 영향에 관한 연구 : 국내 철강 구조물용 내화 피복재 산업의 사례연구)

  • Chang, Chul Kwon;Ji, Ilyong
    • Journal of Korea Technology Innovation Society
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    • v.20 no.4
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    • pp.939-969
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    • 2017
  • The interest in social regulation and its influence on innovation are increasing as the society concerns more for environment and safety. There have been plenty of literature about the impact of social regulation on innovation and its mechanism. Majority of research have been influenced by or based on the famous Porter's hypothesis. However, majority of the literature focus on internal factors such as expected benefits from change of regulations, and it is hard to find one studying social regulation's influence on innovation through external factors such as market or industrial structure. This study addresses this issue of the impact of social regulation on innovation by analyzing the case of fire-retardant coating material for steel structure industry in Korea. It scrutinizes the impact of social regulation which affects competition and innovation on substitute competing market, and tries to reveal that there might exist the other path to innovation, besides the way that the expected benefit from compliance of regulation directly drives innovation. As a result of the case study, we have found that changes in social regulation may act like economic regulation and restructure the market segment and this effect may lead to innovation. It can be explained by the fact that expected benefits from compliance of regulation can be a direct source of innovation, as Porter suggested, but the change of industry structure and competitive strength caused by the change in social regulation can also act as a driving force of innovation.