• BMB Reports
• /
• 제41권3호
• /
• pp.184-193
• /
• 2008

Living organisms are comprised of various systems at different levels, i.e., organs, tissues, and cells. Each system carries out its diverse functions in response to environmental and genetic perturbations, by utilizing biological networks, in which nodal components, such as, DNA, mRNAs, proteins, and metabolites, closely interact with each other. Systems biology investigates such systems by producing comprehensive global data that represent different levels of biological information, i.e., at the DNA, mRNA, protein, or metabolite levels, and by integrating this data into network models that generate coherent hypotheses for given biological situations. This review presents a systems biology framework, called the 'Integrative Proteomics Data Analysis Pipeline' (IPDAP), which generates mechanistic hypotheses from network models reconstructed by integrating diverse types of proteomic data generated by mass spectrometry-based proteomic analyses. The devised framework includes a serial set of computational and network analysis tools. Here, we demonstrate its functionalities by applying these tools to several conceptual examples.

• 영재교육연구
• /
• 제13권1호
• /
• pp.21-42
• /
• 2003

통합교과적-다중교수전략적 과학 교육 프로그램(Interdisciplinary -Multistrategic Science Education Program; IMSEP)이 과학영재들을 위한 효과적인 과학 교육 프로그램으로 고안, 개발되었다. 이 프로그램의 실제 예시로서 여러 가지 과학 교수 방법을 사용하여 수학, 물리, 화학, 천문학, 생물학을 통합한 예가 개발되었다. 이 프로그램에서는 과학적 지식의 복합성 또는 통합 교과성(complexity 또는 interdisciplinarity)이 커질수록 그것을 학습하는 과정에서 얻게 되는 학생들의 과학적 기술(scientific skill)도 깊어지도록 과학적 내용과 교수전략을 상호 연관시켰다. 이렇게 과학적 내용과 교수전략이 세심하게 균형을 이룬 IMSEP을 통해 과학 영재들의 과학적 지식과 기술은 균형 있게 발전할 것이며 따라서 과학 교육의 효과가 극대화 될 것이다.

• 대한한의진단학회지
• /
• 제15권1호
• /
• pp.95-110
• /
• 2011

Objectives: The aim of the present study is to define breath-holding in spontaneous respiration and to observe the difference of respiratory variables, EEG and HRV. Methods: 46 healthy young volunteers (M:F=31:15) were recruited in the study. By measuring and analysing respiration, EEG and HRV in the spontaneous respiration. We segment subjects by 100% of coefficient of variation in the breath-holding. Results & Conclusions: 1. There is a period of breath-holding after expiration and before endeavored inspiration, in the course of respiration. The greater coefficient of variation in the breath-holding, longer respiration period mean, inspiration period mean and breath-holding mean in respiratory variable. 2. There was no significant difference between HRV parameters. 3. The greater coefficient of variation in the breath-holding, the higher ${\beta}$ frequency and ${\gamma}$ frequency in the left prefrontal lobe.

• Journal of Microbiology and Biotechnology
• /
• 제16권1호
• /
• pp.141-144
• /
• 2006

An antibody layer was fabricated to detect Escherichia coli O157:H7. The micropattern of 16-mercaptohexadecanoic acid (16-MHDA) as alkylthiolate was formed on the gold surface by using the PDMS stamp with microcontact printing $({\mu}CP)$ techniques. In order to form antibody patterns on the template, protein G was chemically bound to the 16-MHDA patterns, and antibody was adsorbed on a self-assembled protein G layer. The formation of the 16-MHDA micropattern, self-assembled protein G layer and antibody pattern on Au substrate was confirmed by surface plasmon resonance (SPR) spectroscopy. Finally, the micropatterning method was applied to fabricate the antibody probe for detection of E. coli O157:H7, and monitoring of antigen by using this probe was successfully achieved.

• Journal of Microbiology and Biotechnology
• /
• 제16권1호
• /
• pp.32-36
• /
• 2006

The genome sequences from several microbes have led to the discovery of numerous open reading frames of unknown functionality. The putative bacterial epoxide hydrolase (EH) genes selected from the genome databases were examined for their activities toward various epoxides. Among the nine open reading frames (ORFs) from four microbial species, the ORF from Caulobacter crescentus showed an epoxide hydrolase activity. The kinetic resolution, using C. crescentus EH (CCEH) of the aryl epoxides such as styrene oxide, could be performed more efficiently than short aliphatic epoxides. The resolution of racemic indene oxide, which could previously be resolved only by fungal epoxide hydrolases, was effectively accomplished by CCEH.

• 대한산업공학회지
• /
• 제43권3호
• /
• pp.164-175
• /
• 2017

Dual response surface optimization (DRSO) attempts to optimize mean and variability of a process response variable using a response surface methodology. In general, mean and variability of the response variable are often in conflict. In such a case, the process engineer need to understand the tradeoffs between the mean and variability in order to obtain a satisfactory solution. Recently, a Posterior preference articulation approach to DRSO (P-DRSO) has been proposed. P-DRSO generates a number of non-dominated solutions and allows the process engineer to select the most preferred solution. By observing the non-dominated solutions, the DM can explore and better understand the trade-offs between the mean and variability. However, the non-dominated solutions generated by the existing P-DRSO is often incomprehensive and unevenly distributed which limits the practicability of the method. In this regard, we propose a modified P-DRSO using multiple objective genetic algorithms. The proposed method has an advantage in that it generates comprehensive and evenly distributed non-dominated solutions.

• 한국콘텐츠학회논문지
• /
• 제6권8호
• /
• pp.114-123
• /
• 2006

유비쿼터스적 디지털 기술에 의한 제 3의 공간의 실용적 가치가 급속도로 상승하고 있는 현실에서, 시대적 변화에 부응하는 선도적 공간디자이너를 양성하기 위하여 디지털 융합기술 영역과의 교류를 기반으로 한 '학제간 연계 교육'이 필수적인 상황이다. 이에 본 연구에서는 새로운 통합적 공간연출에 대한 고찰과 해외사례분석을 통해, 기술적 측면에서의 감성공간구현을 위한 Interdisciplinary Teaching Form으로서 디지털 상호작용 기술, 디지털 통합 기술, 디지털 창작 기술의 3가지 교육영역을 정하고, 시범적으로 교육현장 적용 과정을 거침으로써, 이상적이고 미래지향적인 공간디자인 교육의 기초적 형태와 그 차별화 된 결과물을 제시하였다.

• 대한한의진단학회지
• /
• 제12권2호
• /
• pp.27-40
• /
• 2008

Background : In spite of the predominant of the theory of Pathogenesis, the method of Pathogenesis classification is depending on the doctor's clinical trials because od the lack of the objective test criteria. Methods and Results : This study is trying to improve the objectiveness of classification using a new statistical method, decision tree. Decision tree method -a classification technique in the statistical analysis- was used to analyze the result of pathogenesis questionnaire instead of using discriminant analysis. As a result, 10 among 38 pathogenesis questionnaire was selected as important questions and 12 terminal nodes was built to classify the pathogenesis. Conclusions : Using only 10 questions shown in the result of decision tree, we can classify and interpret the pathogenesis easily and effectively.

• 공학교육연구
• /
• 제18권6호
• /
• pp.80-87
• /
• 2015

The aim of this study suggest the THAMS Clinic Camp program to train the interdisciplinary students with humanistic knowledge as well as the skills to perform the scientific and engineering works. Since the future of society is required students with the ability to elicit an emotional empathy, THAMS Clinic Camp program has been planed and performed from year 2012 based on the comprehensive liberal learning. The average employment rate over the past three years of the students who participated in THAMS Clinic Camp program showed 7% better than the overall average employment rate of Andong National University. The another visible educational outcomes of the THAMS Clinic Camp program are following; i) To take place the conversion of recognition for the interdisciplinary activity by breaking down the walls between fragmented disciplines to students and ii) To provide the opportunity that students will understand the past and refocus the current to have the idea to plan for the future in the right direction.

• 신재생에너지
• /
• 제7권1호
• /
• pp.36-44
• /
• 2011

Technology is developed from the efficient interaction with other technology files while building up its own research field. This study analyzes the structure of solar cell research area and describes its paths of the technology development in terms of interdisciplinary diversity using the Co-Classification method during 1979-2009. As a results, 1,380 studies are determined as the interdisciplinary among the 2,605 studies. It shows that 52.98% of the solar cell researches have interdisciplinary relationships with two or more research fields. In addition, we show that the research area of solar cell technology is composed by Material Science, Multidisciplinary and Energy & Fuel, Physics, Applied, Chemistry, Physical from the Co-Classification matrix and network analysis. It means the complexity of the technological knowledge production increased with the concept of interdisciplinary. The results can be used for the planning of the efficient solar cell technology development.