• 한국산학기술학회논문지
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• 제21권4호
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• pp.525-537
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• 2020

본 연구 목적은 향후 시뮬레이션 기반 운영 과정에 대한 과학적 근거를 제공하기 위해 연구 결과를 종합적으로 검토함으로써 Jeffries 이론적 프레임 워크를 기반으로 한국의 간호 교육에서 시뮬레이션 기반 운영 프로세스의 현재 상태와 특성을 확인하는 것이다. 본 연구는 2017년 11월까지 "시뮬레이션"과"간호"라는 용어를 사용하여 한국 교육연구 정보원, 국립 도서관, 한국학 정보원 서비스 시스템, 국립 디지털 과학 도서관, 한국 과학 기술 정보원, KOREAMED, 한국 의료 데이터베이스 등 8개의 데이터베이스에서 한국어로 출간된 연구들을 검색했다 연구결과 16개의 연구가 확인, 검토 및 평가되었다. 문헌은 연구의 일반적인 특성, 운영 방법, 교수학습방법, 참여자 특성, 결과변수 및 이론적 틀이라는 주제로 분류되었습니다. 본 연구에서 분석한 한국의 간호 교육 시뮬레이션 과정은 NLN Jeffries 시뮬레이션 이론적기틀에서 제안된 주요 개념을 완전히 반영하지는 않았다. 추후 시뮬레이션 프로그램 개발자는 시뮬레이션 효율성을 향상시키기 위해 필수 구성 요소를 확인하고 다양한 전략을 고려하여 통합해야 할 것이다.

• 문화기술의 융합
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• 제9권1호
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• pp.373-381
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• 2023

본 연구의 목적은 남자간호사 이미지와 관련된 연구들을 통합적으로 고찰하여, 남자간호사의 자기 이미지와 영향요인을 알아보기 위함이다. 분석대상 논문은 2009년에서 2019년 사이에 발표된 논문 중 남자간호사의 자기 이미지와 관련된 12개의 논문이다. 우리는 문헌고찰을 통해 남자간호사의 자기 이미지로 1) 그냥 간호사, 2) 기회의 직업, 3) 직업 정체성 모호, 4) 제한된 역할의 4개 주제를 도출되었다. 남자간호사의 자기 이미지에 영향을 미치는 요인은 3개의 주제로 도출되었으며, 구체적으로 1) 간호역량, 2) 사회적 성 고정관념, 3) 남자간호사 롤 모델 부재이다. 본 연구 결과를 통해 남자간호사의 자기 이미지를 향상시키기 위한 전략 마련이 필요하며, 추후 남자간호사의 사회적 역할과 인식 제고를 위해 남자간호사의 대중적 이미지를 알아보는 연구가 필요하다.

• 산업융합연구
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• 제21권5호
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• pp.87-95
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• 2023

본 연구는 국내 노인을 대상으로 한 변비 비약물적 중재 연구에 대한 통합적 문헌고찰을 통해 노인 변비 비약물적 중재에 대한 특성과 효과를 분석하여 노인 변비 비약물적 중재 프로그램 개발을 위한 방향을 제시하기 위해 시행되었다. 2개의 국내 검색엔진을 통해 2010년 1월부터 2023년 1월까지 발표된 문헌을 검색하였으며, 11편의 문헌을 최종 분석하였다. 연구결과 노인 변비 비약물적 중재유형은 복부마사지, 발마사지, 지압, 뜸요법, 생활습관중재, 탄산수 섭취, 복합요법이 있었으며, 중재의 효과로 변비, 수면의 질, 우울을 확인하였다. 비약물적 중재 모두 노인 변비에 유의한 효과가 있었으며, 발마사지, 지압의 경우 노인의 수면의 질, 우울에도 유의한 효과가 있었다. 그러나 노인의 변비 관련 삶의 질을 확인한 연구는 없는 실정으로 추후, 노인의 삶의 질을 고려한 변비 비약물적 중재 프로그램 개발 및 적용이 필요하다.

• 동의신경정신과학회지
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• 제29권4호
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• pp.239-253
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• 2018

Objectives: This is one of the manuals of East-West integrative medicine, which was created by the Committee on integrative medicine of Chung-Yeon Korean Medicine Hospital. To support clinical decision making and communication in the East-West cooperative treatment of mild cognitive impairment. Methods: Drafting was based on literature review from the MEDLINE, EMBASE, OASIS, and CNKI databases using search terms such as 'mild cognitive impairment', 'mild neurocognitive disorder', 'acupuncture', 'herbal medicine' and 'traditional Chinese medicine'. An amendment reflecting the goal of consultation and detailed treatment contents was made by reviewing the draft and holding discussion with the rehabilitation specialist of western medicine. The committee then agreed to adopt the manual through the process of review and feedback in addition to face-to-face discussions. Results: This manual contains the diagnosis of mild cognitive impairment, the goal of consultation, and the cooperative treatment contents of the East-West medicine for mild cognitive impairment. Conclusions: This manual provides significant information about the decision making process and contents of treatment in one medical institution for East-West cooperative treatment of mild cognitive impairment.

• Journal of Microbiology and Biotechnology
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• 제29권6호
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• pp.845-855
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• 2019

Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.

• 대한통합의학회지
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• 제8권4호
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• pp.277-289
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• 2020

Purpose : This study aims to confirm the clinical usefulness of computerized cognitive therapy program for patients with brain diseases in Korea and to present basic data that can confirm the effectiveness of computerized cognitive therapy program to experts related to rehabilitation in the future. Methods : A systematic review and meta-analysis research method was used to confirm the clinical effectiveness of computerized cognitive therapy applied to patients with brain diseases in Korea. Based on the national institute of health and medical colleges association (NECA) systematic literature manual and preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines for conducting research through systematic review and meta-analysis methods. Systematic review was PICOST-SD was used to research and select papers. For meta-analysis, the data was input and analyzed separately by literature result using the revman manager 5.3 program and the results were presented visually through tables and forest, funnel plot figure. Results : As a result of comprehensive analysis of the contents of the finally selected literature, it as found that studies on stroke and dementia were mainly conducted. In addition, through the evaluation of the quality of the literature, most of the existing computerized cognitive therapy studies were identified as high-quality studies, but the results were insufficient for randomization and blinding. And through meta-analysis, the clinical effectiveness of computerized cognitive therapy on cognitive function, activities of daily living, and visual perception function of patients with brain disease was found. Conclusion : The research literature that applied computerized cognitive therapy to brain disease subjects was comprehensively analyzed and identified. It is thought that this could be used as basic data on the characteristics of cognitive therapy that should be applied to patients with brain diseases in the future and the usefulness of computerized cognitive therapy program in actual clinical practice.

• BMB Reports
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• 제37권1호
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• pp.93-106
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• 2004

The new complexity arising from the genome sequencing projects requires new comprehensive post-genomic strategies: advanced studies in regulatory mechanisms, application of new high-throughput technologies at a genome-wide scale, at the different levels of cellular complexity (genome, transcriptome, proteome and metabolome), efficient analysis of the results, and application of new bioinformatic methods in an integrative or systems biology perspective. This can be accomplished in studies with model organisms under controlled conditions. In this review a perspective of the favourable characteristics of yeast as a touchstone model in post-genomic research is presented. The state-of-the art, latest advances in the field and bottlenecks, new strategies, new regulatory mechanisms, applications (patents) and high-throughput technologies, most of them being developed and validated in yeast, are presented. The optimal characteristics of yeast as a well-defined system for comprehensive studies under controlled conditions makes it a perfect model to be used in integrative, 'systems biology' studies to get new insights into the mechanisms of regulation (regulatory networks) responsible of specific phenotypes under particular environmental conditions, to be applied to more complex organisms (e.g. plants, human).

• Animal cells and systems
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• 제4권2호
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• pp.123-129
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• 2000

Lynceid conchostracans of the order Laevicaudata in East Asia are reviewed. Validity of the three older species, Lynceus mandsuricus Daday, Lynceus biformis (Ishikawa), and Lynceus dauricus Thiele, is examined and discussed. Two species among them were acknowledged but L. dauricus was synonymized to L. biformis and redescribed and illustrated in the present paper, based on the materials collected from the rice-fields at 15 localities in Korea.

• Radiation Oncology Journal
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• 제34권4호
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• pp.239-249
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• 2016

Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized. In this review, we will highlight some of the past attempts to overcome tumor hypoxia including hypoxic radiosensitizers and hypoxia-selective cytotoxin. Although they were (still are) a very clever idea, they lacked clinical efficacy largely because of 'reoxygenation' phenomenon occurring in the conventional low dose hyperfractionation radiotherapy prevented proper activation of these compounds. Recent meta-analysis and imaging studies do however indicate that there may be a significant clinical benefit in lowering the locoregional failures by using these compounds. Latest technological advancement in radiotherapy has allowed to deliver high doses of radiation conformally to the tumor volume. Although this technology has brought superb clinical responses for many types of cancer, recent modeling studies have predicted that tumor hypoxia is even more serious because 'reoxygenation' is low thereby leaving a large portion of hypoxic tumor cells behind. Wouldn't it be then reasonable to combine hypoxic radiosensitizers and/or hypoxia-selective cytotoxin with the latest radiotherapy? We will provide some preclinical and clinical evidence to support this idea hoping to revamp an enthusiasm for hypoxic radiosensitizers or hypoxia-selective cytotoxins as an adjunct therapy for radiotherapy.

• 한국동물학회지
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• 제31권1호
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• pp.71-79
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• 1988

In the present review, the history of zoological expeditions that were undertaken on the Jordanian fauna are presented. The published zoological studies reg&ding mammals, birds, reptiles, freshwater fishes, freshwater Mollusca, Siphonaptera and lxodidae are reviewed.Some remarks are made on recent trends in zoological studies carried out by Jordanian zoologists.