• Biomolecules & Therapeutics
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• 제26권2호
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• pp.93-100
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• 2018

Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In mammals, especially humans, a proper neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia, and neurons is essential for the homeostasis and survival of the central nervous system (CNS). In addition, the regeneration of neurovascular systems from neural stem cells and endothelial precursor cells after CNS diseases is responsible for functional repair. This review focused on the possible role of CO/HO in the neurovascular unit in terms of neurogenesis, angiogenesis, and synaptic plasticity, ultimately leading to behavioral changes in CNS diseases. CO/HO may also enhance cellular networks among endothelial cells, pericytes, astrocytes, and neural stem cells. This review highlights the therapeutic effects of CO/HO on CNS diseases involved in neurogenesis, synaptic plasticity, and angiogenesis. Moreover, the cellular mechanisms and interactions by which CO/HO are exploited for disease prevention and their therapeutic applications in traumatic brain injury, Alzheimer's disease, and stroke are also discussed.

• Animal cells and systems
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• 제4권3호
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• pp.239-243
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• 2000

Most space-related life science programs are expensive and time-consuming, requiring international cooperation and resources with trans-disciplinary expertise. A comprehensive future program in "life sciences in space" needs, therefore, well-defined research goals and strategies as well as a sound ground-based program. The first half of this review will describe four key aspects such as the environment in space, previous accomplishments in space (primarily focusing on amphibian embryogenesis), available resources, and recent advances in bioinformatics and biotechnology, whose clear understanding is imperative for defining future directions. The second half of this review will focus on a broad range of interdisciplinary research opportunities currently supported by the National Aeronautics and Space Administration (NASA), National Institute of Health (NIH), and National Science Foundation (NSF). By listing numerous research topics such as alterations in a diffusion-limited metabolic process, bone loss and skeletal) muscle weakness of astronauts, behavioral and cognitive ability in space, life in extreme environment, etc., we will attempt to suggest future opportunities.

• 아동학회지
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• 제21권4호
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• pp.197-210
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• 2000

This integrative review of research on the role of toys in the pretend play of young children investigated claims about the relative effects of abstract or unrealistic compared with concrete or realistic toys. Researchers and educators acknowledge the benefits of pretend play as an expression of the child's capacity of symbolic functioning and they attend to strategies for promoting pretend play at each stage of its development, including the selection and presentation of playthings. Highly structured or realistic toys were once thought to impede pretend play because they can only be used for a single intended purpose whereas less structured toys are pliant and hold the child's interest over longer periods of time as new ideas are tried out. However, the present review suggests that realistic toys are effective for very young children who still have limited representational capacity, and that realistic toys continue to give impetus to make-believe even for kindergarten children.

• Animal Bioscience
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• 제34권8호
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• pp.1271-1282
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• 2021

Genome-wide studies provide considerable insights into the genetic background of animals; however, the inheritance of several heritable factors cannot be elucidated. Epigenetics explains these heritabilities, including those of genes influenced by environmental factors. Knowledge of the mechanisms underlying epigenetics enables understanding the processes of gene regulation through interactions with the environment. Recently developed next-generation sequencing (NGS) technologies help understand the interactional changes in epigenetic mechanisms. There are large sets of NGS data available; however, the integrative data analysis approaches still have limitations with regard to reliably interpreting the epigenetic changes. This review focuses on the epigenetic mechanisms and profiling methods and multi-omics integration methods that can provide comprehensive biological insights in animal genetic studies.

• Molecules and Cells
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• 제46권2호
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• pp.106-119
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• 2023

With the increased number of single-cell RNA sequencing (scRNA-seq) datasets in public repositories, integrative analysis of multiple scRNA-seq datasets has become commonplace. Batch effects among different datasets are inevitable because of differences in cell isolation and handling protocols, library preparation technology, and sequencing platforms. To remove these batch effects for effective integration of multiple scRNA-seq datasets, a number of methodologies have been developed based on diverse concepts and approaches. These methods have proven useful for examining whether cellular features, such as cell subpopulations and marker genes, identified from a certain dataset, are consistently present, or whether their condition-dependent variations, such as increases in cell subpopulations in particular disease-related conditions, are consistently observed in different datasets generated under similar or distinct conditions. In this review, we summarize the concepts and approaches of the integration methods and their pros and cons as has been reported in previous literature.

• 종양간호연구
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• 제3권2호
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• pp.112-121
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• 2003

The purpose of these study was to analyze the contents and trend of researches done on oncology nursing in the past five years in Korea and to suggest its direction for the future research. Methods: 214 nursing studies published from 1998 to 2003 were selected for the analysis. They were examined for the source, design of study, type of subjects, the intervention outcomes of experimental research, the key words and theme of the oncology research. Results: 1. 139(64.9%) of 214 studies were masters thesis and doctoral dissertations. There were 196(91.6%) quantitative researches and 18 qualitative researches. Quantitative research consisted of 28(14.3%) experimental and 168(85.7%) non- experimental studies. Among non-experimental studies, there were 53 correlations, 78 descriptives, 14 comparatives and 23 methodological studies. 2.The main subjects of the study were cancer patients in general(43.7%) and breast cancer patients (18.3%). According to the treatment types, patients receiving chemotherapy were the highest number distribution as 23 of all researches. 3. Social support, fatigue, stress, hope, and quality of life were the most frequently used concepts in correlational studies.4. Education, providing information, oral care, exercise, relaxation and foot massage were the most frequent nursing interventions. Most frequently measured outcomes variable were self-care, pain control, nausea & vomiting, oral discomfort and anxiety. 5. Key words used most frequently were quality of life, educational need, pain controls and fatigue. 6. The themes of qualitative researches were illness experience, family experience and adaptation process. More than 50% of qualitative researches used phenomenologic method. Conclusion: Researches on cancer nursing in Korea have been increased. Descriptive design is being dominant and few experimental studies are being done For the future, it is necessary to conduct international studies to compare, replicate and to establish the effective nursing interventions.

• 대한통합의학회지
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• 제9권2호
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• pp.63-73
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• 2021

Purpose : Selective functional movement assessment(SFMA) is a movement-based assessment tool designed for clinicians to diagnose and treat pain and functional physical problems. This concept is used for assistance in occupations related to movement, including clinical medical personnel, such as physical therapists, physical education instructors, and athlete coaches. Although this concept is widely used by clinicians, research and scientific proofs are relatively insufficient. This study aimed to review the literature on the understanding, reliability and effectiveness of SFMA, and to consider its role in the future of rehabilitation. Methods : In this review, a total of nine articles were selected according to the eligibility criteria of three major thesis topics. The main topics covered in the literature are reliability and effectiveness of clinical use of SFMA. To gather research articles, we searched official term 'Selective Functional Movement Assessment'. Among the searched 60 studies, nine were mentioned in this study that contained overlapping information and matched our desired topic. We reviewed four reliability analyses, four case reports, and one experimental study. Results : Reliability has an intermediate degree between high raters and within raters. The validity of the SFMA system is influenced by a combination of experience and logic; hence, further improvement is needed. Therefore, if the intervention was effective based on the diagnosis result, then biomechanical evidence is necessary to further support the claim. Conclusion : In future research, to use SFMA as a diagnostic tool with high accuracy, it is necessary to improve the reliability of the main problem through breakout, support for guidelines and validity and efficiency.

• 대한통합의학회지
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• 제9권2호
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• pp.131-140
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• 2021

Purpose : The purpose of this study was to systematically review the studies on the effects of social story intervention on the individuals with autism spectrum disorders(ASD) to provide the basis for evidence-based practice. Methods : In order to find out the studies on the effect of social story intervention on individuals with ASD, studies published from 2011 to December 2020 were searched on Google Academic Search. The keywords used were "autism spectrum disorder AND social story". A total of 16,900 studies were searched, and from these, 12 studies were selected based on the application of the selection and exclusion criteria. The included studies comprised of 10 single subject design studies and 2 randomized controlled trials design studies. The included studies were analyzed in accordance to population, intervention, outcome measures and results. Results : As a result of analysing the subjects of the included studies, we found out that pre-school children and adolescents were the most common groups of individuals diagnozsed with ASD. In addition to ASD, the diagnosis of the subjects included intellectual disability, Asperger, and Prader-willi. We found out that there were more interventions that were mixed with other interventions, than just the pure social story interventions. In particular, video modeling was found to be the most frequent intervention. This was followed by photo-based social stories. For outcome measure, autism social skills profile was found to be the most often used standardized assessment. For a non-standardized assessment, social desired behavior was found to be the most frequently evaluated behavior, followed by personal problem behavior. Of all the dependent variables, the dependent variable reported as "effective" was the most, followed by "some effective". Conclusion : This study is organized to help the individuals with ASD, families, researchers, and therapists understand the effects of social story intervention on the individuals with ASD in an easy fashion. Further, therapists can use this study as the basic data for evidence-based practice.

• Korean Journal of Acupuncture
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• 제36권1호
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• pp.19-35
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• 2019

Objectives : The purpose of this study is to review which acupoints and meridians are selected to treat visceral pain in articles published in international journals and to investigate quality of reporting acupuncture intervention according to the STRICTA guidelines. Methods : Electrical and hand search were conducted in PubMed, EMBASE, MEDLINE, and Cochrane Library for acupuncture studies on visceral pain in human and animals. Reporting quality of intervention was evaluated using the revised STRICTA guidelines. Results : We included 51 articles (7 clinical studies and 44 animal studies) in this study. The most frequently adopted meridians and acupoints were Stomach meridian, Spleen meridian, Conception Vessel meridian, and ST36, CV4, SP6, LI4, PC6, SP9, ST25, ST37 in clinical studies. In animal studies, Stomach meridian, Conception Vessel meridian, Pericardium meridian and ST36, ST37, CV12, PC6 were most frequently used. Animal studies showed significantly lower quality of reporting compared to clinical studies. According to the analysis on the effect of year of publication of articles, announcement of STRICTA guidelines did not improve the quality of reporting for studies on visceral pain. Conclusions : These results suggest that both proximal and distal acupoints based on meridian theory were used to study the underlying mechanisms of visceral pain both in human and animal studies. Guidelines of acupuncture intervention reporting for animal study is necessary to improve the quality of evidence, and it will also allow us the integrative understanding of the mechanisms and clinical effects of acupuncture treatment in human and animal.

• 대한통합의학회지
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• 제9권4호
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• pp.159-166
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• 2021

Purpose : This study systematically assessed programs self-esteem programs for schizophrenic individuals that have been implemented over the past 10 years in South Korea, with the objective of providing clinical grounds and data for further programs that can be implemented in the Korean environment. Methods : For this study, a data search was conducted from 2012 to 2021, using search terms 'schizophrenia' AND 'self-esteem' among the studies registered in the RISS, KISS, Google Scholar, and National Library of Korea databases. A total of 988 studies were searched, and among them, 40 studies meeting the selection criteria had been taken by reviewing the titles and abstracts. After, 33 studies were excluded according to the exclusion criteria, and finally, the 7 studies were selected. Results : As a result, research into self-esteem programs for schizophrenic individuals has progressed steady, and most studies tend to be non-randomized controlled studies. All studies used the Self-Esteem Scale to evaluate self-esteem. All studies used the Self-Esteem Scale to evaluate self-esteem. The interventions of the selected studies were classified as were social skill programs, cognitive behavioral therapy programs, art therapy programs, and emotional management programs. And among them, the cognitive behavioral therapy programs were the most frequently used (42.8 %). Typically, the majority of the intervention sessions consisted of 11~15 sessions, the frequency of intervention was twice a week, and each session lasted 40~80 minutes were the most (each 57.1 %). In the programs for self-esteem, significant effects were reported for cognitive behavioral and art therapy programs, and there is no significant effect on social skill programs and emotional management programs. Conclusion : Future studies should expand the research scope, both domestically and internationally, and suggest more comprehensive conditions for a literature search by widening the research subject coverage.