• Nonlinear Functional Analysis and Applications
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• 제28권2호
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• pp.497-520
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• 2023

Numerous problems in science and engineering defined by nonlinear functional equations can be solved by reducing them to an equivalent fixed point problem. Fixed point theory provides essential tools for solving problems arising in various branches of mathematical analysis, such as split feasibility problems, variational inequality problems, nonlinear optimization problems, equilibrium problems, complementarity problems, selection and matching problems, and problems of proving the existence of solution of integral and differential equations.The theory of fixed is known to find its applications in many fields of science and technology. For instance, the whole world has been profoundly impacted by the novel Coronavirus since 2019 and it is imperative to depict the spread of the coronavirus. Panda et al. [24] applied fractional derivatives to improve the 2019-nCoV/SARS-CoV-2 models, and by means of fixed point theory, existence and uniqueness of solutions of the models were proved. For more information on applications of fixed point theory to real life problems, authors should (see [6, 13, 24] and the references contained in).

• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.176-181
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• 2011

A role of cost modeler is that of facilitating design process by the systematic application of cost factors so as to maintain sensible and economic relationships between cost, quantity, utility and appearance. These relationships help to achieve the client's requirements within an agreed budget. The purpose of this study is to develop a parametric cost estimating model for the early design stage by using the multi-dimensional system of OLAP (On-line Analytical Processing) based on the case of quantity data related to architectural design features. The parametric cost estimating models have been adopted to support decision making in the early design stage. These models typically use a similar instance or a pattern of historical case. In order to effectively use this type of data model, it is required to set data classification and prediction methods. One of the methods is to find the similar class in line with attribute selection measure in the multi-dimensional data model. Therefore, this research is to analyze the relevance attribute influenced by architectural design features with the subject of case-based quantity data used for the parametric cost estimating model. The relevance attributes can be analyzed by Analytical Characterization. It helps determine what attributes to be included in the OLAP multi-dimension.

• 한국잠사곤충학회지
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• 제13권2호
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• pp.123-133
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• 1971

The author is the first man who tried to use an anesthetic on insect specially for silkworm in orde to evaluate the silkworm health and silk yielding ability and the obtained results are as followings. 1. The necessary ether vapor induction for narcosis on silkworms is varied by the glowth of the silkworm which the larger worm is, the longer induction is required. For instance, it was 2∼3 minutes for the worms of third day fifth instar silkworm in case use of ether anesthetic. 2. The longer anesthetic induction for silkworms, the longer recovery needs from anesthesia. In case five minutes ether vapor induction, silkworms recovered narcosis during in 5∼130 minutes which had varied very much by the health variation. 3. The ether induction caused silkworm to vomit digestive juice from a few per cent of the worms, but the chloroform induction showed majority of the worms to vomit the digestive juice out of mouth. So, the ether was found as better anesthetic for silkworms. 4. When ether induction last more than 20∼30 minutes, the recovered silkworms can eat mulberry, but when it gets more than three hours they can not eat mulberry. And when it last more than ten minutes, the silkworm may eat mulberry leaf, but they can not spinn cocoon properly. 5. In case five minutes ether induction for silkworms on third day fifth instar, the stronger variety is, the rallier recovered from narcosis. 6. The recovering duration from narcosis varies regarding with each worm health which shows Poisson′s distribution even in a same variety silkworm. 7. The female worms recover from narcosis earlier than male worms which means the female worm is stronger than male one. 8. The later recovered silkworm from narcosis spinned more rich cocoon silk and ended with smaller pupae weight. Such a tendency showed until at some recovery duration, then the silk yield droped down on the worms recovered in more longer duration. The author (Choe) had named such a relation curve as "Silk Yield Curve against Silkworm Health." 9. The silk yield or cocoon layer ratio had varied from 13 to 27% even in a same worm varity cocoon which showed serious variation and call attention carefulness for the duplication work of a variety silkworm eggs. 10. Not always the rich silk yielding worm is the best worm during the silkworm selection and it should be considered with the silkworm health evaluation. 11. At present situation, only specific breeding expert is allowed to join in the selection service because of need many years experience by use of visual observation, but the ether anesthesia method may help such an evaluation with more accuracy and easy way even for the people in fresh on the field. 12. The effect of the narcosis on the silkworm for the next generation or hybrid worm will be reported in next publication.

• Plant Biotechnology Reports
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• 제5권2호
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• pp.157-167
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• 2011

In order to establish a reliable and highly efficient method for genetic transformation of pepper, a monitoring system featuring GFP (green fluorescent protein) as a report marker was applied to Agrobacteriummediated transformation. A callus-induced transformation (CIT) system was used to transform the GFP gene. GFP expression was observed in all tissues of $T_0$, $T_1$ and $T_2$ peppers, constituting the first instance in which the whole pepper plant has exhibited GFP fluorescence. A total of 38 T0 peppers were obtained from 4,200 explants. The transformation rate ranged from 0.47 to 1.83% depending on the genotype, which was higher than that obtained by CIT without the GFP monitoring system. This technique could enhance selection power by monitoring GFP expression at the early stage of callus in vitro. The detection of GFP expression in the callus led to successful identification of the shoot that contained the transgene. Thus, this technique saved lots of time and money for conducting the genetic transformation process of pepper. In addition, a co-transformation technique was applied to the target transgene, CaCS (encoding capsaicinoid synthetase of Capsicum) along with GFP. Paprika varieties were transformed by the CaCS::GFP construct, and GFP expression in callus tissues of paprika was monitored to select the right transformant.

• 전자공학회논문지
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• 제51권1호
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• pp.161-171
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• 2014

허프변환은 이미지 영역에서 패러미터 영역으로의 변환을 통해 주어진 이미지에서 모델 인스턴스를 추출해내는 방식으로 허프변환된 결과는 패러미터 영역 좌표에 해당하는 Cell 카운터들의 히스토그램 형태가 된다. 다음 단계로 임계값을 정한 후 이를 상회하는 카운터 값에 해당하는 패러미터 값을 통해 모델 인스턴스를 추출하게 되는데 일반적으로 그 임계값은 최고 Cell 카운터 값의 일정 부분에 해당하는 값을 주로 선택하게 된다. 임계점이 너무 낮을 경우 잘못된 모델 인스턴스를 추출할 가능성이 있으며(false positives) 반대로 너무 높은 임계점을 선택할 경우 존재하는 모델 인스턴스를 추출해내지 못하는 오류(false negatives)를 초래하게 된다. 본 논문에서는 일반화된 허프변환(Generalized Hough Transform) 적용 시 패러미터 영역에서의 Cell 카운터 값의 임계점 선택을 위한 방법으로 확률적인 접근방식을 제시하며 이를 위해 Cell 카운터 분포에 해당하는 조건부 확률을 도출하여 과학적인 임계점 선택이 가능함을 입증한다.

• Journal of Microbiology and Biotechnology
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• 제16권5호
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• pp.651-660
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• 2006

Natural products are a rich source of biologically active small molecules and a fertile area for lead discovery of new drugs [10, 52]. For instance, 5% of the 1,031 new chemical entities approved as drugs by the US Food and Drug Administration (FDA) were natural products between 1981 and 2002, and another 23% were natural product-derived molecules [53]. These molecules have evolved through millions of years of natural selection to interact with biomolecules in the cells or organisms and offer unrivaled chemical and structural diversity [14, 37]. Nonetheless, a large percentage of nature remains unexplored, in particular, in the marine and microbial environments. Therefore, natural products are still major valuable sources of innovative therapeutic agents for human diseases. However, even when a natural product is found to exhibit biological activity, the cellular target and mode of action of the compound are mostly mysterious. This is also true of many natural products that are currently under clinical trials or have already been approved as clinical drugs [11]. The lack of information on a definitive cellular target for a biologically active natural product prevents the rational design and development of more potent therapeutics. Therefore, there is a great need for new techniques to expedite the rapid identification and validation of cellular targets for biologically active natural products. Chemical genomics is a new integrated research engine toward functional studies of genome and drug discovery [40, 69]. The identification and validation of cellular receptors of biologically active small molecules is one of the key goals of the discipline. This eventually facilitates subsequent rational drug design, and provides valuable information on the receptors in cellular processes. Indeed, several biologically crucial proteins have already been identified as targets for natural products using chemical genomics approach (Table 1). Herein, the representative case studies of chemical genomics using natural products derived from microbes, marine sources, and plants will be introduced.

• 한국환경과학회지
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• 제16권5호
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• pp.603-610
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• 2007

Recent urban sprawl has destroyed various kinds of green space in tile city. It has affected duality of people's life in the city, as well as urban ecosystem. Recent study shows the possibilities of roofs as green spaces in urban central site where the land costs are generally high. This research focuses on Jung-Gu district in Daegu Metropolitan city as a study area and calculates possible area of green roof using 2002 Autocad program based on aerial photographs and land registration maps. And the purpose of this research is to analyze environmental and economic effects of green roof. The environmental effects are as follows. It is expected that $91,106m^2$ green spaces, 12.13 % of study site, will be added if green roof is performed in the study site. It is assumed that the expanded areas could reduce the highest temperature to $0.5-1.0^{\circ}C$ during the summer in terms of environmental effect. And the following shows the economic effects. If green roof and greening urban central site are created as a same size of $91,106m^2$, it will be expected that the costs of green roof will be much more in-expensive than about 98 billions won. It will be also found that the expense of cooling energy can be saved out about 8 millions won per day in summer, if grass planting is accomplished on the possible areas of green roof in the study site. Therefore, it is desirable to take legal supports such as enacting regulations to activate green roof for more environmental and economic effects. For instance, green roof for public institutions, school and model area selection are desirable method to publicize the effect of greening program for citizen's participation.

• Korean Membrane Journal
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• 제7권1호
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• pp.1-18
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• 2005

The permeate flux decline due to membrane fouling can be addressed using a variety of theoretical stand-points. Judicious selection of an appropriate theory is a key toward successful prediction of the permeate flux. The essential criterion f3r such a decision appears to be a detailed characterization of the feed solution and membrane properties. Modem theories are capable of accurately predicting several properties of colloidal systems that are important in membrane separation processes from fundamental information pertaining to the particle size, charge, and solution ionic strength. Based on such information, it is relatively straight-forward to determine the properties of the concentrated colloidal dispersion in a polarized layer or the cake layer properties. Incorporation of such information in the framework of the standard theories of membrane filtration, namely, the convective diffusion equation coupled with an appropriate permeate transport model, can lead to reasonably accurate prediction of the permeate flux due to colloidal fouling. The schematic of the essential approach has been delineated in Figure 5. The modern approaches based on appropriate cell models appear to predict the permeate flux behavior in crossflow membrane filtration processes quite accurately without invoking novel theoretical descriptions of particle back transport mechanisms or depending on adjust-able parameters. Such agreements have been observed for a wide range of particle size ranging from small proteins like BSA (diameter ${\~}$6 nm) to latex suspensions (diameter ${\~}1\;{\mu}m$). There we, however, several areas that need further exploration. Some of these include: 1) A clear mechanistic description of the cake formation mechanisms that clearly identifies the disorder to order transition point in different colloidal systems. 2) Determining the structure of a cake layer based on the interparticle and hydrodynamic interactions instead of assuming a fixed geometrical structure on the basis of cell models. 3) Performing well controlled experiments where the cake deposition mechanism can be observed for small colloidal particles (< $1\;{\mu}m$). 4) A clear mechanistic description of the critical operating conditions (for instance, critical pressure) which can minimize the propensity of colloidal membrane fluting. 5) Developing theoretical approaches to account for polydisperse systems that can render the models capable of handing realistic feed solutions typically encountered in diverse applications of membrane filtration.

• 상하수도학회지
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• 제27권1호
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• pp.101-112
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• 2013

Integrated process with coagulation and microfiltration as an advanced water treatment has been expanded its application in recent years due to its superb removal of particles and natural organic matter. In usual, effectiveness of coagulation sometimes determines performance of the whole system. Several new polymeric coagulants introduced to water utilities for better efficiency were studied in this paper. Three polymeric coagulants (i.e., PACl, PACs, and PAHCs) along with alum were evaluated for removal of natural organic matter, especially for reduction of trihalomethane formation potential, for which regulation has become stringent. Turbidity removal was closely related to pH variation showing the reduced turbidity removal by PACs due to the decreases in the pH of supernants at high doses. The four coagulants showed different organic matter removal during coagulation and affected the removal in microfiltration. For instance, DOC concentration was not reduced by microfiltration when PAHCs were used however 10 % of DOC removal was observed by microfiltration with alum coagulation. Coagulation pretreatment also impacted the THM removals, i.e., approximately 30 % of THMs and 13 % of DOC was removed by microfiltration only, but 40 to 67 % of THMs and 30 % of DOC was removed by the integrated process. Strategies on selection of coagulants are needed depending on characteristics of target pollutants in raw waters.

• 한국응용과학기술학회지
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• 제28권2호
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• pp.170-177
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• 2011

Transdermal drug delivery(TDS) offers many important advantages. For instance, it is easy and painless, it protects the active compound from gastric enzymes, and it avoids the hepatic first-pass effect. Also, it is simple to terminate the therapy if any adverse or undesired effect occurs. But skin is a natural barrier, and only a few drugs can penetrate the skin easily and in sufficient quantities to be effective. Therefore, in recent years, numerous studies have been conducted in the area of penetration enhancement. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other method of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharide, such as xanthan gum and algin were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers and drug contents. Among these polysaccharide, the permeation rate of Paroxetine such as lipophilic drug was the fastest in xanthan gum matrix in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.