• Microbiology and Biotechnology Letters
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• v.24 no.6
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• pp.717-725
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• 1996

We have developed an efficient immobilized cell separator for continuous operation of immobilized fungal cell cultures, and applied this separator to actual fermentation process for the production of cyclosporin A (CyA), a powerful immunosuppressant. In the experiments employing highly viscous polymer (carboxymethyl cellulose) solution, the decantor showed good separating performances at high solution viscosites and fast dilution rates. Air duct and cylindrical separator installed inside the decantor turned out to play key roles for the efficient separation of the immobilized cells. By installing the decantor in an immobilized perfusion reactor system (IPRS), continuous immobilized culture was stably carried out even at high dilution rate for a long period, leading to high productivities of free cells and CyA. Almost no immobilized biomass existed in effuluent stream of the IPRS, demonstrating the effectiveness of the decan- tor system for a long-term continuous fermentation. It was noteworthy that we could obtain these results despite of the unfavorable fermentation conditions, i.e., reduced density of the biosupports caused by overgrowth of cells inside the bead particles and existence of high density of suspended fungal cells (10g/l) in the fermentation broth.

• Journal of the Korea Society of Computer and Information
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• v.21 no.3
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• pp.91-96
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• 2016

We have surrounded undesired living noises in our life. One of biggest noises coming out of range hood during cooking in the kitchen. A range hood is one of the most important appliances in the kitchen because it ventilates polluted air out during cooking, and maintains air quality in the kitchen. But current kitchen range hoods bring up some issues; First, the range hoods consume massive amount of standby power not in use condition. Second, current models have designed manual fan operating system with sudden onset of noise with starting. In this paper, we propose an auto control system entire processes from air ventilation to noise reduction. Our system is consist of three parts (Eco-sensors pack, Main Controller and Active Noise Controller); Eco-sensors pack detects air pollution of kitchen areas and sends the detection values to Main Controller. Main Controller determines operation of range hood by detected values. Active Noise Controller is located inside of the range hood. It received starting signals from Main Controller which elicits degrees of polluted air condition and fan operating speed from 1 to 3. Once Active Noise Controller detected the signals, it runs a ventilating fan until new value from Main Controller becomes 0. while the range hood works, A noise cancellation algorithm inside of Active Noise Controller become activated to reduce levels of noise. As a result, the proposed system clearly shows reduction in power consumption include standby power and decreases in levels of noise.

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.176-176
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• 2001

목적： 기존의 역수신코일(inside-out receiver coil)로 관벽의 MR 영상을 얻을 때 영상영역이 좁고 수신감도가 불균일한 단점을 보완하면서 신호대 잡음비(S/N ratio)도 높일 수 있는 회전자계역수 신코일(quadratic inside-out receiver coil)의 개발을 목적으로 한다. 대상 및 방법： 8극형코일, 선형자계수신코일, 회전자계수신코일에 대하여 컴퓨터 모의실험으로 영상영역 및 감도의 균일성을 비교하였다. 회전자계수신코일은 안장 모양을 한 두 개의 선형자계코일이 서로 간섭이 일어나지 않도록 수직 방향으로 배열된 구조를 갖도록 하였다. 지름 3 cm 크기로 각 코일을 제작하였으며 지름 20 cm의 원통 중앙에 내경 4 cm의 관이 있는 팬텀을 만들어 MnC1$_2$를 섞은 물을 채운 다음 1.5T 초전도 MRI 장치와 0.3T 영구자석 MRI 장치에서 팬텀의 관벽 영상을 얻었다. 본 실험을 시행한 1.5T 장치의 구조 때문에 회전자계코일의 두 안장코일을 결합하는 회로를 제작하여 사용하였고 0.3T에서는 장치에 내장된 결합회로를 사용하였다. 또한 포르말린 용액에 보관된 소의 대장 조직 단면 영상을 FOV 10-12 cm로 얻어 회전자 계안장코일의 성능을 평가하였다.

• 한국가시화정보학회:학술대회논문집
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• 2002.04a
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• pp.79-84
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• 2002

Most microfluidic devices such as heat sinks for cooling micro-chips, DNA chip, Lab-On-Chip, and micro pumps etc. have microchannels of various size. Therefore, the design of practical microfluidics demands detail information on flow structure inside the microchannels. However, detail velocity field measurements are rare and difficult to carry out. In addition, as the microfluidics expands, accurate understanding of microscale transport phenomena becomes very important. In this research, micro-PIV system was employed to measure the velocity fields of flow inside a micro-channel. We carried out PIV measurements for several microchannels with varying channels width, inlet and outlet shape, filters, CCD camera and ICCD camera, etc. For effective composition of micro-PIV system, first of all, it is essential to understand optics related with micro-imaging of particles and the particle dynamics encountered in micro-scale channel flows. In addition, it is necessary to find the optimal condition for given experimental environment and? micro-scale flow to be investigated. The problems encountered in measuring velocity field of micro-channel flows are discussed in this paper.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1996.04a
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• pp.19-23
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• 1996

Deburring and edge finishing technology as the last process of machining operation is required for manufacturing of advanced procesion components, duburring has treated as a difficult problem on going tothe highefficency, automation in the FMS. Removal of butt with various shapes, dimensions and properties coultn't has a standard and has depended on manual treatment. Especially, deburring for cross hole inside owing to passing through out perpendicular to a main hole is more difficult, the electrolytic method is proper as its solution at practical aspects. Therefore, for the high effciency and automation of intermal deburring in the cross hole, development of electrolytic debutting technology is needed. So, the new process in the burr treatment is supposed. In this study, in the eliminating burr inside cross hole, the principle and machining performances of electrochemical deburring by Cubic-Boron-Nitrade abrasive electroplate wheel are investigated, Design and manufacture of CBN electroplated wheel and analysis of characteristics with electrolytic debutting are achieved. Also deburring efficiency and electrolytic performance for cross hole were examined according to electrolytic current and electrolytic deburring condition corresponding to acquired edge quality was found out.

• Applied Microscopy
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• v.43 no.2
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• pp.88-97
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• 2013

Technical investigation to figure out the problems arising during in-situ heating electron backscatter diffraction (EBSD) analysis inside scanning electron microscopy (SEM) was carried out. EBSD patterns were successfully acquired up to $830^{\circ}C$ without degradation of EBSD pattern quality in steels. Several technical problems such as image drift and surface microstructure pinning were taking place during in-situ experiments. Image drift problem was successfully prevented in constant current supplying mode. It was revealed that the surface pinning problem was resulted from the $TiO_2$ oxide particle formation during heating inside SEM chamber. Surface pinning phenomenon was fairly reduced by additional platinum and carbon multi-layer coating before in-situ heating experiment, furthermore was perfectly prevented by improvement of vacuum level of SEM chamber via leakage control. Plane view in-situ observation provides better understanding on the overall feature of recrystallization phenomena and cross sectional in-situ observation provides clearer understanding on the recrystallization mechanism.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.6
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• pp.685-692
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• 2003

A numerical simulation of flame propagation in a micro combustor was carried out. Combustor has a sub -millimeter depth cylindrical internal volume and axisymmetric one-dimensional was used to simplify the geometry. Semi-empirical heat transfer model was used to account for the heat loss to the walls during the flame propagation. A detailed chemical kinetics model of $H_2/Air$ with 10 species and 16 reaction steps was used to calculate the combustion. An operator-splitting PISO scheme that is non-iterative, time-dependent, and implicit was used to solve the system of transport equations. The computation was validated for adiabatic flame propagation and showed good agreement with existing results of adiabatic flame propagation. A full simulation including the heat loss model was carried out and results were compared with measurements made at corresponding test conditions. The heat loss that adds its significance at smaller value of combust or height obviously affected the flame propagation speed as final temperature of the burnt gas inside the combustor. Also, the distribution of gas properties such as temperature and species concentration showed wide variation inside the combustor, which affected the evaluation of total work available of the gases.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.05a
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• pp.991-995
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• 2002

The engine booming noise heard inside a vehicle's cabin is due to the engine vibration that's transferred to the chassis in the form of structural vibration and it often causes discomfort to the passenger. In an effort to seek out the possible relation between the engine booming noise and the engine vibration of a vehicle, a position on the engine mount was selected and the vibration transmission through the position was attenuated to observe the corresponding change in the noise level inside the cabin. A system consisting of an actuator and a hybrid controller that has both the feed-forward and feed-back capabilities was developed in order to carry out the experiment.

• Journal of The Korean Astronomical Society
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• v.48 no.2
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• pp.139-154
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• 2015

We carry out three-dimensional hydrodynamic simulations of the supernova remnants (SNRs) produced inside molecular clouds (MCs) near their surface using the HLL code (Harten et al. 1983). We explore the dynamical evolution and the X-ray morphology of SNRs after breaking through the MC surface for ranges of the explosion depths below the surface and the density ratios of the clouds to the intercloud media (ICM). We find that if an SNR breaks out through an MC surface in its Sedov stage, the outermost dense shell of the remnant is divided into several layers. The divided layers are subject to the Rayleigh-Taylor instability and fragmented. On the other hand, if an SNR breaks through an MC after the remnant enters the snowplow phase, the radiative shell is not divided to layers. We also compare the predictions of previous analytic solutions for the expansion of SNRs in stratified media with our onedimensional simulations. Moreover, we produce synthetic X-ray surface brightness in order to research the center-bright X-ray morphology shown in thermal composite SNRs. In the late stages, a breakout SNR shows the center-bright X-ray morphology inside an MC in our results. We apply our model to the observational results of the X-ray morphology of the thermal composite SNR 3C 391.

• International Journal of Naval Architecture and Ocean Engineering
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• v.7 no.1
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• pp.70-86
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• 2015

Short crested waves play an important role for planning and design of harbours. In this context a numerical simulation is carried out to evaluate wave tranquility inside a real harbour located in east coast of India. The annual offshore wave climate proximity to harbour site is established using Wave Model (WAM) hindcast wave data. The deep water waves are transformed to harbour front using a Near Shore spectral Wave model (NSW). A directional analysis is carried out to determine the probable incident wave directions towards the harbour. Most critical threshold wave height and wave period is chosen for normal operating conditions using exceedence probability analysis. Irregular random waves from various directions are generated confirming to Pierson Moskowitz spectrum at 20m water depth. Wave incident into inner harbor through harbor entrance is performed using Boussinesq Wave model (BW). Wave disturbance experienced inside the harbour and at various berths are analysed. The paper discusses the progresses took place in short wave modeling and it demonstrates application of wave climate for the evaluation of harbor tranquility using various types of wave models.