• Design & Manufacturing
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• 제2권2호
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• pp.33-37
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• 2008

This paper describes the optimization of injection molding conditions to minimize sink marks. Sink marks, which refer to a small depression on the surface opposite a thick wall thickness, are often encounted in injection molded plastic parts. Part geometry, material properties and processing conditions during injection molding can affect the sink mark depth. We designed the runner system which is possible balanced filling to cavities using CAE program and then obtained optimal processing conditions by Taguchi's Robust Design technique. By actual injection molding using optimized mold and molding conditions, it confirmed that sink mark depth decreased zero compared to 1mm level in the conventional mold and process.

• 천문학회지
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• 제34권4호
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• pp.293-295
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• 2001

A numerical scheme that incorporates a self-consistent cosmic-ray (CR, hereafter) injection model into the combined gas dynamics and CR diffusion-convection code has been developed. The hydro/CR code can follow in a very cos-effective way the evolution of CR modified shocks by adopting subzone shock-tracking and multi-level Adaptive Mesh Refinement techniques. The injection model is based on interactions of the suprathermal particles with self-generated MHD waves in quasi-parallel shocks. The particle injection is followed numerically by filtering the diffusive flux of suprathermal particles across the shock to upstream region according to a velocity-dependent transparency function, which represents the fraction of leaking suprathermal particles. In the strong shock limit of Mach numbers $\ge$20, significant physical processes such as the injection and acceleration seem to become independent of M, while they are sensitively dependent on M for M < 10. Although some particles injected early in the evolution continue to be accelerated to higher energies, the postshock CR pressure reaches a time asymptotic value due to balance between acceleration and diffusion of the CR particles.

• 한국정밀공학회지
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• 제25권7호
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• pp.111-115
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• 2008

This paper describes the optimization of injection molding conditions to minimize sink marks. Sink marks, which refer to a small depression on the surface opposite a thick wall thickness, are often encounted in injection molded plastic parts. Part geometry, material properties and processing conditions during injection molding can affect the sink mark depth. We designed the runner system which is possible balanced filling to cavities using CAE program $Moldflow^{TM}$ and then obtained optimal processing conditions by Taguchi's Robust Design technique. By actual injection molding using optimized mold and molding conditions, it confirmed that sink mark depth decreased zero compared to 1mm level in the conventional mold and process.

• 한국산업융합학회 논문집
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• 제23권3호
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• pp.507-513
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• 2020

Liquid filling machines are frequently used in packaging fields; however, there exists a problem in precisely measuring the quantity of the liquid. In the case where the liquid filling machine is not properly metered, there may be issues, such as the fluid exceeding the capacity or chemicals being exposed outside. In this paper, we propose a smart injection nozzle device that can solve the issues stated above. The proposed smart injection nozzle can raise the nozzle according to the water level to remove bubbles and inject the accurate amount of fluid. In addition, the efficiency of the logistics process is enhanced by the smart QR code. Through experiments using the developed smart injection nozzle device, we have noticed that the accuracy of injection capacity, nozzle position, reaction time and building data exceeded the target value. Therefore, it expected that this machine will give more production and save a lot of manpower for packaging industry.

• Asian-Australasian Journal of Animal Sciences
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• 제13권5호
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• pp.653-658
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• 2000

To examine the effects of lipoic acid on metabolic response to a ${\beta}$-agonist, isoproterenol, in broilers, chicks were fed dietary lipoic acid at levels of 0 (control) or 50 mg/kg for 24 d. At 27 d of age, chickens were randomly selected. Isoproterenol dissolved in 0.9% saline was injected into the wing vein at a dosage of 2 mg per kg BW; then, blood samples were taken at 0, 10, 20, 30, 60, 90, 120, and 180 min. Amounts of plasma glucose, NEFA, triglyceride and total cholesterol were determined. Dietary lipoic acid reduced only plasma total cholesterol by 25%. Following isoproterenol injection, plasma glucose in both groups increased for 20 min; then, it returned to its basal concentration. In contrast, the maximal reductions in plasma NEFA and triglyceride in both groups (20 to 30 min) were confirmed by isoproterenol injection. In addition, while glucose returned to the basal level, plasma NEFA in the lipoic acid-treated chickens increased above the basal or control value during the 60 to 180 min post-injection. The present study suggests that the dietary administration of lipoic acid elicits fatty acid mobilization in ${\beta}$-adrenergic response to isoproterenol when the basal level of plasma glucose is maintained.

• 대한유전성대사질환학회지
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• 제5권1호
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• pp.9-17
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• 2005

Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine ${\beta}$-synthase (CBS). Patients with homocystinuria show clinical symptoms such as mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms and skeletal deformities. Generally, the major treatments for CBS deficiency include pharmacologic doses of pyridoxine or dietary restriction of methionine. However, there is no effective treatment for this disease up till today and gene therapy can be an attractive novel approach to treatment of the disease. We investigated whether a recombinant adeno-associated virus could be used as a CBS gene transfer vector to reduce the excessive homocysteine level in the homocystinuria mouse model. Recombinant adeno-associated virus vector encoding the human CBS gene (rAAV-hCBS), driven by EF1-a promoter, was infused into CBS-deficient mice ($CBS^{-/-}$) via intramuscular (IM) and intraperitoneal (IP) injection. IP injection was more efficient than IM injection for prolongation of lives and reduction of plasma homocysteine levels. After 2 weeks of gene transfer by IP injection, serum homocysteine level was significantly decreased in treated mice compared with the age-matched controls and the life span was extended about 1.5 times. Also, increased expression of CBS gene was observed by immunohistochemical staining in livers of treated $CBS^{-/-}$ mice and microvesicular lipid droplets was decreased in cytoplasm of liver. These results demonstrate the possibility and efficacy of gene therapy by AAV gene transfer in homocystinuria mice.

• 약학회지
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• 제54권5호
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• pp.403-409
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• 2010

Gardenia jasminoides is a popular traditional herb used to treat inflammatory diseases including liver disorders. This study was performed to examine protective effect of G. jasminoides on galactosamine (GalN)-induced acute hepatitis. Rats were treated intraperitoneally with GalN (700 mg/kg). G. jasminoides (30, 100 and 300 mg/kg) was administered orally 48, 24, and 2 h before and 6 h after GalN injection. Serum ALT and AST activities were significantly increased after GalN injection, and these increases were attenuated by G. jasminoides. Histological studies showed that G. jasminoides inhibited hepatocellular necrosis with inflammatory cell infiltration. GalN decreased the serum levels of total cholesterol and this decrease was attenuated by G. jasminoides. Hepatic glutathione content was decreased and lipid peroxidation was increased after GalN treatment and these changes were attenuated by G. jasminoides. Furthermore, the level of tumor necrosis factor-${\alpha}$ mRNA expression was significantly increased after GalN injection, and this increase was attenuated by G. jasminoides. The level of interleukin-10 mRNA expression was significantly increased after GalN injection, and this increase was augmented by G. jasminoides. Our results suggest that G. jasminoides ameliorates GalN-induced acute hepatitis and this protection is likely due to antioxidative activity and regulation of inflammatory mediators.

• Journal of Pharmaceutical Investigation
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• 제17권4호
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• pp.213-216
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• 1987

The distribution features of recombinant human $alpha-interferon(rHuIFN-{\alpha}A)$ and $^{14}C-radiolabeled\;rHuIFN-{\alpha}A\;(^{14}C-rHuIFN-{\alpha}A)$ were investigated in ICR mice after i.v. injection. The level of $rHuIFN-{\alpha}A$ in the kidney was significantly higher than those in lung and liver at 10min after the injection. But the level was reduced significantly at 60min. The level of radioactivity in the kidney was also significantly higher than those in other organs after i.v. injection of $^{14}C-rHuIFN-{\alpha}A$, but it was reduced at much slower speed than was $rHuIFN-{\alpha}A$. These results show that interferon is distributed repidly and the kidney is the main site of distribution and metabolism of $rHuIFN-{\alpha}A$.

• Preventive Nutrition and Food Science
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• 제1권1호
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• pp.69-74
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• 1996

Capsaicin(CAP) is a pungent ingredient of hot pepper that has been used as a spicy food additive, pre-servative, and medicine. In this study, the effect of CAP on L-ascorbic acid(AsA)level in various tissues as well as its urinary excretion. and drug-metabolizing enzyme activity in rats were investigated. Rats fed AsA-deficient diets for 17days were injected intraperitoneally with 1mg of CAP in 0.5ml of ethanol-Tween 80-saline(20 :10 : 70, v/v/v). Control rats received the equal volume of the same solution without CAP. Urine was collected for 3 day after the CAP injection, and after 5 days tissues were removed; their AsA contents were measured by high performance liquid chromatography combined with and electrochemical detector. In addition, hepatic microsomal ethoxyresorfin O-deethylase(EROD) activity as measured. Urinary AsA excretion changed significantly following CAP injection. One and two days after CAP injection, the urinary AsA increased 2-and 3-fold in the CAP injected group, compared to the control, but the contents of adrenal glands and brain were lower than those of the control Dehydroascorbic acid contents in adrenal glands of the CAP injected group were higher than that of the control These results suggested that a single large dose of CAP could temporarily cause the redistribution of AsA in tissues accompanying by its urinary excretion, by affecting probably a biological system including mixed function oxygenase system(MFOS)

• Journal of Power Electronics
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• 제19권6호
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• pp.1496-1504
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• 2019

This paper proposes a new THD reduction algorithm for modular multilevel converters (MMCs) with offset voltage injection operated in nearest level modulation (NLM). High voltage direct current (HVDC) is actively introduced to the grid connection of offshore wind powers, and this paper deals with a voltage generation technique with an MMC for wind power generation. In the proposed method, third harmonic voltage is added for reducing the THD. The third harmonic voltage is adjusted so that each of the pole voltage magnitudes maintains a constant value with a maximum number of (N+1) levels, where N is the number of sub-modules per arm. By using the proposed method, the THD of the output voltage is mitigated without increasing the switching frequency. In addition, the proposed method has advantageous characteristics such as simple implementation. As a part of this study, this paper compares the THD results of the conventional method and the proposed method with offset voltage injection to reduce the THD. In this paper, simulations have been carried out to verify the effectiveness of the proposed scheme, and the proposed method is implemented by a HILS (Hardware in the Loop Simulation) system. The obtained results show agreement with the simulation results. It is confirmed that the new scheme achieved the maximum level output voltage and improved the THD quality.