• 품질경영학회지
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• 제46권3호
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• pp.441-452
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• 2018

Purpose: The purpose of this paper is to study quantitative risk grade assessment for objective government quality assurance activities based on risk management in initial mass production for weapon systems. Methods: The Defense quality management regulations and foreign risk assessment documents are referred to analyze problems performing quality assurance actives. The failure rate data, maintainability and cost of products have been studied to quantify the risk Likelihood and impact. The analyzed data were classified as risk grade assessment through K-means Cluster Analysis method. Results: Results show that a proposed method can objectively evaluate risk grade. The analyzed results are clustered into three levels such as high, middle and low. Two products are allocated high, eleven low and seven middle. Conclusion: In this paper, quantitative risk grade assessment methods were presented by analyzing risk ratings based on objective data. The findings showed that the methods would be effective for initial mass production for weapon systems.

• 농약과학회지
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• 제9권3호
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• pp.214-220
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• 2005

초기위해성평가는 신물질 개발시 급성자료와 물리화학적 특성자료를 이용하여 위해성평가를 수행하고 정책결정자들에게 위해성에 관한 정보를 제공하여 의사결정 수단으로 활용되고 있다. 본 연구에서는 초기위해성평가 체계의 틀을 구축하고 구축된 위해성평가 체계를 검증하기 위하여 captan, glyphosate, paraquat dichloride의 세 가지 농약을 대상물질로 하여 인체 및 생태의 초기위해성을 평가하였다. 이때 두 종류의 수계 예측 모형인 GENEEC (GENeric Estimated Environmental Concentration)과 FOCUS (FOrum for the Co-ordination of pesticide models and their USe)가 농약의 노출평가를 위하여 사용되었으며 glyphosate와 paraquat dichloride는 인체 및 생태에 위해성이 낮은 것으로 나타났으나 captan의 어류 위해성은 급성독성이 높은 것으로 나타났다. 이 결과는 U.S. EPA RED (Reregistration Eligibility Decision) 결과와 유사한 경향성을 보여 본 연구체계의 신뢰성을 검증할 수 있었다.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2017년도 추계학술발표회
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• pp.155-155
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• 2017

• 설비공학논문집
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• 제25권10호
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• pp.534-539
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• 2013

In general, entire supply air of the BSL3 laboratory should be vented to the outside for its biosafety and the air conditioning system should always be operating to maintain a room pressure difference. In this regard, annual energy consumption is approximately five or ten times greater than the magnitude of the office building. In addition, to adjust room pressure difference to the set value efficiently, the supply and exhaust duct system are installed in each room of the BSL3 lab. Thus, initial construction cost is extremely high. In this study, multizone simulation is performed to estimate maintaining the appropriate room pressure difference in the case of changing model A (each room supply and exhaust system) to model B (each zone supply and exhaust system) for verification of the BSL3 lab biosafety. Also, in the case of these two models, the multizone simulation for three kinds of biohazard scenario is performed as part of risk assessment. The analysis of initial construction cost of two models is conducted for comparison. According to the studies, initial construction cost of model B is less than about 22% of existing model A. Moreover, biosafety of the BSL3 lab is still maintaining in the case of the two models.

• 환경영향평가
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• 제14권5호
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• pp.347-353
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• 2005

The risk assessment is the qualitative or quantitative evaluation of the risk posed to human health and the environment by the actual or potential presence or release of hazardous substances, pollutants or contaminants. The environmental impact assessment (EIA) is assessed by the environmental criteria, and risk assessment is assessed by the risk rate. Risk rate based on dose-response values may not be easy to apply on regulatory basis like EIA for uncertainty. Internationally there is an example of OECD program. Risk assessment of High Production Volume (HPV) Chemicals has started since the OECD Program with the 1990 Council Act on the Co-operative Investigation and Risk Reduction of Existing Chemicals. These HPV chemicals include all chemicals produced or imported at levels greater than 1,000 tonnes per year in at least one Member country or in the European Union region. The SIDS called the Screening Information Data Set is regarded as the minimum information needed to assess an HPV chemical to determine whether any further work should be carried out or not. All the data elements of SIDS including assessment for environment and health are prepared as three formats of the full SIDS Dossier, the SIDS Initial Assessment Report (SIAR), and the SIDS Initial Assessment Profile (SIAP) of an HPV chemical. In 1998 the global chemical industry through the International Council of Chemical Associations (ICCA) has joined to work with OECD. The OECD has assessed approximately 1,000 chemicals from 1991 through 2004 with ICCA. Till the February of 2005, 592 chemicals of those chemicals completed SIDS reports. Member countries have been targeted the goal of 1,000 new chemicals from 2005 to 2010 and Korea shared 36 chemicals from the 1,000 new chemicals. Currently Korea has completed SIDS reports of 7 chemicals among sponsored 24 chemicals. In conclusion SIDS project will be linked to national program for outputs application with more reliable production. Both the OECD and industry will carry out their commitment to complete assessments for more and the remaining chemicals assessment. The major outputs will contribute to cope with international chemical management.

• 시스템엔지니어링학술지
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• 제11권1호
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• pp.9-24
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• 2015

Construction industry faces a lot of inherent uncertainties and issues and the construction phase of nuclear power project is not free from this risk. This paper investigates promising methodologies to be used on nuclear power plant (NPP) construction schedule delay risk assessment by using entry level systems engineering approach. This study contains how the initial concept for the risk assessment methodology has been developed. In this point of view, this work structured on three main phases: needs analysis (NA), concept exploration (CE), and concept definition (CD) through systems engineering (SE) approach. Traditionally, the SE process is applied to technical development programs but this study opens up a new avenue that SE can also be successfully applied to the development and optimization of the risk assessment model. This study provides a rational and systematic process for developing and selecting the best risk assessment model. This paper selects analytic hierarchy process (AHP) method to assess NPP construction schedule delay risk for international project. As conclusion, the proposed concept and selected method can discriminate successfully and clearly among schedule delay risk assessment methods.

• Toxicological Research
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• 제18권1호
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• pp.23-29
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• 2002

Disodium disulphite, the HPV chemical, was assigned to Korea in order to implement OECD SIDS program in 1999. It was produced about 3,200 ton/year in 1998. This report evaluates the toxic potency of disodium disulphite based on the environmental and mammalian effects as well as human exposure. Oral $LD_{50}$ in rats is 1,540 mg/kg b.w. and effects was observed to the stomach, liver and the GI track that was filled with blood. For repeated dose toxicity, the predominant effect was the induction of stomach lesion due to local irritation. The no observed adverse effect lever for local (stomach irritation) was about 217 mg/kg bw/day. There is no evidence that disodium disulphite is genotoxic in vivo. No reproductive or developmental toxicty of disodium disulphite was observed for the period up to 2 yr and over three generation. In humans, urticaria and asthma with itching, edema, rhinitis, and nasal congestion were reported. Disodium disulphite is unlikely to induce respiratory sensitization but may enhance symptom of asthma in sensitive individuals. This chemical would be mainly transported to water compartment when released to environmental compartments since it is highly water soluble (470 g/l at 20). Low K oc (2.447) indicates disodium disulphite is so mobile in soil that it may not stay in the terrestrial compartment. The chemical has been tested in a limited number of aquatic species. hem acute toxicity test to fish, 96 hr-$LC_{50}$ was > 100 mg/1. For algae, 72 hr-$XC_{50}$ was 48.1 mg/1. For daphnid, the acute toxicity value of 48 hr-$EC_{50}$ was 88.76 mg/1, and chronic value of 21day-NOEC was > 10 mg/1. Therefore, PNEC of 0.1 mg/l for the aquatic organism was obtained from the chronic value of daphnid using the assessment factor of 100. Based on these data the disodium disulphite was recommended as low priority for further post-SIDS work in OECD.

• Toxicological Research
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• 제18권1호
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• pp.13-22
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• 2002

In Korea, 2,320 tonnes of acetanilide were mostly wed as intermediates for synthesis in phar-maceuticals or additives in synthesizing hydrogen peroxide, varnishes, polymers and rubber. Only small amount of 120 kg were wed as a stabilizer for hydrogen peroxide solution for hair colouring agents in 1998. Readily available environmental or human exposure data do not exist in Korea at the present time. However, potential human exposures from drinking water, food, ambient water and in work places are expected to be negligible because this chemical is produced in the closed system in only one company in Korea and the processing factory is equipped with local ventilation and air filtering system. Acetanilide could be distributed mainly to water based on EQC model. This substance is readily biodegradable and its bioaccumulation is low. Acute toxicity of acetanilide is low since the L $D_{50}$ of oral exposure in rats is 1,959 mg/kg bw. The chemical is not irritating to skin, but slightly irritating to the eyes of rabbits. horn repeated dose toxicity, the adverse effects in rats were red pulp hyperplasia of spleen, bone marrow hyperplasia of femur and decreased hemoglobin, hematocrit and mean corpuscular hemoglobin concentration. The LOAEL for repeated dose toxicity in rats was 22 mg/kg/day for both sexes. Acetanilide is not considered to be genotoxic. In a reproductive/developmental toxicity study, no treatment-related changes in precoital time and rate of copulation, impregnation, pregnancy were shown in all treated groups. The NOAELs for reproduction and developmental toxicity (off-spring toxicity) are considered to be 200 mg/kg bw/day and 67 mg/kg bw/day, respectively. Ecotoxicity data has been generated in a limited number of aquatic species of algae (72 hr- $E_{b}$ $C_{50}$; 13.5 mg/l), daphnid (48hr-E $C_{50}$ > 100 mg/l) and fish (Oryzias latipes, 96hr-L $C_{50}$; 100 mg/l). Form the acute toxicity values, the predicted no effect concentration (PNEC) of 0.135 mg/1 was derived win an assessment factor of 100. On the basis of these data, acetanilide was suggested as currently of low priority for further post-SIDS work in OECD.in OECD.D.

• 한국환경과학회지
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• 제24권7호
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• pp.865-874
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• 2015

This study was conducted to investigate the correlation between the distribution chart and input data of the predicted 3-second gust and damage cost, by using the forecast field and analysis field of Regional Data Assimilation Prediction System (RDAPS) as initial input data of Korea risk assessment model (RAM) developed in the preceding study. In this study the cases of typhoon Rusa which caused occurred great damage to the Korean peninsula was analyzed to assess the suitability of initial input data. As a result, this study has found out that the distribution chart from the forecast field and analysis field predicted from the point where the effect due to the typhoon began had similarity in both 3-second gust and damage cost with the course of time. As a result of examining the correlation, the 3-second gust had over 0.8, and it means that the forecast field and analysis field show similar results. This study has shown that utilizing the forecast field as initial input data of Korea RAM could suit the purpose of pre-disaster prevention.

• 한국농공학회논문집
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• 제48권2호
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• pp.77-87
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• 2006

The reuse of wastewater for agricultural irrigation may cause human health risk as a result of exposure to pathogens. This study conducted the quantitative microbial risk assessment in paddy field irrigated with treated wastewater. Six treatments were used to irrigate the paddy field from Year 2003 to Year 2005: biofilter-effluent, UV-disinfected water (6, 16, 40, 68 $mW s cm^{-2}$), pond-treated water, wetland-treated water, conventional irrigation water and tap water. Total coliforms, fecal coliforms and E. coli were monitored during rice growing period. Beta - Poisson model was employed to calculate the microbial risk of pathogens ingestion that may occur to farmers and neighbor children. Uncertainty of risk was estimated using Monte Carlo simulation. In this study, the microbial risk was higher during initial cultivation (end of May$\sim$June), and it decreased with time. Biofilter effluent (secondary effluent) irrigation showed higher risk values than others (>$10^{-4}$) and irrigation with UV-disinfected water has the lowest risk range ($10^{-6}{\sim}10^{-5}$). The risk value estimated in 2005 was lower than risk value in 2003 and 2004, it is likely due to clean tap water irrigation in initial transplanting stage. It is suggested that irrigation with UV-disinfected water and pond-treated water would reduce the microbial risk associated with wastewater irrigation in paddy field. In addition, the first irrigation water quality significantly affected the subsequent microbial risk.