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Determination of Translocation and Deacylation Rate Constants for Complex Formation between Serpin and Protease

  • Shin, Jong-Shik;Yu, Myeong-Hee
    • Proceedings of the Korean Biophysical Society Conference
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    • 2001.06a
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    • pp.62-62
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    • 2001
  • Serpins inhibit target proteases by forming tight acyl complex Via incorporation of the reactive center loop into ${\beta}$-sheet A. Metastability of the serpins control the translocation of the protease from the initial binding site to the opposite pole of the serpin. Recently the crystal structure of a serpin-protease complex revealed that the active site of the protease is distorted.(omitted)

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Clinic Study on Herb Medication for Patients Who have a Chronic Respiratory Disease from the Cold Sequelae (감모후유증(感冒後遺症)으로 기허형(氣虛型)호흡기 질환을 호소하는 환자의 한약치료에 관한 임상연구)

  • Kim, Hyun-Jin;Han, Hyo-Jung;Jang, Jeong-A;Park, Eun-Young;An, Tae-Han;Seo, Ho-Seok;Kim, Jin-Won
    • Herbal Formula Science
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    • v.18 no.1
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    • pp.181-189
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    • 2010
  • Objectives : In order to confirm a remedial effect and related influence of the clinic treatment by prescribing Samchuljojung-tang(蔘朮調中湯), Bojungikqi-tang(補中益氣湯) and Samso-um(蔘蘇飮) to patients who suffering from a chronic cough and rhinorrhea. Methods : 1. In a clinical observation and analysis method, we have selected the 23 patients who have visited National Oriental Medical Center, date from 2007.8.21 to 2008.7.31 and suffering from a chronic cough and rhinorrhea caused by the common cold sequelae. 2. Separated them into three types(I: cough type, II: rhinorrhea type, III: cough & rhinorrhea type). 3. Observed thoroughly the level of symptom and recorded it for each type with questionnaire survey at the beginning set 4. Prescribed Samchuljojung-tang, Bojungikqi-tang and Samso-um for type I, II, III respectively. 5. Observed the level of symptom and treatment afterwards affect, and recorded movements of intensity level for 3 types with same questionnaires. Results : 1. Type I : The survey turned out to be from 9 patients, initial level recorded 31.89 at the entry diagnosis, and next level that means changing of symptoms, recorded to 12.67 after prescribing herb medication. 2. Type II : From 11 patients, initial level was 32.82 and next level was 13.45. 3. Type III : From 3 patients, initial level was 37.67 and next one was 16.00. Conclusions : It is concluded that there is a significant remedial effect and related influence of the clinic treatment for each type of patients who suffering from a chronic cough and rhinorrhea caused by the common cold sequelae.

Verification of a Relationship between Ultraviolet Radiation and Initial Microalgal Cell Density Using a Floating Marine Photobioreactor (부유형 해양 광생물반응기를 이용한 자외선과 초기 미세조류 접종 농도와의 상관관계 규명)

  • Kim, Z-Hun;Park, Hanwool;Jung, Seong-Gyun;Kim, Su-Kwon;Kim, Hee-Yun;Park, Yong Sung;Hong, Han Ma Roo;Lee, Choul-Gyun
    • Journal of Marine Bioscience and Biotechnology
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    • v.7 no.2
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    • pp.52-57
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    • 2015
  • The purpose of this study was to investigate a relationship between ultraviolet radiation and initial cell density (ICD) of microalgae using a floating marine photobioreactor (PBR). To examine the effect of ultraviolet (UV) radiation in sunlight on biomass productivity as a function of ICD, 0.5-L floating PBRs covered with or without UV cut-off film were placed in an outdoor rectangular tank containing 200 L of water. At the lower ICDs, 0.01 and 0.05 g/L, biomass productivities in the PBRs without UV cut-off film decreased by $278{\pm}21%$ and $222{\pm}3%$ compared with those with the film, respectively. In contrast, the presence of UV cut-off film did not have a significant effect on biomass productivities at the higher ICDs, 0.25 and 1.25 g/L. When the differences in biomass productivity made by the UV cut-off film were plotted against the sum of cell projection area per light receiving area of the PBR, the results revealed that the inhibitory effect of UV on biomass productivity can be negligible when the sum of cell projection area is equal to the light receiving area of the PBR. These results show that photoinhibition caused by UV radiation could be eliminated via operating the PBR with a proper ICD.

Improvement of Alignment Accuracy in Electron Tomography

  • Jou, Hyeong-Tae;Lee, Sujeong;Kim, Han-Joon
    • Applied Microscopy
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    • v.43 no.1
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    • pp.1-8
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    • 2013
  • We developed an improved method for tilt series alignment with fiducial markers in electron tomography. Based on previous works regarding alignment, we adapted the Levenberg-Marquardt method to solve the nonlinear least squares problem by incorporating a new formula for the alignment model. We also suggested a new method to estimate the initial value for inversion with higher accuracy. The proposed approach was applied to geopolymers. A better alignment of the tilt series was achieved than that by IMOD S/W. The initial value estimation provided both stability and a good rate of convergence since the new method uses all marker positions, including those partly covering the tilt images.

Effect of Initial Orientation and Austenitic Phase on Texture Evolution in Ferritic Stainless Steels (페라이트계 스테인레스강의 집합조직 형성에 미치는 초기 방위 및 오스테나이트사의 영향)

  • 이용득
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 1999.03a
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    • pp.149-152
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    • 1999
  • The effect of initial orientation on the microstructure and texture evolution of two ferritic stainless steels was investigated. the columnar and equiaxed crystal specimens which were prepared from continuous casting slab were hot rolled annealed cold rolled and annealed respectively. The rolling and recrystallization textures at each process stage were examined by orientation distribution function (ODF) and electron back-scattered diffraction (EBSD); The observation showed that the orientation density of the $\alpha$-fibre of hot rolled band of columnar crystal specimen was more pronounced than that of the equaxed one at the center layer. Nevertheless the cold rolled textures of Type 430 steel have demonstrated a rather similar development . Compared to Type 430 steel the development of the $\alpha$-fibre in the center layer of Type 409L steel was much more pronounced. The relation between texture evolution and ridging behaviour has been discussed.

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A Geometrical Center based Two-way Search Heuristic Algorithm for Vehicle Routing Problem with Pickups and Deliveries

  • Shin, Kwang-Cheol
    • Journal of Information Processing Systems
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    • v.5 no.4
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    • pp.237-242
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    • 2009
  • The classical vehicle routing problem (VRP) can be extended by including customers who want to send goods to the depot. This type of VRP is called the vehicle routing problem with pickups and deliveries (VRPPD). This study proposes a novel way to solve VRPPD by introducing a two-phase heuristic routing algorithm which consists of a clustering phase and uses the geometrical center of a cluster and route establishment phase by applying a two-way search of each route after applying the TSP algorithm on each route. Experimental results show that the suggested algorithm can generate better initial solutions for more computer-intensive meta-heuristics than other existing methods such as the giant-tour-based partitioning method or the insertion-based method.

Improved dynamical modeling of the Arches cluster

  • Lee, Joowon;Kim, Sungsoo S.;Shin, Jihye
    • The Bulletin of The Korean Astronomical Society
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    • v.39 no.2
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    • pp.76.2-76.2
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    • 2014
  • The Arches cluster is one of the compact, young, massive star clusters near the center of our galaxy. Since it is located only ~30 pc away in projection from the galactic center (GC), the cluster is an excellent target for studying the effects of star forming environment on, for example, the initial mass function under the extreme condition of GC. To estimate the initial condition of the Arches cluster, we compare our calculation results from the anisotropic Fokker-Planck method with the most recent observational data sets for the surface density and velocity dispersion profiles and the present-day mass function.

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RK- Methods for Robot Application problems

  • Senthilkumar, Sukumar;Lee, Malrey;Kwon, Tae-Kyu
    • International journal of advanced smart convergence
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    • v.2 no.1
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    • pp.18-20
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    • 2013
  • The significance, is to introduce a novel way to employ the improved Runge-Kutta fifth order five stage method, here after called as Modified IRK(5,5) method, for system of second order robot arm problem and variations in angles at the joints in which parameters governing with two degrees of freedom which requires lesser number of function evaluations per time step as compared to the existing ones, in order to save time and spaceAn ultimate aim of this present paper is to solve application problem such as robot arm and initial value problems by applying Runge-Kutta fifth order five stage numerical techniques. The calculated output for robot arm coincides with exact solution which is found to be better, suitable and feasible for solving real time problems.

A Study on Structural Analysis and Optimum Shape Design of Tilting Index Table (틸팅 인덱스 테이블 구조해석 및 최적형상 설계에 관한 연구)

  • Lee, Mun-Jae;Lee, Choon-Man
    • Journal of the Korean Society for Precision Engineering
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    • v.27 no.2
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    • pp.86-93
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    • 2010
  • The tilting index table has attached to CNC machining center with 3axes, it can be improvement of its performance and its machining efficiency. The tilting index table is a key unit in order to manufacture some non-rotational and 3-dimensional parts, using the conventional machining center. In this study, structural analysis is carried out by FEM simulation using the commercial software ANSYS Workbench 11 to develop tilting index table using direct drive motor. The shape of the tilting index table obtained from the optimization was analyzed and compared with the initial model. Also, the initial model was modified based on the optimization model and the result was verified to have the acceptable improvement.

The Effect of Initial DC Bias Voltage on Highly Oriented Diamond Film Growth on Silicon

  • Dae Hwan Kang;Seok Hong Min;Ki Bum Kim
    • The Korean Journal of Ceramics
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    • v.3 no.1
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    • pp.13-17
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    • 1997
  • It is identified that the diamond films grown o bias-treated (100) silicon showed different surface morphologies and film textures according to the initial applied dc bias voltage at the same growth condition. The highly oriented diamond film (HODF) was successfully grown on -200 V bias-treated silicon substrate in which the heteroepitaxial relation of $(100)_{dimond}//(100)_{si}\; and\; [110]_{diamond}//[110]_{si}$ was identified. On the contrary, the heteroepitaxial relation was considerably disturbed in the samples bias-voltage was a key factor in growing the highly oriented diamond film on (100) silicon substrate. Considering the experimental results, we proposed a new model about heteroepitaxial diamond growth on silicon, in which 9 diamond unit cell are matched with 4 silicon cells and the bond covalency of both atoms is satisfied via the intermediate layer at the interface as well.

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