• 공업화학
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• 제33권1호
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• pp.17-27
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• 2022

형광 이미징은 시간 분해능과 공간 해상도가 높기 때문에 기초연구에서 세포나 소동물 이미징에 널리 활용된다. 기존의 형광 이미징은 가시광선 영역의 광원을 활용하기 때문에 조직 내 광투과도가 낮고, 광원에 의한 광독성이 생길 수 있으며, 자가형광에 의한 간섭으로 검출 민감도가 떨어지는 한계가 있다. 이러한 점을 개선하기 위해 에너지가 낮은 장파장의 광원을 활용하고자 하며, 700~900 nm 영역을 활용하는 근적외선-I 형광 이미징이 개발되었고, 이미징 성능을 대폭 향상시키기 위해서 1000~1700 nm 영역의 장파장을 이용하는 근적외선-II 이미징이 연구자들의 관심을 받고 있다. 근적외선-II 영역은 광산란이 최소화되어 생체조직 내 투과도를 약 10 mm까지 향상시킬 수 있고, 생체조직의 자가형광도 최소화되어 고민감도와 고해상도의 형광 이미징이 가능하다. 본 총설에서는 다양한 근적외선-II 형광 이미징 탐침 중에서 광안정성이 뛰어나고 발광 파장 조절이 용이한 무기 나노입자 기반 탐침에 대해 살펴보았고, 그 중에서 단층 탄소 나노튜브와 양자점 및 란탄족 나노입자에 대해 중점적으로 기술하였다.

• Journal of the Korean Physical Society
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• 제73권12호
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• pp.1821-1826
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• 2018

Uniformity is a key feature of state-of-the-art infrared focal planed array (IRFPA) and infrared imaging system. Unlike traditional infrared telescope facility, a ground-based infrared radiant characteristics measurement system with an IRFPA not only provides a series of high signal-to-noise ratio (SNR) infrared image but also ensures the validity of radiant measurement data. Normally, a long integration time tends to produce a high SNR infrared image for infrared radiant characteristics radiometry system. In view of the variability of and uncertainty in the measured target's energy, the operation of switching the integration time and attenuators usually guarantees the guality of the infrared radiation measurement data obtainted during the infrared radiant characteristics radiometry process. Non-uniformity correction (NUC) coefficients in a given integration time are often applied to a specified integration time. If the integration time is switched, the SNR for the infrared imaging will degenerate rapidly. Considering the effect of the SNR for the infrared image and the infrared radiant characteristics radiometry above, we propose a-wide-dynamic-range NUC algorithm. In addition, this essasy derives and establishes the mathematical modal of the algorithm in detail. Then, we conduct verification experiments by using a ground-based MWIR(Mid-wave Infared) radiant characteristics radiometry system with an Ø400 mm aperture. The experimental results obtained using the proposed algorithm and the traditional algorithm for different integration time are compared. The statistical data shows that the average non-uniformity for the proposed algorithm decreased from 0.77% to 0.21% at 2.5 ms and from 1.33% to 0.26% at 5.5 ms. The testing results demonstrate that the usage of suggested algorithm can improve infrared imaging quality and radiation measurement accuracy.

• 센서학회지
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• 제27권5호
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• pp.280-293
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• 2018

The conversion of an invisible thermal radiation pattern of an object into a visible image using infrared (IR) thermal technology is very useful to understand phenomena what we are interested in. Although IR thermal images were originally developed for military and space applications, they are currently employed to determine thermal properties and heat features in various applications, such as the non-destructive evaluation of industrial equipment, power plants, electricity, military or drive-assisted night vision, and medical applications to monitor heat generation or loss. Recently, IR imaging-based monitoring systems have been considered for application in agricultural, including crop care, plant-disease detection, bruise detection of fruits, and the evaluation of fruit maturity. This paper reviews recent progress in the development of IR thermal imaging techniques and suggests possible applications of thermal imaging techniques in agriculture.

• 대한방사성의약품학회지
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• 제1권1호
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• pp.62-73
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• 2015

We developed an evans blue-indocyanine green-$^{99m}Tc$-human serum albumin conjugate for sentinel lymph node mapping and we describe its unique potential usage for clinical implications. This conjugate has combined the strengths of visible blue dye, near-infrared fluorescence and radioisotope into one single conjugate without any additional weakness/disadvantage. All the components of evans blue-indocyanine green-$^{99m}Tc$-human serum albumin are safe and of low cost, and they have already been clinically used. This conjugate was stable in the serum, it showed a long retention time in the lymphatic system and the lymph nodes showed a much higher signal-to-noise ratio after the conjugate was injected intradermally into the paw of mice. Both the single-photon emission computed tomography and near-infrared fluorescent images of the mice were successfully obtained at the same time as the excised sentinel lymph nodes showed blue color. The visual color, near-infrared fluorescence and gamma ray from this agent could be complementary for each other in all the steps of sentinel lymph node sampling: exploring and planning sentinel lymph node before excision with visualization of the exact sentinel lymph node location during an operation. Therefore, the triple modal agent will possibly be very ideal for sentinel lymph node mapping because of the high signal-to-noise ratio for non-invasive imaging and its complementary multimodal nature, easy preparation and safety. It is promising for clinical applications and it may have great advantages over the traditional single modal methods.

• 비파괴검사학회지
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• 제33권4호
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• pp.342-348
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• 2013

본 논문에서는 비접촉 비파괴검사에 사용되는 적외선열화상카메라의 응답 및 노이즈 특성을 평가할 수 있는 방법을 제시하고 있으며 차동모드흑체의 적외선 표적과 그 주변의 온도차 ${\Delta}$T를 이용하여 상용 적외선열화상카메라의 신호전달함수 및 온도분해능을 구하고 그 결과를 카메라 사양과 비교함으로써 본 평가 방법의 적합성을 검증하였다. 또한 비균일성 보정의 적용 유무로부터 나타나는 온도분해능의 차이 0.01 K을 통하여 적외선열화상카메라의 성능평가에 있어서 비균일성 보정이 필수적인 과정임을 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제15권1호
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• pp.97-104
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• 1994

In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensionaloptic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the infrared thermography system composed ofthe proposed optic system has the temperature resolution of $0.1{\circ}C$ under the spatial resolution of 1mrad, the image matrix size of $256{\times}240$, and the imaging time of 4 seconds.

• Journal of Chest Surgery
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• 제52권4호
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• pp.205-220
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• 2019

Near-infrared (NIR) fluorescence imaging provides a safe and cost-efficient method for immediate data acquisition and visualization of tissues, with technical advantages including minimal autofluorescence, reduced photon absorption, and low scattering in tissue. In this review, we introduce recent advances in NIR fluorescence imaging systems for thoracic surgery that improve the identification of vital tissues and facilitate the resection of tumorous tissues. When coupled with appropriate NIR fluorophores, NIR fluorescence imaging may transform current intraoperative thoracic surgery methods by enhancing the precision of surgical procedures and augmenting postoperative outcomes through improvements in diagnostic accuracy and reductions in the remission rate.

• 한국의학물리학회지:의학물리
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• 제5권1호
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• pp.13-24
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• 1994

고속촬영이 요구되는 일반적인 적외선 촬영시스템에서는 고속 광주사기에 적외선 광다발을 입력시키기 위해 고가이면서 가공이 어려운 적외선대역 렌즈를 사용하고 있다. 본 논문에서는 고속 촬영이 요구되지 않고 0.1$^{\circ}C$이하의 온도분해능이 크게 요구되는 의료용 적외선 체열촬영 시스템을 저가이면서 가공이 용이한 반사경을 이용한 광학계를 써서 구현하는 방법을 결과와 함께 제시하였다. 적외선 체열촬영시스템은 인체의 표피에서 복사되는 적외선의 양을 계측하여 인체의 표피 온도분포를 2차원 영상으로 보여준다. 구현한 적외선 체열촬영시스템으로 실험한 결과 영상의 화소수를 256$\times$240으로 하고 촬영시간을 4초로 했을 때 온도분해능이 0.1$^{\circ}C$이하인 것을 확인하였다. 인체의 여러 부위에 대한 체열 영상을 시각적으로 잘 보이게 하기 위해 16가지색으로 의사색체화를 하여 예시하였다.

• 대한방사선기술학회지:방사선기술과학
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• 제42권5호
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• pp.365-371
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• 2019

We have developed and applied a diagnostic Multi-Leaf Collimator (MLC) to optimized the X-ray field in medical imaging and the usefulness evaluated through the fusion of infrared image and X-ray image acquired by infrared camera. The hand and skull radiography with multi-leaf collimator(MLC) showed significant area dose reductions of 22.9% and 31.3% compared to ARC and leakage dose was compliant with KS A 4732. Also scattering doses of 50 cm and 100 cm showed a significant decrease to confirm the usefulness of MLC. It was confirmed that the fusion of infrared images with an adjustable degree of transparency was possible in the X-ray images. Therefore, fusion of anatomical information with physiological convergence is expected to contribute and improvement of diagnostic ability. In addition, the feasibility of convergence X-ray imaging and DITI devices and the possibility of driving MLC with infrared images were confirmed.

• Journal of Acupuncture Research
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• 제15권2호
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• pp.301-310
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• 1998

Infrared thermographic imaging visualizes noninvasively various abnormal condition by detecting the skin temperature. As the imaging represents the objective condition by the changes in blood flow under the control of autonomic nervous system, it is used to diagnosis and monitor the lumboscral radiculopathy. And asymmetry is important in the diagnosis of disc herniation. The most common type of disc herniation occurs psoterolaterally. This frequently causes nerve root compression leading to a radiculopathy in the distribution of the involved nerve root, most of which also provoke the asymmetric changes in thermography. Central disc herniation, which accounts for 5% to 35% of disc herniation, is typically associated with low back pain. But radiculopathy is usually abscent unless central disc heriniaton is large enough to cause compression of the cauda equina. To evalute the diagnostic value of the thermographic imaging in the diagnosis of central disc herniation, the imaging of 15 normal subjects and 48 patients with central disc herniation documented by CT scan were analyzed. The patients had either bilateral radiculophathy or no radiculopathy. The imaging of patient group with non rediculopathy did not show any significant thermal difference to control. While bilateral radiculopathy group reveled hypothermic pattern compared twith control. Thermal difference between left and right side did not present any significance in non radiculopathy group but hypothermia in bilateral radiculopathy group. Large herniation group demonstrated hyperthemic pattern while the others showed no significant change. Cranial caudal thermal difference did not show any difference between experiment groups. These results shows that infrared thermographic imaging can be used central disc herniation with bilateral radiculopathy, while it seems to little useful on the diagnosis of non radiculopathic disc herniation.