• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1158-1163
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• 2006

More than 95% of lead, a environmental heavy metal, entering into blood accumulates in erythrocytes suggesting erythrocytes as an important target of lead toxicity. Recent studies reported that erythrocytes could contribute to blood coagulation via phosphatidylserine (PS) exposure in erythrocytes. However, in vivo effects of chronic lead exposure especially by drink-ing water on procoagulant activity of erythrocytes have not been studied yet. In the present study, we investigated the effects of chronic exposure of lead by drinking water on erythrocytes in rats. Groups of 40 male rats were provided with drinking water containing various concentrations of lead for 4 weeks and complete blood cell count, procoagulant activities of erythrocytes and platelets were evaluated with basic inspections on body weight and food/water consumption. The administration of lead containing drinking water increased the blood lead level (BLL) in a dose-dependent manner up to $22.39{\pm}2.26\;{\mu}g/dL$. Water consumption was significantly decreased while food consumption or body weight gain was not affected. In contrast to the previous findings with acute lead exposure, chronic lead exposure failed to increase PS exposure in erythrocytes with statistical significance although some trends of enhancement were observed. It implies that a certain adaptation might have happened in body during repeated exposure to lead, resulting in attenuation of PS exposure. With this study, we believe that a valuable information was provided for the study on the toxicological significance and the risk assessment of lead contaminated drinking water.

• Archives of Pharmacal Research
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• v.26 no.4
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• pp.294-300
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• 2003

A polysaccharide fraction, AIP1, purified from Artemisia iwayomogi was shown to have immunomodulating and anti-tumor activities in mice. In order to determine how the AIP1 fraction exhibits the immunomodulating activity, the effect of the fraction on the apoptosis of mouse spleen cells was investigated. Treatment of the mouse spleen cells with the AIP1 fraction resulted ,in the suppression of apoptotic death and an extension of cell survival in culture, indicating that the fraction might modulate the death of spleen cells. Treatment of the mice with the AIP1 fraction in vivo also resulted in less apoptosis of the spleen cells, which indicates the physiological relevance of the anti-apoptosis effect of the fraction in vitro. A mouse gene array was used to determine the profile of the gene expression change showing a pattern of up- and down-regulated genes by the AIP1 treatment. This study provides preliminary information regarding the immunomodulatory mechanism of the AIP1 fraction.

• Korean Journal of Plant Taxonomy
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• v.43 no.4
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• pp.285-295
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• 2013

The genus Actinidia has been recorded as having total six taxa, composed of four species and two varieties, in Korea. However, its taxonomy remains complex because of disagreement on taxonomic characters used for species boundaries. Based upon morphological, anatomical, and palynological characters, we re-evaluated species delimitations in the genus Actinidia. Critical observation of wild populations and extensive herbarium materials including types were also carried out. It is generally considered that leaf thickness and shape, hair type and color were important diagnostic characters to identify species, but these characters were insufficient to be diagnostic characters because of their wide variation ranges. On the other hands, pith pattern, winter bud protrusion rate, scale leaf number, anther color, fruit shape, and maturity season were taxonomic significance. A. arguta var. platyphylla and A. arguta var. rufinervis have been identified by hair type and color, but these characters showed continuous variation in A. arguta. Therefore, two varieties are treated as synonyms of A. arguta. Consequently four species are recognized in Korea: A. polygama, A. kolomikta, A. rufa, and A. arguta. A key is provided, as well as complete descriptions of the species examined, including information on nomenclatural types, and synonymies.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.9 no.1
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• pp.61-66
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• 2015

Chest X-ray images is the most common and widely used in clinical findings for a wide range of anatomical information about the prognosis of the disease in patients with cardiopulmonary rehabilitation. Many analysis algorithm was developed by a number of studies regarding the region segmentation and image analysis, there are specific differences due to the complexity and diversity of the image. In this paper, a diagnosis support system of the chest X-ray image based on image processing and analysis methods to detect the cardiopulmonary disease. The threshold value and morphological method was applied to segment the pulmonary region in a chest X-ray image. Anatomical measurements and texture analysis was performed on the segmented regions. The effectiveness of the proposed method is shown through experiments and comparison with diagnosis results by clinical experts to show that the proposed method can be used for decision support system.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.6 no.1
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• pp.17-27
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• 2012

This study provides development information on Omni-Wheel Drive Rider Robot, futuristic electric scooters, with autonomous driving systems that are used for people including the disabled and senior. Also, it is meaningful in suggesting alternatives to replace motorized wheelchairs or electric scooters for the future. Prior to development of Omni-Wheel Drive Rider Robot with autonomous driving systems, it surveyed 49 people, including 18 people who own electric scooters and 31 senior people who have not. The summary of the survey is as follows. First, inconveniences during riding and exiting and short mileage due and safety driving to problems of recharging batteries are the most urgent task. For these problems, the study shows that charging time of batteries, mileage, armrests, footrests, angle of a seat are the primary considerations. Second, drivers prefer joystick over steering wheels because of convenience in one-handed driving against dangers from footrest and carriageways sloping roads, paving blocks. One-handed driving can reduce driving fatigues with automatic stop systems. Moreover, the study suggests many design factors related to navigation systems, obstacle avoidance systems, omni-wheels, automatic cover-opening systems in rainy.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.1097-1106
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• 2007

Rail provides running tract for train and broadly and widely conveys the weight of the train exerted from the train wheels that the rail directly supports onto the cross tie and roadbed, and supports the cross-sectional pressure exerted by centrifugal force at curvatures. That is, stationary rail provides surface on which dynamic train runs and guarantees cross-sectional resistance to enable the vertical snake motion of the train wheels as well as to maintain lateral force at curvatures. Rail provides running surface on which train wheels can run smoothly, and secures vertical and lateral force. However, it undergoes continuous destructive reactions (wearing and damages) and abrasion of the cladding by the train wheels. It is obvious that wearing will result when two metal parts act against each other. However, occurrence of abnormal wearing such as rapid wearing of the rail side due to complex generation of various mechanisms at the contact surface between the rail and train wheel flange. It is not easy to simply examine the causes of occurrence of abnormal wearing of rail and train wheel flange. Although countless number of academicians and specialists are conducting researches on abnormal wearing of rail and vertical wearing of train wheels, I believe it is too early to argue on pros and cons due to insufficiency of officially verified information on the issue. This review will be focusing on the examples of repairs that reduced the generation of abnormal wearing of rail by reviewing and improving characteristics of wearing and slack, speed of the train and cant as well as status of lubricator by choosing the compound curves present in the section between the $Anguk{\sim}Jongno3-ga$ Stations of the Route No. 3 among the compound curve tracks of the Seoul Metro Routes No. 3 & 4 at which abnormal wearing is generated continuously.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1437-1443
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• 2010

Thermal stresses due to the heat of hydration can cause extensive cracking in subway structures. In order to reduce heat cracks, construction methods (e.g. sequential or skipping construction methods) need to be changed. However, to our knowledge, the existing literature contains little information on the correlation between heat cracks and construction methods. Thus, in this study, the temperature crack index table was suggested based on construction lengths (6 m, 9 m and 18 m), concrete mixtures (Type I cement with FA of 20 % in cement weight, Type IV cement with FA of 10 % in cement weight, and mixture of three different cements), construction seasons (spring or autumn, summer and winter) and construction method (sequential or skipping construction methods). The index table can be easily used corresponding to changes in concrete placing method at the construction site. Also, the correlation of cracking due to sequential or skipping construction methods was derived based on the statistical approaches.

• International Journal of Knowledge Content Development & Technology
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• v.9 no.4
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• pp.95-114
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• 2019

The digitization of traditional medical knowledge in Tanzania will greatly enhance its preservation and dissemination. This is especially important given the challenges facing the current methods of preserving and managing such knowledge. This study presents the requirements engineering approaches and requirements for a web-mobile application that would successfully digitize indigenous knowledge of phytomedicine and relevant practitioners licensing and registration processes. To establish the requirements of such a digital system application, the study sought the opinion of 224 stakeholders whose suggestions were used to analyze and model the requirements for designing such a web-mobile tool. The study was carried out in Arusha, Kagera and Dar es Salaam regions of Tanzania which involved ethnobotanical researchers, herb practitioners, curators from herbaria and registrar officers from Traditional and Alternatives Health Practice Council. Structured interview, survey, observation and document review were employed to find out the basic functional and non-functional requirements for possible designing and implementation a web-mobile application that would digitize indigenous knowledge of medicinal plants. The requirements were modelled using the use case and context diagrams. Finally, the study came up with a list of items for both functional and non-functional requirements that can be used as guidelines to develop a web-mobile application that will capture and document traditional medical knowledge of medicinal plants in Tanzania and, enabling relevant authorities to regulate and manage stakeholders.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.640-649
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• 2010

Coarse granular materials such as gravel and crushed stone have been used as an important fill materials to large soil structure of railway, road, dam and so on. Although much studies for general soil materials have been carried out domestically, the studies for coarse materials were insufficient. Particularly, it is the level in which the study for dynamic properties(Elastic modulus and damping ratio) of coarse materials, applies the foreign country literature. This is due to the lack of large equipment for element test. But large soil structures made of coarse granular materials are generally important infrastructures. Therefore, the reliable design parameters for coarse materials should be obtained for safe and economic design, construction and maintenance. Triaxial test is the laboratory test method that is capable of controlling a confining pressure and boundary condition. In this project, we made a multi-purpose large triaxial testing system. This testing system is able to test coarse granular materials with maximum particle diameter of 100mm and support both the load control and displacement control. The load cell is installed inside of triaxial cell and the axial displacement is measured locally in order to control and measure more accurately in the small strain level. The verification test of this testing system was carried out with urethane verification specimens. So, from now on the useful information for coarse granular materials are expected to suggested by performing many tests with various material and condition.

• Journal of Korean Society of Archives and Records Management
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• v.1 no.1
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• pp.53-67
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• 2001

The idea of the vertical filing had been introduced in Japan at the beginning of the 20th century. This is regarded as a root of the management of business records and office works. After the Secund World War, The Occupied Army introduced the American method of the document management and the method as the filing system had been generalized among many offices. However, the filing method bad been regarded the needed skills for clerical staff. The business documents and records have increased in volumes and recognized their value as information resources in business and management. These movements have become a good grounding in introducing and development of records management. To spread the idea and method of records management in business offices, it is required that academic research and training systems must be developed and established. In such situation, The Records management Society, Japan has been established in1989 and the graduate corse on records management has been established in Surugadai Univ. in 1999. Those are the center of research and studying activities on records management in Japan.