• Journal of Microbiology and Biotechnology
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• v.29 no.1
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• pp.171-177
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• 2019

Parasitic infections have remained a significant burden on human and animal health. In part, this is due to lack of clinically-approved, novel antimicrobials and a lack of interest by the pharmaceutical industry. An alternative approach is to modify existing clinically-approved drugs for efficient delivery formulations to ensure minimum inhibitory concentration is achieved at the target site. Nanotechnology offers the potential to enhance the therapeutic efficacy of drugs through modification of nanoparticles with ligands. Amphotericin B, nystatin, and fluconazole are clinically available drugs in the treatment of amoebal and fungal infections. These drugs were conjugated with gold nanoparticles. To characterize these gold-conjugated drug, atomic force microscopy, ultraviolet-visible spectrophotometry and Fourier transform infrared spectroscopy were performed. These drugs and their gold nanoconjugates were examined for antimicrobial activity against the protist pathogen, Acanthamoeba castellanii of the T4 genotype. Moreover, host cell cytotoxicity assays were accomplished. Cytotoxicity of these drugs and drug-conjugated gold nanoparticles was also determined by lactate dehydrogenase assay. Gold nanoparticles conjugation resulted in enhanced bioactivity of all three drugs with amphotericin B producing the most significant effects against Acanthamoeba castellanii (p < 0.05). In contrast, bare gold nanoparticles did not exhibit antimicrobial potency. Furthermore, amoebae treated with drugs-conjugated gold nanoparticles showed reduced cytotoxicity against HeLa cells. In this report, we demonstrated the use of nanotechnology to modify existing clinically-approved drugs and enhance their efficacy against pathogenic amoebae. Given the lack of development of novel drugs, this is a viable approach in the treatment of neglected diseases.

• Journal of the Korean Society of Safety
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• v.36 no.4
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• pp.37-46
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• 2021

According to the Korean Statistical Information Service, the number of fatal occupational accidents per 100,000 workers is the highest in Korea, among all the OECD countries. The safety of construction workers is managed by the construction technology promotion act (CTPA) and the occupational safety and health act (OHSA). A review of the current safety management laws is required to improve them for the construction industry, where the numbers of accidents and deaths are constantly increasing. Accordingly, the aim of this study was to identify the problems in unclear business areas through comparison and analysis of the CTPA and OHSA guidelines and establish effective site-dependent construction safety management plans. The overlapping safety and health management terms and tasks of organizations were derived along with identifying the overlapping items of the safety management and hazard and risk prevention plans. Based on these results, several improvements for the design stage, safety cost, and safety education have been suggested in this paper. In addition, an improved model based on the integration and an optimized compromise between these two laws for safety management in areas where many accidents have occurred in recent years has been reported here.

• Journal of the Korea Institute of Building Construction
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• v.20 no.6
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• pp.527-535
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• 2020

This study analyzed main causes of claims in EPC/Turnkey projects. For this purpose, this study referred to the FIDIC silver book, which lists the international standard contract conditions for EPC/Turnkey projects. The most frequent cause of claim was delay. A process was then proposed to determine whether the owner or contractor was the responsible party when the delay claim occurred. The proposed process was for damages for delay which is the conditions of contract for indemnities against delay claim. The process was based on conditions of the contract of two previous EPC/Turnkey projects that were constructed in 2010, the FIDIC silver book, as well as the obligations of owner and contactors. The proposed process is applicable depending on the conditions of the contract and the owner's meaning. Furthermore, by identifying the responsible party, this study will contribute in identifying the possible claim types before concluding a contract and writing the specific contract.

• Journal of Distribution Science
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• v.18 no.12
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• pp.79-90
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• 2020

Purpose: This study aims to explore the service improvement and marketing strategy to measure the effect of the DISC (dominance, influence, steadiness, conscientiousness) behavior type of hair salon workers on service quality and marketing. Research design, data and methodology: 236 responses were analyzed by distributing questionnaires to hair salon workers through SNS. Factor analysis and reliability analysis were applied and the influence of job factors on work satisfaction and turnover intention, and the statistical significance of the DISC behavioral type adjustment effect verified. Results: First, among the general characteristics of the survey subjects, the most common respondents were women and interns in their twenties, with less than four years of experience and less than three years of work experience on site. Second, the working environment, employee relations and compensation policies caused by work-related factors have shown a major influence on work satisfaction. Third, the working environment and human relationships among the job factors have an impact on turnover intention. Conclusions: The working environment, human relations, and compensation system derived as job factors had a crucial effect in service quality and marketing on job satisfaction, and among job factors, working environment and human relations had a significant influence on turnover intention.

• Transactions of the Korean hydrogen and new energy society
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• v.31 no.6
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• pp.605-613
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• 2020

In July and October of this year, the government announced the 'Green new deal plan within the Korean new deal policy' and 'Strategies for proliferation of future vehicles and market preoccupation'. And, in response to changes in the global climate agreement, it has decided to expand green mobility such as electric vehicles and hydrogen electric vehicles with the aim of a "net-zero" society. Accordingly, the goal is to build 310 hydrogen refueling stations along with the supply of 60,000 hydrogen vehicles in 2022, and the hydrogen infrastructure is being expanded. however, it is difficult to secure hydrogen infrastructure due to expensive construction costs and difficulty the selection of a site. In Korea, it is possible to build a mobile hydrogen station according to the safety standards covering special case of the Ministry of Industry. Since the mobile hydrogen station can be charged while moving between authorized place, it has the advantage of being able to meet a large number of demands with only one hydrogen refueling station, so it is proposed as a model suitable for the early market of hydrogen infrastructure. This study demonstrates the establishment of a hydrogen refueling station by deriving a virtual accident scenario for leakage and catastrupture for each facility for the risk factors in a mobile hydrogen station, and performing a quantitative risk assessment through the derived scenario. Through the virtual accident scenario, direction of demonstration and implications for the construction of a mobile hydrogen refueling station were derived.

• Ecology and Resilient Infrastructure
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• v.7 no.4
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• pp.274-283
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• 2020

A large amount of fine dust is generated during the process of pavement cutting. Consequently, reducing the amount of fine dust generated during pavement cutting is crucial for the overall management of fine dust. Based on this premise, in this study, a conceptual model is proposed for a device that can be employed for recovering scattered dust generated at the site of pavement cutting. The economic feasibility associated with the incorporation of the proposed model was analyzed. Results obtained from the economic feasibility analysis of the proposed conceptual model indicate that the benefit ratio is 2.96, which is significantly higher than 1. The rate of return is found to be 62.78%, which significantly exceeds the minimum expected rate of return (i.e., 10%), as established on the basis of interviews conducted with companies that implement pavement cutting. Furthermore, the break-even point is found to be at approximately 21.6 months. Hence, the proposed pavement cutter, which features dust suction and a low noise level, is economically feasible.

• Journal of Digital Convergence
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• v.19 no.2
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• pp.463-469
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• 2021

The aesthetic value of Korea is rising in various fields through the use of designs using Korean materials. Korean materials contain oriental ideas and are widely used as materials for design development due to the uniqueness of its form. The purpose of this study is to present basic data of nail art design differentiated nail art designs required at the nail art industry site by producing nail works using Korean materials. Accordingly, We proceeded on the basis of theoretical consideration and empirical research for the development of nail art design, a field of beauty in this study, and made a Korean and unique nail art design work using the Four Gracious Plants. For this purpose, we considered theoretically the characteristics of nail art and the Gracious Plants, and made nail art design works derived from empirical research. The work was analyzed by color, texture, and design elements of form. Therefore, the mixed method of Nail Art and the Gracious Plants, which is the core of this study, is considered to be meaningful in laying the foundation for creative nail art design development.

• Food Science and Industry
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• v.54 no.4
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• pp.293-300
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• 2021

Food safety accidents have been increasing by 2% over 5,000 cases every year since 2009. Most people know that the best method to prevent food safety accidents is a quick inspection, but there is a lack of inspection technology that can be used at the non-analytic level to food production and distribution sites. Among the recent on-site diagnostic technologies, the methods for testing gene-based food poisoning bacteria were introduced with the STA technology, which can range from sample to detection. If food safety information can be generated without forgery by directly inspecting food hazard factors by remote, unmanned, not human, pollution sources can be managed by predicting risks more accurately from current big-data and artificial intelligence technology. Since this information processing can be used on smartphones using the current cloud technology, it is judged that it can be used for food safety to small food businesses or catering services.

• Journal of the Korea Society of Computer and Information
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• v.27 no.4
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• pp.27-36
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• 2022

In this paper, to improve the conditions of the fish processing site, we propose a method to predict the cutting point of fish according to the target weight using AI machine vision. The proposed method performs image-based preprocessing by first photographing the top and front views of the input fish. Then, RANSAC(RANdom SAmple Consensus) is used to extract the fish contour line, and then 3D external information of the fish is obtained using 3D modeling. Next, machine learning is performed on the extracted three-dimensional feature information and measured weight information to generate a neural network model. Subsequently, the fish is cut at the cutting point predicted by the proposed technique, and then the weight of the cut piece is measured. We compared the measured weight with the target weight and evaluated the performance using evaluation methods such as MAE(Mean Absolute Error) and MRE(Mean Relative Error). The obtained results indicate that an average error rate of less than 3% was achieved in comparison to the target weight. The proposed technique is expected to contribute greatly to the development of the fishery industry in the future by being linked to the automation system.

• Journal of Industrial Convergence
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• v.20 no.6
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• pp.117-123
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• 2022

Appearance, which is directly related to competitiveness, has become one of the essential self-care for modern people living in the era of the 4th industrial revolution. For the purpose of producing more practical and convenient wigs for suffering customers, data of research subjects were collected through an information search portal site. The trend of new material development of leading wig companies was analyzed. As a result of the study, it was found that many applications for wig attachment and binding technology were applied before 2005, artificial hair-related manufacturing technology for wigs from 2006 to 2013, and functional-related wig technology after 2014. In addition, both H and M companies showed the development trend of new materials for shape memory materials and nanoskins with their own characteristics. We believe that this study will be provided as basic data for the development of functional wigs that can lead to customer satisfaction while providing customers with a comfortable and convenient fit in the wig industry market.