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The Anti-Cancer Effect of β-Gluconsan Calcium on Oral Cancer Cell (β-Gluconsan Calcium이 구강암 세포의 성장에 미치는 영향)

  • Kim, Ji-Hye;Jung, Yun-Sook;Kim, Hye-Young;Lee, Young-kyun;Kim, Jae-Young;Choi, Youn-Hee;Song, Keun-Bae
    • Journal of dental hygiene science
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    • v.15 no.6
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    • pp.794-799
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    • 2015
  • In recent years, there has been a global trend toward the importance of natural extracts for the prevention and treatment of human diseases. ${\beta}$-glucan is known to have anti-inflammatory activity, anti-cancer, and improvement of immune system. Polycan is purified ${\beta}$-glucan from Aureobasidum pullulans SM-2001. The anti-cancer effects of ${\beta}$-gluconsan calcium, polycan and calcium gluconate complex, were evaluated in human oral cancer YD-10B cells. YD-10B cells were cultured in the presence of 0, 0.5, 0.75, 1 mg/ml ${\beta}$-gluconsan calcium for 48 hours. MTT assay, cell counting, and observation of cell morphology were conducted. The number of cells decreased and cell morphology changed in the 0.5 mg/ml of ${\beta}$-gluconsan calcium. Almost all cells were dead in the 0.75 and 1 mg/ml. MTT assay showed a dose-dependent reduction in cell proliferation (p<0.05). These results indicate that ${\beta}$-gluconsan calcium exhibiting anti-cancer effects in YD-10B cells through changes in cell morphology and cell death.

The Thermodynamics of the Formation of Polymethylbenzene-Halogens Charge Transfer Complexes (III) (폴리메틸벤젠과 할로겐 사이의 전하이동착물 생성에 관한 열역학적 연구 (제3보))

  • Oh Cheun Kwun;Jin Burm Kyong;Jung Sung Kim
    • Journal of the Korean Chemical Society
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    • v.25 no.6
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    • pp.351-360
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    • 1981
  • Ultraviolet spectrophotometric investigations have been carried out on the system of durene with iodine, bromine, iodine monochloride and iodine monobromide in carbon tetrachloride. The results reveal the formation of the charge transfer complexes of the type, $C_6H_2(CH_3)_4{\cdot}X_2$ or $C_6H_2(CH_3)_4{\cdot}IX$(X denotes halogen atoms). The equilibrium constant were obtained in consideration of that absorption maxima due to the formation of the charge transfer complexes shift to blue with the increasing temperatures. The thermodynamic parameters, ${\Delta}H,\;{\Delta}G\;and\;{\Delta}S$ for the formation of the charge transfer complexes were calculated from these values. These results indicate that the relative stabilities of the durene complexes at each temperature decrease in the order, $ICl>IBr>I_2>Br_2$. This order may be a measure of their relative acidities toward durene, which is explained in terms of the relative polarizabilities of halogen molecules and the relative electronegativities of halogen atoms. These results combined with previous study of this series indicated that the relative stabilities of the polymethylbenzene complexes with iodine increase in the order; Benzene

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Wife-older Marriage and Economic Factors : Empirical Analysis (우리나라 여성연상 결혼의 경제적 요인 : 실증분석)

  • Sung, Nak-Il;Jo, Dong-Hyuk
    • Korea journal of population studies
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    • v.33 no.3
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    • pp.1-30
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    • 2010
  • This study examines difference in age at marriage between spouses and more importantly, investigates into the economic and social factors affecting the ratio or probability of wife-older marriages. Empirical analysis is carried out by applying both logit model and multinomial logit model to an independently pooled cross-section over 2004-2007. The data was collected mainly from the micro data service system of the Statistics Korea. Empirical results indicate that a wife-older marriage was more likely as a wife was more educated and was a larger income earner than a husband. On the other hand, a wife's educational and income level themselves had few systematic relationships with the probability of a wife-older marriage. The probability of a wife-older marriage tended to decrease(increase) when a husband's(a wife's) marriage was the second' The study calculates the average marginal effect of difference in the income level between spouses on the probability of a wife-older marriage, which is -0.007. That is, the probability of a wife-older marriage increases by 0.7% as a husband's income level is 1 million Korean Won less than a wife's. This results presents empirical evidence against widely distributed misconception on wife-older marriage in the mass media.

Trends of Supply and Demand of Aggregate in Korea (I) (국내 골재자원의 수급현황(I))

  • Hong, Sei Sun;Kim, Ju Yong;Lee, Jin Young
    • The Journal of the Petrological Society of Korea
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    • v.24 no.3
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    • pp.253-272
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    • 2015
  • The necessity of aggregate resources in Korea has been increased with a rapid economic growth since the 1990s. Construction activities have been increased drastically for last two decades. Such economic activities are much concentrated at big cities in Korea, and recently new neighbouring cities, such as multifunctional administrative city, enterprise city and innocity, are under construction at the surroundings of the cities. This new urbanization asked for an appropriate supply of raw construction materials such as cement, sands and gravels. The aim of this study is to understand and discuss the analysis and prospect of supply and demand of domestic sand and gravel. On the early years, 1990s, about 25% of the total consumption of these sands and gravels comes from riverine deposits; 20% to 25% from marine sands, 40% to 45% from forest rocks and the rest 5% to 15% from old fluvial deposits and crushed rocks. But nowaday the river aggregate, including both sands and gravels of a present river channel and those of the old fluviatile system are decreasing, while the crushed and forest aggregates and marine sand are now the main source of infrastructure resources. Thus it is increasingly necessary to investigate the forest and crushed aggregate resources potential in Korea where a current analysis indicate that the supply of riverine aggregates gradually decreases.

Effect on the Measurement of Trace Element by Pressure Bomb and Conventional Teflon Vial Methods in the Digestion Technique (압력용기 산분해법과 테플론 바이알에서의 산분해법이 미량원소의 함량측정에 미치는 영향)

  • Lee, Seung-Gu;Kim, Taehoon;Tanaka, Tsuyoshi;Lee, Seung Ryeol;Lee, Jong Ik
    • The Journal of the Petrological Society of Korea
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    • v.25 no.2
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    • pp.107-119
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    • 2016
  • Trace element abundances in the igneous rocks are important data for petrogenetic interpretation. Their concentrations are generally measured using ICP-MS from the dissolved solution. The acid digestion of rock powder can be performed by conventional teflon vial or pressure bomb. In this paper, we investigated a problem that happened during acid digestion experiment using conventional teflon vial or pressure bomb of BCR2 and GSP2 USGS rock standard materials. The results show that the measured concentrations of the elements like Cr, Ni, Zn, Ta, W in the BCR2 are different from the recommended values of USGS whereas those of the elements like Rb, Sr, Zr, Hf, Ta, W in the GSP2 are different from those values. Our experiment shows that defect of specific elements like Cr, Ni may happen during the sample digestion. Our results also indicate that the Cr, Ni, W, Zr, Hf, Ta concentration obtained based on an acid digestion of geological samples need to be careful in their geochemical interpretation.

The Study on the Possibility of Using Satellite in Monitoring Precursor of Magma Activity in the Baegdusan Volcano (인공위성을 이용한 백두산 화산 마그마 활동의 전조현상 인지 가능성 연구)

  • Lee, Deok-Su;Choi, Sung-Chan;Oh, Chang-Whan;Seo, Min-Ho;Ryu, In-Chang
    • The Journal of the Petrological Society of Korea
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    • v.22 no.1
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    • pp.35-47
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    • 2013
  • The Baegdusan Volcano which erupted violently at 1000 AD is still have possibility of eruption. Therefore, it is necessary to monitor regularly the possibility of eruption. However, it is very difficult to install regular monitoring system or to get regularly monitored data due to geopolitic problems. This is why we have to develop regular monitoring technique using satellite. The geoid in the Baegdusan Volcanic area calculated from gravity data obtained from GRACE satellite, decreased from 2002 to 2005. The period of decreasing is well matched with time when magma activities were recognized in the Baegdusan Volcanic area. The decrease in geoid is interpreted to be caused by the decrease of water storage. Considering that the amount of rainfall from 2002 and 2005 is almost constant, the decrease in geoid may be related to the magma activity under the Baegdusan Volcano. The geomagnetic total force in the Baegdusan Volcanic area measured by CHAMP satellite, decreased from 2000 to 2005 and increased after 2005. The period of decrease is well matched with the time with increased activity of magma chamber under the Baegdusan Volcano indicating that the decrease of geomagnetic total force is caused by demagnetization of surrounding rocks due to the increase of temperature of magma chamber. These data indicate the possbility of using change of geoid and geomagnetic total force observed by GRACE and CHAMP satellites for the monitoring of magma activity under the Baegdusan Volcano.

Synthesis and Properties of SrMoO4 Phosphors Doped with Various Rare Earth Ions for Anti-Counterfeiting Applications (위조 방지 분야에 응용 가능한 다양한 희토류 이온이 도핑된 SrMoO4 형광체의 제조 및 특성)

  • Moon, Tae-Ok;Jung, Jae-Yong;Cho, Shinho
    • Korean Journal of Materials Research
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    • v.30 no.8
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    • pp.406-412
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    • 2020
  • SrMoO4:RE3+ (RE=Dy, Sm, Tb, Eu, Dy/Sm) phosphors are prepared by co-precipitation method. The effects of the type and the molar ratio of activator ions on the structural, morphological, and optical properties of the phosphor particles are investigated. X-ray diffraction data reveal that all the phosphors have a tetragonal system with a main (112) diffraction peak. The emission spectra of the SrMoO4 phosphors doped with several activator ions indicate different multicolor emissions: strong yellow-emitting light at 573 nm for Dy3+, red light at 643 nm for Sm3+, green light at 545 nm for Tb3+, and reddish orange light at 614 nm for Eu3+ activator ions. The Dy3+ singly-doped SrMoO4 phosphor shows two dominant emission peaks at 479 and 573 nm corresponding to the 4F9/26H15/2 magnetic dipole transition and 4F9/26H13/2 electric dipole transition, respectively. For Dy3+ and Sm3+ doubly-doped SrMoO4 phosphors, two kinds of emission peaks are observed. The two emission peaks at 479 and 573 nm are attributed to 4F9/26H15/2 and 4F9/26H13/2 transitions of Dy3+ and two emission bands centered at 599 and 643 nm are ascribed to 4G5/26H7/2 and 4G5/26H9/2 transitions of Sm3+. As the concentration of Sm3+ increases from 1 to 5 mol%, the intensities of the emission bands of Dy3+ gradually decrease; those of Sm3+ slowly increase and reach maxima at 5 mol% of Sm3+ ions, and then rapidly decrease with increasing molar ratio of Sm3+ ions due to the concentration quenching effect. Fluorescent security inks based on as-prepared phosphors are synthesized and designed to demonstrate an anti-counterfeiting application.

Controlled Release of Cefadroxil from Chitosan Beads in Dogs (개에서 키토산 비드를 이용한 cefadroxil 방출제어)

  • Kim Dae-Keun;Park Seung-Chun;Kim Tae-Wan;Lee Keun-Woo;Oh Tae-Ho
    • Journal of Veterinary Clinics
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    • v.22 no.3
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    • pp.175-180
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    • 2005
  • The purpose of this study is to investigate the effects of formulation variables on the release of cefadroxil form chitosan beads, to optimize the preparation of chitosan beads loaded with the drug for controlled release, and to evaluate the drug release form chitosan beads in dogs. Chitosan beads were prepared with tripolyphosphate (TPP) by ionic cross-linking and those sizes were less than 1 mm in diameter. The release behaviour of cefadroxil was affected various factors. As pH of TPP solutions decreased, the entrapment efficiency of cefadroxil increased, whereas the release of cefadroxil decreased. The release rate of cefadroxil form chitosan beads decreaed with the increased TPP solution concentration. When cross-linking time increased, the release of the drug from chitosan beads decreased. The cefadroxil loaded beads were implanted to 4 mixed breed dogs. The concentration of cefadroxil in sera due to chitosan beads implanted with 50 mg/kg body weight of beads was sustained more than 1 ug/ml for the whole 7 days period. Therefore, the cefadroxil loaded beads can be used successfully in pyoderma of dogs. These results indicate that chitosan beads may become a potential delivery system to control the release of drug.

Korean Companies' Understanding of Carbon Pricing and Its Influence on Policy Acceptance and Practices (한국 기업의 탄소가격 정책에 대한 이해가 정책 수락 및 대응에 미치는 영향)

  • Suk, Sunhee
    • Environmental and Resource Economics Review
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    • v.26 no.4
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    • pp.577-612
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    • 2017
  • In response to climate change, Korea is attempting to shift the paradigm of energy and climate change policies by introducing carbon pricing based on market mechanisms. While policy adoption is proceeding at a rapid pace, the introduction of carbon pricing has been faced with great opposition from industry. This study measures to what extent Korean companies understand and accept carbon pricing, using data from a questionnaire survey covering energy consuming companies in 2012, when discussions between the government and such companies about the introduction of a domestic emission trading system were active. It further identifies how preparations and practices for carbon and energy management of companies correlate with their policy understanding and acceptance. The analysis results show that the surveyed companies indicate moderate understanding of, as well as resistance to carbon pricing policies, while appreciating the economic incentives and accepting the mandatory regulations in this phase. Companies' understanding is more related to characteristics, i.e., sector, size, etc. than external pressures. This study found that the extent to which companies understand policy is the essential factor in their policy acceptance and related practices. In particular, understanding of carbon policy significantly influences their managerial practices and voluntary activities for carbon and energy practices. This study substantiates the correlation between the level of policy understanding of a company and its carbon and energy practices - something that all countries seeking to introduce carbon pricing in response to climate change should consider prior to policy actually being implemented; in other words, enhancing the understanding of major policy subjects of the new instrument is a key policy strategy that should be elaborated as it will lead to better performance of companies and smoother policy implementation.

Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats

  • Lu, Huan-Jun;Li, Mei-Han;Li, Mei-Zhi;Park, Sang Eon;Kim, Min Sun;Jin, Yuan-Zhe;Park, Byung Rim
    • The Korean Journal of Physiology and Pharmacology
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    • v.19 no.5
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    • pp.427-434
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    • 2015
  • Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.